GREMLIN Database
ARCD - Putative arginine/ornithine antiporter
UniProt: O32204 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (421)
Sequences: 24768 (15949)
Seq/√Len: 777.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_H356_N4.5031.00
338_F350_I4.3011.00
49_G261_L3.2791.00
391_L425_C3.1971.00
341_K350_I3.1391.00
247_R251_R3.0391.00
8_G244_R2.9711.00
74_Q332_A2.8571.00
399_K403_K2.8311.00
243_A248_D2.7941.00
95_V329_A2.7531.00
189_G270_I2.6661.00
330_A340_A2.5841.00
343_N349_V2.5811.00
241_G331_K2.5351.00
150_T360_Q2.5101.00
13_T255_T2.4581.00
298_A302_I2.4551.00
187_V191_F2.4521.00
338_F341_K2.3861.00
9_F255_T2.3451.00
242_R324_E2.3221.00
61_H401_V2.2971.00
78_R91_G2.2641.00
394_A424_A2.2501.00
422_I426_A2.2321.00
353_I357_V2.2051.00
9_F248_D2.2031.00
157_H352_L2.1661.00
327_Y331_K2.1591.00
9_F13_T2.1201.00
81_F399_K2.1191.00
279_K293_A2.1001.00
289_D292_Y2.0911.00
154_W360_Q2.0751.00
12_L243_A2.0721.00
158_A162_A2.0511.00
165_N169_K2.0221.00
50_A54_M2.0061.00
78_R88_N1.9971.00
149_C363_I1.9951.00
161_V349_V1.9931.00
448_L452_G1.9761.00
150_T363_I1.9721.00
333_G337_A1.9631.00
8_G11_L1.9591.00
99_W355_T1.9521.00
176_L180_L1.9411.00
58_V394_A1.9411.00
339_F354_I1.9341.00
32_L41_A1.9221.00
204_P208_E1.9141.00
251_R255_T1.9091.00
454_I458_F1.8861.00
438_D441_T1.8361.00
419_L423_L1.8331.00
254_I258_L1.8151.00
81_F395_I1.8091.00
160_L316_L1.7751.00
426_A430_F1.7491.00
245_S248_D1.7461.00
276_P279_K1.7421.00
289_D293_A1.7371.00
87_G90_A1.7281.00
77_A94_M1.7101.00
96_W452_G1.7031.00
44_A222_A1.7021.00
11_L172_F1.7011.00
154_W356_N1.6891.00
446_I450_F1.6881.00
343_N347_S1.6881.00
94_M392_V1.6831.00
110_I315_M1.6641.00
201_F204_P1.6591.00
16_V256_G1.6481.00
180_L184_F1.6371.00
283_S289_D1.6281.00
161_V353_I1.6171.00
117_L148_V1.6111.00
110_I153_L1.6071.00
399_K402_I1.5921.00
40_G219_V1.5901.00
153_L359_S1.5861.00
258_L262_S1.5761.00
51_G427_Y1.5681.00
54_M423_L1.5671.00
13_T259_I1.5611.00
245_S251_R1.5521.00
7_W11_L1.5511.00
405_E409_Q1.5401.00
404_G407_Y1.5371.00
350_I354_I1.5231.00
239_L320_L1.5061.00
439_L442_F1.5051.00
395_I425_C1.4991.00
327_Y342_T1.4961.00
416_R420_I1.4941.00
70_T241_G1.4781.00
48_T226_T1.4771.00
56_A257_L1.4751.00
437_A441_T1.4671.00
181_G306_L1.4611.00
179_V183_V1.4561.00
404_G409_Q1.4421.00
50_A423_L1.4291.00
322_G355_T1.4201.00
447_G451_V1.4151.00
4_T346_G1.4091.00
301_V305_L1.4081.00
113_L152_L1.4041.00
417_D421_A1.4031.00
106_N359_S1.4001.00
113_L308_I1.3991.00
157_H353_I1.3931.00
190_L270_I1.3851.00
81_F90_A1.3841.00
292_Y300_S1.3731.00
326_P351_A1.3721.00
323_S352_L1.3681.00
153_L356_N1.3621.00
395_I399_K1.3581.00
77_A392_V1.3491.00
56_A253_T1.3451.00
337_A341_K1.3431.00
292_Y297_N1.3421.00
150_T154_W1.3371.00
337_A340_A1.3301.00
200_H204_P1.3241.00
212_S215_I1.3231.00
55_I394_A1.3191.00
42_T269_L1.3171.00
452_G455_V1.3141.00
11_L168_S1.3141.00
193_F196_S1.3101.00
437_A440_T1.3091.00
7_W12_L1.3031.00
27_S112_S1.2951.00
20_M260_A1.2921.00
412_G415_V1.2891.00
89_A459_V1.2871.00
81_F87_G1.2851.00
58_V421_A1.2841.00
193_F273_G1.2761.00
66_K79_A1.2731.00
341_K349_V1.2691.00
159_I170_L1.2651.00
326_P335_F1.2641.00
455_V459_V1.2621.00
109_I314_T1.2601.00
248_D251_R1.2521.00
283_S286_P1.2521.00
262_S266_I1.2501.00
186_I266_I1.2471.00
453_L457_P1.2331.00
156_T315_M1.2301.00
80_L396_Y1.2281.00
9_F251_R1.2111.00
75_S79_A1.2101.00
57_L254_I1.2051.00
437_A442_F1.2021.00
450_F454_I1.1961.00
439_L443_I1.1951.00
295_V299_G1.1901.00
10_W14_A1.1861.00
99_W326_P1.1731.00
350_I353_I1.1691.00
12_L252_A1.1691.00
194_Q197_L1.1651.00
7_W168_S1.1601.00
391_L429_V1.1551.00
77_A90_A1.1521.00
194_Q198_F1.1521.00
33_A41_A1.1491.00
442_F445_G1.1491.00
441_T444_L1.1401.00
161_V347_S1.1361.00
184_F188_A1.1361.00
189_G274_V1.1341.00
342_T346_G1.1321.00
244_R248_D1.1271.00
402_I418_G1.1231.00
398_L422_I1.1171.00
59_F73_P1.1151.00
447_G450_F1.1131.00
185_F189_G1.1131.00
200_H203_F1.1111.00
416_R419_L1.1101.00
92_F96_W1.1031.00
63_S76_Y1.1001.00
429_V433_V1.0991.00
68_E75_S1.0971.00
6_K244_R1.0961.00
170_L174_T1.0951.00
418_G422_I1.0951.00
147_A151_I1.0931.00
331_K340_A1.0921.00
183_V187_V1.0921.00
74_Q328_Q1.0891.00
61_H64_I1.0801.00
151_I155_G1.0721.00
357_V361_V1.0711.00
195_T198_F1.0681.00
419_L422_I1.0661.00
171_N316_L1.0601.00
17_V259_I1.0571.00
215_I218_Q1.0571.00
448_L455_V1.0541.00
455_V458_F1.0341.00
15_F239_L1.0331.00
405_E408_D1.0281.00
16_V236_A1.0251.00
64_I411_K1.0231.00
430_F434_T1.0201.00
441_T445_G1.0191.00
440_T444_L1.0161.00
157_H161_V1.0141.00
161_V343_N1.0081.00
117_L308_I1.0081.00
440_T443_I1.0081.00
442_F446_I1.0061.00
397_S421_A1.0051.00
231_V386_Y1.0051.00
220_H430_F1.0021.00
169_K173_V1.0021.00
199_G202_Y0.9971.00
276_P293_A0.9921.00
154_W158_A0.9891.00
79_A404_G0.9871.00
424_A428_S0.9851.00
114_A148_V0.9801.00
17_V260_A0.9791.00
438_D442_F0.9761.00
240_S249_V0.9701.00
185_F291_L0.9701.00
425_C429_V0.9671.00
445_G448_L0.9671.00
234_E238_I0.9661.00
443_I447_G0.9631.00
46_L265_I0.9611.00
445_G449_F0.9561.00
108_A379_T0.9531.00
114_A149_C0.9461.00
68_E79_A0.9431.00
164_I320_L0.9431.00
174_T313_G0.9411.00
21_V24_G0.9411.00
274_V290_V0.9391.00
391_L395_I0.9321.00
199_G203_F0.9311.00
65_R407_Y0.9281.00
178_K310_C0.9251.00
406_T409_Q0.9211.00
245_S250_K0.9211.00
441_T448_L0.9191.00
444_L447_G0.9171.00
6_K165_N0.9161.00
443_I446_I0.9161.00
186_I190_L0.9091.00
108_A228_W0.9091.00
285_K289_D0.9081.00
210_G213_I0.9021.00
451_V455_V0.9011.00
211_T215_I0.9001.00
114_A145_T0.8991.00
398_L418_G0.8961.00
71_A74_Q0.8931.00
216_G219_V0.8921.00
193_F197_L0.8901.00
440_T455_V0.8901.00
186_I270_I0.8861.00
155_G312_F0.8851.00
65_R409_Q0.8811.00
49_G230_F0.8801.00
424_A427_Y0.8801.00
197_L200_H0.8791.00
179_V263_I0.8791.00
341_K344_K0.8791.00
146_F150_T0.8791.00
319_I356_N0.8781.00
156_T316_L0.8741.00
96_W335_F0.8721.00
71_A75_S0.8661.00
42_T272_M0.8651.00
89_A93_T0.8621.00
335_F339_F0.8571.00
339_F350_I0.8521.00
43_S219_V0.8511.00
394_A425_C0.8491.00
451_V454_I0.8491.00
255_T259_I0.8491.00
269_L273_G0.8461.00
261_L265_I0.8451.00
191_F195_T0.8451.00
235_S321_L0.8441.00
148_V151_I0.8421.00
439_L446_I0.8421.00
122_P125_V0.8411.00
78_R332_A0.8361.00
190_L266_I0.8301.00
11_L169_K0.8281.00
14_A172_F0.8261.00
349_V353_I0.8251.00
202_Y208_E0.8201.00
46_L50_A0.8161.00
296_G299_G0.8161.00
221_N225_S0.8131.00
418_G421_A0.8081.00
417_D420_I0.8071.00
447_G454_I0.8051.00
105_S382_A0.7991.00
356_N360_Q0.7981.00
452_G456_Y0.7961.00
53_L57_L0.7951.00
428_S431_V0.7931.00
398_L402_I0.7911.00
211_T214_G0.7891.00
77_A396_Y0.7871.00
156_T319_I0.7871.00
21_V178_K0.7861.00
250_K253_T0.7861.00
62_L397_S0.7811.00
158_A161_V0.7811.00
391_L428_S0.7801.00
440_T445_G0.7791.00
381_A385_A0.7791.00
13_T252_A0.7781.00
249_V253_T0.7771.00
439_L455_V0.7771.00
324_E327_Y0.7741.00
411_K415_V0.7741.00
407_Y411_K0.7731.00
117_L121_F0.7731.00
9_F252_A0.7691.00
65_R405_E0.7681.00
111_T378_L0.7681.00
153_L363_I0.7651.00
384_L445_G0.7611.00
194_Q202_Y0.7581.00
439_L445_G0.7581.00
193_F198_F0.7571.00
408_D413_S0.7561.00
231_V390_Y0.7551.00
53_L254_I0.7521.00
54_M420_I0.7521.00
10_W172_F0.7511.00
169_K172_F0.7501.00
113_L312_F0.7501.00
448_L451_V0.7501.00
21_V26_F0.7481.00
437_A455_V0.7471.00
438_D455_V0.7471.00
38_P272_M0.7451.00
87_G460_S0.7441.00
403_K406_T0.7431.00
54_M58_V0.7421.00
90_A392_V0.7401.00
197_L201_F0.7381.00
42_T46_L0.7371.00
442_F455_V0.7351.00
209_N213_I0.7321.00
62_L76_Y0.7311.00
416_R421_A0.7271.00
114_A117_L0.7271.00
421_A425_C0.7261.00
444_L448_L0.7261.00
98_Y102_S0.7251.00
55_I428_S0.7241.00
160_L352_L0.7221.00
113_L311_L0.7191.00
338_F354_I0.7181.00
74_Q78_R0.7171.00
87_G91_G0.7171.00
162_A166_G0.7171.00
89_A453_L0.7161.00
20_M256_G0.7151.00
209_N212_S0.7131.00
442_F448_L0.7111.00
121_F125_V0.7101.00
65_R411_K0.7091.00
344_K349_V0.7081.00
81_F396_Y0.7051.00
403_K407_Y0.7041.00
52_V233_I0.7021.00
121_F124_L0.6971.00
430_F433_V0.6971.00
446_I449_F0.6961.00
160_L320_L0.6961.00
25_I267_V0.6951.00
441_T455_V0.6951.00
453_L456_Y0.6941.00
451_V459_V0.6931.00
190_L194_Q0.6921.00
70_T327_Y0.6901.00
398_L421_A0.6891.00
414_R417_D0.6881.00
267_V271_T0.6871.00
255_T258_L0.6871.00
80_L399_K0.6871.00
443_I448_L0.6871.00
326_P354_I0.6861.00
357_V360_Q0.6861.00
397_S401_V0.6851.00
168_S172_F0.6851.00
319_I323_S0.6831.00
40_G212_S0.6831.00
241_G327_Y0.6821.00
10_W169_K0.6801.00
97_G389_P0.6801.00
203_F208_E0.6761.00
198_F273_G0.6761.00
374_A377_F0.6741.00
43_S47_L0.6741.00
196_S199_G0.6731.00
421_A428_S0.6731.00
343_N346_G0.6711.00
18_G175_T0.6691.00
437_A448_L0.6661.00
323_S351_A0.6661.00
13_T16_V0.6651.00
404_G408_D0.6641.00
442_F459_V0.6641.00
103_W358_M0.6621.00
43_S46_L0.6591.00
41_A268_T0.6591.00
438_D448_L0.6591.00
156_T312_F0.6581.00
259_I263_I0.6581.00
456_Y460_S0.6571.00
218_Q221_N0.6551.00
385_A389_P0.6531.00
154_W157_H0.6531.00
402_I405_E0.6531.00
118_T122_P0.6521.00
415_V419_L0.6481.00
266_I270_I0.6481.00
391_L432_I0.6461.00
396_Y400_V0.6451.00
297_N301_V0.6451.00
264_Y268_T0.6451.00
237_V253_T0.6451.00
28_L379_T0.6441.00
161_V352_L0.6441.00
74_Q95_V0.6431.00
445_G455_V0.6431.00
116_Y307_A0.6421.00
345_K349_V0.6401.00
57_L420_I0.6391.00
22_G26_F0.6391.00
457_P460_S0.6381.00
101_A386_Y0.6371.00
403_K409_Q0.6361.00
105_S108_A0.6341.00
90_A93_T0.6341.00
191_F194_Q0.6331.00
29_P268_T0.6311.00
449_F452_G0.6301.00
150_T364_F0.6301.00
330_A339_F0.6301.00
242_R348_P0.6291.00
186_I267_V0.6291.00
438_D445_G0.6271.00
267_V287_F0.6241.00
442_F449_F0.6231.00
59_F393_S0.6211.00
242_R342_T0.6211.00
21_V263_I0.6201.00
442_F457_P0.6191.00
56_A233_I0.6191.00
152_L315_M0.6181.00
197_L204_P0.6171.00
414_R420_I0.6171.00
32_L226_T0.6161.00
73_P234_E0.6131.00
80_L400_V0.6121.00
42_T265_I0.6121.00
177_S306_L0.6111.00
17_V175_T0.6111.00
109_I315_M0.6101.00
279_K282_G0.6081.00
121_F126_D0.6081.00
445_G452_G0.6061.00
166_G169_K0.6051.00
456_Y459_V0.6051.00
376_T379_T0.6031.00
107_V362_F0.6031.00
117_L152_L0.6021.00
231_V234_E0.6011.00
447_G452_G0.5971.00
447_G458_F0.5971.00
450_F453_L0.5961.00
47_L223_A0.5961.00
247_R250_K0.5951.00
103_W355_T0.5941.00
164_I239_L0.5921.00
195_T199_G0.5891.00
168_S316_L0.5881.00
438_D444_L0.5881.00
19_N317_G0.5871.00
73_P238_I0.5861.00
285_K288_V0.5861.00
298_A301_V0.5841.00
146_F363_I0.5841.00
48_T227_L0.5841.00
6_K164_I0.5841.00
63_S237_V0.5831.00
278_D282_G0.5831.00
212_S219_V0.5821.00
452_G459_V0.5821.00
48_T230_F0.5811.00
54_M424_A0.5801.00
63_S249_V0.5801.00
6_K10_W0.5791.00
422_I425_C0.5791.00
454_I457_P0.5781.00
437_A446_I0.5781.00
19_N318_W0.5781.00
119_S122_P0.5781.00
305_L309_L0.5771.00
166_G170_L0.5761.00
348_P351_A0.5751.00
354_I358_M0.5751.00
157_H319_I0.5741.00
60_G64_I0.5741.00
339_F351_A0.5741.00
188_A295_V0.5731.00
74_Q91_G0.5731.00
403_K408_D0.5721.00
31_S376_T0.5711.00
97_G388_I0.5711.00
19_N235_S0.5701.00
152_L156_T0.5701.00
198_F272_M0.5691.00
445_G450_F0.5691.00
322_G326_P0.5681.00
243_A249_V0.5681.00
38_P42_T0.5671.00
62_L80_L0.5661.00
188_A192_V0.5661.00
310_C313_G0.5661.00
246_Q251_R0.5641.00
216_G220_H0.5621.00
153_L360_Q0.5621.00
172_F176_L0.5621.00
58_V414_R0.5611.00
56_A60_G0.5611.00
45_W229_A0.5611.00
120_F305_L0.5591.00
110_I114_A0.5581.00
428_S432_I0.5571.00
10_W13_T0.5551.00
427_Y431_V0.5551.00
163_S166_G0.5541.00
107_V378_L0.5541.00
188_A296_G0.5541.00
119_S304_A0.5531.00
270_I273_G0.5521.00
231_V382_A0.5511.00
454_I459_V0.5501.00
72_G237_V0.5481.00
162_A345_K0.5471.00
80_L87_G0.5471.00
61_H412_G0.5461.00
220_H434_T0.5461.00
94_M389_P0.5461.00
324_E342_T0.5451.00
319_I352_L0.5451.00
171_N313_G0.5441.00
212_S216_G0.5441.00
55_I234_E0.5421.00
259_I266_I0.5421.00
432_I442_F0.5411.00
38_P277_H0.5411.00
61_H415_V0.5411.00
438_D443_I0.5401.00
246_Q411_K0.5391.00
361_V364_F0.5391.00
449_F453_L0.5391.00
16_V20_M0.5381.00
238_I321_L0.5371.00
89_A457_P0.5371.00
433_V436_T0.5371.00
417_D422_I0.5371.00
291_L295_V0.5361.00
426_A429_V0.5351.00
36_A222_A0.5351.00
17_V20_M0.5351.00
102_S318_W0.5341.00
123_I126_D0.5331.00
438_D447_G0.5331.00
446_I452_G0.5321.00
398_L425_C0.5311.00
442_F447_G0.5291.00
405_E411_K0.5281.00
177_S181_G0.5281.00
109_I112_S0.5281.00
200_H208_E0.5261.00
437_A445_G0.5251.00
146_F149_C0.5251.00
444_L450_F0.5251.00
58_V424_A0.5211.00
445_G459_V0.5201.00
155_G159_I0.5201.00
259_I262_S0.5191.00
12_L239_L0.5161.00
234_E390_Y0.5161.00
101_A104_I0.5151.00
324_E348_P0.5131.00
37_S40_G0.5121.00
152_L312_F0.5121.00
199_G204_P0.5121.00
286_P290_V0.5121.00
104_I381_A0.5111.00
439_L452_G0.5101.00
338_F342_T0.5101.00
97_G101_A0.5091.00
175_T178_K0.5081.00
26_F178_K0.5081.00
109_I311_L0.5071.00
51_G54_M0.5071.00
275_L289_D0.5061.00
151_I154_W0.5061.00
167_A320_L0.5061.00
373_D377_F0.5061.00
417_D424_A0.5041.00
121_F148_V0.5041.00
443_I456_Y0.5041.00
45_W268_T0.5041.00
25_I182_F0.5031.00
446_I453_L0.5021.00
444_L452_G0.5021.00
22_G264_Y0.5011.00
91_G95_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8934 100 0.291 Contact Map
3giaA 1 0.8998 100 0.364 Contact Map
4djkA 2 0.8827 100 0.365 Contact Map
3dh4A 3 0.8934 98.9 0.853 Contact Map
2xq2A 2 0.8913 98.8 0.859 Contact Map
2jlnA 1 0.8678 98.6 0.869 Contact Map
2a65A 2 0.9382 98.4 0.879 Contact Map
4wgvA 2 0.7783 97.6 0.9 Contact Map
4xp4A 1 0.9424 97.5 0.902 Contact Map
4us3A 1 0.8806 97.4 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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