GREMLIN Database
IOLW - scyllo-inositol 2-dehydrogenase (NADP(+))
UniProt: O32223 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (315)
Sequences: 25021 (18646)
Seq/√Len: 1050.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_E92_A3.0921.00
134_R192_D2.8681.00
91_M119_A2.8571.00
15_K40_Q2.8221.00
87_Y115_T2.7721.00
203_A226_D2.7721.00
141_T144_K2.7451.00
114_E335_I2.6851.00
153_D252_K2.6791.00
95_Q119_A2.6131.00
49_T53_K2.6011.00
81_T89_H2.4091.00
17_G68_I2.4051.00
143_K147_S2.4001.00
87_Y112_E2.3981.00
91_M95_Q2.3681.00
91_M115_T2.3531.00
99_H126_L2.3171.00
94_I125_V2.3001.00
223_L344_A2.2891.00
346_E350_E2.2161.00
64_E67_E2.1841.00
85_L89_H2.1291.00
13_T40_Q2.1111.00
43_K62_V2.1091.00
118_R122_E2.0851.00
121_D332_E2.0551.00
144_K148_E2.0391.00
319_E323_E2.0211.00
87_Y91_M1.9731.00
141_T145_L1.9631.00
60_E71_D1.9601.00
94_I120_A1.9491.00
76_L317_I1.9381.00
90_T102_M1.9351.00
114_E339_R1.9301.00
114_E118_R1.9031.00
119_A123_K1.9011.00
88_E92_A1.8481.00
81_T85_L1.8271.00
17_G74_I1.8161.00
151_L251_G1.7731.00
95_Q123_K1.7661.00
99_H125_V1.7581.00
48_R51_E1.7241.00
16_V76_L1.7111.00
33_L78_I1.7081.00
227_Y232_A1.7061.00
110_A342_E1.6991.00
77_V93_C1.6911.00
109_T112_E1.6651.00
90_T116_L1.6571.00
74_I98_K1.6471.00
202_K226_D1.6441.00
127_L331_A1.6331.00
63_H67_E1.6301.00
39_Y318_A1.6291.00
36_L315_R1.6181.00
200_M336_N1.6041.00
142_I256_F1.5981.00
70_N96_A1.5861.00
69_T93_C1.5771.00
95_Q122_E1.5721.00
38_E322_R1.5611.00
208_V348_S1.5571.00
130_Y313_Y1.5541.00
126_L324_G1.5501.00
143_K196_H1.5461.00
336_N339_R1.5281.00
65_L92_A1.4941.00
117_K335_I1.4861.00
117_K331_A1.4701.00
195_L200_M1.4681.00
145_L150_S1.4651.00
108_A112_E1.4541.00
155_N252_K1.4511.00
67_E70_N1.4501.00
87_Y116_L1.4421.00
119_A122_E1.4351.00
49_T63_H1.4121.00
66_E70_N1.4121.00
158_Q248_Q1.4101.00
62_V71_D1.4011.00
107_T116_L1.3941.00
198_F230_L1.3901.00
94_I123_K1.3881.00
15_K75_E1.3711.00
62_V68_I1.3481.00
92_A95_Q1.3471.00
26_S55_D1.3461.00
107_T113_G1.3431.00
15_K42_S1.3371.00
151_L254_S1.3361.00
201_P227_Y1.3251.00
316_K320_S1.3201.00
92_A96_A1.3181.00
319_E325_A1.3171.00
195_L336_N1.3031.00
248_Q257_I1.3031.00
113_G335_I1.2941.00
207_N226_D1.2911.00
110_A114_E1.2821.00
21_Y44_I1.2761.00
52_V61_V1.2671.00
110_A339_R1.2571.00
79_V89_H1.2561.00
45_M65_L1.2541.00
154_I249_I1.2521.00
191_I340_I1.2391.00
84_G178_T1.2351.00
115_T118_R1.2301.00
45_M68_I1.2221.00
93_C100_V1.2141.00
79_V90_T1.2091.00
65_L89_H1.2061.00
195_L227_Y1.2011.00
316_K328_P1.1941.00
72_P98_K1.1831.00
97_G123_K1.1811.00
68_I74_I1.1781.00
175_K178_T1.1691.00
145_L148_E1.1681.00
246_R257_I1.1671.00
94_I119_A1.1591.00
117_K332_E1.1571.00
158_Q235_Y1.1511.00
330_T333_E1.1501.00
50_E53_K1.1491.00
73_A98_K1.1471.00
82_P85_L1.1441.00
346_E349_K1.1421.00
43_K68_I1.1421.00
118_R121_D1.1351.00
106_M113_G1.1281.00
16_V39_Y1.1271.00
315_R319_E1.1241.00
205_T224_T1.1231.00
99_H324_G1.1181.00
14_I76_L1.1091.00
139_F196_H1.1071.00
113_G338_I1.1031.00
194_T232_A1.1021.00
91_M116_L1.0981.00
157_Y198_F1.0971.00
67_E71_D1.0931.00
195_L333_E1.0931.00
115_T119_A1.0911.00
35_V311_L1.0881.00
342_E346_E1.0771.00
65_L69_T1.0751.00
112_E115_T1.0711.00
69_T96_A1.0701.00
69_T92_A1.0671.00
318_A322_R1.0641.00
101_V130_Y1.0591.00
151_L256_F1.0511.00
343_A346_E1.0471.00
101_V313_Y1.0451.00
151_L154_I1.0431.00
117_K121_D1.0411.00
316_K325_A1.0401.00
29_H78_I1.0381.00
51_E54_R1.0351.00
43_K74_I1.0271.00
102_M127_L1.0241.00
19_L89_H1.0231.00
14_I321_I1.0191.00
107_T112_E1.0181.00
157_Y232_A1.0091.00
99_H321_I1.0081.00
134_R333_E1.0001.00
144_K147_S0.9921.00
116_L127_L0.9891.00
135_W316_K0.9861.00
14_I322_R0.9811.00
140_L328_P0.9751.00
71_D74_I0.9711.00
106_M331_A0.9701.00
31_P35_V0.9601.00
319_E324_G0.9591.00
111_E114_E0.9551.00
90_T100_V0.9511.00
52_V63_H0.9471.00
316_K319_E0.9461.00
142_I258_K0.9411.00
89_H92_A0.9401.00
120_A123_K0.9361.00
62_V67_E0.9321.00
111_E115_T0.9321.00
110_A335_I0.9301.00
154_I198_F0.9271.00
311_L315_R0.9271.00
201_P225_L0.9241.00
13_T38_E0.9231.00
126_L321_I0.9201.00
60_E73_A0.9111.00
128_S317_I0.9071.00
94_I100_V0.8991.00
87_Y107_T0.8981.00
343_A347_S0.8951.00
132_N309_S0.8931.00
154_I251_G0.8921.00
312_T315_R0.8911.00
332_E336_N0.8911.00
79_V93_C0.8891.00
21_Y46_T0.8801.00
106_M127_L0.8801.00
78_I314_Y0.8771.00
191_I341_I0.8711.00
90_T94_I0.8681.00
53_K61_V0.8641.00
152_E254_S0.8631.00
206_A344_A0.8601.00
222_H233_I0.8601.00
207_N231_Q0.8581.00
71_D98_K0.8571.00
157_Y249_I0.8571.00
29_H314_Y0.8561.00
201_P340_I0.8491.00
85_L88_E0.8491.00
102_M106_M0.8471.00
120_A127_L0.8451.00
17_G43_K0.8431.00
176_E216_E0.8411.00
140_L144_K0.8381.00
114_E117_K0.8371.00
320_S323_E0.8371.00
49_T61_V0.8351.00
42_S60_E0.8341.00
16_V33_L0.8331.00
176_E349_K0.8321.00
345_M349_K0.8321.00
49_T52_V0.8281.00
17_G45_M0.8211.00
50_E54_R0.8181.00
248_Q255_S0.8181.00
15_K74_I0.8181.00
339_R343_A0.8171.00
33_L39_Y0.8151.00
102_M116_L0.8141.00
320_S327_L0.8131.00
159_V247_Y0.8131.00
120_A331_A0.8121.00
205_T347_S0.8121.00
33_L314_Y0.8101.00
42_S73_A0.8091.00
94_I127_L0.8061.00
175_K216_E0.8051.00
158_Q233_I0.8041.00
120_A125_V0.8021.00
157_Y194_T0.8011.00
38_E315_R0.8001.00
55_D58_D0.7991.00
128_S320_S0.7971.00
18_I30_G0.7951.00
83_S185_D0.7951.00
25_G80_T0.7921.00
320_S325_A0.7911.00
25_G31_P0.7871.00
108_A179_A0.7861.00
126_L320_S0.7831.00
38_E319_E0.7821.00
19_L65_L0.7811.00
317_I321_I0.7781.00
152_E251_G0.7761.00
181_G218_V0.7761.00
195_L337_V0.7751.00
207_N224_T0.7671.00
30_G41_I0.7651.00
42_S71_D0.7641.00
42_S74_I0.7621.00
225_L232_A0.7621.00
106_M129_V0.7611.00
24_S310_Y0.7571.00
24_S80_T0.7561.00
146_I251_G0.7561.00
182_T236_G0.7561.00
24_S29_H0.7551.00
246_R259_Y0.7551.00
76_L99_H0.7541.00
46_T52_V0.7501.00
198_F227_Y0.7491.00
113_G117_K0.7481.00
87_Y119_A0.7471.00
159_V190_I0.7421.00
19_L81_T0.7411.00
316_K327_L0.7411.00
180_T184_Y0.7401.00
326_A330_T0.7391.00
36_L39_Y0.7391.00
131_H188_S0.7361.00
185_D238_S0.7351.00
194_T227_Y0.7341.00
188_S337_V0.7341.00
46_T51_E0.7271.00
224_T231_Q0.7271.00
26_S51_E0.7261.00
335_I339_R0.7231.00
183_L341_I0.7181.00
129_V334_G0.7141.00
187_G236_G0.7131.00
338_I342_E0.7131.00
202_K228_G0.7091.00
153_D253_D0.7061.00
19_L45_M0.7041.00
147_S199_G0.7041.00
331_A334_G0.7031.00
91_M94_I0.6981.00
209_M226_D0.6971.00
102_M129_V0.6961.00
17_G77_V0.6951.00
140_L312_T0.6921.00
218_V345_M0.6921.00
21_Y52_V0.6911.00
200_M339_R0.6891.00
26_S54_R0.6841.00
88_E115_T0.6821.00
134_R196_H0.6811.00
156_T231_Q0.6791.00
206_A223_L0.6781.00
16_V318_A0.6771.00
86_H102_M0.6761.00
146_I249_I0.6751.00
226_D231_Q0.6751.00
133_R136_D0.6721.00
203_A207_N0.6721.00
94_I116_L0.6691.00
187_G190_I0.6631.00
160_S246_R0.6631.00
15_K73_A0.6621.00
101_V128_S0.6611.00
227_Y230_L0.6581.00
250_H255_S0.6581.00
139_F193_Q0.6571.00
219_D239_I0.6571.00
183_L221_F0.6561.00
97_G125_V0.6541.00
310_Y313_Y0.6531.00
192_D196_H0.6521.00
38_E318_A0.6511.00
197_L249_I0.6501.00
131_H192_D0.6491.00
56_F59_A0.6491.00
192_D337_V0.6481.00
206_A221_F0.6461.00
159_V194_T0.6461.00
143_K197_L0.6451.00
131_H337_V0.6441.00
62_V72_P0.6431.00
165_R168_V0.6421.00
65_L93_C0.6401.00
132_N310_Y0.6391.00
333_E336_N0.6381.00
189_H192_D0.6361.00
68_I71_D0.6351.00
195_L340_I0.6301.00
16_V78_I0.6301.00
76_L321_I0.6291.00
223_L234_L0.6291.00
126_L326_A0.6261.00
78_I101_V0.6261.00
24_S103_E0.6201.00
98_K125_V0.6201.00
160_S235_Y0.6161.00
267_A270_A0.6131.00
77_V98_K0.6131.00
128_S316_K0.6091.00
237_G240_V0.6091.00
31_P55_D0.6061.00
270_A273_K0.6061.00
268_L271_G0.6031.00
133_R192_D0.5981.00
66_E88_E0.5951.00
44_I52_V0.5941.00
225_L234_L0.5931.00
224_T233_I0.5921.00
146_I197_L0.5911.00
184_Y342_E0.5901.00
104_K185_D0.5901.00
177_G216_E0.5901.00
150_S153_D0.5891.00
142_I197_L0.5881.00
90_T120_A0.5851.00
44_I61_V0.5831.00
40_Q59_A0.5831.00
26_S31_P0.5831.00
90_T127_L0.5831.00
36_L318_A0.5821.00
201_P232_A0.5821.00
41_I58_D0.5801.00
194_T234_L0.5771.00
211_Q219_D0.5761.00
220_Y237_G0.5751.00
191_I344_A0.5741.00
47_S81_T0.5741.00
43_K60_E0.5731.00
88_E91_M0.5731.00
95_Q115_T0.5721.00
319_E322_R0.5701.00
117_K120_A0.5701.00
205_T226_D0.5691.00
39_Y76_L0.5681.00
208_V221_F0.5681.00
337_V341_I0.5671.00
79_V86_H0.5651.00
156_T250_H0.5641.00
36_L311_L0.5621.00
29_H33_L0.5621.00
109_T342_E0.5611.00
48_R53_K0.5601.00
29_H80_T0.5591.00
154_I230_L0.5581.00
19_L77_V0.5561.00
128_S313_Y0.5561.00
204_V340_I0.5561.00
149_G251_G0.5561.00
22_G25_G0.5551.00
103_E130_Y0.5531.00
183_L223_L0.5521.00
45_M62_V0.5521.00
137_N312_T0.5511.00
156_T233_I0.5471.00
23_L28_F0.5411.00
80_T103_E0.5401.00
126_L317_I0.5391.00
19_L79_V0.5391.00
140_L196_H0.5391.00
84_G108_A0.5391.00
260_G263_G0.5371.00
22_G80_T0.5361.00
341_I345_M0.5351.00
129_V189_H0.5341.00
149_G153_D0.5331.00
308_G311_L0.5331.00
301_E304_P0.5321.00
31_P34_D0.5291.00
104_K189_H0.5281.00
161_Y164_Y0.5251.00
60_E72_P0.5231.00
111_E342_E0.5231.00
225_L340_I0.5221.00
75_E322_R0.5211.00
181_G185_D0.5211.00
126_L327_L0.5211.00
179_A217_T0.5201.00
327_L330_T0.5191.00
106_M116_L0.5181.00
143_K199_G0.5181.00
221_F236_G0.5181.00
91_M123_K0.5171.00
14_I318_A0.5161.00
81_T86_H0.5161.00
156_T220_Y0.5161.00
66_E96_A0.5151.00
198_F228_G0.5141.00
13_T322_R0.5141.00
340_I343_A0.5131.00
206_A348_S0.5121.00
18_I78_I0.5121.00
45_M63_H0.5101.00
120_A124_G0.5091.00
135_W329_V0.5081.00
18_I41_I0.5071.00
220_Y235_Y0.5071.00
30_G34_D0.5051.00
140_L143_K0.5051.00
153_D228_G0.5051.00
182_T186_L0.5041.00
154_I157_Y0.5021.00
182_T218_V0.5021.00
74_I77_V0.5001.00
101_V317_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gdoA 2 0.9497 100 0.225 Contact Map
3fhlA 2 0.9385 100 0.227 Contact Map
3kuxA 2 0.9693 100 0.23 Contact Map
3e82A 2 0.9525 100 0.236 Contact Map
1h6dA 8 0.9469 100 0.24 Contact Map
1zh8A 2 0.8743 100 0.245 Contact Map
3dtyA 4 0.933 100 0.247 Contact Map
3v5nA 4 0.905 100 0.252 Contact Map
2nvwA 3 0.9246 100 0.255 Contact Map
3f4lA 2 0.9497 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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