GREMLIN Database
YVSG - Uncharacterized protein YvsG
UniProt: O32205 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (151)
Sequences: 772 (566)
Seq/√Len: 46.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_G105_L5.1011.00
103_L113_I5.0171.00
74_F99_M3.7151.00
49_G64_G3.6291.00
38_I95_L3.3631.00
136_E140_L3.0731.00
74_F78_M2.8641.00
107_A115_L2.8041.00
31_S35_G2.7721.00
31_S91_I2.6261.00
3_G10_G2.3191.00
56_S64_G2.3131.00
105_L109_T2.2891.00
28_M94_G2.1531.00
105_L129_M2.0721.00
75_M100_A2.0701.00
71_S75_M2.0220.99
49_G56_S2.0120.99
14_C28_M1.9230.99
101_S105_L1.8600.99
73_L117_F1.8390.99
52_F56_S1.8270.99
9_G101_S1.8110.99
35_G95_L1.7980.99
54_I58_V1.7900.99
10_G101_S1.7550.98
8_M12_A1.6750.98
114_K123_V1.5780.97
109_T129_M1.5470.96
53_P56_S1.5300.96
1_M6_H1.5280.96
10_G13_S1.5090.96
13_S104_I1.5020.96
32_G36_A1.4690.95
7_I33_A1.4620.95
49_G63_F1.4490.95
117_F136_E1.4130.94
133_S143_L1.3930.93
75_M103_L1.3750.93
69_T72_L1.3750.93
3_G47_K1.3590.93
97_I142_G1.3260.92
71_S115_L1.3150.91
82_T95_L1.2690.90
4_K133_S1.2620.90
94_G98_G1.2620.90
51_K56_S1.2450.89
56_S69_T1.2280.88
13_S101_S1.2110.87
76_L148_C1.2080.87
80_F145_L1.2070.87
46_S49_G1.2040.87
67_T99_M1.1670.85
55_L58_V1.1420.84
5_T15_T1.1190.83
109_T131_T1.0840.81
103_L115_L1.0690.80
44_T67_T1.0600.79
10_G109_T1.0590.79
94_G150_Y1.0560.79
25_P29_A1.0300.77
10_G36_A1.0300.77
42_C99_M1.0130.76
5_T8_M1.0100.76
51_K131_T1.0070.76
71_S125_L0.9900.75
71_S123_V0.9880.74
15_T19_Y0.9810.74
10_G32_G0.9740.73
71_S74_F0.9660.73
140_L144_T0.9610.72
77_I81_I0.9490.71
123_V126_P0.9450.71
49_G60_S0.9300.70
43_H109_T0.9270.70
129_M135_S0.9240.69
109_T117_F0.9240.69
29_A80_F0.9180.69
29_A85_Y0.9180.69
2_T68_F0.9150.69
41_I52_F0.9140.68
27_L91_I0.9140.68
33_A139_V0.9130.68
35_G38_I0.9130.68
36_A47_K0.9000.67
131_T136_E0.8990.67
113_I142_G0.8860.66
130_K133_S0.8760.65
53_P64_G0.8670.64
17_A88_D0.8660.64
119_S122_R0.8620.64
5_T131_T0.8410.62
37_L131_T0.8410.62
61_S131_T0.8400.62
3_G7_I0.8390.62
4_K137_Q0.8380.62
7_I35_G0.8180.60
11_I29_A0.8160.60
5_T140_L0.8160.60
9_G53_P0.8140.59
42_C67_T0.8110.59
17_A97_I0.8070.59
51_K64_G0.8030.58
36_A39_P0.7980.58
23_F38_I0.7970.58
87_P129_M0.7940.58
113_I140_L0.7920.57
12_A98_G0.7920.57
34_V148_C0.7910.57
44_T126_P0.7850.57
72_L113_I0.7830.56
71_S126_P0.7700.55
72_L123_V0.7590.54
53_P71_S0.7300.51
16_A38_I0.7170.50
76_L83_S0.7110.49
27_L55_L0.7100.49
79_F96_M0.7090.49
53_P57_K0.7090.49
89_K148_C0.7080.49
10_G128_Y0.7030.49
51_K67_T0.7010.48
133_S136_E0.6990.48
30_A73_L0.6990.48
27_L30_A0.6970.48
141_A148_C0.6960.48
40_D66_R0.6940.48
49_G61_S0.6940.48
139_V149_Y0.6910.47
42_C66_R0.6810.46
46_S67_T0.6800.46
50_R150_Y0.6780.46
73_L125_L0.6740.46
2_T43_H0.6690.45
14_C33_A0.6670.45
3_G9_G0.6610.45
68_F125_L0.6600.44
75_M96_M0.6580.44
105_L114_K0.6570.44
10_G105_L0.6570.44
86_I101_S0.6570.44
42_C105_L0.6550.44
120_T145_L0.6530.44
71_S117_F0.6520.44
3_G31_S0.6500.43
136_E143_L0.6490.43
93_A141_A0.6490.43
72_L97_I0.6460.43
13_S100_A0.6440.43
38_I91_I0.6410.43
79_F127_L0.6400.42
45_Q104_I0.6290.41
7_I18_A0.6280.41
131_T140_L0.6250.41
91_I142_G0.6240.41
30_A35_G0.6240.41
32_G101_S0.6210.41
43_H67_T0.6210.41
5_T60_S0.6200.41
130_K143_L0.6190.40
66_R70_H0.6160.40
40_D70_H0.6160.40
111_N114_K0.6120.40
4_K61_S0.6120.40
28_M51_K0.6120.40
147_S150_Y0.6100.40
107_A128_Y0.6090.40
117_F120_T0.6090.40
60_S114_K0.6030.39
96_M101_S0.5980.38
66_R106_D0.5930.38
40_D106_D0.5930.38
112_G131_T0.5910.38
2_T131_T0.5860.37
71_S107_A0.5840.37
44_T110_V0.5790.37
31_S109_T0.5770.37
54_I140_L0.5770.37
8_M73_L0.5760.36
15_T147_S0.5750.36
43_H136_E0.5710.36
15_T148_C0.5650.35
73_L115_L0.5640.35
48_I131_T0.5640.35
75_M113_I0.5630.35
9_G64_G0.5560.35
37_L103_L0.5560.35
119_S127_L0.5550.35
71_S118_P0.5550.35
18_A21_Y0.5550.35
80_F96_M0.5510.34
68_F73_L0.5510.34
8_M139_V0.5510.34
42_C106_D0.5440.34
42_C70_H0.5430.34
124_R127_L0.5410.33
78_M109_T0.5380.33
60_S64_G0.5350.33
48_I109_T0.5340.33
34_V82_T0.5320.33
44_T48_I0.5300.32
78_M143_L0.5300.32
133_S145_L0.5280.32
39_P113_I0.5280.32
12_A21_Y0.5280.32
10_G129_M0.5280.32
135_S146_A0.5250.32
27_L133_S0.5200.32
42_C114_K0.5190.31
73_L132_G0.5150.31
33_A113_I0.5140.31
48_I112_G0.5130.31
70_H106_D0.5130.31
26_V98_G0.5120.31
38_I45_Q0.5120.31
110_V130_K0.5100.31
69_T79_F0.5100.31
41_I82_T0.5080.31
108_W150_Y0.5050.30
17_A80_F0.5040.30
64_G76_L0.5030.30
107_A136_E0.5030.30
34_V47_K0.5020.30
99_M103_L0.5020.30
31_S94_G0.5010.30
15_T29_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p6vB 1 0.325 4 0.953 Contact Map
4ednK 1 0.1187 3.8 0.953 Contact Map
2mm4A 1 0.1938 2.1 0.959 Contact Map
2mc7A 1 0.1875 1.5 0.963 Contact Map
3tl8B 1 0.3688 1.3 0.964 Contact Map
2wtgA 2 0.3937 1.3 0.964 Contact Map
2nw8A 4 0.2625 1.2 0.964 Contact Map
3am6A 3 0.3375 1.1 0.965 Contact Map
2b9iC 1 0.0875 1.1 0.966 Contact Map
2lf6A 1 0.4062 0.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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