GREMLIN Database
YVGK - Uncharacterized protein YvgK
UniProt: O32207 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (275)
Sequences: 893 (731)
Seq/√Len: 44.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_A240_G6.3551.00
162_K244_Q5.8111.00
300_L303_K5.3971.00
157_N261_Q4.9001.00
166_Y242_G4.1841.00
202_D218_Y3.6581.00
167_V255_I3.4891.00
244_Q248_H3.4581.00
165_L239_A3.2811.00
170_G253_D3.1281.00
155_L265_V3.0561.00
169_K251_S3.0521.00
190_N217_G2.7031.00
154_C268_K2.7001.00
84_S115_S2.4711.00
163_A197_A2.4211.00
211_N214_D2.2021.00
284_E288_A2.1811.00
173_K185_D2.1511.00
198_R202_D2.1311.00
278_K282_N2.0950.99
160_L259_D2.0860.99
189_I222_V2.0740.99
158_V264_I2.0640.99
190_N218_Y2.0410.99
157_N160_L1.9970.99
173_K238_D1.9970.99
228_A262_Y1.9240.99
193_K221_I1.9190.99
201_L241_I1.9140.99
89_S290_L1.8950.99
298_T301_T1.8840.99
157_N300_L1.8650.99
119_M265_V1.8610.99
179_K208_L1.8460.99
183_R186_I1.8370.99
126_I277_V1.8320.99
168_Q172_P1.7690.98
182_K214_D1.7640.98
188_I222_V1.7530.98
161_R260_E1.7510.98
264_I277_V1.7450.98
173_K186_I1.7240.98
157_N305_I1.6320.97
134_A206_G1.6190.97
96_H289_N1.5820.96
141_A155_L1.5790.96
65_E69_Q1.5650.96
66_A69_Q1.5620.96
179_K182_K1.5470.96
162_K259_D1.5260.95
133_D136_T1.5230.95
173_K187_R1.5110.95
116_L265_V1.5060.95
187_R216_V1.4920.95
229_A295_G1.4880.95
144_V155_L1.4780.95
230_S233_S1.4730.95
178_W257_L1.4690.94
168_Q171_N1.4650.94
167_V253_D1.4610.94
182_K186_I1.4600.94
165_L178_W1.4520.94
130_H196_G1.4250.93
140_N263_D1.4080.93
192_E195_S1.3900.93
259_D299_K1.3590.92
160_L261_Q1.3580.92
133_D142_P1.3470.91
87_D111_G1.3450.91
40_Q43_V1.3340.91
44_D52_K1.3200.91
231_Q236_Q1.3150.90
188_I239_A1.3150.90
28_K38_G1.3110.90
204_Q207_L1.3030.90
141_A144_V1.2950.90
287_K291_S1.2850.89
67_P71_Q1.2760.89
198_R217_G1.2710.89
158_V281_L1.2650.89
164_G254_F1.2390.87
184_A214_D1.2390.87
219_G255_I1.2300.87
86_Q107_R1.2280.87
173_K183_R1.2130.86
112_S130_H1.2120.86
157_N263_D1.2110.86
167_V171_N1.2040.86
185_D216_V1.1940.85
163_A196_G1.1900.85
201_L205_L1.1840.85
131_L140_N1.1820.85
85_G192_E1.1790.85
167_V172_P1.1760.85
174_N275_K1.1730.84
45_E49_K1.1680.84
136_T142_P1.1630.84
190_N198_R1.1580.84
251_S265_V1.1580.84
85_G197_A1.1520.83
283_S301_T1.1510.83
119_M124_C1.1420.83
275_K279_E1.1320.82
232_V240_G1.1300.82
171_N253_D1.1250.82
270_N275_K1.1110.81
175_I181_L1.1060.81
130_H140_N1.0990.80
259_D297_E1.0980.80
124_C129_L1.0950.80
85_G111_G1.0920.80
203_E207_L1.0870.80
90_M231_Q1.0850.79
156_I278_K1.0840.79
39_R43_V1.0740.79
284_E287_K1.0660.78
86_Q161_R1.0600.78
85_G130_H1.0560.78
131_L199_V1.0550.77
175_I186_I1.0540.77
97_L276_A1.0500.77
86_Q128_S1.0460.77
289_N292_H1.0240.75
39_R44_D1.0200.75
99_N102_Q1.0150.75
179_K255_I1.0130.75
39_R51_Y1.0130.75
43_V52_K1.0070.74
39_R84_S0.9970.73
135_E145_K0.9940.73
171_N180_D0.9910.73
49_K52_K0.9860.73
182_K210_V0.9770.72
43_V51_Y0.9590.70
181_L186_I0.9560.70
79_P125_D0.9550.70
35_Y47_D0.9540.70
86_Q192_E0.9520.70
178_W204_Q0.9470.69
111_G161_R0.9380.69
204_Q208_L0.9350.68
177_G186_I0.9320.68
130_H225_H0.9290.68
137_G145_K0.9280.68
228_A232_V0.9250.68
68_K71_Q0.9190.67
29_K41_M0.9120.66
29_K36_R0.9070.66
169_K177_G0.9030.66
77_G168_Q0.9030.66
132_Y139_Y0.9020.66
282_N303_K0.8980.65
40_Q48_L0.8950.65
229_A233_S0.8950.65
231_Q293_L0.8920.65
128_S262_Y0.8820.64
181_L184_A0.8820.64
132_Y137_G0.8760.63
31_V34_A0.8730.63
171_N190_N0.8730.63
129_L265_V0.8670.63
47_D56_R0.8660.62
156_I281_L0.8640.62
116_L131_L0.8630.62
154_C232_V0.8590.62
117_I121_Q0.8540.61
138_Q261_Q0.8510.61
89_S298_T0.8500.61
172_P180_D0.8470.61
160_L300_L0.8450.61
176_Q216_V0.8440.60
290_L301_T0.8400.60
165_L241_I0.8390.60
179_K209_G0.8380.60
180_D183_R0.8320.59
82_M280_I0.8320.59
144_V274_L0.8300.59
161_R196_G0.8280.59
110_K115_S0.8280.59
198_R218_Y0.8270.59
182_K304_V0.8270.59
44_D51_Y0.8260.59
176_Q281_L0.8260.59
171_N217_G0.8250.59
132_Y199_V0.8220.58
248_H294_N0.8210.58
163_A192_E0.8190.58
167_V175_I0.8180.58
109_Y114_N0.8150.58
133_D140_N0.8130.58
50_Q54_N0.8020.56
35_Y52_K0.7980.56
277_V303_K0.7940.56
158_V277_V0.7910.55
82_M105_P0.7890.55
187_R214_D0.7870.55
119_M127_V0.7830.55
84_S132_Y0.7820.55
107_R192_E0.7790.54
67_P72_E0.7720.54
133_D263_D0.7620.53
284_E304_V0.7610.53
29_K32_L0.7610.53
36_R39_R0.7600.52
34_A52_K0.7590.52
44_D54_N0.7570.52
196_G260_E0.7570.52
168_Q282_N0.7560.52
42_R51_Y0.7540.52
65_E68_K0.7510.52
144_V265_V0.7500.52
161_R242_G0.7460.51
241_I257_L0.7450.51
165_L177_G0.7450.51
85_G260_E0.7420.51
196_G262_Y0.7410.51
188_I241_I0.7410.51
65_E72_E0.7400.51
175_I253_D0.7390.50
66_A73_A0.7370.50
172_P253_D0.7360.50
177_G185_D0.7340.50
123_K233_S0.7330.50
87_D161_R0.7320.50
172_P175_I0.7310.50
205_L216_V0.7270.49
187_R237_A0.7170.48
188_I229_A0.7160.48
135_E285_D0.7050.47
41_M44_D0.7040.47
85_G107_R0.7010.47
168_Q210_V0.6960.46
177_G183_R0.6950.46
29_K43_V0.6940.46
195_S274_L0.6930.46
205_L218_Y0.6920.46
186_I284_E0.6910.46
28_K120_Y0.6910.46
91_D107_R0.6910.46
209_G269_K0.6890.46
179_K211_N0.6880.46
138_Q195_S0.6860.45
245_H294_N0.6850.45
81_V125_D0.6840.45
118_D123_K0.6840.45
131_L139_Y0.6830.45
138_Q264_I0.6820.45
288_A291_S0.6800.45
156_I271_E0.6780.45
212_P246_A0.6780.45
275_K287_K0.6760.44
97_L277_V0.6760.44
176_Q180_D0.6740.44
177_G298_T0.6730.44
215_V239_A0.6720.44
38_G232_V0.6720.44
207_L303_K0.6710.44
146_R206_G0.6700.44
90_M244_Q0.6690.44
34_A39_R0.6680.44
197_A260_E0.6670.44
173_K220_D0.6630.43
141_A195_S0.6620.43
130_H262_Y0.6610.43
132_Y142_P0.6570.43
128_S222_V0.6540.42
133_D143_Y0.6540.42
111_G260_E0.6530.42
176_Q206_G0.6460.42
97_L193_K0.6460.42
290_L297_E0.6430.41
277_V281_L0.6410.41
130_H260_E0.6370.41
115_S161_R0.6370.41
161_R197_A0.6350.41
113_L151_E0.6350.41
171_N175_I0.6340.40
86_Q224_D0.6330.40
224_D234_S0.6320.40
146_R155_L0.6320.40
172_P217_G0.6290.40
38_G51_Y0.6280.40
172_P190_N0.6270.40
153_F265_V0.6250.40
29_K34_A0.6250.40
112_S140_N0.6240.40
34_A44_D0.6230.39
82_M107_R0.6230.39
138_Q141_A0.6220.39
85_G163_A0.6210.39
197_A225_H0.6190.39
181_L239_A0.6180.39
202_D217_G0.6160.39
88_I243_A0.6110.38
86_Q109_Y0.6110.38
39_R42_R0.6100.38
64_K285_D0.6090.38
66_A72_E0.6080.38
266_V274_L0.6070.38
89_S93_L0.6060.38
290_L298_T0.6020.38
129_L144_V0.6020.38
170_G174_N0.6020.38
222_V246_A0.6010.37
81_V109_Y0.6010.37
133_D139_Y0.6000.37
229_A246_A0.5980.37
168_Q173_K0.5940.37
95_K289_N0.5930.37
64_K70_V0.5930.37
162_K248_H0.5930.37
154_C275_K0.5910.37
29_K91_D0.5900.36
112_S133_D0.5890.36
165_L281_L0.5880.36
87_D260_E0.5880.36
187_R220_D0.5870.36
286_Y290_L0.5870.36
119_M128_S0.5850.36
287_K301_T0.5850.36
188_I215_V0.5850.36
144_V153_F0.5830.36
29_K39_R0.5820.36
249_M252_V0.5790.35
49_K53_T0.5780.35
69_Q73_A0.5780.35
112_S194_G0.5780.35
160_L299_K0.5780.35
190_N202_D0.5750.35
128_S153_F0.5750.35
33_P39_R0.5740.35
220_D236_Q0.5730.35
275_K303_K0.5700.35
261_Q300_L0.5690.35
171_N174_N0.5670.34
125_D271_E0.5630.34
132_Y136_T0.5630.34
190_N205_L0.5600.34
44_D161_R0.5580.34
257_L286_Y0.5580.34
28_K39_R0.5570.34
204_Q258_I0.5550.33
93_L277_V0.5550.33
229_A250_G0.5530.33
61_I64_K0.5520.33
209_G213_A0.5510.33
130_H163_A0.5500.33
85_G161_R0.5480.33
145_K272_Q0.5480.33
128_S264_I0.5470.33
189_I288_A0.5460.33
88_I189_I0.5450.33
42_R85_G0.5450.33
218_Y221_I0.5450.33
64_K68_K0.5440.32
123_K152_P0.5410.32
126_I287_K0.5400.32
240_G260_E0.5400.32
110_K114_N0.5400.32
124_C289_N0.5380.32
140_N144_V0.5370.32
84_S114_N0.5370.32
126_I193_K0.5350.32
82_M201_L0.5350.32
124_C132_Y0.5340.32
86_Q197_A0.5330.32
225_H262_Y0.5320.31
84_S124_C0.5310.31
261_Q266_V0.5300.31
176_Q284_E0.5300.31
65_E71_Q0.5290.31
182_K287_K0.5290.31
34_A124_C0.5280.31
209_G287_K0.5280.31
214_D275_K0.5280.31
100_A279_E0.5260.31
231_Q235_G0.5250.31
102_Q211_N0.5250.31
29_K38_G0.5240.31
152_P266_V0.5200.30
116_L257_L0.5200.30
181_L185_D0.5200.30
150_G153_F0.5200.30
29_K52_K0.5190.30
52_K197_A0.5180.30
163_A260_E0.5180.30
132_Y196_G0.5170.30
192_E257_L0.5170.30
161_R262_Y0.5170.30
85_G224_D0.5150.30
124_C243_A0.5140.30
121_Q277_V0.5130.30
90_M289_N0.5130.30
275_K278_K0.5120.30
233_S251_S0.5120.30
52_K161_R0.5110.30
87_D90_M0.5110.30
86_Q111_G0.5100.30
34_A41_M0.5100.30
38_G44_D0.5080.30
179_K265_V0.5080.30
102_Q187_R0.5080.30
173_K184_A0.5070.29
159_V297_E0.5070.29
100_A280_I0.5070.29
131_L232_V0.5070.29
166_Y245_H0.5070.29
110_K126_I0.5050.29
126_I291_S0.5030.29
84_S107_R0.5010.29
174_N251_S0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jb7A 2 0.6818 99.5 0.846 Contact Map
2hxwA 2 0.6688 99.4 0.854 Contact Map
1r9lA 1 0.7305 99.3 0.858 Contact Map
4kd5C 3 0.6818 99.3 0.859 Contact Map
1ixhA 1 0.711 99.3 0.86 Contact Map
4n13A 1 0.6656 99.3 0.861 Contact Map
3kn3A 1 0.6786 99.2 0.864 Contact Map
4ecfA 1 0.7013 99.2 0.864 Contact Map
3cvgA 3 0.7175 99.1 0.869 Contact Map
4exlA 1 0.7078 99.1 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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