GREMLIN Database
YVAE - Uncharacterized membrane protein YvaE
UniProt: O32227 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (103)
Sequences: 4697 (3238)
Seq/√Len: 319.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_S99_S2.8481.00
12_F41_G2.6141.00
48_L51_K2.5441.00
75_F82_V2.3131.00
5_F48_L2.2861.00
19_S34_L2.2591.00
2_N52_S2.1901.00
15_A38_F2.0731.00
73_V77_F1.9751.00
10_I65_M1.9171.00
71_T90_I1.8971.00
92_L96_G1.7021.00
50_L58_A1.7001.00
53_I58_A1.6921.00
44_F48_L1.6061.00
16_G38_F1.5911.00
91_G95_A1.5491.00
26_F32_S1.5001.00
39_Y43_L1.4981.00
30_I34_L1.4951.00
84_V88_I1.4861.00
18_V22_L1.4781.00
36_I40_G1.4551.00
50_L55_V1.4501.00
18_V73_V1.4301.00
15_A34_L1.4221.00
92_L95_A1.4201.00
28_K31_P1.4001.00
20_M35_L1.3961.00
16_G39_Y1.3571.00
23_S32_S1.3531.00
5_F45_F1.3441.00
14_V69_L1.3361.00
23_S26_F1.3331.00
49_T58_A1.3271.00
89_S103_I1.3191.00
12_F38_F1.3161.00
22_L78_F1.2831.00
89_S96_G1.2651.00
98_V102_L1.2521.00
93_I96_G1.2361.00
87_V91_G1.2301.00
83_S86_K1.2161.00
85_M103_I1.1921.00
29_L32_S1.1771.00
86_K100_L1.1741.00
93_I97_V1.1661.00
15_A19_S1.1221.00
90_I100_L1.1181.00
67_I71_T1.0951.00
40_G44_F1.0901.00
81_H86_K1.0751.00
46_L58_A1.0691.00
30_I33_L1.0391.00
24_S28_K1.0371.00
82_V87_V1.0271.00
89_S93_I1.0241.00
85_M88_I1.0221.00
74_G80_E1.0091.00
80_E86_K0.9921.00
67_I94_I0.9741.00
3_W61_V0.9431.00
4_V8_L0.9341.00
72_V76_L0.9301.00
19_S22_L0.9281.00
68_V90_I0.9081.00
56_S60_A0.8971.00
21_K25_G0.8951.00
7_C65_M0.8891.00
84_V87_V0.8861.00
82_V86_K0.8831.00
29_L33_L0.8731.00
33_L37_F0.8651.00
8_L45_F0.8561.00
27_T32_S0.8541.00
55_V70_I0.8541.00
24_S27_T0.8521.00
57_V86_K0.8461.00
7_C10_I0.8451.00
73_V78_F0.8381.00
95_A99_S0.8371.00
10_I42_S0.8261.00
60_A63_S0.8201.00
89_S92_L0.8161.00
61_V65_M0.8131.00
19_S38_F0.8121.00
2_N53_I0.7831.00
54_D57_V0.7630.99
14_V73_V0.7600.99
9_A45_F0.7510.99
81_H84_V0.7450.99
27_T51_K0.7430.99
64_G97_V0.7360.99
19_S35_L0.7350.99
85_M89_S0.7270.99
32_S35_L0.7230.99
76_L79_Q0.7120.99
74_G78_F0.7070.99
6_L49_T0.7060.99
17_T70_I0.7050.99
13_E42_S0.7030.99
75_F87_V0.6990.99
2_N5_F0.6900.99
99_S103_I0.6860.99
101_N104_E0.6840.99
94_I98_V0.6810.99
37_F41_G0.6750.99
19_S23_S0.6710.99
27_T31_P0.6700.99
68_V94_I0.6700.99
34_L38_F0.6680.99
20_M62_W0.6640.99
39_Y63_S0.6630.99
26_F31_P0.6630.99
63_S70_I0.6610.98
18_V78_F0.6580.98
11_L69_L0.6530.98
5_F49_T0.6530.98
88_I92_L0.6490.98
18_V74_G0.6350.98
55_V78_F0.6310.98
23_S27_T0.6240.98
80_E83_S0.6200.98
92_L99_S0.6170.98
65_M69_L0.6070.97
39_Y55_V0.6070.97
48_L52_S0.6000.97
17_T39_Y0.5980.97
9_A46_L0.5790.97
64_G67_I0.5740.96
23_S28_K0.5740.96
57_V60_A0.5730.96
33_L36_I0.5680.96
20_M43_L0.5660.96
16_G35_L0.5610.96
60_A90_I0.5580.96
11_L15_A0.5530.96
54_D104_E0.5510.95
63_S74_G0.5500.95
18_V21_K0.5310.94
19_S36_I0.5300.94
60_A100_L0.5250.94
23_S35_L0.5240.94
43_L50_L0.5230.94
10_I97_V0.5230.94
75_F81_H0.5220.94
2_N49_T0.5160.94
74_G86_K0.5140.93
6_L58_A0.5130.93
69_L73_V0.5090.93
26_F29_L0.5090.93
75_F80_E0.5060.93
20_M42_S0.5010.93
18_V55_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.8571 99.9 0.371 Contact Map
2i68A 2 0.6555 99.9 0.388 Contact Map
4ikvA 1 0.916 12.7 0.929 Contact Map
1pw4A 1 0.9832 8.6 0.934 Contact Map
4bgnA 3 0.7395 8.2 0.934 Contact Map
4tphA 2 0.8487 8 0.935 Contact Map
2cfqA 1 0.9664 7.5 0.935 Contact Map
2r9rB 3 0.7059 7.4 0.936 Contact Map
4xnjA 1 0.8908 6.5 0.937 Contact Map
4nv5A 1 0.9496 6.2 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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