GREMLIN Database
LIAH - Protein LiaH
UniProt: O32201 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (212)
Sequences: 1627 (1060)
Seq/√Len: 72.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_F83_E5.6051.00
75_Q212_L4.4471.00
67_A100_A3.1821.00
60_Y104_K2.8991.00
71_K75_Q2.8071.00
57_K61_E2.8061.00
104_K108_E2.7591.00
30_Q34_D2.6921.00
87_K203_E2.6641.00
64_A104_K2.6281.00
141_R178_E2.6141.00
149_E180_R2.4841.00
93_M205_E2.4751.00
204_A207_E2.4061.00
146_K150_H2.3341.00
134_K171_E2.2391.00
83_E210_R2.1831.00
70_R73_Q2.1431.00
60_Y100_A2.1301.00
75_Q79_D2.1281.00
53_A111_N2.1081.00
193_L197_E2.0221.00
69_K73_Q2.0171.00
189_A192_E2.0141.00
207_E211_T2.0111.00
29_N135_K1.9991.00
108_E112_S1.9911.00
75_Q209_M1.9581.00
43_K125_E1.9451.00
203_E207_E1.9401.00
130_D134_K1.9211.00
60_Y64_A1.8191.00
189_A193_L1.8181.00
64_A100_A1.8081.00
97_E101_A1.8031.00
208_K212_L1.7971.00
5_R22_E1.7851.00
7_R11_V1.7661.00
67_A97_E1.7291.00
101_A104_K1.7131.00
36_E132_K1.6711.00
190_G193_L1.6681.00
71_K212_L1.6621.00
30_Q33_R1.6491.00
208_K211_T1.6481.00
203_E213_S1.6391.00
193_L196_K1.6030.99
13_S26_V1.6010.99
68_G72_N1.5980.99
145_A181_A1.5880.99
71_K208_K1.5810.99
78_F213_S1.5600.99
69_K72_N1.5250.99
46_I117_L1.5150.99
176_E180_R1.5060.99
205_E208_K1.4960.99
64_A68_G1.4800.99
112_S116_D1.4790.99
29_N139_I1.4340.99
74_A209_M1.4300.99
19_D22_E1.4290.99
53_A114_L1.4030.98
194_T197_E1.3990.98
82_E192_E1.3940.98
94_K201_D1.3510.98
60_Y107_Y1.3490.98
19_D33_R1.3230.98
188_E191_T1.3200.98
53_A57_K1.2940.97
189_A195_R1.2880.97
46_I121_L1.2800.97
21_M26_V1.2730.97
32_V128_L1.2660.97
55_Q59_K1.2440.97
78_F209_M1.2270.96
12_A16_E1.2200.96
101_A105_A1.2170.96
111_N115_A1.1860.96
65_E69_K1.1840.96
120_Q123_A1.1800.95
93_M97_E1.1790.95
61_E64_A1.1760.95
98_G101_A1.1690.95
79_D213_S1.1670.95
75_Q213_S1.1550.95
11_V34_D1.1300.94
87_K202_V1.1250.94
138_L174_I1.1000.93
14_V17_G1.1000.93
183_Y187_A1.0810.93
67_A93_M1.0550.92
76_L80_A1.0460.92
127_K130_D1.0270.91
142_A146_K1.0240.91
34_D37_S1.0010.90
39_I128_L0.9960.90
78_F210_R0.9940.89
72_N75_Q0.9890.89
57_K107_Y0.9840.89
27_M30_Q0.9790.89
16_E26_V0.9750.88
98_G201_D0.9550.87
126_T130_D0.9550.87
85_L196_K0.9520.87
60_Y108_E0.9420.87
115_A119_E0.9340.86
28_L167_F0.9200.85
84_E192_E0.9200.85
23_N26_V0.9190.85
110_A114_L0.9160.85
9_M28_L0.9150.85
16_E20_K0.9070.85
124_L131_V0.9030.84
211_T214_L0.8940.84
61_E65_E0.8930.84
192_E196_K0.8910.84
139_I143_N0.8880.83
122_A126_T0.8850.83
74_A183_Y0.8780.83
53_A107_Y0.8750.82
63_A96_L0.8740.82
128_L166_E0.8590.81
204_A208_K0.8520.81
25_K29_N0.8440.80
73_Q76_L0.8420.80
74_A90_L0.8410.80
70_R92_E0.8400.80
15_H33_R0.8390.80
149_E153_T0.8330.79
8_D11_V0.8320.79
88_K91_T0.8280.79
8_D13_S0.8240.78
167_F177_M0.8200.78
191_T194_T0.8180.78
34_D38_D0.8150.78
152_N155_F0.8120.77
163_A167_F0.8120.77
71_K93_M0.8110.77
91_T95_Y0.8090.77
8_D166_E0.8090.77
83_E176_E0.8060.77
92_E95_Y0.8050.77
169_R172_N0.8010.76
14_V21_M0.7980.76
63_A99_K0.7930.76
38_D42_A0.7930.76
117_L147_A0.7790.74
78_F203_E0.7780.74
37_S41_K0.7750.74
149_E181_A0.7740.74
28_L135_K0.7720.74
62_E115_A0.7700.74
195_R199_A0.7600.73
153_T184_S0.7600.73
106_S110_A0.7580.72
109_Q113_Q0.7530.72
5_R24_P0.7520.72
90_L93_M0.7500.72
71_K78_F0.7480.71
25_K143_N0.7420.71
62_E68_G0.7390.71
123_A126_T0.7390.71
105_A207_E0.7380.70
28_L35_M0.7340.70
46_I49_Q0.7330.70
25_K127_K0.7280.69
153_T172_N0.7250.69
209_M213_S0.7230.69
12_A27_M0.7190.68
59_K62_E0.7190.68
17_G21_M0.7170.68
12_A20_K0.7130.68
31_Y70_R0.7130.68
209_M212_L0.7100.67
76_L79_D0.7100.67
188_E192_E0.7070.67
47_V55_Q0.7070.67
5_R12_A0.7070.67
77_A196_K0.7050.67
8_D135_K0.7030.67
10_F17_G0.7000.66
108_E111_N0.7000.66
172_N176_E0.6980.66
28_L170_I0.6980.66
66_V96_L0.6980.66
15_H148_K0.6950.66
64_A108_E0.6930.66
167_F171_E0.6930.66
107_Y111_N0.6910.65
25_K131_V0.6890.65
70_R89_A0.6860.65
100_A199_A0.6850.65
18_L22_E0.6850.65
8_D18_L0.6820.64
190_G194_T0.6780.64
83_E87_K0.6770.64
62_E65_E0.6700.63
71_K97_E0.6680.63
189_A194_T0.6640.62
54_Y182_N0.6640.62
76_L185_K0.6610.62
4_K195_R0.6570.61
73_Q143_N0.6530.61
110_A113_Q0.6510.61
39_I47_V0.6450.60
89_A193_L0.6430.60
82_E85_L0.6420.60
191_T195_R0.6420.60
83_E90_L0.6410.60
195_R198_F0.6400.59
129_Q133_D0.6390.59
103_H106_S0.6370.59
11_V30_Q0.6350.59
105_A108_E0.6350.59
89_A127_K0.6340.59
39_I55_Q0.6340.59
113_Q116_D0.6330.59
45_T143_N0.6290.58
32_V36_E0.6270.58
10_F14_V0.6240.58
83_E86_A0.6240.58
50_H118_K0.6220.57
194_T198_F0.6220.57
71_K91_T0.6200.57
29_N137_A0.6190.57
36_E128_L0.6170.57
156_D159_D0.6150.56
73_Q89_A0.6140.56
90_L94_K0.6140.56
98_G102_E0.6080.56
49_Q144_A0.6060.55
8_D27_M0.6050.55
86_A90_L0.6040.55
39_I43_K0.6020.55
67_A102_E0.6010.55
39_I125_E0.5970.54
31_Y170_I0.5960.54
32_V132_K0.5960.54
19_D27_M0.5960.54
104_K107_Y0.5960.54
62_E138_L0.5960.54
35_M131_V0.5900.53
56_F60_Y0.5890.53
63_A103_H0.5880.53
25_K35_M0.5860.53
61_E214_L0.5840.53
192_E197_E0.5830.53
177_M180_R0.5810.52
48_K66_V0.5800.52
22_E27_M0.5740.51
8_D167_F0.5730.51
94_K205_E0.5720.51
147_A150_H0.5670.51
113_Q120_Q0.5650.50
57_K111_N0.5650.50
15_H30_Q0.5640.50
70_R193_L0.5630.50
88_K149_E0.5630.50
190_G195_R0.5590.50
24_P89_A0.5590.50
140_A147_A0.5560.49
75_Q208_K0.5560.49
150_H153_T0.5560.49
160_S181_A0.5550.49
168_L172_N0.5540.49
192_E195_R0.5530.49
91_T202_V0.5530.49
46_I147_A0.5530.49
134_K138_L0.5520.49
174_I179_I0.5510.49
136_Q145_A0.5510.49
32_V135_K0.5510.49
90_L181_A0.5500.48
190_G196_K0.5500.48
59_K169_R0.5480.48
63_A100_A0.5480.48
87_K90_L0.5470.48
18_L21_M0.5470.48
31_Y73_Q0.5460.48
21_M196_K0.5440.48
50_H114_L0.5420.47
119_E161_E0.5390.47
8_D128_L0.5380.47
105_A109_Q0.5370.47
58_K150_H0.5360.47
38_D185_K0.5350.47
204_A213_S0.5350.47
50_H181_A0.5340.46
27_M174_I0.5320.46
13_S21_M0.5290.46
31_Y166_E0.5280.46
87_K94_K0.5260.45
68_G105_A0.5260.45
55_Q62_E0.5230.45
49_Q166_E0.5220.45
38_D152_N0.5210.45
12_A24_P0.5210.45
79_D214_L0.5200.45
45_T52_I0.5200.45
90_L124_L0.5200.45
13_S25_K0.5170.44
8_D34_D0.5170.44
35_M128_L0.5160.44
76_L197_E0.5160.44
70_R127_K0.5160.44
77_A127_K0.5140.44
60_Y96_L0.5140.44
78_F86_A0.5130.44
25_K70_R0.5100.44
78_F93_M0.5090.43
149_E185_K0.5090.43
38_D41_K0.5080.43
116_D120_Q0.5080.43
151_M170_I0.5080.43
80_A200_D0.5060.43
63_A82_E0.5050.43
43_K177_M0.5030.43
21_M37_S0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.0089 89.4 0.899 Contact Map
2gd5A 2 0.6844 87.2 0.902 Contact Map
4abmA 2 0.3511 82.5 0.908 Contact Map
3frtA 1 0.6178 80.8 0.91 Contact Map
3ojaB 1 0.5111 74.1 0.915 Contact Map
2dfsA 2 0.5556 63.6 0.921 Contact Map
1c1gA 2 0.9467 63.1 0.921 Contact Map
3mq9A 4 0.5467 62.3 0.922 Contact Map
4iloA 3 0.7333 52.2 0.926 Contact Map
4cgkA 3 0.6667 51.5 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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