GREMLIN Database
YVGT - UPF0126 membrane protein YvgT
UniProt: O32216 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (193)
Sequences: 2507 (1714)
Seq/√Len: 123.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_A154_A3.8921.00
25_E140_R3.5621.00
53_V108_Y3.3461.00
35_L138_A3.2771.00
36_G72_I3.2511.00
160_I178_V3.1091.00
12_I71_S3.0551.00
185_C189_F2.9341.00
157_G179_L2.7851.00
99_A180_V2.6731.00
38_V137_L2.6631.00
45_A58_L2.6471.00
96_I180_V2.4751.00
106_A158_G2.4551.00
180_V184_V2.4041.00
98_L127_G2.2961.00
110_V119_V2.2151.00
27_Y138_A2.1761.00
124_V155_A2.1121.00
91_N187_Y2.0831.00
53_V112_M2.0571.00
185_C191_W2.0021.00
92_L184_V1.9561.00
21_V138_A1.9441.00
149_I153_W1.9161.00
173_Y177_F1.8891.00
98_L154_A1.8091.00
4_E8_V1.7931.00
40_A68_A1.6531.00
51_I114_H1.6041.00
140_R146_K1.5761.00
14_F97_G1.5751.00
153_W182_C1.5611.00
106_A119_V1.5581.00
37_I68_A1.5281.00
119_V162_G1.5011.00
156_L182_C1.4811.00
106_A162_G1.4801.00
120_I162_G1.4771.00
109_A122_A1.4651.00
16_V75_V1.4471.00
114_H118_A1.4471.00
186_S191_W1.4361.00
62_G66_Q1.4201.00
128_S144_V1.3951.00
10_G14_F1.3841.00
41_F68_A1.3831.00
29_I76_F1.3701.00
7_S64_Y1.3631.00
26_E195_N1.3551.00
42_G133_I1.3421.00
137_L145_L1.3351.00
46_I125_L1.3241.00
50_L59_W1.3191.00
122_A126_T1.3191.00
36_G68_A1.3141.00
120_I159_L1.3061.00
172_L176_F1.3021.00
177_F181_V1.3011.00
33_Y69_L1.3001.00
46_I129_G1.2971.00
30_L151_A1.2701.00
71_S75_V1.2541.00
66_Q70_L1.2521.00
4_E61_Q1.2320.99
171_G175_L1.2140.99
99_A176_F1.2030.99
33_Y72_I1.1920.99
108_Y112_M1.1880.99
38_V133_I1.1810.99
132_I144_V1.1800.99
116_L162_G1.1770.99
4_E63_A1.1730.99
12_I67_I1.1600.99
102_A106_A1.1580.99
95_A184_V1.1400.99
51_I112_M1.1310.99
32_V76_F1.1300.99
116_L120_I1.1250.99
95_A180_V1.1070.99
103_I179_L1.1050.99
99_A157_G1.0920.99
45_A129_G1.0910.99
19_A32_V1.0580.98
102_A179_L1.0530.98
99_A103_I1.0490.98
159_L163_L1.0470.98
182_C191_W1.0470.98
167_G170_F1.0460.98
11_I14_F1.0360.98
37_I65_F1.0280.98
46_I133_I1.0180.98
164_G171_G1.0160.98
106_A161_V1.0090.98
184_V188_M1.0020.98
34_I151_A1.0010.98
147_A192_K0.9980.98
34_I145_L0.9880.97
58_L129_G0.9880.97
152_V193_L0.9870.97
107_L111_K0.9810.97
156_L178_V0.9770.97
106_A123_A0.9740.97
6_L100_A0.9710.97
153_W157_G0.9700.97
102_A158_G0.9660.97
142_P145_L0.9600.97
91_N95_A0.9600.97
69_L73_T0.9600.97
17_S93_S0.9580.97
100_A176_F0.9520.97
23_M32_V0.9500.97
58_L118_A0.9500.97
16_V93_S0.9280.96
161_V175_L0.9200.96
100_A104_Q0.9120.96
124_V128_S0.9080.96
166_L171_G0.9070.96
166_L170_F0.9020.96
45_A57_A0.8910.95
97_G101_F0.8860.95
11_I15_A0.8860.95
186_S190_N0.8810.95
11_I41_F0.8810.95
192_K195_N0.8730.95
157_G175_L0.8690.95
30_L128_S0.8610.94
13_A97_G0.8570.94
14_F17_S0.8550.94
12_I16_V0.8550.94
178_V182_C0.8520.94
10_G101_F0.8470.94
103_I175_L0.8470.94
52_G55_V0.8390.93
22_A32_V0.8360.93
49_L54_P0.8290.93
27_Y141_K0.8280.93
127_G179_L0.8170.93
99_A179_L0.8170.93
149_I182_C0.8150.92
124_V151_A0.8090.92
118_A122_A0.8070.92
8_V67_I0.8040.92
96_I100_A0.8020.92
9_I191_W0.7990.92
149_I193_L0.7970.92
120_I155_A0.7960.92
90_G93_S0.7840.91
123_A175_L0.7840.91
16_V71_S0.7760.91
23_M79_P0.7760.91
30_L34_I0.7730.90
70_L74_I0.7700.90
51_I109_A0.7660.90
107_L161_V0.7580.90
103_I161_V0.7560.89
68_A72_I0.7540.89
86_W89_W0.7500.89
7_S21_V0.7360.88
141_K144_V0.7350.88
28_D142_P0.7280.88
119_V123_A0.7230.87
51_I54_P0.7210.87
99_A123_A0.7210.87
101_F127_G0.7200.87
35_L133_I0.7160.87
160_I175_L0.7150.87
65_F121_V0.7130.86
132_I137_L0.7100.86
6_L176_F0.7100.86
25_E106_A0.7050.86
58_L161_V0.7050.86
160_I174_V0.6930.85
170_F174_V0.6900.85
45_A56_S0.6830.84
132_I143_L0.6810.84
3_W100_A0.6790.84
45_A50_L0.6750.83
114_H119_V0.6750.83
7_S14_F0.6740.83
171_G179_L0.6720.83
104_Q175_L0.6660.82
59_W118_A0.6600.82
168_N171_G0.6590.82
50_L125_L0.6570.82
98_L179_L0.6540.81
132_I145_L0.6530.81
155_A158_G0.6500.81
66_Q117_S0.6460.81
147_A179_L0.6450.80
8_V12_I0.6410.80
72_I76_F0.6410.80
14_F18_G0.6390.80
74_I163_L0.6380.80
9_I13_A0.6380.80
115_P122_A0.6370.80
41_F65_F0.6370.80
76_F196_R0.6360.80
23_M196_R0.6360.80
68_A71_S0.6360.80
156_L184_V0.6340.79
8_V63_A0.6330.79
7_S16_V0.6330.79
21_V25_E0.6320.79
19_A75_V0.6280.79
35_L139_G0.6240.78
106_A179_L0.6220.78
128_S151_A0.6190.78
104_Q126_T0.6180.78
30_L155_A0.6160.77
54_P59_W0.6120.77
30_L147_A0.6080.76
39_T42_G0.6050.76
18_G144_V0.6040.76
68_A76_F0.6030.76
45_A49_L0.6020.76
37_I40_A0.5980.75
132_I170_F0.5950.75
85_H88_K0.5950.75
141_K146_K0.5940.75
37_I41_F0.5940.75
34_I129_G0.5930.75
153_W186_S0.5920.75
31_G35_L0.5920.75
35_L126_T0.5890.74
65_F117_S0.5880.74
17_S97_G0.5880.74
184_V187_Y0.5880.74
69_L117_S0.5860.74
3_W170_F0.5850.74
52_G56_S0.5850.74
136_L178_V0.5830.73
41_F153_W0.5820.73
46_I50_L0.5790.73
51_I108_Y0.5760.73
92_L180_V0.5760.73
174_V178_V0.5730.72
28_D150_Y0.5730.72
24_E27_Y0.5730.72
19_A72_I0.5720.72
32_V72_I0.5720.72
19_A36_G0.5710.72
115_P118_A0.5690.72
102_A157_G0.5650.71
99_A119_V0.5640.71
99_A187_Y0.5640.71
75_V79_P0.5630.71
92_L96_I0.5620.71
113_G116_L0.5620.71
22_A35_L0.5610.71
77_L81_L0.5580.70
27_Y145_L0.5570.70
38_V42_G0.5560.70
23_M75_V0.5520.69
27_Y31_G0.5520.69
92_L187_Y0.5510.69
19_A23_M0.5500.69
13_A93_S0.5470.69
155_A159_L0.5470.69
34_I121_V0.5440.68
3_W104_Q0.5430.68
35_L65_F0.5410.68
146_K187_Y0.5400.68
125_L133_I0.5390.68
9_I37_I0.5380.67
62_G115_P0.5360.67
13_A67_I0.5350.67
101_F183_R0.5340.67
7_S11_I0.5300.66
33_Y155_A0.5300.66
106_A154_A0.5290.66
154_A161_V0.5240.65
52_G149_I0.5230.65
21_V140_R0.5200.65
148_E190_N0.5200.65
170_F173_Y0.5190.65
74_I177_F0.5180.64
61_Q65_F0.5160.64
29_I188_M0.5160.64
10_G93_S0.5150.64
23_M39_T0.5100.63
67_I71_S0.5100.63
139_G185_C0.5090.63
57_A64_Y0.5080.63
56_S59_W0.5070.63
49_L165_W0.5060.63
106_A109_A0.5060.63
7_S104_Q0.5050.63
48_N108_Y0.5040.62
28_D31_G0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f2bA 4 0.4059 8.8 0.959 Contact Map
3llqA 3 0.4109 2.7 0.968 Contact Map
2o9gA 3 0.4109 2.7 0.968 Contact Map
3gd8A 4 0.4109 2.3 0.969 Contact Map
4b19A 1 0.1485 1.6 0.972 Contact Map
1s4zC 1 0.1436 1.5 0.972 Contact Map
4qncA 2 0.3812 1.4 0.973 Contact Map
3wfpA 2 0.4505 1.2 0.974 Contact Map
3cn5A 3 0.4257 1.2 0.974 Contact Map
2l9uA 2 0.1931 1.1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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