GREMLIN Database
SSRP - SsrA-binding protein
UniProt: O32230 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (146)
Sequences: 3057 (1602)
Seq/√Len: 132.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_L63_M2.5621.00
49_S63_M2.5031.00
24_T120_L2.3831.00
138_R142_K2.3101.00
142_K146_E2.2641.00
22_E103_Y2.2321.00
44_V110_L2.1831.00
21_I108_L2.1611.00
57_E83_K2.1551.00
58_V86_M2.1291.00
109_K120_L2.1281.00
134_E138_R2.1071.00
21_I124_G1.9671.00
21_I122_G1.9511.00
30_V83_K1.8931.00
88_R92_N1.8261.00
61_H81_T1.8251.00
36_I117_A1.8111.00
52_K61_H1.7831.00
60_L119_V1.7721.00
51_A58_V1.7421.00
141_A145_I1.7331.00
22_E125_K1.6931.00
53_I58_V1.6861.00
51_A121_L1.6771.00
16_N24_T1.6481.00
39_I44_V1.6321.00
34_T76_H1.6211.00
14_K18_D1.6191.00
9_L112_L1.5921.00
136_L139_K1.5841.00
58_V91_I1.5691.00
34_T71_G1.5341.00
95_I99_K1.5281.00
26_E111_Y1.5211.00
53_I91_I1.4871.00
54_E81_T1.4721.00
11_Q16_N1.4691.00
36_I112_L1.4691.00
136_L140_D1.4641.00
25_Y94_L1.4641.00
127_K135_D1.4551.00
64_H79_L1.4191.00
27_T86_M1.3761.00
20_F125_K1.3721.00
11_Q109_K1.3671.00
34_T75_N1.3461.00
145_I148_A1.3441.00
29_I119_V1.3351.00
105_L121_L1.2931.00
141_A148_A1.2861.00
103_Y125_K1.2851.00
46_L63_M1.2811.00
92_N96_G1.2791.00
9_L117_A1.2691.00
140_D144_E1.2571.00
51_A105_L1.2451.00
137_K141_A1.2321.00
86_M91_I1.2221.00
87_H116_F1.2201.00
97_L100_E1.2171.00
135_D138_R1.2111.00
110_L119_V1.2020.99
25_Y86_M1.1970.99
97_L123_L1.1810.99
6_G109_K1.1640.99
71_G75_N1.1280.99
39_I65_V1.1230.99
36_I39_I1.1210.99
41_A69_E1.1080.99
134_E137_K1.0960.99
144_E147_R1.0890.99
50_F61_H1.0790.99
26_E87_H1.0750.99
45_N48_D1.0690.99
142_K145_I1.0580.99
53_I105_L1.0530.99
140_D143_R1.0380.99
21_I24_T1.0200.98
108_L122_G1.0130.98
16_N21_I1.0040.98
59_F81_T1.0030.98
8_V11_Q0.9920.98
98_T105_L0.9760.98
143_R146_E0.9730.98
39_I112_L0.9660.98
63_M110_L0.9610.98
54_E61_H0.9580.97
40_R112_L0.9550.97
92_N95_I0.9400.97
39_I117_A0.9370.97
20_F135_D0.9340.97
90_E93_K0.9320.97
94_L105_L0.9190.97
9_L40_R0.9180.97
67_P77_D0.9150.97
64_H78_P0.9120.97
56_G95_I0.9060.96
111_Y120_L0.9030.96
86_M123_L0.8940.96
14_K47_K0.8880.96
139_K142_K0.8750.96
41_A70_Q0.8660.95
58_V105_L0.8620.95
24_T109_K0.8580.95
72_N75_N0.8580.95
52_K81_T0.8540.95
6_G113_K0.8440.95
110_L117_A0.8390.95
29_I117_A0.8350.94
9_L110_L0.8340.94
68_Y71_G0.8330.94
146_E150_R0.8240.94
29_I84_L0.8240.94
135_D139_K0.8220.94
8_V109_K0.8110.94
25_Y123_L0.8090.94
44_V63_M0.8040.93
10_S44_V0.7990.93
27_T119_V0.7970.93
20_F127_K0.7960.93
59_F83_K0.7860.93
95_I98_T0.7810.92
101_K125_K0.7810.92
32_Q76_H0.7750.92
145_I149_F0.7700.92
96_G100_E0.7680.92
26_E113_K0.7620.91
49_S107_P0.7450.90
18_D129_N0.7450.90
43_R66_S0.7390.90
25_Y90_E0.7360.90
89_K92_N0.7290.89
50_F62_N0.7270.89
112_L116_F0.7200.89
104_S124_G0.7100.88
107_P119_V0.7090.88
94_L98_T0.6990.87
112_L117_A0.6950.87
15_A108_L0.6880.87
106_V124_G0.6860.86
60_L82_R0.6850.86
14_K17_H0.6830.86
96_G99_K0.6790.86
113_K116_F0.6760.86
29_I110_L0.6740.85
79_L82_R0.6740.85
67_P78_P0.6700.85
89_K97_L0.6640.85
100_E103_Y0.6640.85
18_D47_K0.6640.85
97_L101_K0.6620.84
97_L103_Y0.6580.84
47_K79_L0.6580.84
34_T73_R0.6560.84
16_N108_L0.6520.83
104_S126_G0.6500.83
30_V116_F0.6470.83
45_N64_H0.6450.83
24_T122_G0.6420.83
94_L123_L0.6330.82
67_P76_H0.6320.82
34_T74_Y0.6190.80
38_S66_S0.6160.80
53_I95_I0.6150.80
56_G88_R0.6110.79
15_A106_V0.6110.79
87_H90_E0.6100.79
17_H20_F0.6060.79
10_S49_S0.6060.79
34_T72_N0.6050.79
146_E149_F0.6040.79
10_S26_E0.6040.79
96_G123_L0.6000.78
138_R141_A0.5970.78
112_L115_G0.5940.77
27_T105_L0.5940.77
58_V87_H0.5900.77
23_E93_K0.5900.77
38_S68_Y0.5880.77
16_N139_K0.5790.76
32_Q80_R0.5760.75
9_L39_I0.5760.75
56_G96_G0.5740.75
46_L145_I0.5670.74
45_N66_S0.5650.74
39_I66_S0.5620.73
48_D63_M0.5590.73
143_R147_R0.5570.73
13_K17_H0.5500.72
17_H135_D0.5490.72
26_E120_L0.5450.71
15_A124_G0.5430.71
25_Y93_K0.5420.71
62_N79_L0.5410.71
140_D147_R0.5400.71
47_K66_S0.5360.70
37_K90_E0.5350.70
9_L44_V0.5330.70
32_Q72_N0.5330.70
32_Q82_R0.5310.69
17_H132_K0.5300.69
20_F124_G0.5280.69
144_E148_A0.5240.68
17_H127_K0.5220.68
46_L66_S0.5180.67
20_F103_Y0.5180.67
103_Y128_K0.5140.67
9_L13_K0.5130.67
38_S67_P0.5100.66
83_K91_I0.5100.66
16_N135_D0.5090.66
39_I110_L0.5080.66
18_D50_F0.5060.66
7_K42_G0.5060.66
22_E97_L0.5060.66
108_L124_G0.5030.65
17_H136_L0.5000.65
34_T112_L0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p6vA 1 0.7949 100 0.053 Contact Map
1j1hA 1 0.7821 100 0.065 Contact Map
1wjxA 1 0.7115 100 0.197 Contact Map
4q28A 1 0.3462 7.7 0.961 Contact Map
1pmhX 1 0.4103 5.1 0.964 Contact Map
4cycA 1 0.3269 4.7 0.964 Contact Map
4pasA 1 0.2244 3 0.968 Contact Map
1t6aA 1 0.4359 2.5 0.969 Contact Map
3wx4A 2 0.2051 2.3 0.97 Contact Map
1ri9A 1 0.3333 2.2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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