GREMLIN Database
YVGL - Putative ABC transporter substrate-binding lipoprotein YvgL
UniProt: O32208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (238)
Sequences: 19580 (14606)
Seq/√Len: 946.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_T65_Q3.2921.00
54_N242_Y3.0351.00
37_T65_Q2.8691.00
62_I235_E2.8051.00
105_A233_R2.7711.00
108_D111_E2.7031.00
59_H238_E2.6791.00
35_T63_T2.5751.00
56_E63_T2.5291.00
233_R237_K2.4001.00
54_N251_V2.3521.00
142_A190_V2.2681.00
34_V235_E2.2471.00
245_S248_A2.2221.00
123_K210_D2.2191.00
58_D245_S2.1351.00
52_Q239_F2.1291.00
79_S101_D2.0821.00
49_E53_K2.0561.00
238_E241_E2.0511.00
224_L240_Y2.0341.00
232_H235_E2.0241.00
58_D247_E1.9841.00
54_N57_K1.9771.00
125_G191_D1.9761.00
69_G73_A1.8941.00
246_D250_K1.8851.00
237_K241_E1.8621.00
104_I225_G1.8251.00
55_Y62_I1.7971.00
250_K254_K1.7851.00
234_K238_E1.7811.00
52_Q56_E1.7291.00
122_P125_G1.7051.00
235_E238_E1.6861.00
76_K80_Q1.6761.00
54_N58_D1.6551.00
134_N137_E1.6491.00
184_Y189_N1.6481.00
53_K57_K1.6261.00
56_E59_H1.6231.00
164_L167_K1.5651.00
226_I240_Y1.5611.00
52_Q66_D1.5511.00
140_K191_D1.5441.00
230_T233_R1.5411.00
55_Y238_E1.5391.00
131_S134_N1.5371.00
234_K237_K1.5351.00
54_N247_E1.5281.00
96_K100_D1.5261.00
50_E53_K1.5131.00
45_Q49_E1.4721.00
105_A228_K1.4581.00
124_N208_I1.4561.00
36_L235_E1.4491.00
52_Q64_I1.4381.00
52_Q63_T1.4371.00
73_A77_Q1.4361.00
226_I237_K1.4261.00
34_V232_H1.4261.00
224_L243_L1.3881.00
247_E250_K1.3871.00
14_A17_L1.3831.00
53_K56_E1.3791.00
17_L20_G1.3491.00
248_A251_V1.3461.00
226_I236_A1.3341.00
59_H62_I1.3311.00
39_S84_A1.3291.00
156_K160_T1.3141.00
97_K101_D1.3081.00
130_T134_N1.2931.00
102_G228_K1.2921.00
98_L104_I1.2911.00
251_V254_K1.2871.00
86_L240_Y1.2851.00
133_S136_A1.2811.00
88_F224_L1.2721.00
18_V21_C1.2641.00
86_L236_A1.2541.00
242_Y248_A1.2421.00
177_D180_Q1.2391.00
120_V200_A1.2391.00
129_V134_N1.2281.00
50_E54_N1.2231.00
111_E237_K1.2041.00
164_L168_V1.1991.00
77_Q81_G1.1981.00
51_I248_A1.1951.00
115_N220_I1.1871.00
19_A22_S1.1851.00
55_Y242_Y1.1831.00
181_V193_G1.1791.00
130_T214_A1.1791.00
158_S162_L1.1611.00
40_A66_D1.1561.00
54_N248_A1.1551.00
184_Y190_V1.1401.00
75_Q79_S1.1371.00
50_E254_K1.1351.00
86_L239_F1.1291.00
13_T16_L1.1231.00
123_K208_I1.1211.00
62_I238_E1.1181.00
16_L19_A1.1161.00
183_S187_T1.1161.00
131_S215_D1.1011.00
127_S130_T1.1001.00
46_D49_E1.0901.00
99_V104_I1.0851.00
55_Y235_E1.0851.00
87_F225_G1.0761.00
157_E160_T1.0761.00
166_D170_D1.0641.00
55_Y59_H1.0551.00
166_D169_K1.0531.00
159_L162_L1.0521.00
136_A167_K1.0511.00
58_D242_Y1.0461.00
55_Y239_F1.0461.00
227_V230_T1.0451.00
75_Q98_L1.0441.00
120_V195_V1.0431.00
33_K63_T1.0431.00
51_I242_Y1.0351.00
119_L192_A1.0321.00
159_L163_S1.0231.00
76_K79_S1.0161.00
56_E64_I1.0131.00
157_E218_S1.0091.00
78_I87_F1.0051.00
167_K170_D1.0001.00
87_F227_V0.9981.00
105_A230_T0.9981.00
15_F18_V0.9921.00
126_D192_A0.9891.00
239_F243_L0.9831.00
169_K172_I0.9751.00
156_K159_L0.9631.00
226_I233_R0.9551.00
195_V200_A0.9471.00
33_K61_H0.9421.00
50_E251_V0.9411.00
11_A15_F0.9411.00
94_K97_K0.9341.00
121_V210_D0.9231.00
105_A237_K0.9141.00
91_A94_K0.9141.00
78_I227_V0.9131.00
36_L239_F0.9121.00
75_Q94_K0.9121.00
62_I66_D0.9111.00
79_S103_D0.9091.00
77_Q80_Q0.9081.00
73_A76_K0.9071.00
45_Q48_L0.9011.00
141_I146_P0.8991.00
247_E251_V0.8921.00
176_K180_Q0.8901.00
136_A168_V0.8881.00
10_A13_T0.8851.00
85_D232_H0.8841.00
121_V128_P0.8771.00
38_I239_F0.8711.00
206_V209_V0.8681.00
75_Q97_K0.8611.00
11_A14_A0.8601.00
183_S186_E0.8541.00
59_H235_E0.8501.00
140_K143_L0.8471.00
241_E245_S0.8461.00
185_V193_G0.8441.00
110_T244_Q0.8361.00
136_A164_L0.8341.00
21_C30_S0.8301.00
99_V109_S0.8291.00
173_V176_K0.8291.00
116_E197_K0.8291.00
197_K201_L0.8241.00
155_G158_S0.8241.00
133_S137_E0.8241.00
139_E142_A0.8221.00
97_K100_D0.8201.00
31_E34_V0.8191.00
95_F225_G0.8151.00
165_W168_V0.8131.00
10_A14_A0.8111.00
127_S134_N0.8111.00
107_K237_K0.8101.00
13_T17_L0.8101.00
184_Y187_T0.8061.00
20_G23_S0.8021.00
249_M253_E0.7931.00
120_V185_V0.7891.00
32_K35_T0.7861.00
88_F112_L0.7821.00
73_A81_G0.7801.00
151_A154_Y0.7801.00
12_L15_F0.7761.00
230_T236_A0.7761.00
98_L103_D0.7751.00
139_E171_K0.7731.00
241_E244_Q0.7711.00
30_S33_K0.7691.00
157_E161_K0.7671.00
143_L146_P0.7661.00
186_E205_K0.7651.00
77_Q82_A0.7621.00
19_A23_S0.7581.00
165_W169_K0.7441.00
51_I54_N0.7441.00
70_S73_A0.7431.00
34_V62_I0.7411.00
175_G184_Y0.7361.00
182_L186_E0.7351.00
36_L236_A0.7331.00
34_V61_H0.7321.00
121_V211_E0.7321.00
21_C31_E0.7291.00
56_E61_H0.7281.00
158_S163_S0.7281.00
115_N222_Y0.7231.00
36_L64_I0.7211.00
226_I230_T0.7211.00
92_E221_V0.7191.00
196_Y199_D0.7171.00
139_E143_L0.7161.00
153_A156_K0.7081.00
38_I52_Q0.7061.00
49_E52_Q0.7031.00
142_A145_T0.7031.00
85_D230_T0.6981.00
146_P149_V0.6981.00
243_L248_A0.6961.00
15_F19_A0.6941.00
141_I145_T0.6931.00
39_S67_N0.6881.00
205_K208_I0.6861.00
9_I13_T0.6851.00
122_P208_I0.6851.00
157_E163_S0.6781.00
71_S89_S0.6771.00
38_I224_L0.6741.00
150_P154_Y0.6731.00
67_N77_Q0.6721.00
151_A159_L0.6721.00
79_S97_K0.6701.00
21_C29_D0.6691.00
156_K165_W0.6631.00
112_L224_L0.6631.00
121_V192_A0.6631.00
132_F194_V0.6601.00
160_T163_S0.6581.00
180_Q183_S0.6561.00
131_S214_A0.6531.00
240_Y244_Q0.6521.00
151_A155_G0.6471.00
141_I144_G0.6441.00
69_G77_Q0.6401.00
17_L21_C0.6391.00
9_I12_L0.6391.00
78_I103_D0.6371.00
250_K253_E0.6361.00
203_S210_D0.6351.00
34_V238_E0.6331.00
32_K238_E0.6281.00
48_L51_I0.6281.00
92_E96_K0.6231.00
150_P153_A0.6181.00
107_K241_E0.6161.00
210_D213_K0.6151.00
33_K232_H0.6111.00
157_E162_L0.6111.00
168_V172_I0.6101.00
38_I66_D0.6101.00
124_N207_N0.6061.00
14_A18_V0.6051.00
224_L244_Q0.6041.00
155_G163_S0.6041.00
38_I86_L0.6041.00
156_K161_K0.6031.00
128_P134_N0.6021.00
204_K207_N0.6021.00
122_P191_D0.5991.00
107_K240_Y0.5981.00
105_A108_D0.5971.00
138_S171_K0.5971.00
56_E62_I0.5961.00
105_A229_D0.5961.00
175_G180_Q0.5901.00
122_P126_D0.5881.00
43_S46_D0.5871.00
74_L77_Q0.5861.00
18_V22_S0.5841.00
12_L16_L0.5831.00
51_I251_V0.5811.00
113_V222_Y0.5801.00
84_A227_V0.5791.00
40_A48_L0.5781.00
34_V38_I0.5761.00
118_V200_A0.5751.00
124_N188_G0.5731.00
33_K62_I0.5711.00
203_S206_V0.5691.00
79_S82_A0.5681.00
95_F223_P0.5661.00
176_K179_R0.5651.00
158_S161_K0.5641.00
149_V152_G0.5641.00
201_L204_K0.5621.00
195_V199_D0.5621.00
180_Q184_Y0.5611.00
190_V193_G0.5611.00
114_G219_P0.5591.00
144_G151_A0.5551.00
154_Y157_E0.5551.00
114_G221_V0.5531.00
74_L81_G0.5501.00
119_L194_V0.5491.00
38_I64_I0.5491.00
136_A171_K0.5471.00
92_E223_P0.5451.00
113_V252_F0.5431.00
167_K171_K0.5431.00
55_Y64_I0.5411.00
107_K110_T0.5391.00
140_K144_G0.5361.00
48_L252_F0.5351.00
182_L199_D0.5341.00
87_F98_L0.5341.00
120_V209_V0.5321.00
174_Y178_V0.5311.00
10_A16_L0.5291.00
47_A50_E0.5291.00
198_T201_L0.5281.00
152_G156_K0.5281.00
204_K208_I0.5221.00
46_D50_E0.5211.00
155_G159_L0.5201.00
134_N138_S0.5171.00
9_I16_L0.5161.00
81_G84_A0.5141.00
12_L17_L0.5141.00
191_D194_V0.5141.00
89_S225_G0.5121.00
141_I147_E0.5111.00
121_V126_D0.5111.00
36_L62_I0.5091.00
59_H64_I0.5081.00
117_I194_V0.5081.00
168_V171_K0.5061.00
11_A16_L0.5051.00
132_F135_L0.5051.00
123_K207_N0.5021.00
121_V125_G0.5001.00
228_K233_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k6vA 1 0.8577 100 0.36 Contact Map
3c9hA 1 0.9308 100 0.361 Contact Map
4edpA 1 0.8538 100 0.367 Contact Map
3r26A 1 0.8654 100 0.374 Contact Map
4rxlA 1 0.8538 100 0.387 Contact Map
2vozA 3 0.85 100 0.396 Contact Map
3rpwA 1 0.8577 100 0.405 Contact Map
3waeA 2 0.8615 100 0.406 Contact Map
4kd5C 3 0.8692 100 0.424 Contact Map
1atgA 1 0.8577 100 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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