GREMLIN Database
GR - Glyoxal reductase
UniProt: O32210 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (251)
Sequences: 32604 (20989)
Seq/√Len: 1324.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_A240_I3.0641.00
95_E134_K2.8621.00
65_K102_Q2.7141.00
30_G62_I2.7021.00
210_H254_D2.6081.00
251_S254_D2.4031.00
94_F129_L2.3851.00
34_T66_E2.3711.00
10_K16_E2.3381.00
91_L128_K2.3341.00
91_L132_D2.2911.00
39_A43_N2.2441.00
209_K257_K2.0801.00
34_T62_I1.9951.00
204_T208_E1.9641.00
127_E131_K1.9481.00
96_K100_R1.9461.00
105_Y136_R1.9201.00
224_Q255_M1.9081.00
178_Y182_Q1.8961.00
9_V19_W1.8891.00
209_K254_D1.8881.00
128_K132_D1.8801.00
70_A73_E1.8611.00
252_Q256_D1.8501.00
236_E240_I1.8401.00
179_C186_L1.8151.00
205_Q257_K1.7841.00
39_A236_E1.7511.00
21_G47_S1.7481.00
87_Y128_K1.7321.00
110_L161_V1.7011.00
212_K248_F1.6911.00
43_N240_I1.6911.00
149_E153_K1.6631.00
225_H259_D1.6581.00
76_I103_L1.6571.00
128_K131_K1.6431.00
40_A45_Y1.6131.00
185_Q228_V1.6081.00
8_T16_E1.5951.00
43_N243_A1.5851.00
149_E178_Y1.5781.00
58_E100_R1.5731.00
78_S106_L1.5701.00
87_Y91_L1.5671.00
34_T38_K1.5621.00
34_T63_G1.5561.00
80_V109_Y1.5471.00
220_R248_F1.5461.00
78_S97_S1.5441.00
38_K66_E1.5341.00
91_L95_E1.5301.00
202_V205_Q1.5111.00
256_D260_A1.5101.00
213_S241_E1.5071.00
80_V90_T1.5051.00
39_A42_K1.5041.00
94_F109_Y1.4971.00
244_D247_D1.4891.00
125_A128_K1.4841.00
77_T110_L1.4781.00
29_N32_E1.4701.00
24_V48_I1.4481.00
52_A93_A1.4131.00
127_E157_I1.4101.00
92_A96_K1.4001.00
41_I74_L1.4001.00
30_G34_T1.3991.00
174_E177_D1.3891.00
177_D181_G1.3831.00
15_V137_A1.3801.00
32_E35_E1.3761.00
180_K226_G1.3651.00
37_V63_G1.3471.00
95_E99_E1.3421.00
110_L187_E1.3391.00
212_K216_Q1.3271.00
144_Q147_H1.3211.00
106_L135_I1.3181.00
130_Y157_I1.3141.00
152_L182_Q1.3051.00
240_I244_D1.3001.00
164_V186_L1.2851.00
137_A160_M1.2691.00
15_V75_F1.2661.00
87_Y124_R1.2651.00
220_R224_Q1.2631.00
233_S238_R1.2541.00
38_K42_K1.2471.00
96_K99_E1.2361.00
152_L178_Y1.2351.00
129_L135_I1.2271.00
35_E39_A1.2241.00
87_Y125_A1.2221.00
257_K260_A1.2221.00
91_L125_A1.2071.00
233_S239_I1.2021.00
75_F108_L1.1921.00
205_Q209_K1.1901.00
202_V257_K1.1881.00
212_K217_V1.1851.00
135_I138_I1.1821.00
145_V178_Y1.1791.00
57_E97_S1.1741.00
62_I102_Q1.1641.00
120_K154_D1.1571.00
176_R180_K1.1501.00
101_L106_L1.1491.00
71_R103_L1.1491.00
131_K156_E1.1491.00
61_G102_Q1.1391.00
166_F225_H1.1391.00
213_S216_Q1.1331.00
71_R105_Y1.1301.00
31_N35_E1.1271.00
169_R200_N1.1241.00
204_T214_V1.1081.00
108_L161_V1.1001.00
114_P147_H1.0921.00
88_E92_A1.0921.00
86_G89_T1.0911.00
48_I60_V1.0841.00
237_H240_I1.0841.00
149_E181_G1.0831.00
94_F106_L1.0801.00
89_T92_A1.0781.00
47_S187_E1.0661.00
130_Y160_M1.0651.00
13_N137_A1.0631.00
58_E62_I1.0621.00
121_D124_R1.0561.00
38_K63_G1.0421.00
206_I217_V1.0421.00
205_Q208_E1.0421.00
149_E182_Q1.0361.00
95_E132_D1.0331.00
127_E130_Y1.0311.00
47_S77_T1.0291.00
126_L138_I1.0231.00
85_Q111_I1.0181.00
24_V60_V1.0161.00
129_L134_K1.0111.00
111_I126_L1.0101.00
36_S239_I1.0011.00
35_E236_E1.0011.00
222_D229_T1.0001.00
171_T262_N0.9951.00
12_H160_M0.9881.00
201_E204_T0.9871.00
165_E170_L0.9851.00
223_L245_I0.9821.00
168_P258_I0.9801.00
216_Q244_D0.9791.00
150_E154_D0.9781.00
46_R75_F0.9711.00
57_E100_R0.9701.00
201_E205_Q0.9701.00
10_K14_G0.9631.00
203_L214_V0.9611.00
145_V149_E0.9601.00
173_K177_D0.9511.00
18_P46_R0.9421.00
161_V187_E0.9321.00
177_D180_K0.9311.00
168_P218_I0.9281.00
62_I66_E0.9211.00
52_A89_T0.9181.00
18_P45_Y0.9161.00
239_I243_A0.9151.00
120_K150_E0.9111.00
58_E99_E0.9091.00
107_D136_R0.9081.00
140_V159_P0.9051.00
91_L94_F0.9001.00
84_D89_T0.8991.00
64_I74_L0.8991.00
216_Q241_E0.8951.00
19_W223_L0.8931.00
19_W246_F0.8861.00
241_E244_D0.8851.00
237_H241_E0.8761.00
37_V48_I0.8701.00
187_E228_V0.8681.00
52_A84_D0.8671.00
129_L132_D0.8661.00
124_R128_K0.8651.00
125_A129_L0.8611.00
66_E70_A0.8551.00
41_I70_A0.8521.00
92_A95_E0.8521.00
35_E38_K0.8511.00
87_Y121_D0.8471.00
256_D259_D0.8451.00
77_T187_E0.8431.00
206_I210_H0.8381.00
127_E156_E0.8381.00
140_V148_L0.8371.00
219_L245_I0.8341.00
162_N179_C0.8321.00
30_G59_G0.8321.00
224_Q249_E0.8311.00
235_K238_R0.8311.00
13_N160_M0.8291.00
138_I159_P0.8191.00
253_E257_K0.8131.00
52_A100_R0.8111.00
253_E256_D0.8091.00
150_E153_K0.8061.00
178_Y181_G0.8061.00
91_L129_L0.7961.00
148_L184_I0.7931.00
225_H255_M0.7881.00
127_E138_I0.7871.00
13_N130_Y0.7851.00
209_K251_S0.7731.00
124_R127_E0.7721.00
77_T108_L0.7711.00
142_N189_W0.7701.00
218_I222_D0.7691.00
171_T259_D0.7691.00
210_H251_S0.7691.00
220_R245_I0.7631.00
52_A96_K0.7621.00
176_R186_L0.7621.00
9_V185_Q0.7481.00
22_L40_A0.7471.00
24_V56_N0.7411.00
166_F176_R0.7391.00
98_L134_K0.7381.00
234_I238_R0.7361.00
224_Q252_Q0.7361.00
43_N244_D0.7351.00
38_K70_A0.7311.00
31_N34_T0.7301.00
191_P231_P0.7291.00
113_W142_N0.7261.00
78_S109_Y0.7231.00
175_L179_C0.7211.00
39_A239_I0.7201.00
188_A191_P0.7171.00
118_K121_D0.7151.00
85_Q122_T0.7081.00
145_V175_L0.7061.00
50_T60_V0.7041.00
202_V261_L0.7001.00
152_L158_K0.7001.00
28_E32_E0.6971.00
123_W151_L0.6941.00
22_L27_V0.6941.00
127_E155_A0.6931.00
36_S236_E0.6931.00
188_A229_T0.6921.00
94_F134_K0.6881.00
123_W159_P0.6871.00
208_E211_N0.6821.00
93_A96_K0.6821.00
41_I48_I0.6811.00
215_A241_E0.6801.00
21_G231_P0.6791.00
212_K247_D0.6791.00
98_L103_L0.6771.00
145_V174_E0.6771.00
97_S109_Y0.6741.00
176_R225_H0.6741.00
70_A74_L0.6731.00
45_Y243_A0.6701.00
33_A59_G0.6691.00
123_W138_I0.6651.00
210_H217_V0.6631.00
140_V162_N0.6611.00
90_T129_L0.6601.00
72_E105_Y0.6591.00
140_V143_F0.6581.00
179_C184_I0.6531.00
110_L139_G0.6471.00
221_W259_D0.6421.00
20_F223_L0.6391.00
25_F190_S0.6341.00
26_K194_Q0.6341.00
212_K244_D0.6331.00
46_R73_E0.6331.00
166_F171_T0.6321.00
238_R241_E0.6281.00
191_P222_D0.6251.00
200_N204_T0.6221.00
207_A217_V0.6221.00
15_V136_R0.6211.00
37_V41_I0.6201.00
90_T122_T0.6191.00
250_L255_M0.6181.00
106_L109_Y0.6151.00
206_I254_D0.6141.00
43_N239_I0.6141.00
203_L258_I0.6131.00
122_T125_A0.6121.00
196_Q200_N0.6091.00
217_V250_L0.6081.00
222_D227_V0.6041.00
203_L218_I0.6001.00
185_Q227_V0.6001.00
126_L130_Y0.5991.00
130_Y135_I0.5991.00
166_F222_D0.5981.00
119_Y154_D0.5961.00
27_V33_A0.5951.00
90_T125_A0.5941.00
130_Y137_A0.5941.00
32_E236_E0.5931.00
119_Y122_T0.5921.00
169_R196_Q0.5911.00
94_F98_L0.5861.00
17_M228_V0.5851.00
42_K236_E0.5851.00
41_I46_R0.5841.00
120_K124_R0.5841.00
98_L105_Y0.5841.00
217_V248_F0.5811.00
29_N59_G0.5801.00
98_L104_D0.5781.00
166_F186_L0.5781.00
49_D163_Q0.5771.00
98_L106_L0.5741.00
80_V85_Q0.5741.00
206_I257_K0.5741.00
149_E152_L0.5701.00
8_T46_R0.5661.00
91_L134_K0.5651.00
118_K122_T0.5641.00
207_A214_V0.5631.00
250_L254_D0.5601.00
86_G122_T0.5581.00
12_H158_K0.5561.00
254_D257_K0.5551.00
41_I73_E0.5531.00
109_Y135_I0.5531.00
212_K220_R0.5511.00
28_E33_A0.5511.00
217_V254_D0.5511.00
80_V93_A0.5501.00
12_H183_G0.5491.00
53_I81_W0.5481.00
147_H150_E0.5481.00
8_T18_P0.5481.00
190_S194_Q0.5451.00
36_S233_S0.5451.00
233_S242_N0.5441.00
82_N85_Q0.5441.00
11_L185_Q0.5391.00
20_F246_F0.5361.00
207_A210_H0.5361.00
140_V151_L0.5341.00
197_L218_I0.5311.00
27_V36_S0.5301.00
217_V258_I0.5301.00
50_T56_N0.5291.00
131_K157_I0.5241.00
119_Y147_H0.5241.00
48_I64_I0.5241.00
166_F227_V0.5241.00
109_Y126_L0.5231.00
119_Y150_E0.5211.00
138_I157_I0.5191.00
22_L36_S0.5191.00
41_I63_G0.5171.00
216_Q248_F0.5171.00
17_M47_S0.5171.00
37_V60_V0.5161.00
236_E239_I0.5151.00
60_V63_G0.5141.00
146_H149_E0.5141.00
206_I209_K0.5081.00
87_Y90_T0.5061.00
64_I70_A0.5041.00
168_P221_W0.5021.00
111_I122_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f7jA 1 1 100 0.08 Contact Map
3b3dA 1 0.9964 100 0.088 Contact Map
4f40A 1 0.9819 100 0.093 Contact Map
4q3mA 2 0.9746 100 0.101 Contact Map
4otkA 1 0.9891 100 0.101 Contact Map
1vbjA 1 0.9928 100 0.102 Contact Map
2wzmA 1 0.9819 100 0.104 Contact Map
1hw6A 1 0.9167 100 0.108 Contact Map
3wbwA 1 0.971 100 0.11 Contact Map
4mhbA 4 0.9746 100 0.113 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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