GREMLIN Database
CSOR - Copper-sensing transcriptional repressor CsoR
UniProt: O32222 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 101 (88)
Sequences: 1875 (1054)
Seq/√Len: 112.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E33_R4.2291.00
26_K36_Q3.4041.00
35_I55_V3.1351.00
19_D23_N2.9811.00
37_N41_N2.8721.00
32_V55_V2.3091.00
56_Q60_K1.9941.00
25_L32_V1.9121.00
29_E32_V1.7421.00
18_K42_D1.7311.00
89_S93_D1.7211.00
28_I62_V1.6651.00
20_Q23_N1.6521.00
17_E20_Q1.6191.00
23_N27_R1.6171.00
28_I32_V1.5651.00
21_I39_V1.5571.00
44_Y47_D1.4261.00
46_V90_E1.3991.00
52_I59_M1.3921.00
76_A85_E1.3891.00
22_T36_Q1.3831.00
52_I63_A1.3441.00
25_L39_V1.3311.00
27_R58_A1.2960.99
44_Y90_E1.2770.99
44_Y70_H1.2730.99
23_N26_K1.2680.99
22_T40_E1.2340.99
76_A80_K1.2210.99
68_E72_H1.1910.99
24_R58_A1.1570.99
85_E89_S1.1530.99
15_S42_D1.1430.99
77_D81_S1.0990.98
57_A61_N1.0620.98
29_E36_Q1.0450.98
28_I55_V1.0420.97
64_L99_T1.0360.97
43_R48_I1.0170.97
54_A61_N1.0120.97
76_A79_I1.0020.97
64_L96_K1.0010.97
68_E89_S0.9990.97
46_V50_V0.9990.97
67_L95_F0.9980.97
60_K100_K0.9840.96
61_N65_H0.9810.96
71_A75_V0.9570.96
21_I65_H0.9560.96
91_L95_F0.9540.96
27_R31_Q0.9510.96
52_I62_V0.9310.95
68_E96_K0.9300.95
68_E92_L0.9220.95
63_A98_F0.9210.95
79_I82_G0.9200.95
49_L63_A0.9060.94
79_I88_I0.8930.94
65_H68_E0.8810.94
33_R59_M0.8730.93
44_Y75_V0.8700.93
20_Q65_H0.8670.93
57_A60_K0.8590.93
78_A87_A0.8570.93
92_L96_K0.8570.93
78_A83_D0.8540.92
16_K20_Q0.8480.92
72_H85_E0.8200.91
77_D80_K0.8160.91
24_R28_I0.8140.91
53_S63_A0.7900.89
95_F99_T0.7820.89
22_T39_V0.7650.88
86_Q90_E0.7570.87
83_D87_A0.7500.87
86_Q93_D0.7480.86
21_I69_D0.7380.86
75_V87_A0.7370.86
61_N64_L0.7340.85
55_V59_M0.7280.85
50_V97_K0.7260.85
46_V78_A0.7230.85
73_H77_D0.7160.84
76_A84_G0.7090.83
28_I58_A0.7050.83
46_V87_A0.7050.83
62_V65_H0.7020.83
83_D86_Q0.6980.82
71_A91_L0.6950.82
37_N40_E0.6940.82
72_H89_S0.6940.82
60_K63_A0.6890.82
33_R37_N0.6860.81
70_H75_V0.6520.78
33_R36_Q0.6500.78
21_I62_V0.6490.78
31_Q55_V0.6420.77
81_S86_Q0.6180.74
80_K84_G0.6000.72
15_S19_D0.5970.72
20_Q61_N0.5910.71
57_A100_K0.5860.70
13_K17_E0.5730.68
64_L68_E0.5710.68
39_V62_V0.5620.67
46_V94_V0.5610.67
87_A90_E0.5570.66
20_Q42_D0.5560.66
76_A88_I0.5560.66
79_I87_A0.5540.66
43_R47_D0.5470.65
60_K64_L0.5440.64
50_V98_F0.5410.64
60_K99_T0.5360.63
57_A91_L0.5310.63
18_K100_K0.5310.63
61_N96_K0.5280.62
18_K40_E0.5240.62
28_I33_R0.5220.61
88_I92_L0.5190.61
44_Y73_H0.5180.61
21_I73_H0.5180.61
54_A67_L0.5140.60
30_G51_Q0.5120.60
80_K83_D0.5120.60
75_V78_A0.5110.60
15_S18_K0.5110.60
38_M43_R0.5100.60
18_K39_V0.5060.59
27_R32_V0.5010.58
75_V90_E0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m1pA 3 0.9505 100 0.156 Contact Map
4adzA 4 0.8713 100 0.168 Contact Map
2hh7A 3 0.8416 100 0.22 Contact Map
3aaiA 3 0.802 100 0.237 Contact Map
2fb5A 3 0.8812 76.6 0.874 Contact Map
4qinA 2 0.8317 27.7 0.908 Contact Map
4r3zB 1 0.8416 13.2 0.921 Contact Map
3n00A 2 0.3564 10.7 0.924 Contact Map
3hglA 1 0.7228 9.5 0.925 Contact Map
4ltoA 3 0.3861 9.5 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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