NHAK - BACSU - GREMLIN Contacts

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NHAK - Sodium, potassium, lithium and rubidium/H(+) antiporter

UniProt:	O32212	Sequences: MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFPQGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYTIHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLVAFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTMHMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNIILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFWNGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILFLAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNKTASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPEETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRATRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLEVKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	670 (511)
Sequences:	2163 (1463)
Seq/√Len:	64.7

ECOLI - YJCE NHAP2
BACSU - NHAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
367_T	394_A	7.012	1.00
319_T	400_C	5.299	1.00
315_I	396_G	5.270	1.00
180_A	184_V	4.888	1.00
496_A	499_K	4.557	1.00
359_I	408_V	4.239	1.00
101_Y	112_L	3.753	1.00
102_T	321_T	3.546	1.00
189_G	239_V	3.379	1.00
77_L	84_I	3.373	1.00
166_I	374_I	3.275	1.00
316_L	320_F	3.226	1.00
500_M	506_I	3.126	1.00
327_F	358_S	3.073	1.00
400_C	404_I	2.995	1.00
195_V	251_T	2.991	1.00
17_S	36_L	2.729	1.00
78_W	81_R	2.639	1.00
125_T	365_A	2.628	1.00
96_V	161_A	2.588	1.00
35_A	39_L	2.551	1.00
426_L	430_R	2.473	1.00
289_L	365_A	2.469	1.00
316_L	400_C	2.466	1.00
100_G	112_L	2.461	1.00
203_R	207_F	2.435	1.00
494_Q	522_E	2.377	1.00
94_A	325_L	2.298	1.00
440_T	443_E	2.279	1.00
104_H	112_L	2.248	1.00
174_F	179_A	2.223	1.00
433_L	497_L	2.206	1.00
460_Y	463_K	2.109	1.00
508_E	512_N	2.104	1.00
411_I	415_K	2.100	1.00
434_I	438_L	2.083	1.00
312_I	316_L	2.051	1.00
159_L	370_G	2.000	1.00
315_I	392_F	1.994	1.00
468_R	472_Y	1.988	1.00
65_L	245_V	1.982	1.00
464_M	467_L	1.981	1.00
433_L	437_A	1.970	1.00
338_W	341_N	1.964	1.00
127_V	147_L	1.951	1.00
117_G	374_I	1.951	1.00
430_R	438_L	1.916	1.00
494_Q	519_N	1.902	1.00
242_I	245_V	1.897	1.00
201_I	226_T	1.888	1.00
98_V	325_L	1.886	1.00
152_L	246_V	1.881	1.00
143_I	357_I	1.881	1.00
355_L	412_L	1.880	1.00
118_L	394_A	1.860	1.00
62_A	223_Q	1.854	1.00
115_A	228_F	1.854	1.00
285_V	365_A	1.847	1.00
193_C	237_I	1.835	1.00
90_G	94_A	1.831	1.00
457_I	461_N	1.828	1.00
299_V	388_N	1.814	1.00
430_R	437_A	1.802	1.00
514_L	517_R	1.800	1.00
435_K	439_Q	1.799	1.00
123_S	363_R	1.798	1.00
452_A	456_V	1.798	1.00
429_A	433_L	1.785	1.00
230_I	248_G	1.783	1.00
125_T	130_V	1.772	1.00
506_I	510_T	1.758	1.00
83_P	86_L	1.752	1.00
464_M	468_R	1.752	1.00
130_V	365_A	1.744	1.00
337_K	341_N	1.722	0.99
188_L	191_L	1.712	0.99
243_L	247_A	1.709	0.99
102_T	317_V	1.699	0.99
499_K	503_R	1.684	0.99
103_I	318_I	1.674	0.99
126_D	150_E	1.671	0.99
177_A	181_V	1.661	0.99
130_V	362_V	1.655	0.99
249_G	285_V	1.651	0.99
222_I	226_T	1.631	0.99
84_I	403_V	1.611	0.99
177_A	180_A	1.609	0.99
127_V	151_G	1.601	0.99
191_L	247_A	1.601	0.99
428_T	432_K	1.600	0.99
453_S	460_Y	1.599	0.99
151_G	190_G	1.585	0.99
429_A	437_A	1.583	0.99
426_L	513_V	1.574	0.99
313_G	317_V	1.573	0.99
172_G	175_S	1.571	0.99
491_K	495_E	1.569	0.99
441_I	446_N	1.566	0.99
101_Y	105_W	1.565	0.99
111_P	114_A	1.557	0.99
171_T	174_F	1.557	0.99
444_D	449_N	1.554	0.99
162_F	373_S	1.551	0.99
43_F	288_I	1.547	0.99
200_L	203_R	1.543	0.99
56_F	289_L	1.542	0.99
65_L	92_V	1.539	0.99
440_T	444_D	1.537	0.99
126_D	154_N	1.531	0.99
231_Y	241_G	1.531	0.99
453_S	456_V	1.530	0.99
81_R	85_L	1.529	0.99
422_R	425_K	1.526	0.99
10_L	14_I	1.516	0.99
235_E	241_G	1.514	0.99
460_Y	467_L	1.514	0.99
94_A	329_W	1.508	0.99
309_M	313_G	1.493	0.98
110_I	114_A	1.487	0.98
458_A	462_E	1.478	0.98
39_L	404_I	1.472	0.98
121_I	371_S	1.467	0.98
501_L	511_A	1.465	0.98
311_V	393_L	1.459	0.98
519_N	525_Y	1.450	0.98
378_L	382_T	1.448	0.98
62_A	228_F	1.445	0.98
53_T	243_L	1.441	0.98
200_L	204_F	1.433	0.98
113_A	169_A	1.426	0.98
455_A	459_E	1.425	0.98
185_F	239_V	1.425	0.98
219_H	261_S	1.424	0.98
224_I	277_I	1.420	0.98
67_N	278_L	1.417	0.98
247_A	251_T	1.416	0.98
169_A	385_P	1.415	0.98
519_N	522_E	1.410	0.98
87_L	132_A	1.405	0.98
331_L	355_L	1.404	0.98
319_T	401_T	1.400	0.98
168_A	171_T	1.398	0.98
190_G	245_V	1.390	0.98
337_K	340_F	1.380	0.97
101_Y	104_H	1.375	0.97
29_V	282_N	1.374	0.97
237_I	307_S	1.372	0.97
453_S	457_I	1.369	0.97
150_E	361_G	1.366	0.97
460_Y	468_R	1.363	0.97
359_I	406_T	1.359	0.97
88_A	153_M	1.350	0.97
445_M	449_N	1.349	0.97
264_I	267_Q	1.344	0.97
92_V	157_S	1.337	0.97
113_A	168_A	1.332	0.97
456_V	460_Y	1.331	0.97
191_L	243_L	1.321	0.97
199_F	203_R	1.315	0.97
493_E	497_L	1.310	0.97
432_K	443_E	1.297	0.96
442_K	449_N	1.293	0.96
184_V	188_L	1.282	0.96
197_I	233_A	1.280	0.96
84_I	222_I	1.272	0.96
181_V	185_F	1.272	0.96
24_I	27_I	1.257	0.96
330_V	354_T	1.253	0.95
124_P	367_T	1.248	0.95
195_V	247_A	1.247	0.95
181_V	184_V	1.243	0.95
147_L	165_A	1.242	0.95
63_P	156_A	1.241	0.95
28_P	127_V	1.237	0.95
433_L	444_D	1.233	0.95
102_T	105_W	1.230	0.95
188_L	192_L	1.227	0.95
426_L	429_A	1.226	0.95
495_E	499_K	1.225	0.95
34_V	289_L	1.224	0.95
154_N	361_G	1.222	0.95
438_L	444_D	1.208	0.94
465_K	468_R	1.207	0.94
10_L	284_L	1.206	0.94
375_P	384_F	1.201	0.94
125_T	289_L	1.197	0.94
371_S	390_I	1.195	0.94
451_T	454_L	1.192	0.94
117_G	169_A	1.190	0.94
238_G	245_V	1.189	0.94
350_G	353_S	1.185	0.94
226_T	248_G	1.185	0.94
192_L	196_V	1.184	0.94
193_C	239_V	1.172	0.94
365_A	395_A	1.157	0.93
106_M	317_V	1.157	0.93
490_V	518_F	1.155	0.93
433_L	440_T	1.145	0.93
450_K	457_I	1.143	0.93
362_V	405_A	1.142	0.93
381_G	384_F	1.141	0.93
456_V	472_Y	1.138	0.93
522_E	526_A	1.133	0.92
30_P	131_S	1.132	0.92
16_I	27_I	1.125	0.92
73_P	145_R	1.117	0.92
60_F	278_L	1.108	0.91
156_A	367_T	1.107	0.91
235_E	238_G	1.106	0.91
117_G	166_I	1.104	0.91
130_V	133_L	1.097	0.91
74_R	253_A	1.092	0.91
33_Q	405_A	1.092	0.91
91_L	329_W	1.090	0.91
227_P	410_P	1.088	0.91
450_K	453_S	1.085	0.91
440_T	488_Q	1.081	0.90
12_T	225_L	1.076	0.90
518_F	522_E	1.072	0.90
464_M	470_Q	1.069	0.90
72_T	77_L	1.064	0.90
50_E	54_E	1.063	0.90
126_D	361_G	1.060	0.90
485_V	493_E	1.053	0.89
511_A	515_Q	1.043	0.89
437_A	440_T	1.042	0.89
480_K	483_R	1.040	0.89
77_L	294_P	1.040	0.89
150_E	154_N	1.040	0.89
363_R	401_T	1.039	0.89
403_V	407_V	1.037	0.89
30_P	362_V	1.034	0.88
305_A	309_M	1.027	0.88
99_G	321_T	1.024	0.88
426_L	433_L	1.022	0.88
75_A	79_N	1.022	0.88
114_A	169_A	1.019	0.88
90_G	329_W	1.018	0.88
467_L	472_Y	1.016	0.88
428_T	431_R	1.015	0.87
377_F	381_G	1.012	0.87
96_V	119_A	1.011	0.87
458_A	461_N	1.010	0.87
14_I	17_S	1.007	0.87
110_I	319_T	1.006	0.87
456_V	461_N	1.005	0.87
126_D	129_A	1.005	0.87
214_Q	219_H	1.003	0.87
16_I	21_N	1.003	0.87
104_H	116_F	1.002	0.87
194_G	198_S	0.998	0.87
374_I	464_M	0.991	0.86
118_L	393_L	0.991	0.86
484_K	488_Q	0.989	0.86
28_P	492_A	0.987	0.86
56_F	119_A	0.987	0.86
341_N	346_I	0.984	0.86
362_V	365_A	0.984	0.86
310_K	313_G	0.982	0.86
384_F	387_R	0.979	0.85
97_I	100_G	0.977	0.85
433_L	443_E	0.975	0.85
442_K	446_N	0.974	0.85
497_L	511_A	0.974	0.85
369_A	522_E	0.971	0.85
454_L	457_I	0.970	0.85
14_I	283_G	0.969	0.85
115_A	485_V	0.968	0.85
95_T	159_L	0.968	0.85
148_E	368_L	0.967	0.85
148_E	220_M	0.963	0.85
461_N	465_K	0.962	0.84
96_V	322_L	0.959	0.84
250_I	367_T	0.957	0.84
155_D	286_F	0.954	0.84
150_E	326_R	0.953	0.84
432_K	436_T	0.951	0.84
194_G	326_R	0.950	0.84
62_A	416_E	0.950	0.84
99_G	318_I	0.944	0.83
126_D	151_G	0.944	0.83
87_L	330_V	0.941	0.83
83_P	146_L	0.940	0.83
429_A	436_T	0.938	0.83
434_I	444_D	0.936	0.83
439_Q	444_D	0.927	0.82
127_V	130_V	0.927	0.82
390_I	394_A	0.925	0.82
458_A	463_K	0.920	0.82
430_R	433_L	0.919	0.82
450_K	456_V	0.919	0.82
7_V	358_S	0.916	0.81
80_L	83_P	0.910	0.81
175_S	414_E	0.908	0.81
467_L	473_T	0.906	0.81
124_P	158_G	0.904	0.81
60_F	365_A	0.902	0.80
342_K	346_I	0.898	0.80
371_S	404_I	0.898	0.80
122_L	395_A	0.897	0.80
451_T	455_A	0.896	0.80
498_M	515_Q	0.893	0.80
314_Y	393_L	0.893	0.80
246_V	368_L	0.893	0.80
125_T	238_G	0.892	0.80
442_K	445_M	0.890	0.80
193_C	197_I	0.890	0.80
434_I	437_A	0.889	0.79
159_L	360_S	0.889	0.79
223_Q	274_W	0.886	0.79
128_V	282_N	0.884	0.79
55_L	87_L	0.883	0.79
62_A	77_L	0.882	0.79
97_I	101_Y	0.881	0.79
489_G	492_A	0.880	0.79
238_G	455_A	0.879	0.79
160_V	278_L	0.878	0.79
65_L	127_V	0.875	0.78
170_V	379_E	0.874	0.78
122_L	371_S	0.869	0.78
431_R	435_K	0.869	0.78
80_L	146_L	0.869	0.78
309_M	312_I	0.868	0.78
227_P	394_A	0.866	0.78
117_G	165_A	0.864	0.78
4_F	59_L	0.862	0.77
30_P	410_P	0.861	0.77
124_P	165_A	0.859	0.77
461_N	468_R	0.856	0.77
359_I	362_V	0.856	0.77
93_F	97_I	0.856	0.77
220_M	357_I	0.856	0.77
453_S	458_A	0.856	0.77
76_E	79_N	0.855	0.77
436_T	441_I	0.853	0.77
486_R	490_V	0.847	0.76
35_A	320_F	0.847	0.76
465_K	472_Y	0.847	0.76
332_F	347_Y	0.845	0.76
193_C	230_I	0.844	0.76
44_P	47_L	0.843	0.76
332_F	346_I	0.839	0.75
173_A	177_A	0.838	0.75
60_F	70_K	0.838	0.75
30_P	292_Q	0.837	0.75
332_F	335_N	0.836	0.75
28_P	70_K	0.836	0.75
62_A	363_R	0.835	0.75
356_L	412_L	0.834	0.75
185_F	189_G	0.833	0.75
466_N	473_T	0.833	0.75
217_T	245_V	0.832	0.75
121_I	370_G	0.831	0.75
224_I	516_E	0.830	0.75
20_V	24_I	0.826	0.74
124_P	127_V	0.824	0.74
378_L	381_G	0.823	0.74
62_A	230_I	0.822	0.74
455_A	458_A	0.822	0.74
476_N	479_K	0.820	0.74
139_M	413_T	0.818	0.74
438_L	445_M	0.818	0.74
133_L	232_L	0.811	0.73
65_L	156_A	0.808	0.73
438_L	442_K	0.807	0.73
40_A	490_V	0.806	0.72
338_W	342_K	0.803	0.72
125_T	395_A	0.802	0.72
217_T	222_I	0.800	0.72
236_E	465_K	0.799	0.72
201_I	222_I	0.798	0.72
197_I	230_I	0.798	0.72
365_A	405_A	0.798	0.72
437_A	441_I	0.797	0.72
47_L	153_M	0.794	0.71
127_V	370_G	0.793	0.71
60_F	279_F	0.789	0.71
91_L	124_P	0.789	0.71
150_E	194_G	0.789	0.71
130_V	134_S	0.787	0.71
450_K	469_F	0.786	0.71
100_G	103_I	0.786	0.71
147_L	228_F	0.783	0.70
58_V	232_L	0.783	0.70
196_V	476_N	0.782	0.70
492_A	496_A	0.782	0.70
16_I	20_V	0.780	0.70
332_F	403_V	0.779	0.70
69_G	250_I	0.779	0.70
426_L	437_A	0.774	0.69
506_I	516_E	0.774	0.69
470_Q	484_K	0.772	0.69
167_A	171_T	0.771	0.69
33_Q	406_T	0.769	0.69
14_I	18_N	0.768	0.69
159_L	369_A	0.767	0.69
162_F	374_I	0.765	0.68
100_G	253_A	0.765	0.68
354_T	358_S	0.763	0.68
10_L	18_N	0.762	0.68
80_L	142_G	0.762	0.68
240_S	363_R	0.760	0.68
182_S	186_I	0.759	0.68
483_R	510_T	0.758	0.68
152_L	235_E	0.758	0.68
125_T	362_V	0.756	0.68
141_K	235_E	0.756	0.68
43_F	46_G	0.754	0.67
129_A	154_N	0.753	0.67
15_A	458_A	0.752	0.67
106_M	177_A	0.752	0.67
330_V	357_I	0.752	0.67
69_G	370_G	0.751	0.67
445_M	448_T	0.750	0.67
125_T	282_N	0.750	0.67
97_I	116_F	0.745	0.66
122_L	322_L	0.745	0.66
67_N	253_A	0.744	0.66
189_G	237_I	0.743	0.66
116_F	174_F	0.743	0.66
105_W	109_A	0.742	0.66
84_I	149_G	0.742	0.66
432_K	438_L	0.740	0.66
34_V	68_D	0.739	0.66
485_V	495_E	0.738	0.66
515_Q	518_F	0.737	0.66
16_I	219_H	0.737	0.66
401_T	415_K	0.734	0.65
65_L	132_A	0.732	0.65
203_R	206_L	0.732	0.65
77_L	330_V	0.729	0.65
66_F	227_P	0.727	0.65
406_T	413_T	0.727	0.65
126_D	156_A	0.726	0.64
506_I	511_A	0.726	0.64
443_E	452_A	0.724	0.64
77_L	353_S	0.723	0.64
127_V	143_I	0.722	0.64
100_G	116_F	0.722	0.64
69_G	493_E	0.717	0.63
93_F	157_S	0.715	0.63
11_L	55_L	0.715	0.63
261_S	267_Q	0.714	0.63
84_I	235_E	0.713	0.63
348_K	354_T	0.712	0.63
153_M	243_L	0.712	0.63
466_N	469_F	0.711	0.63
60_F	80_L	0.710	0.63
259_L	262_T	0.710	0.63
132_A	315_I	0.708	0.62
72_T	355_L	0.708	0.62
4_F	220_M	0.707	0.62
150_E	241_G	0.705	0.62
64_L	203_R	0.703	0.62
163_K	374_I	0.698	0.61
273_T	276_I	0.698	0.61
146_L	183_F	0.697	0.61
134_S	493_E	0.697	0.61
467_L	506_I	0.697	0.61
235_E	246_V	0.697	0.61
242_I	289_L	0.697	0.61
121_I	162_F	0.697	0.61
124_P	274_W	0.695	0.61
66_F	204_F	0.695	0.61
332_F	336_G	0.694	0.61
201_I	248_G	0.694	0.61
56_F	156_A	0.693	0.61
114_A	390_I	0.693	0.61
87_L	90_G	0.692	0.61
39_L	195_V	0.691	0.61
128_V	360_S	0.691	0.61
159_L	363_R	0.690	0.60
497_L	514_L	0.690	0.60
255_E	258_R	0.688	0.60
154_N	282_N	0.685	0.60
446_N	449_N	0.684	0.60
389_L	393_L	0.684	0.60
160_V	372_F	0.682	0.60
319_T	404_I	0.681	0.59
120_A	375_P	0.680	0.59
432_K	435_K	0.680	0.59
79_N	230_I	0.678	0.59
42_S	294_P	0.677	0.59
110_I	118_L	0.677	0.59
124_P	410_P	0.677	0.59
56_F	74_R	0.676	0.59
472_Y	475_S	0.675	0.59
152_L	240_S	0.675	0.59
430_R	440_T	0.674	0.59
114_A	226_T	0.674	0.59
110_I	117_G	0.673	0.59
129_A	152_L	0.672	0.58
130_V	160_V	0.672	0.58
74_R	77_L	0.670	0.58
137_V	413_T	0.665	0.58
12_T	499_K	0.665	0.58
309_M	320_F	0.664	0.58
234_A	239_V	0.664	0.58
319_T	323_M	0.663	0.57
33_Q	359_I	0.663	0.57
386_E	389_L	0.661	0.57
89_L	187_S	0.660	0.57
130_V	395_A	0.660	0.57
156_A	273_T	0.659	0.57
122_L	125_T	0.658	0.57
223_Q	226_T	0.658	0.57
164_F	179_A	0.655	0.57
162_F	166_I	0.655	0.57
187_S	243_L	0.655	0.57
148_E	223_Q	0.655	0.57
289_L	395_A	0.653	0.56
149_G	152_L	0.653	0.56
454_L	458_A	0.653	0.56
430_R	436_T	0.652	0.56
233_A	447_E	0.652	0.56
91_L	325_L	0.651	0.56
281_L	370_G	0.651	0.56
121_I	151_G	0.650	0.56
123_S	398_I	0.650	0.56
250_I	371_S	0.649	0.56
241_G	361_G	0.649	0.56
487_A	522_E	0.649	0.56
465_K	470_Q	0.648	0.56
193_C	252_H	0.647	0.56
12_T	15_A	0.647	0.56
71_R	148_E	0.643	0.55
86_L	335_N	0.643	0.55
64_L	365_A	0.643	0.55
202_I	371_S	0.641	0.55
215_D	358_S	0.641	0.55
322_L	397_V	0.640	0.55
272_S	275_N	0.638	0.55
230_I	233_A	0.638	0.55
117_G	390_I	0.638	0.55
117_G	162_F	0.636	0.54
399_L	466_N	0.636	0.54
134_S	139_M	0.635	0.54
60_F	285_V	0.635	0.54
122_L	394_A	0.634	0.54
64_L	125_T	0.633	0.54
489_G	493_E	0.633	0.54
359_I	365_A	0.632	0.54
70_K	134_S	0.631	0.54
126_D	241_G	0.630	0.54
496_A	500_M	0.630	0.54
460_Y	464_M	0.629	0.54
430_R	517_R	0.628	0.53
104_H	111_P	0.628	0.53
116_F	164_F	0.626	0.53
131_S	148_E	0.626	0.53
289_L	398_I	0.625	0.53
262_T	500_M	0.624	0.53
229_V	475_S	0.623	0.53
83_P	137_V	0.618	0.52
96_V	123_S	0.618	0.52
464_M	474_S	0.617	0.52
306_I	435_K	0.614	0.52
43_F	188_L	0.613	0.52
67_N	367_T	0.613	0.52
469_F	472_Y	0.611	0.51
377_F	495_E	0.611	0.51
6_V	39_L	0.610	0.51
156_A	240_S	0.609	0.51
427_L	442_K	0.609	0.51
191_L	195_V	0.608	0.51
17_S	24_I	0.608	0.51
126_D	364_G	0.607	0.51
363_R	406_T	0.607	0.51
61_I	399_L	0.606	0.51
454_L	460_Y	0.604	0.51
445_M	450_K	0.603	0.50
315_I	400_C	0.603	0.50
39_L	42_S	0.602	0.50
70_K	245_V	0.601	0.50
156_A	394_A	0.601	0.50
362_V	406_T	0.599	0.50
154_N	364_G	0.599	0.50
63_P	231_Y	0.599	0.50
366_V	369_A	0.598	0.50
463_K	466_N	0.598	0.50
117_G	120_A	0.598	0.50
282_N	394_A	0.598	0.50
224_I	273_T	0.597	0.50
198_S	358_S	0.596	0.50
44_P	371_S	0.596	0.50
118_L	122_L	0.595	0.50
61_I	406_T	0.594	0.49
38_I	41_A	0.593	0.49
199_F	324_L	0.592	0.49
451_T	473_T	0.592	0.49
373_S	377_F	0.591	0.49
275_N	282_N	0.590	0.49
193_C	306_I	0.588	0.49
184_V	436_T	0.588	0.49
90_G	147_L	0.587	0.49
448_T	451_T	0.587	0.49
17_S	32_I	0.585	0.48
78_W	272_S	0.584	0.48
411_I	507_P	0.584	0.48
457_I	460_Y	0.584	0.48
79_N	504_G	0.583	0.48
288_I	356_L	0.582	0.48
119_A	265_K	0.582	0.48
227_P	230_I	0.582	0.48
156_A	282_N	0.581	0.48
467_L	470_Q	0.581	0.48
68_D	362_V	0.580	0.48
85_L	192_L	0.579	0.48
360_S	365_A	0.579	0.48
15_A	218_M	0.579	0.48
4_F	55_L	0.576	0.47
324_L	411_I	0.575	0.47
156_A	365_A	0.575	0.47
132_A	447_E	0.574	0.47
433_L	439_Q	0.573	0.47
431_R	448_T	0.573	0.47
129_A	155_D	0.573	0.47
9_V	458_A	0.572	0.47
382_T	385_P	0.571	0.47
177_A	442_K	0.571	0.47
132_A	151_G	0.570	0.47
177_A	414_E	0.570	0.47
229_V	421_E	0.570	0.47
133_L	396_G	0.569	0.47
434_I	440_T	0.568	0.46
72_T	185_F	0.568	0.46
501_L	515_Q	0.568	0.46
16_I	176_L	0.567	0.46
439_Q	446_N	0.567	0.46
443_E	449_N	0.567	0.46
183_F	401_T	0.566	0.46
468_R	471_Q	0.566	0.46
7_V	10_L	0.566	0.46
128_V	366_V	0.565	0.46
31_L	410_P	0.564	0.46
464_M	469_F	0.564	0.46
19_I	200_L	0.564	0.46
323_M	358_S	0.564	0.46
221_L	280_I	0.563	0.46
256_Q	366_V	0.563	0.46
441_I	449_N	0.562	0.46
430_R	449_N	0.562	0.46
195_V	199_F	0.562	0.46
480_K	484_K	0.562	0.46
62_A	231_Y	0.562	0.46
28_P	396_G	0.562	0.46
226_T	259_L	0.561	0.46
194_G	241_G	0.560	0.45
431_R	485_V	0.560	0.45
428_T	434_I	0.559	0.45
157_S	282_N	0.559	0.45
126_D	326_R	0.558	0.45
85_L	476_N	0.558	0.45
395_A	405_A	0.557	0.45
39_L	336_G	0.557	0.45
471_Q	475_S	0.555	0.45
377_F	469_F	0.554	0.45
145_R	322_L	0.553	0.45
12_T	224_I	0.553	0.45
295_D	328_L	0.553	0.45
36_L	166_I	0.553	0.45
88_A	96_V	0.552	0.45
16_I	93_F	0.551	0.44
196_V	491_K	0.551	0.44
57_F	139_M	0.551	0.44
214_Q	341_N	0.550	0.44
341_N	348_K	0.550	0.44
26_F	69_G	0.549	0.44
241_G	326_R	0.547	0.44
155_D	361_G	0.547	0.44
469_F	473_T	0.547	0.44
157_S	164_F	0.547	0.44
500_M	505_D	0.546	0.44
220_M	270_S	0.546	0.44
41_A	367_T	0.544	0.44
163_K	167_A	0.543	0.44
196_V	451_T	0.543	0.44
17_S	33_Q	0.543	0.44
450_K	466_N	0.543	0.44
426_L	434_I	0.542	0.43
336_G	341_N	0.541	0.43
41_A	394_A	0.541	0.43
66_F	145_R	0.541	0.43
500_M	510_T	0.540	0.43
226_T	252_H	0.540	0.43
522_E	525_Y	0.540	0.43
87_L	357_I	0.539	0.43
352_R	427_L	0.539	0.43
510_T	513_V	0.538	0.43
120_A	155_D	0.538	0.43
158_G	406_T	0.538	0.43
363_R	414_E	0.537	0.43
290_G	364_G	0.537	0.43
9_V	20_V	0.536	0.43
51_L	56_F	0.536	0.43
136_R	161_A	0.535	0.43
10_L	409_L	0.533	0.42
60_F	162_F	0.533	0.42
338_W	346_I	0.532	0.42
93_F	161_A	0.531	0.42
377_F	383_P	0.531	0.42
230_I	245_V	0.530	0.42
200_L	472_Y	0.528	0.42
243_L	511_A	0.528	0.42
412_L	416_E	0.528	0.42
11_L	15_A	0.527	0.42
298_S	328_L	0.526	0.42
33_Q	37_G	0.526	0.42
71_R	394_A	0.525	0.41
31_L	407_V	0.525	0.41
69_G	247_A	0.525	0.41
205_R	226_T	0.524	0.41
376_Y	383_P	0.523	0.41
12_T	16_I	0.523	0.41
443_E	446_N	0.523	0.41
56_F	145_R	0.522	0.41
202_I	251_T	0.522	0.41
103_I	119_A	0.522	0.41
189_G	242_I	0.521	0.41
132_A	262_T	0.521	0.41
494_Q	515_Q	0.521	0.41
29_V	245_V	0.521	0.41
67_N	282_N	0.521	0.41
202_I	207_F	0.520	0.41
494_Q	498_M	0.519	0.41
65_L	124_P	0.518	0.41
245_V	401_T	0.518	0.41
103_I	215_D	0.518	0.41
137_V	371_S	0.518	0.41
28_P	407_V	0.516	0.40
394_A	398_I	0.516	0.40
32_I	215_D	0.515	0.40
317_V	320_F	0.515	0.40
492_A	495_E	0.514	0.40
22_R	111_P	0.514	0.40
65_L	164_F	0.513	0.40
181_V	200_L	0.513	0.40
434_I	465_K	0.512	0.40
29_V	139_M	0.512	0.40
37_G	41_A	0.512	0.40
23_F	406_T	0.511	0.40
156_A	246_V	0.510	0.40
198_S	202_I	0.510	0.40
183_F	205_R	0.510	0.40
131_S	332_F	0.510	0.40
92_V	152_L	0.509	0.40
304_T	400_C	0.509	0.40
52_N	188_L	0.508	0.40
188_L	414_E	0.508	0.40
233_A	379_E	0.508	0.40
69_G	117_G	0.505	0.39
430_R	434_I	0.505	0.39
429_A	435_K	0.505	0.39
325_L	328_L	0.505	0.39
150_E	156_A	0.504	0.39
478_I	485_V	0.504	0.39
106_M	298_S	0.504	0.39
66_F	223_Q	0.504	0.39
66_F	69_G	0.503	0.39
428_T	457_I	0.503	0.39
126_D	240_S	0.502	0.39
324_L	497_L	0.501	0.39
282_N	398_I	0.501	0.39
145_R	220_M	0.500	0.39
263_M	377_F	0.500	0.39
511_A	521_L	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cz8A	2	0.5821	100	0.576	Contact Map
4czbA	2	0.5836	100	0.58	Contact Map
4bwzA	2	0.5657	100	0.642	Contact Map
2mdfA	1	0.0851	99.6	0.875	Contact Map
1zcdA	1	0.5418	99.6	0.878	Contact Map
2l0eA	1	0.0463	98.6	0.923	Contact Map
2htgA	1	0.0403	98.2	0.931	Contact Map
2k3cA	1	0.0463	98.2	0.931	Contact Map
2m7xA	1	0.0448	97.7	0.939	Contact Map
2kbvA	1	0.0388	96.4	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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