GREMLIN Database
YVGM - Putative molybdenum transport system permease protein YvgM
UniProt: O32209 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (204)
Sequences: 68498 (41047)
Seq/√Len: 2873.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_K145_H3.8671.00
18_V22_Q3.0291.00
118_K122_A2.7861.00
133_M142_V2.7381.00
129_Q147_S2.5941.00
44_R129_Q2.4801.00
16_P190_A2.4361.00
120_G154_S2.4041.00
132_A142_V2.3901.00
15_T18_V2.3841.00
138_S141_K2.3131.00
26_V102_V2.3061.00
185_Q193_V2.2861.00
28_G159_S2.2761.00
5_P9_S2.2591.00
30_V106_A2.2561.00
117_A155_L2.1771.00
139_R142_V2.1571.00
140_W144_I2.1501.00
14_F18_V2.1361.00
199_N202_L2.1041.00
47_F50_K2.0571.00
137_A141_K1.9851.00
36_T143_F1.9251.00
43_S122_A1.9111.00
141_K144_I1.9101.00
113_M158_G1.9011.00
121_F151_A1.9011.00
128_I150_L1.7581.00
54_E118_K1.7301.00
22_Q98_W1.7091.00
32_I159_S1.6881.00
24_A163_L1.6871.00
132_A137_A1.6831.00
129_Q142_V1.6801.00
133_M139_R1.6781.00
36_T151_A1.6671.00
15_T19_L1.6221.00
42_M114_Y1.6001.00
6_S202_L1.5651.00
35_G113_M1.5471.00
182_G185_Q1.5411.00
129_Q133_M1.5361.00
190_A194_A1.5151.00
36_T117_A1.5051.00
22_Q26_V1.4961.00
27_A166_A1.4851.00
38_A114_Y1.4541.00
33_I37_L1.4531.00
113_M162_S1.4441.00
39_G117_A1.4231.00
98_W184_T1.4131.00
46_S50_K1.4051.00
148_V155_L1.3771.00
49_G52_A1.3691.00
126_P129_Q1.3501.00
170_F174_L1.3341.00
157_T161_L1.3281.00
43_S118_K1.3041.00
117_A158_G1.3011.00
104_A176_F1.2891.00
4_L208_V1.2621.00
121_F147_S1.2571.00
44_R126_P1.2461.00
6_S9_S1.2411.00
179_N183_V1.2261.00
12_E15_T1.2201.00
170_F192_Y1.2181.00
172_A176_F1.2111.00
31_V162_S1.2051.00
23_V186_T1.2021.00
132_A146_I1.1911.00
36_T155_L1.1761.00
20_S187_L1.1711.00
94_V97_T1.1701.00
40_A121_F1.1681.00
185_Q190_A1.1561.00
177_A184_T1.1531.00
194_A199_N1.1521.00
126_P130_G1.1471.00
76_F100_A1.1461.00
194_A197_S1.1261.00
138_S142_V1.1261.00
124_I150_L1.1251.00
186_T189_T1.1241.00
110_F114_Y1.1111.00
19_L22_Q1.1091.00
179_N184_T1.1071.00
26_V29_I1.1041.00
152_Y156_L1.0971.00
127_D130_G1.0941.00
29_I33_I1.0871.00
52_A55_T1.0851.00
17_V187_L1.0661.00
173_T186_T1.0651.00
43_S121_F1.0591.00
8_I14_F1.0561.00
30_V102_V1.0241.00
52_A56_C1.0181.00
37_L41_W1.0091.00
150_L153_P1.0031.00
169_E173_T1.0021.00
40_A143_F0.9931.00
50_K122_A0.9931.00
32_I155_L0.9871.00
27_A105_S0.9861.00
101_A173_T0.9821.00
190_A206_W0.9761.00
4_L205_A0.9711.00
214_S218_L0.9691.00
117_A154_S0.9671.00
137_A142_V0.9641.00
26_V30_V0.9641.00
99_W103_I0.9641.00
27_A31_V0.9631.00
105_S166_A0.9581.00
116_S158_G0.9561.00
129_Q139_R0.9551.00
169_E172_A0.9531.00
185_Q189_T0.9521.00
142_V145_H0.9481.00
6_S10_A0.9391.00
40_A139_R0.9241.00
21_F25_A0.9221.00
7_S209_C0.9211.00
74_V78_K0.9121.00
39_G43_S0.9081.00
98_W102_V0.9021.00
17_V21_F0.8961.00
6_S199_N0.8951.00
48_F51_T0.8951.00
102_V106_A0.8881.00
25_A29_I0.8871.00
117_A151_A0.8861.00
19_L98_W0.8841.00
69_G171_G0.8751.00
104_A172_A0.8741.00
94_V99_W0.8681.00
152_Y155_L0.8641.00
96_F179_N0.8621.00
137_A145_H0.8621.00
65_P108_V0.8601.00
193_V196_D0.8601.00
120_G151_A0.8551.00
13_F206_W0.8511.00
22_Q25_A0.8491.00
35_G114_Y0.8481.00
72_L176_F0.8461.00
151_A154_S0.8421.00
29_I159_S0.8411.00
144_I148_V0.8411.00
22_Q99_W0.8401.00
58_M115_Q0.8391.00
72_L104_A0.8361.00
39_G121_F0.8331.00
27_A102_V0.8291.00
23_V98_W0.8271.00
143_F148_V0.8261.00
200_N203_A0.8251.00
51_T54_E0.8191.00
73_I77_G0.8181.00
142_V147_S0.8161.00
41_W47_F0.8151.00
194_A206_W0.8121.00
100_A104_A0.8111.00
30_V33_I0.8081.00
113_M117_A0.8051.00
194_A202_L0.7961.00
39_G114_Y0.7951.00
174_L189_T0.7941.00
24_A28_G0.7871.00
58_M61_L0.7811.00
31_V35_G0.7711.00
162_S166_A0.7691.00
12_E182_G0.7691.00
7_S202_L0.7621.00
69_G175_M0.7601.00
32_I117_A0.7591.00
177_A185_Q0.7491.00
169_E186_T0.7481.00
31_V109_A0.7461.00
202_L206_W0.7441.00
26_V106_A0.7431.00
117_A121_F0.7391.00
128_I146_I0.7381.00
200_N204_W0.7361.00
38_A110_F0.7331.00
126_P133_M0.7321.00
18_V21_F0.7301.00
139_R143_F0.7291.00
190_A193_V0.7241.00
35_G117_A0.7241.00
191_I206_W0.7231.00
68_V107_V0.7221.00
10_A14_F0.7211.00
216_L220_F0.7171.00
204_W208_V0.7091.00
42_M53_L0.7081.00
143_F147_S0.7061.00
23_V105_S0.7021.00
42_M54_E0.6961.00
42_M118_K0.6951.00
124_I151_A0.6911.00
41_W45_A0.6901.00
131_A135_D0.6901.00
16_P19_L0.6891.00
65_P171_G0.6821.00
99_W102_V0.6781.00
101_A177_A0.6741.00
77_G95_I0.6721.00
173_T189_T0.6721.00
28_G163_L0.6721.00
155_L158_G0.6661.00
54_E115_Q0.6661.00
5_P8_I0.6621.00
7_S206_W0.6591.00
20_S188_P0.6531.00
28_G32_I0.6531.00
16_P187_L0.6511.00
193_V197_S0.6511.00
131_A134_V0.6501.00
47_F53_L0.6461.00
61_L111_P0.6461.00
109_A162_S0.6421.00
201_T204_W0.6411.00
31_V113_M0.6381.00
100_A176_F0.6341.00
46_S51_T0.6291.00
138_S144_I0.6281.00
14_F17_V0.6281.00
188_P210_I0.6281.00
34_L106_A0.6251.00
20_S167_L0.6231.00
8_I209_C0.6171.00
207_V210_I0.6161.00
154_S158_G0.6111.00
147_S150_L0.6101.00
74_V77_G0.6081.00
23_V101_A0.6061.00
210_I214_S0.5991.00
31_V106_A0.5981.00
213_I216_L0.5971.00
105_S173_T0.5961.00
12_E185_Q0.5951.00
28_G166_A0.5941.00
187_L210_I0.5911.00
189_T193_V0.5871.00
155_L159_S0.5861.00
66_T175_M0.5841.00
179_N185_Q0.5821.00
34_L110_F0.5821.00
10_A202_L0.5801.00
38_A57_F0.5771.00
11_S14_F0.5741.00
116_S154_S0.5721.00
73_I95_I0.5721.00
11_S15_T0.5691.00
109_A165_R0.5681.00
165_R168_G0.5671.00
142_V146_I0.5671.00
101_A105_S0.5631.00
204_W207_V0.5621.00
164_A168_G0.5571.00
31_V166_A0.5551.00
65_P69_G0.5521.00
95_I99_W0.5511.00
39_G118_K0.5511.00
63_L67_V0.5501.00
215_F219_F0.5501.00
24_A167_L0.5441.00
23_V102_V0.5431.00
49_G53_L0.5431.00
36_T121_F0.5431.00
40_A147_S0.5421.00
147_S151_A0.5411.00
34_L37_L0.5391.00
124_I129_Q0.5381.00
171_G174_L0.5371.00
56_C60_P0.5351.00
48_F52_A0.5341.00
156_L159_S0.5341.00
61_L112_L0.5331.00
144_I147_S0.5331.00
15_T22_Q0.5301.00
55_T59_L0.5291.00
53_L57_F0.5281.00
72_L75_I0.5241.00
201_T205_A0.5221.00
159_S162_S0.5191.00
42_M47_F0.5191.00
173_T177_A0.5171.00
45_A139_R0.5161.00
46_S126_P0.5161.00
202_L205_A0.5121.00
125_D128_I0.5111.00
33_I36_T0.5101.00
27_A106_A0.5101.00
51_T55_T0.5081.00
189_T192_Y0.5061.00
32_I36_T0.5051.00
19_L186_T0.5041.00
97_T100_A0.5041.00
211_V214_S0.5031.00
23_V27_A0.5021.00
22_Q102_V0.5021.00
8_I11_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9604 100 0.224 Contact Map
3d31C 2 0.9515 100 0.228 Contact Map
4tquM 1 1 100 0.259 Contact Map
3rlfF 1 0.9648 100 0.267 Contact Map
3rlfG 1 0.9559 100 0.308 Contact Map
4tquN 1 0.9163 100 0.315 Contact Map
4ymuD 2 0.9295 99.9 0.4 Contact Map
3tuiA 2 0.9031 99.9 0.449 Contact Map
4mrsA 2 0.3744 7.8 0.943 Contact Map
2cfqA 1 0.8326 3.9 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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