GREMLIN Database
HELD - Helicase IV
UniProt: O32215 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 774 (698)
Sequences: 2473 (1918)
Seq/√Len: 72.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
446_F450_Q3.7881.00
612_Q633_S3.6831.00
671_C677_C3.4741.00
520_D525_L3.4121.00
519_E522_A3.3011.00
495_F499_K3.2151.00
495_F498_E3.1981.00
526_Y531_I3.1961.00
522_A525_L3.1461.00
496_Q499_K3.0121.00
499_K502_A2.9591.00
496_Q502_A2.9121.00
528_Q531_I2.8731.00
516_L520_D2.7601.00
431_V438_R2.7541.00
517_L520_D2.7101.00
495_F500_M2.6951.00
427_D431_V2.6911.00
520_D524_F2.6561.00
445_T449_Y2.6421.00
497_H501_D2.6421.00
722_V742_A2.6191.00
497_H500_M2.5511.00
728_E732_T2.5451.00
446_F449_Y2.5121.00
526_Y530_L2.4971.00
430_D437_E2.4901.00
139_A142_S2.4791.00
528_Q533_G2.4471.00
505_E508_R2.4461.00
435_L438_R2.4321.00
496_Q500_M2.3931.00
500_M504_G2.3891.00
516_L525_L2.3781.00
526_Y533_G2.3771.00
675_H727_E2.3761.00
503_I507_T2.3741.00
495_F502_A2.3711.00
266_F559_M2.3411.00
671_C680_A2.3201.00
447_N450_Q2.2901.00
506_L509_S2.2731.00
516_L524_F2.2631.00
502_A506_L2.2361.00
503_I506_L2.2341.00
497_H502_A2.2301.00
464_A469_K2.2211.00
496_Q503_I2.1921.00
499_K503_I2.1851.00
530_L533_G2.1441.00
502_A507_T2.1351.00
583_I586_D2.1311.00
434_K437_E2.1171.00
498_E502_A2.1171.00
500_M503_I2.0841.00
709_V742_A2.0831.00
724_D727_E2.0821.00
586_D590_D2.0761.00
655_E658_R2.0691.00
44_R48_W2.0341.00
433_K437_E2.0121.00
559_M568_M2.0101.00
461_V467_P2.0101.00
662_K749_M2.0081.00
506_L510_A1.9921.00
497_H504_G1.9811.00
734_H737_R1.9761.00
521_A524_F1.9561.00
668_A671_C1.9521.00
47_F51_V1.9491.00
732_T735_D1.9341.00
507_T510_A1.9321.00
247_V544_F1.9281.00
651_K655_E1.9231.00
500_M507_T1.8911.00
519_E524_F1.8761.00
653_A657_G1.8581.00
635_E749_M1.8581.00
499_K504_G1.8531.00
428_Y432_Y1.8531.00
432_Y438_R1.8521.00
649_C653_A1.8401.00
654_Q657_G1.8301.00
105_D116_R1.8291.00
529_D533_G1.8171.00
655_E659_L1.8051.00
433_K438_R1.8021.00
517_L522_A1.7961.00
611_R615_E1.7951.00
431_V435_L1.7811.00
495_F507_T1.7801.00
495_F506_L1.7771.00
399_L402_E1.7751.00
508_R511_F1.7601.00
728_E731_H1.7491.00
477_F480_V1.7411.00
427_D435_L1.7381.00
670_I712_A1.7361.00
528_Q532_E1.7351.00
724_D755_T1.7351.00
45_K49_E1.7311.00
427_D432_Y1.7281.00
431_V437_E1.7271.00
496_Q507_T1.7261.00
526_Y529_D1.7251.00
632_R635_E1.7201.00
519_E525_L1.7111.00
427_D438_R1.7051.00
517_L523_P1.6821.00
708_P711_L1.6761.00
432_Y437_E1.6751.00
484_Y488_F1.6731.00
460_I464_A1.6731.00
672_K675_H1.6731.00
655_E753_F1.6641.00
502_A509_S1.6631.00
652_L655_E1.6621.00
516_L522_A1.6581.00
315_E319_T1.6571.00
427_D430_D1.6571.00
479_D484_Y1.6501.00
518_Y524_F1.6411.00
518_Y522_A1.6391.00
418_H421_E1.6391.00
507_T512_T1.6371.00
515_K525_L1.6340.99
656_I659_L1.6320.99
67_S70_Q1.6260.99
429_L433_K1.6250.99
498_E507_T1.6140.99
445_T450_Q1.6140.99
501_D504_G1.6100.99
527_M530_L1.6030.99
520_D523_P1.5980.99
40_I43_L1.5930.99
519_E523_P1.5880.99
529_D532_E1.5860.99
496_Q506_L1.5830.99
44_R47_F1.5810.99
326_F329_R1.5810.99
589_M592_C1.5810.99
728_E733_E1.5780.99
493_G496_Q1.5770.99
429_L435_L1.5760.99
429_L432_Y1.5750.99
729_H732_T1.5730.99
613_I746_A1.5720.99
638_L751_A1.5700.99
432_Y435_L1.5670.99
504_G507_T1.5670.99
493_G497_H1.5500.99
431_V434_K1.5490.99
666_T669_V1.5470.99
371_T374_Q1.5400.99
507_T511_F1.5360.99
582_T586_D1.5350.99
515_K518_Y1.5320.99
434_K438_R1.5290.99
487_L491_W1.5280.99
101_F146_Y1.5260.99
406_L409_K1.5260.99
497_H507_T1.5230.99
656_I669_V1.5070.99
402_E405_K1.5040.99
435_L439_K1.4920.99
499_K506_L1.4870.99
180_K185_T1.4860.99
518_Y525_L1.4850.99
585_G590_D1.4770.99
517_L525_L1.4730.99
505_E509_S1.4720.99
223_N599_E1.4690.99
550_D713_K1.4670.99
515_K520_D1.4510.99
430_D434_K1.4500.99
498_E504_G1.4450.99
516_L519_E1.4430.99
402_E406_L1.4380.99
57_D60_E1.4370.99
616_F743_C1.4370.99
143_S147_N1.4330.99
677_C706_V1.4330.99
478_L486_Q1.4290.99
314_L317_C1.4230.99
616_F639_V1.4130.99
444_S450_Q1.4120.99
640_V753_F1.4080.98
429_L438_R1.4080.98
498_E501_D1.4040.98
582_T585_G1.4040.98
513_D517_L1.4040.98
721_L753_F1.3990.98
627_I630_F1.3890.98
498_E506_L1.3860.98
451_R454_Q1.3810.98
640_V751_A1.3740.98
479_D488_F1.3630.98
54_N57_D1.3550.98
461_V464_A1.3530.98
514_N524_F1.3490.98
480_V487_L1.3480.98
630_F635_E1.3470.98
503_I509_S1.3470.98
678_I682_A1.3460.98
464_A467_P1.3450.98
496_Q501_D1.3450.98
495_F501_D1.3410.98
359_F369_L1.3380.98
657_G661_K1.3370.98
456_L459_I1.3310.98
76_S80_H1.3250.98
499_K507_T1.3190.98
228_I570_V1.3170.98
493_G498_E1.3160.98
500_M505_E1.3090.98
429_L437_E1.3050.98
387_S390_N1.3050.98
454_Q457_A1.3050.98
634_G637_P1.3030.97
484_Y487_L1.3000.97
438_R445_T1.2990.97
617_T744_T1.2940.97
628_E631_N1.2940.97
504_G508_R1.2930.97
345_I348_Y1.2920.97
656_I660_K1.2900.97
543_L559_M1.2900.97
72_A75_L1.2900.97
589_M593_F1.2880.97
495_F504_G1.2860.97
427_D433_K1.2840.97
209_I241_S1.2830.97
430_D435_L1.2810.97
713_K740_Y1.2770.97
467_P470_Q1.2720.97
500_M506_L1.2710.97
667_I670_I1.2700.97
449_Y453_Q1.2620.97
651_K654_Q1.2560.97
54_N58_A1.2540.97
55_F62_I1.2510.97
666_T670_I1.2490.97
464_A476_A1.2480.97
612_Q634_G1.2450.97
659_L719_A1.2440.97
477_F486_Q1.2420.97
522_A528_Q1.2410.97
47_F50_D1.2400.97
514_N520_D1.2360.97
680_A706_V1.2330.96
414_D417_V1.2320.96
501_D506_L1.2280.96
460_I467_P1.2250.96
485_L489_S1.2230.96
430_D433_K1.2210.96
265_L276_V1.2200.96
124_C134_I1.2190.96
469_K476_A1.2150.96
327_P330_L1.2090.96
209_I213_I1.2070.96
365_R368_K1.2020.96
430_D438_R1.2010.96
365_R369_L1.2010.96
641_K754_Y1.2010.96
147_N218_N1.1980.96
156_E161_T1.1940.96
248_A285_E1.1910.96
218_N222_R1.1880.96
499_K505_E1.1850.96
307_C311_F1.1840.96
648_L753_F1.1830.96
232_Q600_Y1.1830.96
496_Q509_S1.1800.95
504_G509_S1.1790.95
574_I577_S1.1780.95
430_D439_K1.1770.95
650_Q687_Y1.1770.95
427_D437_E1.1750.95
325_D430_D1.1700.95
653_A659_L1.1700.95
239_K547_E1.1680.95
478_L481_T1.1660.95
346_N350_T1.1650.95
280_L284_G1.1650.95
239_K576_Q1.1640.95
515_K521_A1.1640.95
419_E422_L1.1620.95
429_L439_K1.1600.95
653_A656_I1.1580.95
336_K341_F1.1550.95
460_I469_K1.1520.95
510_A514_N1.1510.95
506_L511_F1.1490.95
659_L663_G1.1460.95
220_I231_V1.1450.95
347_E350_T1.1420.95
311_F314_L1.1420.95
138_R146_Y1.1390.95
181_A184_N1.1380.94
577_S582_T1.1370.94
420_A425_K1.1350.94
495_F503_I1.1330.94
431_V439_K1.1330.94
308_E311_F1.1320.94
232_Q574_I1.1290.94
526_Y532_E1.1290.94
502_A508_R1.1270.94
629_P632_R1.1240.94
455_L458_A1.1240.94
658_R662_K1.1230.94
493_G502_A1.1190.94
88_Q91_R1.1180.94
647_S650_Q1.1180.94
652_L753_F1.1170.94
615_E636_M1.1170.94
448_D451_R1.1130.94
497_H503_I1.1110.94
228_I568_M1.1100.94
309_S314_L1.1070.94
405_K409_K1.0990.93
513_D516_L1.0980.93
515_K522_A1.0980.93
461_V466_K1.0980.93
588_R591_A1.0970.93
522_A527_M1.0940.93
461_V469_K1.0910.93
498_E505_E1.0880.93
499_K508_R1.0870.93
614_V629_P1.0860.93
665_E670_I1.0850.93
312_D315_E1.0850.93
480_V486_Q1.0840.93
495_F512_T1.0830.93
580_A583_I1.0820.93
430_D445_T1.0810.93
502_A510_A1.0790.93
467_P476_A1.0780.93
514_N517_L1.0780.93
44_R52_K1.0780.93
497_H505_E1.0780.93
652_L656_I1.0770.93
673_T676_Q1.0740.93
460_I463_K1.0730.93
605_R628_E1.0730.93
74_L77_D1.0700.92
497_H506_L1.0680.92
516_L523_P1.0650.92
581_H585_G1.0640.92
531_I534_R1.0620.92
48_W100_Y1.0620.92
585_G589_M1.0600.92
509_S512_T1.0530.92
461_V468_L1.0520.92
512_T517_L1.0510.92
429_L434_K1.0490.92
495_F509_S1.0490.92
680_A683_H1.0460.92
192_E196_E1.0460.92
47_F118_Y1.0450.92
58_A61_A1.0440.91
270_F295_E1.0420.91
590_D593_F1.0390.91
547_E576_Q1.0380.91
508_R512_T1.0330.91
452_E455_L1.0320.91
136_D146_Y1.0310.91
477_F484_Y1.0270.91
468_L472_V1.0200.91
370_I378_Y1.0190.90
504_G510_A1.0190.90
377_S381_S1.0180.90
514_N525_L1.0160.90
502_A513_D1.0150.90
549_Q740_Y1.0130.90
39_D42_G1.0120.90
516_L521_A1.0110.90
503_I508_R1.0110.90
648_L656_I1.0090.90
398_W404_N1.0050.90
398_W402_E1.0020.90
518_Y521_A0.9980.90
213_I221_I0.9960.89
506_L512_T0.9920.89
433_K439_K0.9910.89
399_L406_L0.9900.89
549_Q713_K0.9900.89
310_P314_L0.9890.89
246_R569_T0.9860.89
273_N292_T0.9850.89
275_Y715_I0.9840.89
517_L524_F0.9830.89
239_K716_E0.9810.89
361_N368_K0.9810.89
464_A472_V0.9810.89
466_K476_A0.9800.89
447_N451_R0.9780.89
246_R740_Y0.9760.88
502_A511_F0.9760.88
244_L276_V0.9750.88
505_E510_A0.9740.88
479_D486_Q0.9740.88
498_E509_S0.9730.88
609_S614_V0.9700.88
673_T708_P0.9650.88
654_Q658_R0.9630.88
135_Y141_I0.9610.88
628_E632_R0.9590.88
586_D592_C0.9590.88
450_Q453_Q0.9590.88
487_L490_G0.9580.88
675_H679_Q0.9570.87
587_Q591_A0.9560.87
657_G660_K0.9530.87
724_D754_Y0.9480.87
246_R713_K0.9460.87
439_K444_S0.9450.87
656_I667_I0.9430.87
317_C320_E0.9430.87
470_Q474_L0.9400.87
508_R514_N0.9390.86
669_V672_K0.9350.86
502_A512_T0.9300.86
467_P474_L0.9280.86
466_K469_K0.9280.86
512_T520_D0.9270.86
469_K474_L0.9230.86
44_R59_H0.9230.86
234_A575_N0.9220.85
104_I276_V0.9210.85
513_D522_A0.9200.85
104_I119_I0.9200.85
514_N519_E0.9180.85
307_C313_Q0.9180.85
146_Y248_A0.9170.85
95_L247_V0.9150.85
448_D452_E0.9140.85
612_Q632_R0.9110.85
248_A284_G0.9110.85
673_T710_Y0.9100.85
434_K439_K0.9100.85
446_F453_Q0.9100.85
502_A505_E0.9080.85
138_R248_A0.9070.85
43_L46_S0.9070.85
493_G503_I0.9060.84
637_P640_V0.9040.84
449_Y452_E0.9030.84
719_A749_M0.8970.84
728_E735_D0.8970.84
548_A556_M0.8970.84
722_V743_C0.8960.84
656_I662_K0.8950.84
522_A531_I0.8930.84
514_N523_P0.8920.84
651_K753_F0.8920.84
726_S754_Y0.8910.83
660_K663_G0.8910.83
495_F510_A0.8850.83
496_Q512_T0.8850.83
498_E503_I0.8830.83
59_H65_M0.8820.83
505_E511_F0.8810.83
550_D740_Y0.8800.83
233_G239_K0.8790.83
650_Q653_A0.8790.83
145_Y193_M0.8780.83
524_F528_Q0.8780.83
635_E638_L0.8770.82
40_I44_R0.8760.82
446_F452_E0.8740.82
714_G745_R0.8730.82
722_V739_L0.8720.82
486_Q491_W0.8690.82
547_E716_E0.8670.82
409_K412_R0.8660.82
504_G511_F0.8650.82
444_S451_R0.8630.81
479_D482_Q0.8630.81
667_I719_A0.8630.81
477_F485_L0.8500.80
403_L406_L0.8500.80
495_F505_E0.8490.80
400_L406_L0.8480.80
576_Q716_E0.8480.80
232_Q602_R0.8460.80
669_V704_V0.8460.80
241_S285_E0.8430.80
667_I704_V0.8420.80
420_A423_L0.8410.80
435_L449_Y0.8410.80
508_R513_D0.8390.80
452_E456_L0.8380.80
478_L485_L0.8370.79
363_I367_Q0.8350.79
481_T484_Y0.8350.79
384_Q587_Q0.8340.79
335_W344_F0.8330.79
48_W52_K0.8300.79
223_N226_S0.8280.79
138_R285_E0.8250.78
642_T651_K0.8240.78
477_F488_F0.8230.78
478_L488_F0.8220.78
239_K546_D0.8220.78
233_G547_E0.8210.78
592_C595_D0.8210.78
735_D739_L0.8190.78
640_V651_K0.8190.78
234_A621_L0.8190.78
126_D131_H0.8170.78
542_H569_T0.8170.78
527_M533_G0.8150.78
578_I738_L0.8140.78
731_H734_H0.8140.78
486_Q490_G0.8140.78
446_F456_L0.8130.77
469_K472_V0.8120.77
329_R332_G0.8110.77
510_A513_D0.8090.77
726_S730_Y0.8080.77
493_G500_M0.8050.77
275_Y279_V0.8040.77
182_M185_T0.8040.77
728_E734_H0.8030.77
643_E647_S0.8030.77
629_P717_F0.8020.76
669_V680_A0.8020.76
246_R549_Q0.8020.76
512_T524_F0.8000.76
313_Q318_L0.7970.76
401_S404_N0.7950.76
438_R446_F0.7950.76
452_E458_A0.7930.76
512_T525_L0.7920.76
653_A687_Y0.7920.76
501_D507_T0.7890.75
469_K475_L0.7880.75
585_G592_C0.7870.75
524_F530_L0.7870.75
389_P392_M0.7850.75
488_F491_W0.7840.75
496_Q504_G0.7840.75
588_R593_F0.7830.75
493_G509_S0.7820.75
649_C683_H0.7820.75
498_E512_T0.7800.74
585_G588_R0.7800.74
668_A672_K0.7790.74
138_R252_Y0.7790.74
614_V617_T0.7770.74
503_I510_A0.7770.74
297_I426_E0.7770.74
136_D252_Y0.7760.74
667_I671_C0.7750.74
375_I395_T0.7740.74
262_Q541_K0.7720.74
515_K524_F0.7710.74
136_D285_E0.7710.74
647_S651_K0.7700.74
42_G46_S0.7700.74
390_N394_Q0.7690.73
73_E76_S0.7690.73
499_K510_A0.7690.73
509_S514_N0.7680.73
642_T648_L0.7670.73
233_G576_Q0.7660.73
68_I71_Q0.7660.73
495_F508_R0.7650.73
88_Q92_I0.7640.73
464_A474_L0.7630.73
41_I48_W0.7630.73
267_S273_N0.7620.73
248_A279_V0.7620.73
272_F279_V0.7620.73
249_Y275_Y0.7610.73
227_K567_S0.7590.72
428_Y436_Q0.7590.72
478_L484_Y0.7590.72
679_Q683_H0.7590.72
501_D508_R0.7570.72
239_K714_G0.7560.72
418_H422_L0.7550.72
289_E540_I0.7540.72
501_D510_A0.7520.72
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461_V465_F0.7500.72
611_R632_R0.7490.71
439_K446_F0.7490.71
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268_P272_F0.7470.71
503_I512_T0.7470.71
180_K183_F0.7460.71
60_E64_T0.7450.71
528_Q534_R0.7450.71
665_E668_A0.7450.71
590_D594_E0.7450.71
527_M531_I0.7430.71
314_L318_L0.7430.71
483_L487_L0.7410.71
482_Q485_L0.7400.71
191_D194_L0.7400.71
120_G137_W0.7390.70
458_A462_K0.7380.70
433_K453_Q0.7370.70
648_L651_K0.7370.70
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501_D505_E0.7360.70
212_T283_L0.7300.69
509_S513_D0.7290.69
498_E508_R0.7280.69
627_I631_N0.7270.69
175_K192_E0.7260.69
251_L285_E0.7260.69
376_Q380_Y0.7250.69
493_G499_K0.7250.69
233_G716_E0.7240.69
549_Q715_I0.7240.69
499_K512_T0.7220.69
73_E77_D0.7220.69
89_L93_H0.7220.69
473_R561_S0.7220.69
42_G45_K0.7210.69
92_I124_C0.7210.69
498_E510_A0.7200.68
463_K467_P0.7200.68
514_N522_A0.7180.68
213_I245_Q0.7170.68
741_T745_R0.7170.68
446_F451_R0.7170.68
515_K523_P0.7160.68
715_I740_Y0.7160.68
62_I89_L0.7150.68
650_Q654_Q0.7130.68
136_D248_A0.7120.68
464_A468_L0.7100.67
313_Q317_C0.7090.67
513_D524_F0.7090.67
400_L404_N0.7080.67
458_A461_V0.7070.67
667_I672_K0.7070.67
219_Q601_V0.7060.67
464_A470_Q0.7050.67
630_F633_S0.7040.67
543_L568_M0.7040.67
243_A571_L0.7030.67
546_D716_E0.7030.67
44_R54_N0.7030.67
587_Q594_E0.7010.66
431_V445_T0.7000.66
479_D483_L0.6990.66
53_V64_T0.6990.66
350_T353_S0.6960.66
137_W281_P0.6960.66
420_A426_E0.6940.66
382_L386_H0.6940.66
245_Q275_Y0.6930.65
342_Q346_N0.6920.65
404_N408_K0.6910.65
354_S358_I0.6900.65
649_C656_I0.6900.65
222_R281_P0.6900.65
266_F293_F0.6890.65
188_T191_D0.6890.65
548_A570_V0.6890.65
145_Y250_L0.6890.65
514_N521_A0.6890.65
649_C652_L0.6880.65
283_L549_Q0.6860.65
232_Q571_L0.6850.65
244_L272_F0.6850.65
551_Y575_N0.6840.64
279_V285_E0.6830.64
211_S249_Y0.6830.64
243_A569_T0.6820.64
462_K465_F0.6810.64
572_G745_R0.6810.64
644_G647_S0.6790.64
707_I712_A0.6780.64
102_G145_Y0.6770.64
680_A723_Y0.6770.64
67_S71_Q0.6770.64
137_W146_Y0.6770.64
406_L413_K0.6760.64
231_V603_L0.6760.64
154_E161_T0.6760.64
646_E649_C0.6750.63
589_M595_D0.6740.63
315_E318_L0.6740.63
444_S447_N0.6730.63
471_A476_A0.6720.63
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125_L132_F0.6720.63
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497_H509_S0.6620.62
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682_A686_E0.6600.62
275_Y740_Y0.6600.62
511_F514_N0.6590.62
326_F330_L0.6580.61
549_Q569_T0.6580.61
51_V54_N0.6570.61
431_V446_F0.6570.61
722_V728_E0.6550.61
375_I378_Y0.6550.61
245_Q283_L0.6540.61
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229_L601_V0.6530.61
481_T485_L0.6520.61
138_R222_R0.6510.61
510_A515_K0.6500.61
611_R633_S0.6500.61
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103_R116_R0.6480.60
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546_D607_Y0.6440.60
722_V725_A0.6440.60
59_H62_I0.6420.60
44_R55_F0.6420.60
79_E83_R0.6410.59
206_M285_E0.6410.59
427_D439_K0.6390.59
505_E512_T0.6390.59
51_V55_F0.6390.59
498_E513_D0.6380.59
701_Q706_V0.6380.59
669_V723_Y0.6380.59
414_D418_H0.6360.59
641_K644_G0.6350.59
481_T486_Q0.6320.58
486_Q489_S0.6300.58
720_V750_L0.6300.58
146_Y272_F0.6300.58
484_Y491_W0.6290.58
238_G608_R0.6290.58
295_E301_L0.6280.58
655_E721_L0.6280.58
471_A475_L0.6270.58
435_L446_F0.6260.58
235_A578_I0.6260.58
95_L134_I0.6240.57
670_I742_A0.6230.57
194_L214_Q0.6230.57
493_G510_A0.6230.57
222_R251_L0.6220.57
71_Q74_L0.6220.57
244_L279_V0.6210.57
614_V668_A0.6210.57
50_D60_E0.6200.57
429_L457_A0.6190.57
69_K73_E0.6180.57
364_F367_Q0.6180.57
448_D455_L0.6180.57
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471_A474_L0.6160.56
552_S555_Q0.6150.56
205_Q277_S0.6140.56
146_Y252_Y0.6120.56
432_Y439_K0.6120.56
663_G667_I0.6120.56
55_F58_A0.6120.56
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452_E457_A0.6100.56
453_Q456_L0.6090.56
48_W51_V0.6090.56
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246_R268_P0.6080.55
108_E113_Q0.6080.55
308_E314_L0.6060.55
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432_Y445_T0.6020.55
438_R449_Y0.6020.55
713_K717_F0.6010.55
619_A636_M0.6010.55
291_A295_E0.6000.54
498_E511_F0.6000.54
142_S318_L0.6000.54
215_K219_Q0.5990.54
39_D43_L0.5980.54
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513_D520_D0.5810.52
107_I153_A0.5810.52
724_D756_G0.5800.52
499_K509_S0.5800.52
106_F144_L0.5800.52
38_H42_G0.5800.52
328_T332_G0.5780.52
51_V133_L0.5770.52
244_L268_P0.5760.52
459_I466_K0.5760.52
244_L718_D0.5760.52
58_A65_M0.5750.51
666_T703_G0.5730.51
311_F318_L0.5730.51
306_K309_S0.5720.51
374_Q378_Y0.5720.51
272_F713_K0.5710.51
445_T451_R0.5700.51
319_T350_T0.5700.51
593_F596_E0.5700.51
275_Y550_D0.5700.51
61_A66_A0.5690.51
387_S392_M0.5680.51
279_V284_G0.5670.50
55_F60_E0.5670.50
275_Y549_Q0.5670.50
670_I709_V0.5660.50
180_K184_N0.5650.50
547_E741_T0.5650.50
632_R637_P0.5640.50
245_Q715_I0.5630.50
246_R272_F0.5630.50
485_L490_G0.5630.50
246_R550_D0.5620.50
245_Q279_V0.5620.50
171_Q185_T0.5620.50
547_E714_G0.5620.50
572_G608_R0.5610.50
118_Y184_N0.5610.50
75_L78_R0.5600.50
248_A280_L0.5600.50
419_E424_D0.5590.49
236_G572_G0.5590.49
378_Y381_S0.5590.49
138_R218_N0.5590.49
54_N61_A0.5580.49
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242_A245_Q0.5580.49
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683_H687_Y0.5550.49
312_D316_Y0.5550.49
54_N63_E0.5550.49
615_E618_K0.5550.49
639_V754_Y0.5550.49
616_F620_M0.5540.49
700_F705_C0.5540.49
510_A516_L0.5540.49
171_Q184_N0.5530.49
569_T713_K0.5530.49
470_Q475_L0.5530.49
516_L530_L0.5530.49
213_I252_Y0.5530.49
75_L255_R0.5520.49
606_T713_K0.5520.49
743_C746_A0.5520.49
672_K738_L0.5520.49
655_E751_A0.5520.49
530_L534_R0.5520.49
378_Y383_D0.5500.48
576_Q741_T0.5500.48
573_D608_R0.5490.48
70_Q75_L0.5490.48
259_D291_A0.5490.48
451_R456_L0.5490.48
81_N84_R0.5480.48
53_V63_E0.5480.48
236_G573_D0.5470.48
340_S343_Q0.5470.48
517_L521_A0.5470.48
681_H685_S0.5460.48
206_M279_V0.5460.48
305_F308_E0.5450.48
493_G504_G0.5440.48
608_R745_R0.5440.48
214_Q222_R0.5440.48
236_G745_R0.5430.47
406_L412_R0.5420.47
439_K447_N0.5420.47
463_K469_K0.5420.47
228_I598_A0.5420.47
485_L491_W0.5410.47
545_I559_M0.5410.47
451_R455_L0.5400.47
240_T285_E0.5400.47
712_A720_V0.5400.47
146_Y240_T0.5400.47
216_E249_Y0.5390.47
274_S277_S0.5390.47
146_Y281_P0.5390.47
524_F527_M0.5370.47
350_T354_S0.5370.47
717_F740_Y0.5360.47
636_M639_V0.5360.47
645_H648_L0.5360.47
75_L79_E0.5350.46
643_E658_R0.5350.46
101_F194_L0.5340.46
268_P549_Q0.5340.46
547_E572_G0.5330.46
179_L248_A0.5330.46
664_H670_I0.5320.46
447_N454_Q0.5300.46
464_A471_A0.5300.46
214_Q272_F0.5290.46
677_C680_A0.5290.46
121_L285_E0.5290.46
104_I156_E0.5290.46
560_R564_P0.5290.46
145_Y218_N0.5290.46
433_K458_A0.5280.46
648_L652_L0.5280.46
146_Y214_Q0.5270.46
572_G576_Q0.5270.46
555_Q712_A0.5270.46
514_N518_Y0.5270.46
40_I47_F0.5270.46
513_D519_E0.5260.45
666_T671_C0.5260.45
587_Q590_D0.5260.45
588_R595_D0.5260.45
172_F179_L0.5260.45
577_S738_L0.5260.45
266_F558_Y0.5260.45
175_K180_K0.5250.45
729_H734_H0.5250.45
500_M509_S0.5250.45
312_D319_T0.5240.45
512_T521_A0.5240.45
119_I222_R0.5240.45
576_Q714_G0.5230.45
717_F720_V0.5230.45
238_G714_G0.5230.45
402_E409_K0.5230.45
310_P313_Q0.5220.45
638_L655_E0.5210.45
268_P279_V0.5210.45
53_V57_D0.5210.45
347_E351_R0.5200.45
179_L182_M0.5200.45
547_E573_D0.5190.45
665_E669_V0.5190.45
63_E66_A0.5190.45
61_A259_D0.5190.45
171_Q182_M0.5180.44
512_T519_E0.5180.44
660_K667_I0.5180.44
371_T416_V0.5170.44
496_Q510_A0.5170.44
479_D485_L0.5160.44
50_D64_T0.5160.44
252_Y281_P0.5160.44
180_K263_I0.5150.44
547_E745_R0.5150.44
432_Y447_N0.5150.44
216_E272_F0.5150.44
397_K404_N0.5150.44
268_P740_Y0.5150.44
268_P717_F0.5150.44
206_M267_S0.5140.44
470_Q476_A0.5140.44
478_L483_L0.5140.44
72_A76_S0.5130.44
491_W502_A0.5130.44
51_V100_Y0.5120.44
275_Y281_P0.5120.44
275_Y717_F0.5120.44
311_F316_Y0.5120.44
59_H63_E0.5110.44
104_I147_N0.5100.43
495_F511_F0.5090.43
671_C675_H0.5090.43
137_W549_Q0.5090.43
138_R145_Y0.5080.43
137_W279_V0.5070.43
576_Q745_R0.5070.43
433_K436_Q0.5070.43
671_C706_V0.5070.43
82_H86_D0.5070.43
137_W221_I0.5060.43
559_M574_I0.5060.43
635_E662_K0.5050.43
148_Y153_A0.5050.43
735_D738_L0.5040.43
466_K470_Q0.5040.43
573_D745_R0.5040.43
243_A267_S0.5030.43
743_C750_L0.5020.42
39_D46_S0.5020.42
363_I366_G0.5020.42
605_R613_I0.5010.42
388_I392_M0.5010.42
70_Q76_S0.5000.42
733_E736_R0.5000.42
213_I617_T0.5000.42
244_L252_Y0.5000.42
76_S85_M0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjrA 1 0.562 100 0.603 Contact Map
4c2tA 1 0.5762 100 0.608 Contact Map
3lfuA 1 0.5633 100 0.615 Contact Map
4c2uA 1 0.5724 100 0.62 Contact Map
1uaaA 2 0.5568 100 0.623 Contact Map
4b3fX 1 0.7171 100 0.623 Contact Map
4pj3A 1 0.7972 100 0.624 Contact Map
2xzlA 1 0.7054 100 0.63 Contact Map
2wjyA 1 0.7287 100 0.644 Contact Map
2gk6A 1 0.6809 100 0.652 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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