GREMLIN Database
BDBD - Disulfide bond formation protein D
UniProt: O32218 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (198)
Sequences: 4726 (4022)
Seq/√Len: 285.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_E167_N5.7221.00
150_G165_K2.9831.00
67_Y129_H2.9471.00
60_T94_K2.8231.00
86_D212_K2.8011.00
124_S127_D2.6791.00
61_V197_V2.6391.00
100_V184_N2.4571.00
61_V93_V2.4401.00
212_K216_E2.3871.00
160_K163_T2.3811.00
71_S74_V2.3361.00
62_V98_V2.1691.00
73_K77_S2.1691.00
67_Y114_S2.1431.00
53_G57_A1.9461.00
208_Y212_K1.9411.00
163_T167_N1.9311.00
109_L146_P1.9151.00
175_S179_K1.8951.00
148_L151_D1.8871.00
87_F216_E1.8691.00
182_D186_K1.8671.00
214_T218_E1.8371.00
117_V123_D1.8261.00
131_K155_S1.8181.00
75_F195_I1.8081.00
62_V96_S1.7991.00
65_G97_F1.7561.00
51_V94_K1.7331.00
26_I29_I1.7201.00
99_N115_E1.6991.00
114_S125_F1.6741.00
128_F153_A1.6511.00
196_Y201_V1.6231.00
112_L174_A1.6141.00
194_T201_V1.5801.00
131_K135_K1.5331.00
81_P208_Y1.5321.00
60_T96_S1.5251.00
119_K172_T1.5191.00
174_A178_E1.5131.00
117_V122_P1.5021.00
161_P165_K1.4911.00
119_K173_F1.4721.00
146_P169_D1.4531.00
27_V30_N1.4311.00
210_E213_E1.4061.00
64_F183_L1.3921.00
151_D155_S1.3711.00
69_C72_C1.3681.00
154_K161_P1.3521.00
54_K57_A1.3211.00
213_E217_K1.3211.00
207_D210_E1.3121.00
76_N130_E1.3101.00
117_V164_L1.3011.00
101_M181_S1.2921.00
74_V78_D1.2861.00
80_F130_E1.2851.00
119_K167_N1.2811.00
29_I32_K1.2801.00
145_T148_L1.2771.00
108_R178_E1.2691.00
25_A29_I1.2601.00
115_E176_Q1.2561.00
128_F132_L1.2461.00
162_E165_K1.2441.00
131_K152_L1.2441.00
108_R112_L1.2301.00
104_G107_S1.2031.00
151_D154_K1.1961.00
76_N129_H1.1781.00
182_D185_Q1.1751.00
80_F84_Q1.1711.00
130_E134_E1.1691.00
86_D208_Y1.1651.00
209_D213_E1.1551.00
165_K169_D1.1521.00
82_K208_Y1.1381.00
64_F98_V1.1361.00
67_Y111_A1.1331.00
63_E95_F1.1271.00
84_Q89_D1.1221.00
113_A164_L1.1221.00
112_L173_F1.1211.00
175_S178_E1.1101.00
27_V31_N1.0971.00
79_I195_I1.0841.00
67_Y99_N1.0771.00
71_S191_A1.0701.00
163_T166_E1.0671.00
28_I31_N1.0591.00
195_I211_I1.0581.00
206_A210_E1.0571.00
63_E195_I1.0501.00
30_N33_T1.0491.00
59_V215_I1.0311.00
178_E182_D1.0241.00
73_K136_Q1.0221.00
200_K218_E1.0191.00
135_K152_L1.0191.00
113_A128_F1.0111.00
191_A194_T0.9961.00
103_H107_S0.9931.00
88_I91_G0.9861.00
58_P92_D0.9801.00
59_V197_V0.9631.00
166_E170_K0.9571.00
49_Q96_S0.9521.00
59_V198_N0.9481.00
26_I30_N0.9361.00
44_P47_K0.9361.00
78_D81_P0.9351.00
110_A132_L0.9261.00
76_N80_F0.9231.00
62_V196_Y0.9151.00
117_V159_I0.9141.00
28_I32_K0.9141.00
104_G108_R0.9061.00
214_T217_K0.8961.00
112_L168_L0.8931.00
81_P84_Q0.8901.00
75_F79_I0.8841.00
189_I196_Y0.8831.00
114_S132_L0.8711.00
35_Q39_A0.8671.00
128_F157_T0.8651.00
86_D90_K0.8641.00
117_V128_F0.8571.00
80_F88_I0.8551.00
84_Q88_I0.8431.00
66_D107_S0.8421.00
68_K104_G0.8401.00
99_N125_F0.8391.00
122_P161_P0.8371.00
37_N40_V0.8371.00
147_G151_D0.8361.00
115_E180_D0.8361.00
170_K173_F0.8321.00
114_S118_W0.8191.00
115_E119_K0.8141.00
23_L27_V0.8100.99
98_V183_L0.8080.99
171_E175_S0.8070.99
80_F95_F0.8060.99
146_P150_G0.8060.99
114_S128_F0.8040.99
49_Q98_V0.7990.99
197_V202_I0.7950.99
22_L26_I0.7900.99
109_L149_L0.7900.99
24_A28_I0.7890.99
64_F187_M0.7790.99
29_I33_T0.7750.99
50_P118_W0.7740.99
171_E174_A0.7720.99
44_P48_G0.7720.99
81_P86_D0.7690.99
100_V189_I0.7680.99
77_S81_P0.7660.99
24_A29_I0.7630.99
51_V54_K0.7620.99
110_A149_L0.7580.99
184_N189_I0.7570.99
99_N180_D0.7550.99
100_V181_S0.7510.99
102_F107_S0.7510.99
128_F164_L0.7460.99
31_N34_E0.7420.99
172_T175_S0.7410.99
111_A177_V0.7410.99
112_L171_E0.7370.99
33_T36_G0.7360.99
200_K217_K0.7310.99
65_G129_H0.7300.99
115_E177_V0.7260.99
211_I214_T0.7150.99
197_V214_T0.7090.99
68_K103_H0.7070.99
92_D216_E0.7060.99
122_P167_N0.7030.99
135_K138_D0.7020.99
150_G161_P0.7010.99
124_S159_I0.6970.98
17_V22_L0.6970.98
122_P159_I0.6940.98
20_V24_A0.6930.98
34_E37_N0.6920.98
15_L19_V0.6910.98
164_L168_L0.6900.98
103_H106_G0.6890.98
65_G126_W0.6880.98
68_K107_S0.6870.98
59_V93_V0.6860.98
32_K35_Q0.6860.98
183_L187_M0.6820.98
115_E173_F0.6800.98
82_K86_D0.6790.98
51_V55_D0.6780.98
70_P76_N0.6750.98
210_E214_T0.6700.98
113_A117_V0.6700.98
202_I214_T0.6690.98
36_G40_V0.6670.98
209_D212_K0.6670.98
152_L157_T0.6640.98
38_D41_S0.6630.98
101_M177_V0.6600.98
21_V24_A0.6600.98
113_A132_L0.6590.98
61_V95_F0.6590.98
68_K106_G0.6580.98
71_S205_F0.6570.98
162_E166_E0.6560.98
45_S48_G0.6550.98
97_F125_F0.6520.98
37_N41_S0.6520.98
52_L126_W0.6510.98
69_C192_T0.6460.97
198_N218_E0.6440.97
46_I98_V0.6430.97
35_Q38_D0.6430.97
181_S185_Q0.6420.97
190_Q201_V0.6410.97
116_E173_F0.6380.97
79_I95_F0.6360.97
179_K183_L0.6360.97
127_D157_T0.6320.97
203_K206_A0.6310.97
112_L177_V0.6310.97
119_K170_K0.6310.97
53_G94_K0.6300.97
113_A149_L0.6270.97
57_A94_K0.6240.97
36_G39_A0.6240.97
200_K214_T0.6210.97
30_N34_E0.6200.97
87_F212_K0.6200.97
28_I33_T0.6160.97
173_F176_Q0.6140.97
25_A28_I0.6100.96
109_L112_L0.6100.96
33_T37_N0.6090.96
43_Q46_I0.6090.96
126_W130_E0.6080.96
71_S206_A0.6020.96
82_K215_I0.6000.96
17_V21_V0.5960.96
16_T19_V0.5940.96
144_V147_G0.5930.96
31_N41_S0.5930.96
46_I49_Q0.5890.96
154_K165_K0.5880.96
20_V32_K0.5880.96
131_K134_E0.5850.96
71_S204_N0.5810.95
19_V25_A0.5810.95
132_L149_L0.5800.95
82_K87_F0.5760.95
65_G133_F0.5760.95
61_V83_I0.5730.95
32_K36_G0.5660.95
55_D94_K0.5650.95
113_A153_A0.5640.95
153_A159_I0.5590.94
52_L80_F0.5580.94
148_L152_L0.5560.94
57_A60_T0.5520.94
123_D127_D0.5510.94
99_N114_S0.5500.94
97_F126_W0.5490.94
116_E119_K0.5460.94
23_L26_I0.5430.93
150_G164_L0.5430.93
29_I34_E0.5430.93
178_E181_S0.5420.93
87_F215_I0.5400.93
34_E39_A0.5360.93
152_L155_S0.5350.93
50_P126_W0.5320.93
42_G45_S0.5320.93
112_L116_E0.5310.93
111_A114_S0.5240.92
49_Q64_F0.5220.92
127_D130_E0.5220.92
167_N173_F0.5210.92
128_F149_L0.5190.92
150_G169_D0.5160.92
187_M196_Y0.5140.91
52_L57_A0.5090.91
54_K94_K0.5080.91
71_S203_K0.5070.91
18_V28_I0.5070.91
126_W129_H0.5030.91
33_T38_D0.5010.90
131_K157_T0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ghaA 1 0.8378 100 0.339 Contact Map
3bciA 1 0.7207 100 0.365 Contact Map
4z7xA 1 0.8874 100 0.372 Contact Map
3f4sA 1 0.8153 100 0.378 Contact Map
3gmfA 1 0.7748 100 0.38 Contact Map
4pwoA 1 0.955 100 0.383 Contact Map
4ihuA 3 0.8378 100 0.388 Contact Map
4n30A 1 0.7658 100 0.405 Contact Map
3gl5A 2 0.7252 100 0.432 Contact Map
3l9sA 1 0.7748 100 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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