GREMLIN Database
BDBC - Disulfide bond formation protein C
UniProt: O32217 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (129)
Sequences: 450 (347)
Seq/√Len: 30.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_S118_A3.2661.00
66_V129_M3.1191.00
24_Y29_R2.9881.00
25_F106_I2.9401.00
39_Y43_L2.8791.00
81_Y116_F2.7801.00
14_V124_L2.5390.99
71_I126_I2.4820.99
109_F112_I2.4000.99
74_A123_I2.3770.99
81_Y85_K2.3710.99
25_F117_L2.2800.99
70_A126_I2.1560.98
22_S26_S2.0620.98
57_Q64_K1.9820.97
95_C98_G1.9220.96
22_S45_Y1.8680.96
82_L86_V1.7840.95
10_A14_V1.7240.94
74_A78_I1.6930.93
107_N111_F1.6330.92
57_Q65_Y1.6100.91
32_I35_E1.5960.91
71_I75_F1.5950.91
26_S45_Y1.5870.90
8_L54_A1.5650.90
59_D65_Y1.5300.89
79_M83_E1.5240.88
82_L89_F1.4930.87
11_S51_L1.4770.87
74_A119_L1.4620.86
32_I98_G1.4400.85
8_L62_V1.3710.82
10_A128_F1.3510.81
11_S129_M1.3390.81
54_A62_V1.3320.80
49_L69_M1.3250.80
108_W117_L1.3060.79
66_V133_K1.3050.79
17_I48_V1.2800.78
83_E93_K1.2680.77
22_S25_F1.2680.77
94_P98_G1.2140.74
67_L126_I1.2050.73
18_A21_G1.1960.73
35_E39_Y1.1940.73
50_I62_V1.1880.72
24_Y28_I1.1810.72
63_K133_K1.1780.71
47_L68_P1.1730.71
127_I130_C1.1640.71
25_F31_F1.1580.70
10_A124_L1.1560.70
12_W52_G1.1200.68
117_L120_I1.1190.67
15_A48_V1.1180.67
18_A121_A1.0990.66
86_V89_F1.0670.64
92_I95_C1.0600.63
21_G114_I1.0590.63
19_M42_I1.0510.63
120_I124_L1.0450.62
43_L72_I1.0430.62
78_I82_L1.0370.61
74_A126_I1.0180.60
68_P129_M1.0080.59
47_L52_G1.0010.59
11_S65_Y0.9610.56
54_A90_S0.9530.55
13_V120_I0.9430.54
5_I58_G0.9310.53
106_I117_L0.9170.52
31_F45_Y0.9140.52
51_L65_Y0.9120.52
77_S119_L0.9090.51
108_W111_F0.8920.50
17_I120_I0.8920.50
112_I116_F0.8890.50
11_S47_L0.8830.49
14_V128_F0.8830.49
43_L74_A0.8800.49
81_Y84_Q0.8660.48
84_Q113_T0.8630.48
25_F105_Y0.8610.48
43_L76_I0.8560.47
63_K66_V0.8500.47
50_I130_C0.8420.46
81_Y86_V0.8390.46
10_A131_L0.8360.46
54_A65_Y0.8300.45
21_G44_M0.8200.44
18_A44_M0.8160.44
70_A74_A0.8080.43
102_S129_M0.8060.43
51_L66_V0.8010.43
106_I116_F0.7840.41
25_F108_W0.7760.41
14_V17_I0.7760.41
39_Y42_I0.7720.41
107_N114_I0.7580.39
26_S113_T0.7570.39
9_Y90_S0.7570.39
21_G25_F0.7510.39
7_F124_L0.7490.39
19_M39_Y0.7470.39
21_G106_I0.7460.39
47_L66_V0.7420.38
13_V49_L0.7410.38
9_Y55_T0.7380.38
111_F116_F0.7280.37
11_S59_D0.7260.37
53_I68_P0.7250.37
77_S80_H0.7240.37
11_S94_P0.7230.37
55_T128_F0.7130.36
78_I109_F0.7110.36
36_L76_I0.7090.36
104_Q107_N0.7090.36
11_S16_L0.7080.36
52_G55_T0.7050.35
81_Y89_F0.7040.35
19_M48_V0.7000.35
25_F113_T0.6900.34
49_L70_A0.6880.34
23_L45_Y0.6850.34
68_P126_I0.6840.34
72_I121_A0.6820.34
75_F90_S0.6800.34
53_I64_K0.6740.33
120_I123_I0.6690.33
31_F113_T0.6620.32
53_I62_V0.6610.32
47_L51_L0.6560.32
22_S105_Y0.6560.32
44_M122_F0.6550.32
86_V92_I0.6540.32
53_I72_I0.6500.32
45_Y105_Y0.6460.31
129_M133_K0.6410.31
78_I121_A0.6390.31
22_S113_T0.6390.31
55_T60_T0.6380.31
80_H118_A0.6370.31
75_F130_C0.6320.30
11_S14_V0.6310.30
25_F107_N0.6300.30
26_S31_F0.6300.30
29_R104_Q0.6270.30
29_R35_E0.6180.29
63_K129_M0.6140.29
14_V66_V0.6100.29
14_V119_L0.6080.29
36_L51_L0.6000.28
128_F131_L0.5930.28
100_P116_F0.5860.27
25_F114_I0.5830.27
59_D128_F0.5800.27
6_V55_T0.5770.27
77_S100_P0.5760.27
12_W67_L0.5750.27
84_Q105_Y0.5720.26
100_P103_G0.5710.26
64_K68_P0.5690.26
78_I119_L0.5660.26
38_W44_M0.5650.26
33_P44_M0.5640.26
87_P94_P0.5590.26
63_K83_E0.5570.26
60_T76_I0.5550.25
119_L123_I0.5540.25
49_L72_I0.5540.25
65_Y129_M0.5530.25
35_E76_I0.5500.25
9_Y83_E0.5480.25
51_L129_M0.5470.25
50_I65_Y0.5460.25
43_L90_S0.5460.25
12_W54_A0.5450.25
7_F17_I0.5450.25
108_W113_T0.5400.24
9_Y97_S0.5390.24
85_K110_G0.5320.24
53_I65_Y0.5280.24
11_S63_K0.5270.24
9_Y63_K0.5250.24
68_P95_C0.5230.23
59_D62_V0.5230.23
72_I76_I0.5210.23
13_V130_C0.5190.23
35_E128_F0.5160.23
107_N110_G0.5140.23
18_A89_F0.5100.23
84_Q89_F0.5080.23
22_S42_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hi7B 1 0.7826 99.9 0.564 Contact Map
4nv5A 1 0.5 87.1 0.916 Contact Map
2l0lA 1 0.1957 54.9 0.935 Contact Map
1xioA 2 0.6594 18.3 0.95 Contact Map
3qapA 1 0.7029 9.6 0.956 Contact Map
3am6A 3 0.6667 9 0.956 Contact Map
4qi1A 3 0.7174 8.5 0.957 Contact Map
3wu2M 2 0.2319 8 0.957 Contact Map
2l0nA 1 0.1884 7.7 0.958 Contact Map
3wt9A 1 0.7101 7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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