HELD - BACSU - GREMLIN Contacts

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HELD - Helicase IV

UniProt:	O32215	Sequences: MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLRKSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFGRIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGETIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQNQIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYVSSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGITWKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRMEQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQREQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTRSAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAASMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDGADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHAHMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLYTACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	774 (698)
Sequences:	2473 (1918)
Seq/√Len:	72.6

ECOLI - HELD
BACSU - HELD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
446_F	450_Q	3.788	1.00
612_Q	633_S	3.683	1.00
671_C	677_C	3.474	1.00
520_D	525_L	3.412	1.00
519_E	522_A	3.301	1.00
495_F	499_K	3.215	1.00
495_F	498_E	3.198	1.00
526_Y	531_I	3.196	1.00
522_A	525_L	3.146	1.00
496_Q	499_K	3.012	1.00
499_K	502_A	2.959	1.00
496_Q	502_A	2.912	1.00
528_Q	531_I	2.873	1.00
516_L	520_D	2.760	1.00
431_V	438_R	2.754	1.00
517_L	520_D	2.710	1.00
495_F	500_M	2.695	1.00
427_D	431_V	2.691	1.00
520_D	524_F	2.656	1.00
445_T	449_Y	2.642	1.00
497_H	501_D	2.642	1.00
722_V	742_A	2.619	1.00
497_H	500_M	2.551	1.00
728_E	732_T	2.545	1.00
446_F	449_Y	2.512	1.00
526_Y	530_L	2.497	1.00
430_D	437_E	2.490	1.00
139_A	142_S	2.479	1.00
528_Q	533_G	2.447	1.00
505_E	508_R	2.446	1.00
435_L	438_R	2.432	1.00
496_Q	500_M	2.393	1.00
500_M	504_G	2.389	1.00
516_L	525_L	2.378	1.00
526_Y	533_G	2.377	1.00
675_H	727_E	2.376	1.00
503_I	507_T	2.374	1.00
495_F	502_A	2.371	1.00
266_F	559_M	2.341	1.00
671_C	680_A	2.320	1.00
447_N	450_Q	2.290	1.00
506_L	509_S	2.273	1.00
516_L	524_F	2.263	1.00
502_A	506_L	2.236	1.00
503_I	506_L	2.234	1.00
497_H	502_A	2.230	1.00
464_A	469_K	2.221	1.00
496_Q	503_I	2.192	1.00
499_K	503_I	2.185	1.00
530_L	533_G	2.144	1.00
502_A	507_T	2.135	1.00
583_I	586_D	2.131	1.00
434_K	437_E	2.117	1.00
498_E	502_A	2.117	1.00
500_M	503_I	2.084	1.00
709_V	742_A	2.083	1.00
724_D	727_E	2.082	1.00
586_D	590_D	2.076	1.00
655_E	658_R	2.069	1.00
44_R	48_W	2.034	1.00
433_K	437_E	2.012	1.00
559_M	568_M	2.010	1.00
461_V	467_P	2.010	1.00
662_K	749_M	2.008	1.00
506_L	510_A	1.992	1.00
497_H	504_G	1.981	1.00
734_H	737_R	1.976	1.00
521_A	524_F	1.956	1.00
668_A	671_C	1.952	1.00
47_F	51_V	1.949	1.00
732_T	735_D	1.934	1.00
507_T	510_A	1.932	1.00
247_V	544_F	1.928	1.00
651_K	655_E	1.923	1.00
500_M	507_T	1.891	1.00
519_E	524_F	1.876	1.00
653_A	657_G	1.858	1.00
635_E	749_M	1.858	1.00
499_K	504_G	1.853	1.00
428_Y	432_Y	1.853	1.00
432_Y	438_R	1.852	1.00
649_C	653_A	1.840	1.00
654_Q	657_G	1.830	1.00
105_D	116_R	1.829	1.00
529_D	533_G	1.817	1.00
655_E	659_L	1.805	1.00
433_K	438_R	1.802	1.00
517_L	522_A	1.796	1.00
611_R	615_E	1.795	1.00
431_V	435_L	1.781	1.00
495_F	507_T	1.780	1.00
495_F	506_L	1.777	1.00
399_L	402_E	1.775	1.00
508_R	511_F	1.760	1.00
728_E	731_H	1.749	1.00
477_F	480_V	1.741	1.00
427_D	435_L	1.738	1.00
670_I	712_A	1.736	1.00
528_Q	532_E	1.735	1.00
724_D	755_T	1.735	1.00
45_K	49_E	1.731	1.00
427_D	432_Y	1.728	1.00
431_V	437_E	1.727	1.00
496_Q	507_T	1.726	1.00
526_Y	529_D	1.725	1.00
632_R	635_E	1.720	1.00
519_E	525_L	1.711	1.00
427_D	438_R	1.705	1.00
517_L	523_P	1.682	1.00
708_P	711_L	1.676	1.00
432_Y	437_E	1.675	1.00
484_Y	488_F	1.673	1.00
460_I	464_A	1.673	1.00
672_K	675_H	1.673	1.00
655_E	753_F	1.664	1.00
502_A	509_S	1.663	1.00
652_L	655_E	1.662	1.00
516_L	522_A	1.658	1.00
315_E	319_T	1.657	1.00
427_D	430_D	1.657	1.00
479_D	484_Y	1.650	1.00
518_Y	524_F	1.641	1.00
518_Y	522_A	1.639	1.00
418_H	421_E	1.639	1.00
507_T	512_T	1.637	1.00
515_K	525_L	1.634	0.99
656_I	659_L	1.632	0.99
67_S	70_Q	1.626	0.99
429_L	433_K	1.625	0.99
498_E	507_T	1.614	0.99
445_T	450_Q	1.614	0.99
501_D	504_G	1.610	0.99
527_M	530_L	1.603	0.99
520_D	523_P	1.598	0.99
40_I	43_L	1.593	0.99
519_E	523_P	1.588	0.99
529_D	532_E	1.586	0.99
496_Q	506_L	1.583	0.99
44_R	47_F	1.581	0.99
326_F	329_R	1.581	0.99
589_M	592_C	1.581	0.99
728_E	733_E	1.578	0.99
493_G	496_Q	1.577	0.99
429_L	435_L	1.576	0.99
429_L	432_Y	1.575	0.99
729_H	732_T	1.573	0.99
613_I	746_A	1.572	0.99
638_L	751_A	1.570	0.99
432_Y	435_L	1.567	0.99
504_G	507_T	1.567	0.99
493_G	497_H	1.550	0.99
431_V	434_K	1.549	0.99
666_T	669_V	1.547	0.99
371_T	374_Q	1.540	0.99
507_T	511_F	1.536	0.99
582_T	586_D	1.535	0.99
515_K	518_Y	1.532	0.99
434_K	438_R	1.529	0.99
487_L	491_W	1.528	0.99
101_F	146_Y	1.526	0.99
406_L	409_K	1.526	0.99
497_H	507_T	1.523	0.99
656_I	669_V	1.507	0.99
402_E	405_K	1.504	0.99
435_L	439_K	1.492	0.99
499_K	506_L	1.487	0.99
180_K	185_T	1.486	0.99
518_Y	525_L	1.485	0.99
585_G	590_D	1.477	0.99
517_L	525_L	1.473	0.99
505_E	509_S	1.472	0.99
223_N	599_E	1.469	0.99
550_D	713_K	1.467	0.99
515_K	520_D	1.451	0.99
430_D	434_K	1.450	0.99
498_E	504_G	1.445	0.99
516_L	519_E	1.443	0.99
402_E	406_L	1.438	0.99
57_D	60_E	1.437	0.99
616_F	743_C	1.437	0.99
143_S	147_N	1.433	0.99
677_C	706_V	1.433	0.99
478_L	486_Q	1.429	0.99
314_L	317_C	1.423	0.99
616_F	639_V	1.413	0.99
444_S	450_Q	1.412	0.99
640_V	753_F	1.408	0.98
429_L	438_R	1.408	0.98
498_E	501_D	1.404	0.98
582_T	585_G	1.404	0.98
513_D	517_L	1.404	0.98
721_L	753_F	1.399	0.98
627_I	630_F	1.389	0.98
498_E	506_L	1.386	0.98
451_R	454_Q	1.381	0.98
640_V	751_A	1.374	0.98
479_D	488_F	1.363	0.98
54_N	57_D	1.355	0.98
461_V	464_A	1.353	0.98
514_N	524_F	1.349	0.98
480_V	487_L	1.348	0.98
630_F	635_E	1.347	0.98
503_I	509_S	1.347	0.98
678_I	682_A	1.346	0.98
464_A	467_P	1.345	0.98
496_Q	501_D	1.345	0.98
495_F	501_D	1.341	0.98
359_F	369_L	1.338	0.98
657_G	661_K	1.337	0.98
456_L	459_I	1.331	0.98
76_S	80_H	1.325	0.98
499_K	507_T	1.319	0.98
228_I	570_V	1.317	0.98
493_G	498_E	1.316	0.98
500_M	505_E	1.309	0.98
429_L	437_E	1.305	0.98
387_S	390_N	1.305	0.98
454_Q	457_A	1.305	0.98
634_G	637_P	1.303	0.97
484_Y	487_L	1.300	0.97
438_R	445_T	1.299	0.97
617_T	744_T	1.294	0.97
628_E	631_N	1.294	0.97
504_G	508_R	1.293	0.97
345_I	348_Y	1.292	0.97
656_I	660_K	1.290	0.97
543_L	559_M	1.290	0.97
72_A	75_L	1.290	0.97
589_M	593_F	1.288	0.97
495_F	504_G	1.286	0.97
427_D	433_K	1.284	0.97
209_I	241_S	1.283	0.97
430_D	435_L	1.281	0.97
713_K	740_Y	1.277	0.97
467_P	470_Q	1.272	0.97
500_M	506_L	1.271	0.97
667_I	670_I	1.270	0.97
449_Y	453_Q	1.262	0.97
651_K	654_Q	1.256	0.97
54_N	58_A	1.254	0.97
55_F	62_I	1.251	0.97
666_T	670_I	1.249	0.97
464_A	476_A	1.248	0.97
612_Q	634_G	1.245	0.97
659_L	719_A	1.244	0.97
477_F	486_Q	1.242	0.97
522_A	528_Q	1.241	0.97
47_F	50_D	1.240	0.97
514_N	520_D	1.236	0.97
680_A	706_V	1.233	0.96
414_D	417_V	1.232	0.96
501_D	506_L	1.228	0.96
460_I	467_P	1.225	0.96
485_L	489_S	1.223	0.96
430_D	433_K	1.221	0.96
265_L	276_V	1.220	0.96
124_C	134_I	1.219	0.96
469_K	476_A	1.215	0.96
327_P	330_L	1.209	0.96
209_I	213_I	1.207	0.96
365_R	368_K	1.202	0.96
430_D	438_R	1.201	0.96
365_R	369_L	1.201	0.96
641_K	754_Y	1.201	0.96
147_N	218_N	1.198	0.96
156_E	161_T	1.194	0.96
248_A	285_E	1.191	0.96
218_N	222_R	1.188	0.96
499_K	505_E	1.185	0.96
307_C	311_F	1.184	0.96
648_L	753_F	1.183	0.96
232_Q	600_Y	1.183	0.96
496_Q	509_S	1.180	0.95
504_G	509_S	1.179	0.95
574_I	577_S	1.178	0.95
430_D	439_K	1.177	0.95
650_Q	687_Y	1.177	0.95
427_D	437_E	1.175	0.95
325_D	430_D	1.170	0.95
653_A	659_L	1.170	0.95
239_K	547_E	1.168	0.95
478_L	481_T	1.166	0.95
346_N	350_T	1.165	0.95
280_L	284_G	1.165	0.95
239_K	576_Q	1.164	0.95
515_K	521_A	1.164	0.95
419_E	422_L	1.162	0.95
429_L	439_K	1.160	0.95
653_A	656_I	1.158	0.95
336_K	341_F	1.155	0.95
460_I	469_K	1.152	0.95
510_A	514_N	1.151	0.95
506_L	511_F	1.149	0.95
659_L	663_G	1.146	0.95
220_I	231_V	1.145	0.95
347_E	350_T	1.142	0.95
311_F	314_L	1.142	0.95
138_R	146_Y	1.139	0.95
181_A	184_N	1.138	0.94
577_S	582_T	1.137	0.94
420_A	425_K	1.135	0.94
495_F	503_I	1.133	0.94
431_V	439_K	1.133	0.94
308_E	311_F	1.132	0.94
232_Q	574_I	1.129	0.94
526_Y	532_E	1.129	0.94
502_A	508_R	1.127	0.94
629_P	632_R	1.124	0.94
455_L	458_A	1.124	0.94
658_R	662_K	1.123	0.94
493_G	502_A	1.119	0.94
88_Q	91_R	1.118	0.94
647_S	650_Q	1.118	0.94
652_L	753_F	1.117	0.94
615_E	636_M	1.117	0.94
448_D	451_R	1.113	0.94
497_H	503_I	1.111	0.94
228_I	568_M	1.110	0.94
309_S	314_L	1.107	0.94
405_K	409_K	1.099	0.93
513_D	516_L	1.098	0.93
515_K	522_A	1.098	0.93
461_V	466_K	1.098	0.93
588_R	591_A	1.097	0.93
522_A	527_M	1.094	0.93
461_V	469_K	1.091	0.93
498_E	505_E	1.088	0.93
499_K	508_R	1.087	0.93
614_V	629_P	1.086	0.93
665_E	670_I	1.085	0.93
312_D	315_E	1.085	0.93
480_V	486_Q	1.084	0.93
495_F	512_T	1.083	0.93
580_A	583_I	1.082	0.93
430_D	445_T	1.081	0.93
502_A	510_A	1.079	0.93
467_P	476_A	1.078	0.93
514_N	517_L	1.078	0.93
44_R	52_K	1.078	0.93
497_H	505_E	1.078	0.93
652_L	656_I	1.077	0.93
673_T	676_Q	1.074	0.93
460_I	463_K	1.073	0.93
605_R	628_E	1.073	0.93
74_L	77_D	1.070	0.92
497_H	506_L	1.068	0.92
516_L	523_P	1.065	0.92
581_H	585_G	1.064	0.92
531_I	534_R	1.062	0.92
48_W	100_Y	1.062	0.92
585_G	589_M	1.060	0.92
509_S	512_T	1.053	0.92
461_V	468_L	1.052	0.92
512_T	517_L	1.051	0.92
429_L	434_K	1.049	0.92
495_F	509_S	1.049	0.92
680_A	683_H	1.046	0.92
192_E	196_E	1.046	0.92
47_F	118_Y	1.045	0.92
58_A	61_A	1.044	0.91
270_F	295_E	1.042	0.91
590_D	593_F	1.039	0.91
547_E	576_Q	1.038	0.91
508_R	512_T	1.033	0.91
452_E	455_L	1.032	0.91
136_D	146_Y	1.031	0.91
477_F	484_Y	1.027	0.91
468_L	472_V	1.020	0.91
370_I	378_Y	1.019	0.90
504_G	510_A	1.019	0.90
377_S	381_S	1.018	0.90
514_N	525_L	1.016	0.90
502_A	513_D	1.015	0.90
549_Q	740_Y	1.013	0.90
39_D	42_G	1.012	0.90
516_L	521_A	1.011	0.90
503_I	508_R	1.011	0.90
648_L	656_I	1.009	0.90
398_W	404_N	1.005	0.90
398_W	402_E	1.002	0.90
518_Y	521_A	0.998	0.90
213_I	221_I	0.996	0.89
506_L	512_T	0.992	0.89
433_K	439_K	0.991	0.89
399_L	406_L	0.990	0.89
549_Q	713_K	0.990	0.89
310_P	314_L	0.989	0.89
246_R	569_T	0.986	0.89
273_N	292_T	0.985	0.89
275_Y	715_I	0.984	0.89
517_L	524_F	0.983	0.89
239_K	716_E	0.981	0.89
361_N	368_K	0.981	0.89
464_A	472_V	0.981	0.89
466_K	476_A	0.980	0.89
447_N	451_R	0.978	0.89
246_R	740_Y	0.976	0.88
502_A	511_F	0.976	0.88
244_L	276_V	0.975	0.88
505_E	510_A	0.974	0.88
479_D	486_Q	0.974	0.88
498_E	509_S	0.973	0.88
609_S	614_V	0.970	0.88
673_T	708_P	0.965	0.88
654_Q	658_R	0.963	0.88
135_Y	141_I	0.961	0.88
628_E	632_R	0.959	0.88
586_D	592_C	0.959	0.88
450_Q	453_Q	0.959	0.88
487_L	490_G	0.958	0.88
675_H	679_Q	0.957	0.87
587_Q	591_A	0.956	0.87
657_G	660_K	0.953	0.87
724_D	754_Y	0.948	0.87
246_R	713_K	0.946	0.87
439_K	444_S	0.945	0.87
656_I	667_I	0.943	0.87
317_C	320_E	0.943	0.87
470_Q	474_L	0.940	0.87
508_R	514_N	0.939	0.86
669_V	672_K	0.935	0.86
502_A	512_T	0.930	0.86
467_P	474_L	0.928	0.86
466_K	469_K	0.928	0.86
512_T	520_D	0.927	0.86
469_K	474_L	0.923	0.86
44_R	59_H	0.923	0.86
234_A	575_N	0.922	0.85
104_I	276_V	0.921	0.85
513_D	522_A	0.920	0.85
104_I	119_I	0.920	0.85
514_N	519_E	0.918	0.85
307_C	313_Q	0.918	0.85
146_Y	248_A	0.917	0.85
95_L	247_V	0.915	0.85
448_D	452_E	0.914	0.85
612_Q	632_R	0.911	0.85
248_A	284_G	0.911	0.85
673_T	710_Y	0.910	0.85
434_K	439_K	0.910	0.85
446_F	453_Q	0.910	0.85
502_A	505_E	0.908	0.85
138_R	248_A	0.907	0.85
43_L	46_S	0.907	0.85
493_G	503_I	0.906	0.84
637_P	640_V	0.904	0.84
449_Y	452_E	0.903	0.84
719_A	749_M	0.897	0.84
728_E	735_D	0.897	0.84
548_A	556_M	0.897	0.84
722_V	743_C	0.896	0.84
656_I	662_K	0.895	0.84
522_A	531_I	0.893	0.84
514_N	523_P	0.892	0.84
651_K	753_F	0.892	0.84
726_S	754_Y	0.891	0.83
660_K	663_G	0.891	0.83
495_F	510_A	0.885	0.83
496_Q	512_T	0.885	0.83
498_E	503_I	0.883	0.83
59_H	65_M	0.882	0.83
505_E	511_F	0.881	0.83
550_D	740_Y	0.880	0.83
233_G	239_K	0.879	0.83
650_Q	653_A	0.879	0.83
145_Y	193_M	0.878	0.83
524_F	528_Q	0.878	0.83
635_E	638_L	0.877	0.82
40_I	44_R	0.876	0.82
446_F	452_E	0.874	0.82
714_G	745_R	0.873	0.82
722_V	739_L	0.872	0.82
486_Q	491_W	0.869	0.82
547_E	716_E	0.867	0.82
409_K	412_R	0.866	0.82
504_G	511_F	0.865	0.82
444_S	451_R	0.863	0.81
479_D	482_Q	0.863	0.81
667_I	719_A	0.863	0.81
477_F	485_L	0.850	0.80
403_L	406_L	0.850	0.80
495_F	505_E	0.849	0.80
400_L	406_L	0.848	0.80
576_Q	716_E	0.848	0.80
232_Q	602_R	0.846	0.80
669_V	704_V	0.846	0.80
241_S	285_E	0.843	0.80
667_I	704_V	0.842	0.80
420_A	423_L	0.841	0.80
435_L	449_Y	0.841	0.80
508_R	513_D	0.839	0.80
452_E	456_L	0.838	0.80
478_L	485_L	0.837	0.79
363_I	367_Q	0.835	0.79
481_T	484_Y	0.835	0.79
384_Q	587_Q	0.834	0.79
335_W	344_F	0.833	0.79
48_W	52_K	0.830	0.79
223_N	226_S	0.828	0.79
138_R	285_E	0.825	0.78
642_T	651_K	0.824	0.78
477_F	488_F	0.823	0.78
478_L	488_F	0.822	0.78
239_K	546_D	0.822	0.78
233_G	547_E	0.821	0.78
592_C	595_D	0.821	0.78
735_D	739_L	0.819	0.78
640_V	651_K	0.819	0.78
234_A	621_L	0.819	0.78
126_D	131_H	0.817	0.78
542_H	569_T	0.817	0.78
527_M	533_G	0.815	0.78
578_I	738_L	0.814	0.78
731_H	734_H	0.814	0.78
486_Q	490_G	0.814	0.78
446_F	456_L	0.813	0.77
469_K	472_V	0.812	0.77
329_R	332_G	0.811	0.77
510_A	513_D	0.809	0.77
726_S	730_Y	0.808	0.77
493_G	500_M	0.805	0.77
275_Y	279_V	0.804	0.77
182_M	185_T	0.804	0.77
728_E	734_H	0.803	0.77
643_E	647_S	0.803	0.77
629_P	717_F	0.802	0.76
669_V	680_A	0.802	0.76
246_R	549_Q	0.802	0.76
512_T	524_F	0.800	0.76
313_Q	318_L	0.797	0.76
401_S	404_N	0.795	0.76
438_R	446_F	0.795	0.76
452_E	458_A	0.793	0.76
512_T	525_L	0.792	0.76
653_A	687_Y	0.792	0.76
501_D	507_T	0.789	0.75
469_K	475_L	0.788	0.75
585_G	592_C	0.787	0.75
524_F	530_L	0.787	0.75
389_P	392_M	0.785	0.75
488_F	491_W	0.784	0.75
496_Q	504_G	0.784	0.75
588_R	593_F	0.783	0.75
493_G	509_S	0.782	0.75
649_C	683_H	0.782	0.75
498_E	512_T	0.780	0.74
585_G	588_R	0.780	0.74
668_A	672_K	0.779	0.74
138_R	252_Y	0.779	0.74
614_V	617_T	0.777	0.74
503_I	510_A	0.777	0.74
297_I	426_E	0.777	0.74
136_D	252_Y	0.776	0.74
667_I	671_C	0.775	0.74
375_I	395_T	0.774	0.74
262_Q	541_K	0.772	0.74
515_K	524_F	0.771	0.74
136_D	285_E	0.771	0.74
647_S	651_K	0.770	0.74
42_G	46_S	0.770	0.74
390_N	394_Q	0.769	0.73
73_E	76_S	0.769	0.73
499_K	510_A	0.769	0.73
509_S	514_N	0.768	0.73
642_T	648_L	0.767	0.73
233_G	576_Q	0.766	0.73
68_I	71_Q	0.766	0.73
495_F	508_R	0.765	0.73
88_Q	92_I	0.764	0.73
464_A	474_L	0.763	0.73
41_I	48_W	0.763	0.73
267_S	273_N	0.762	0.73
248_A	279_V	0.762	0.73
272_F	279_V	0.762	0.73
249_Y	275_Y	0.761	0.73
227_K	567_S	0.759	0.72
428_Y	436_Q	0.759	0.72
478_L	484_Y	0.759	0.72
679_Q	683_H	0.759	0.72
501_D	508_R	0.757	0.72
239_K	714_G	0.756	0.72
418_H	422_L	0.755	0.72
289_E	540_I	0.754	0.72
501_D	510_A	0.752	0.72
420_A	424_D	0.752	0.72
461_V	465_F	0.750	0.72
611_R	632_R	0.749	0.71
439_K	446_F	0.749	0.71
676_Q	724_D	0.747	0.71
268_P	272_F	0.747	0.71
503_I	512_T	0.747	0.71
180_K	183_F	0.746	0.71
60_E	64_T	0.745	0.71
528_Q	534_R	0.745	0.71
665_E	668_A	0.745	0.71
590_D	594_E	0.745	0.71
527_M	531_I	0.743	0.71
314_L	318_L	0.743	0.71
483_L	487_L	0.741	0.71
482_Q	485_L	0.740	0.71
191_D	194_L	0.740	0.71
120_G	137_W	0.739	0.70
458_A	462_K	0.738	0.70
433_K	453_Q	0.737	0.70
648_L	651_K	0.737	0.70
44_R	51_V	0.736	0.70
501_D	505_E	0.736	0.70
212_T	283_L	0.730	0.69
509_S	513_D	0.729	0.69
498_E	508_R	0.728	0.69
627_I	631_N	0.727	0.69
175_K	192_E	0.726	0.69
251_L	285_E	0.726	0.69
376_Q	380_Y	0.725	0.69
493_G	499_K	0.725	0.69
233_G	716_E	0.724	0.69
549_Q	715_I	0.724	0.69
499_K	512_T	0.722	0.69
73_E	77_D	0.722	0.69
89_L	93_H	0.722	0.69
473_R	561_S	0.722	0.69
42_G	45_K	0.721	0.69
92_I	124_C	0.721	0.69
498_E	510_A	0.720	0.68
463_K	467_P	0.720	0.68
514_N	522_A	0.718	0.68
213_I	245_Q	0.717	0.68
741_T	745_R	0.717	0.68
446_F	451_R	0.717	0.68
515_K	523_P	0.716	0.68
715_I	740_Y	0.716	0.68
62_I	89_L	0.715	0.68
650_Q	654_Q	0.713	0.68
136_D	248_A	0.712	0.68
464_A	468_L	0.710	0.67
313_Q	317_C	0.709	0.67
513_D	524_F	0.709	0.67
400_L	404_N	0.708	0.67
458_A	461_V	0.707	0.67
667_I	672_K	0.707	0.67
219_Q	601_V	0.706	0.67
464_A	470_Q	0.705	0.67
630_F	633_S	0.704	0.67
543_L	568_M	0.704	0.67
243_A	571_L	0.703	0.67
546_D	716_E	0.703	0.67
44_R	54_N	0.703	0.67
587_Q	594_E	0.701	0.66
431_V	445_T	0.700	0.66
479_D	483_L	0.699	0.66
53_V	64_T	0.699	0.66
350_T	353_S	0.696	0.66
137_W	281_P	0.696	0.66
420_A	426_E	0.694	0.66
382_L	386_H	0.694	0.66
245_Q	275_Y	0.693	0.65
342_Q	346_N	0.692	0.65
404_N	408_K	0.691	0.65
354_S	358_I	0.690	0.65
649_C	656_I	0.690	0.65
222_R	281_P	0.690	0.65
266_F	293_F	0.689	0.65
188_T	191_D	0.689	0.65
548_A	570_V	0.689	0.65
145_Y	250_L	0.689	0.65
514_N	521_A	0.689	0.65
649_C	652_L	0.688	0.65
283_L	549_Q	0.686	0.65
232_Q	571_L	0.685	0.65
244_L	272_F	0.685	0.65
551_Y	575_N	0.684	0.64
279_V	285_E	0.683	0.64
211_S	249_Y	0.683	0.64
243_A	569_T	0.682	0.64
462_K	465_F	0.681	0.64
572_G	745_R	0.681	0.64
644_G	647_S	0.679	0.64
707_I	712_A	0.678	0.64
102_G	145_Y	0.677	0.64
680_A	723_Y	0.677	0.64
67_S	71_Q	0.677	0.64
137_W	146_Y	0.677	0.64
406_L	413_K	0.676	0.64
231_V	603_L	0.676	0.64
154_E	161_T	0.676	0.64
646_E	649_C	0.675	0.63
589_M	595_D	0.674	0.63
315_E	318_L	0.674	0.63
444_S	447_N	0.673	0.63
471_A	476_A	0.672	0.63
172_F	182_M	0.672	0.63
546_D	576_Q	0.672	0.63
125_L	132_F	0.672	0.63
563_F	568_M	0.671	0.63
467_P	471_A	0.670	0.63
479_D	487_L	0.670	0.63
525_L	528_Q	0.670	0.63
515_K	519_E	0.670	0.63
427_D	434_K	0.669	0.63
716_E	745_R	0.668	0.63
171_Q	174_I	0.667	0.63
66_A	70_Q	0.667	0.63
468_L	471_A	0.667	0.63
61_A	64_T	0.667	0.63
585_G	593_F	0.666	0.62
313_Q	316_Y	0.666	0.62
404_N	407_E	0.666	0.62
245_Q	549_Q	0.666	0.62
314_L	322_K	0.664	0.62
586_D	589_M	0.663	0.62
497_H	509_S	0.662	0.62
648_L	655_E	0.662	0.62
518_Y	523_P	0.661	0.62
136_D	249_Y	0.660	0.62
49_E	53_V	0.660	0.62
682_A	686_E	0.660	0.62
275_Y	740_Y	0.660	0.62
511_F	514_N	0.659	0.62
326_F	330_L	0.658	0.61
549_Q	569_T	0.658	0.61
51_V	54_N	0.657	0.61
431_V	446_F	0.657	0.61
722_V	728_E	0.655	0.61
375_I	378_Y	0.655	0.61
245_Q	283_L	0.654	0.61
496_Q	511_F	0.654	0.61
229_L	601_V	0.653	0.61
481_T	485_L	0.652	0.61
138_R	222_R	0.651	0.61
510_A	515_K	0.650	0.61
611_R	633_S	0.650	0.61
510_A	522_A	0.650	0.61
495_F	513_D	0.649	0.60
103_R	116_R	0.648	0.60
52_K	56_D	0.645	0.60
136_D	145_Y	0.644	0.60
546_D	607_Y	0.644	0.60
722_V	725_A	0.644	0.60
59_H	62_I	0.642	0.60
44_R	55_F	0.642	0.60
79_E	83_R	0.641	0.59
206_M	285_E	0.641	0.59
427_D	439_K	0.639	0.59
505_E	512_T	0.639	0.59
51_V	55_F	0.639	0.59
498_E	513_D	0.638	0.59
701_Q	706_V	0.638	0.59
669_V	723_Y	0.638	0.59
414_D	418_H	0.636	0.59
641_K	644_G	0.635	0.59
481_T	486_Q	0.632	0.58
486_Q	489_S	0.630	0.58
720_V	750_L	0.630	0.58
146_Y	272_F	0.630	0.58
484_Y	491_W	0.629	0.58
238_G	608_R	0.629	0.58
295_E	301_L	0.628	0.58
655_E	721_L	0.628	0.58
471_A	475_L	0.627	0.58
435_L	446_F	0.626	0.58
235_A	578_I	0.626	0.58
95_L	134_I	0.624	0.57
670_I	742_A	0.623	0.57
194_L	214_Q	0.623	0.57
493_G	510_A	0.623	0.57
222_R	251_L	0.622	0.57
71_Q	74_L	0.622	0.57
244_L	279_V	0.621	0.57
614_V	668_A	0.621	0.57
50_D	60_E	0.620	0.57
429_L	457_A	0.619	0.57
69_K	73_E	0.618	0.57
364_F	367_Q	0.618	0.57
448_D	455_L	0.618	0.57
511_F	517_L	0.617	0.57
471_A	474_L	0.616	0.56
552_S	555_Q	0.615	0.56
205_Q	277_S	0.614	0.56
146_Y	252_Y	0.612	0.56
432_Y	439_K	0.612	0.56
663_G	667_I	0.612	0.56
55_F	58_A	0.612	0.56
146_Y	279_V	0.611	0.56
452_E	457_A	0.610	0.56
453_Q	456_L	0.609	0.56
48_W	51_V	0.609	0.56
272_F	275_Y	0.608	0.55
246_R	268_P	0.608	0.55
108_E	113_Q	0.608	0.55
308_E	314_L	0.606	0.55
266_F	711_L	0.605	0.55
238_G	572_G	0.604	0.55
583_I	592_C	0.603	0.55
432_Y	445_T	0.602	0.55
438_R	449_Y	0.602	0.55
713_K	717_F	0.601	0.55
619_A	636_M	0.601	0.55
291_A	295_E	0.600	0.54
498_E	511_F	0.600	0.54
142_S	318_L	0.600	0.54
215_K	219_Q	0.599	0.54
39_D	43_L	0.598	0.54
101_F	138_R	0.597	0.54
435_L	445_T	0.597	0.54
524_F	531_I	0.596	0.54
275_Y	713_K	0.596	0.54
432_Y	446_F	0.596	0.54
640_V	655_E	0.595	0.54
725_A	742_A	0.594	0.54
412_R	417_V	0.594	0.54
41_I	44_R	0.593	0.54
439_K	445_T	0.593	0.54
500_M	508_R	0.592	0.54
238_G	573_D	0.592	0.54
542_H	567_S	0.591	0.53
238_G	745_R	0.589	0.53
206_M	241_S	0.589	0.53
56_D	169_K	0.589	0.53
549_Q	606_T	0.588	0.53
491_W	495_F	0.588	0.53
465_F	468_L	0.587	0.53
268_P	607_Y	0.586	0.53
79_E	82_H	0.585	0.53
43_L	108_E	0.585	0.53
496_Q	508_R	0.585	0.53
410_E	417_V	0.583	0.52
206_M	564_P	0.583	0.52
236_G	608_R	0.583	0.52
542_H	570_V	0.583	0.52
308_E	313_Q	0.583	0.52
213_I	713_K	0.582	0.52
214_Q	281_P	0.582	0.52
400_L	409_K	0.582	0.52
631_N	635_E	0.581	0.52
138_R	249_Y	0.581	0.52
730_Y	735_D	0.581	0.52
513_D	520_D	0.581	0.52
107_I	153_A	0.581	0.52
724_D	756_G	0.580	0.52
499_K	509_S	0.580	0.52
106_F	144_L	0.580	0.52
38_H	42_G	0.580	0.52
328_T	332_G	0.578	0.52
51_V	133_L	0.577	0.52
244_L	268_P	0.576	0.52
459_I	466_K	0.576	0.52
244_L	718_D	0.576	0.52
58_A	65_M	0.575	0.51
666_T	703_G	0.573	0.51
311_F	318_L	0.573	0.51
306_K	309_S	0.572	0.51
374_Q	378_Y	0.572	0.51
272_F	713_K	0.571	0.51
445_T	451_R	0.570	0.51
319_T	350_T	0.570	0.51
593_F	596_E	0.570	0.51
275_Y	550_D	0.570	0.51
61_A	66_A	0.569	0.51
387_S	392_M	0.568	0.51
279_V	284_G	0.567	0.50
55_F	60_E	0.567	0.50
275_Y	549_Q	0.567	0.50
670_I	709_V	0.566	0.50
180_K	184_N	0.565	0.50
547_E	741_T	0.565	0.50
632_R	637_P	0.564	0.50
245_Q	715_I	0.563	0.50
246_R	272_F	0.563	0.50
485_L	490_G	0.563	0.50
246_R	550_D	0.562	0.50
245_Q	279_V	0.562	0.50
171_Q	185_T	0.562	0.50
547_E	714_G	0.562	0.50
572_G	608_R	0.561	0.50
118_Y	184_N	0.561	0.50
75_L	78_R	0.560	0.50
248_A	280_L	0.560	0.50
419_E	424_D	0.559	0.49
236_G	572_G	0.559	0.49
378_Y	381_S	0.559	0.49
138_R	218_N	0.559	0.49
54_N	61_A	0.558	0.49
222_R	279_V	0.558	0.49
242_A	245_Q	0.558	0.49
246_R	275_Y	0.558	0.49
57_D	61_A	0.558	0.49
107_I	167_V	0.557	0.49
437_E	446_F	0.557	0.49
224_E	229_L	0.557	0.49
46_S	49_E	0.556	0.49
683_H	687_Y	0.555	0.49
312_D	316_Y	0.555	0.49
54_N	63_E	0.555	0.49
615_E	618_K	0.555	0.49
639_V	754_Y	0.555	0.49
616_F	620_M	0.554	0.49
700_F	705_C	0.554	0.49
510_A	516_L	0.554	0.49
171_Q	184_N	0.553	0.49
569_T	713_K	0.553	0.49
470_Q	475_L	0.553	0.49
516_L	530_L	0.553	0.49
213_I	252_Y	0.553	0.49
75_L	255_R	0.552	0.49
606_T	713_K	0.552	0.49
743_C	746_A	0.552	0.49
672_K	738_L	0.552	0.49
655_E	751_A	0.552	0.49
530_L	534_R	0.552	0.49
378_Y	383_D	0.550	0.48
576_Q	741_T	0.550	0.48
573_D	608_R	0.549	0.48
70_Q	75_L	0.549	0.48
259_D	291_A	0.549	0.48
451_R	456_L	0.549	0.48
81_N	84_R	0.548	0.48
53_V	63_E	0.548	0.48
236_G	573_D	0.547	0.48
340_S	343_Q	0.547	0.48
517_L	521_A	0.547	0.48
681_H	685_S	0.546	0.48
206_M	279_V	0.546	0.48
305_F	308_E	0.545	0.48
493_G	504_G	0.544	0.48
608_R	745_R	0.544	0.48
214_Q	222_R	0.544	0.48
236_G	745_R	0.543	0.47
406_L	412_R	0.542	0.47
439_K	447_N	0.542	0.47
463_K	469_K	0.542	0.47
228_I	598_A	0.542	0.47
485_L	491_W	0.541	0.47
545_I	559_M	0.541	0.47
451_R	455_L	0.540	0.47
240_T	285_E	0.540	0.47
712_A	720_V	0.540	0.47
146_Y	240_T	0.540	0.47
216_E	249_Y	0.539	0.47
274_S	277_S	0.539	0.47
146_Y	281_P	0.539	0.47
524_F	527_M	0.537	0.47
350_T	354_S	0.537	0.47
717_F	740_Y	0.536	0.47
636_M	639_V	0.536	0.47
645_H	648_L	0.536	0.47
75_L	79_E	0.535	0.46
643_E	658_R	0.535	0.46
101_F	194_L	0.534	0.46
268_P	549_Q	0.534	0.46
547_E	572_G	0.533	0.46
179_L	248_A	0.533	0.46
664_H	670_I	0.532	0.46
447_N	454_Q	0.530	0.46
464_A	471_A	0.530	0.46
214_Q	272_F	0.529	0.46
677_C	680_A	0.529	0.46
121_L	285_E	0.529	0.46
104_I	156_E	0.529	0.46
560_R	564_P	0.529	0.46
145_Y	218_N	0.529	0.46
433_K	458_A	0.528	0.46
648_L	652_L	0.528	0.46
146_Y	214_Q	0.527	0.46
572_G	576_Q	0.527	0.46
555_Q	712_A	0.527	0.46
514_N	518_Y	0.527	0.46
40_I	47_F	0.527	0.46
513_D	519_E	0.526	0.45
666_T	671_C	0.526	0.45
587_Q	590_D	0.526	0.45
588_R	595_D	0.526	0.45
172_F	179_L	0.526	0.45
577_S	738_L	0.526	0.45
266_F	558_Y	0.526	0.45
175_K	180_K	0.525	0.45
729_H	734_H	0.525	0.45
500_M	509_S	0.525	0.45
312_D	319_T	0.524	0.45
512_T	521_A	0.524	0.45
119_I	222_R	0.524	0.45
576_Q	714_G	0.523	0.45
717_F	720_V	0.523	0.45
238_G	714_G	0.523	0.45
402_E	409_K	0.523	0.45
310_P	313_Q	0.522	0.45
638_L	655_E	0.521	0.45
268_P	279_V	0.521	0.45
53_V	57_D	0.521	0.45
347_E	351_R	0.520	0.45
179_L	182_M	0.520	0.45
547_E	573_D	0.519	0.45
665_E	669_V	0.519	0.45
63_E	66_A	0.519	0.45
61_A	259_D	0.519	0.45
171_Q	182_M	0.518	0.44
512_T	519_E	0.518	0.44
660_K	667_I	0.518	0.44
371_T	416_V	0.517	0.44
496_Q	510_A	0.517	0.44
479_D	485_L	0.516	0.44
50_D	64_T	0.516	0.44
252_Y	281_P	0.516	0.44
180_K	263_I	0.515	0.44
547_E	745_R	0.515	0.44
432_Y	447_N	0.515	0.44
216_E	272_F	0.515	0.44
397_K	404_N	0.515	0.44
268_P	740_Y	0.515	0.44
268_P	717_F	0.515	0.44
206_M	267_S	0.514	0.44
470_Q	476_A	0.514	0.44
478_L	483_L	0.514	0.44
72_A	76_S	0.513	0.44
491_W	502_A	0.513	0.44
51_V	100_Y	0.512	0.44
275_Y	281_P	0.512	0.44
275_Y	717_F	0.512	0.44
311_F	316_Y	0.512	0.44
59_H	63_E	0.511	0.44
104_I	147_N	0.510	0.43
495_F	511_F	0.509	0.43
671_C	675_H	0.509	0.43
137_W	549_Q	0.509	0.43
138_R	145_Y	0.508	0.43
137_W	279_V	0.507	0.43
576_Q	745_R	0.507	0.43
433_K	436_Q	0.507	0.43
671_C	706_V	0.507	0.43
82_H	86_D	0.507	0.43
137_W	221_I	0.506	0.43
559_M	574_I	0.506	0.43
635_E	662_K	0.505	0.43
148_Y	153_A	0.505	0.43
735_D	738_L	0.504	0.43
466_K	470_Q	0.504	0.43
573_D	745_R	0.504	0.43
243_A	267_S	0.503	0.43
743_C	750_L	0.502	0.42
39_D	46_S	0.502	0.42
363_I	366_G	0.502	0.42
605_R	613_I	0.501	0.42
388_I	392_M	0.501	0.42
70_Q	76_S	0.500	0.42
733_E	736_R	0.500	0.42
213_I	617_T	0.500	0.42
244_L	252_Y	0.500	0.42
76_S	85_M	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pjrA	1	0.562	100	0.603	Contact Map
4c2tA	1	0.5762	100	0.608	Contact Map
3lfuA	1	0.5633	100	0.615	Contact Map
4c2uA	1	0.5724	100	0.62	Contact Map
1uaaA	2	0.5568	100	0.623	Contact Map
4b3fX	1	0.7171	100	0.623	Contact Map
4pj3A	1	0.7972	100	0.624	Contact Map
2xzlA	1	0.7054	100	0.63	Contact Map
2wjyA	1	0.7287	100	0.644	Contact Map
2gk6A	1	0.6809	100	0.652	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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