GREMLIN Database
LIAG - Protein LiaG
UniProt: O32200 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (246)
Sequences: 1116 (947)
Seq/√Len: 60.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_S205_T3.9541.00
169_S206_S3.7661.00
188_S206_S3.6211.00
206_S226_S3.3541.00
150_S169_S3.2511.00
150_S188_S3.2211.00
169_S188_S3.1681.00
168_S187_A3.1671.00
187_A205_T3.0421.00
127_S149_A2.9851.00
128_S150_S2.9111.00
205_T225_T2.9001.00
149_A168_S2.7911.00
150_S206_S2.7851.00
187_A225_T2.7361.00
128_S169_S2.6921.00
149_A225_T2.6571.00
72_A112_V2.6471.00
226_S247_S2.6281.00
188_S226_S2.5531.00
149_A187_A2.5421.00
127_S168_S2.5301.00
150_S226_S2.4261.00
127_S205_T2.4011.00
128_S188_S2.3751.00
149_A205_T2.2811.00
206_S284_S2.2111.00
152_N190_D2.1921.00
128_S226_S2.1791.00
226_S284_S2.1541.00
128_S206_S2.1161.00
225_T283_D2.0691.00
167_A172_V2.0421.00
188_S247_S2.0011.00
169_S226_S1.9981.00
168_S283_D1.9611.00
205_T283_D1.9571.00
169_S284_S1.9451.00
168_S225_T1.8611.00
246_A283_D1.8511.00
150_S247_S1.8021.00
228_D286_D1.8001.00
127_S187_A1.7260.99
127_S225_T1.6890.99
225_T246_A1.6810.99
150_S284_S1.6700.99
149_A283_D1.6590.99
169_S247_S1.6430.99
206_S247_S1.6430.99
57_S128_S1.6040.99
171_D228_D1.6020.99
53_I112_V1.5930.99
171_D208_D1.5340.98
229_A280_I1.5260.98
130_D171_D1.5200.98
65_E113_R1.5120.98
208_D228_D1.5110.98
190_D228_D1.5000.98
128_S284_S1.4880.98
174_I177_T1.4800.98
128_S247_S1.4610.98
188_S284_S1.4580.98
152_N228_D1.4510.98
187_A283_D1.4410.98
208_D286_D1.4370.98
126_T129_G1.4050.97
187_A246_A1.4050.97
130_D152_N1.3990.97
130_D208_D1.3670.97
148_S186_L1.3510.96
67_R71_S1.3440.96
59_D130_D1.3380.96
171_D190_D1.3370.96
250_V287_L1.3350.96
193_L196_V1.3220.96
71_S113_R1.3040.96
269_G272_G1.2990.96
85_E90_L1.2840.95
57_S188_S1.2730.95
247_S284_S1.2670.95
59_D190_D1.2660.95
222_V280_I1.2630.95
171_D249_D1.2520.94
280_I287_L1.2310.94
276_H280_I1.2110.93
50_S89_K1.2070.93
189_G227_G1.1910.93
63_I111_I1.1710.92
190_D208_D1.1570.92
59_D129_G1.1340.91
126_T131_V1.1300.91
127_S283_D1.1130.90
57_S150_S1.1060.90
249_D286_D1.0960.89
57_S226_S1.0910.89
167_A204_M1.0880.89
149_A246_A1.0650.88
83_V92_L1.0520.87
58_K108_S1.0480.87
37_E76_G1.0470.87
59_D152_N1.0380.87
129_G177_T1.0280.86
245_S248_G1.0270.86
238_S272_G1.0260.86
165_V174_I1.0180.86
111_I115_P1.0100.85
66_E116_Y1.0080.85
133_V139_L1.0050.85
153_T165_V0.9930.84
56_D127_S0.9880.84
151_G189_G0.9850.84
146_A155_V0.9830.84
85_E88_R0.9800.83
221_S279_D0.9780.83
110_L115_P0.9680.83
200_L203_K0.9680.83
140_A159_R0.9660.83
148_S167_A0.9500.81
228_D249_D0.9470.81
159_R178_V0.9390.81
161_Q180_K0.9330.80
59_D228_D0.9330.80
51_M85_E0.9310.80
48_I90_L0.9300.80
55_S58_K0.9260.80
122_L194_V0.9250.80
168_S246_A0.9220.80
186_L191_A0.9190.79
243_A287_L0.9190.79
186_L204_M0.9190.79
57_S206_S0.9160.79
205_T246_A0.9060.78
63_I113_R0.9020.78
231_V278_I0.8990.78
52_V123_A0.8950.77
127_S246_A0.8950.77
166_K203_K0.8930.77
59_D286_D0.8920.77
148_S204_M0.8920.77
130_D286_D0.8900.77
202_V222_V0.8880.77
141_L144_L0.8850.77
131_V146_A0.8820.76
55_S110_L0.8790.76
148_S224_L0.8780.76
152_N208_D0.8780.76
209_F229_A0.8550.74
169_S172_V0.8480.74
122_L133_V0.8470.73
130_D228_D0.8400.73
165_V172_V0.8280.72
45_P70_I0.8280.72
65_E71_S0.8200.71
142_S161_Q0.8200.71
96_E112_V0.8170.71
157_D176_N0.8160.71
204_M209_F0.8030.69
170_G227_G0.8020.69
126_T148_S0.8020.69
65_E116_Y0.7990.69
62_I114_L0.7940.69
186_L224_L0.7920.68
190_D286_D0.7910.68
176_N195_H0.7880.68
170_G189_G0.7870.68
222_V229_A0.7850.68
240_A277_P0.7790.67
241_V269_G0.7780.67
155_V242_N0.7750.67
227_G248_G0.7740.67
43_A74_I0.7690.66
222_V281_K0.7630.65
242_N279_D0.7630.65
258_D269_G0.7620.65
213_L220_V0.7610.65
234_P254_Y0.7600.65
172_V186_L0.7570.65
54_E112_V0.7560.65
144_L152_N0.7500.64
152_N171_D0.7490.64
40_S73_G0.7490.64
151_G227_G0.7460.64
70_I90_L0.7390.63
152_N169_S0.7360.63
51_M92_L0.7300.62
151_G248_G0.7270.62
147_V203_K0.7250.61
76_G110_L0.7240.61
57_S169_S0.7230.61
269_G276_H0.7220.61
155_V158_V0.7210.61
74_I112_V0.7200.61
51_M114_L0.7160.61
199_S219_P0.7140.60
189_G248_G0.7130.60
197_S209_F0.7110.60
130_D190_D0.7110.60
201_D245_S0.7110.60
154_S158_V0.7080.60
45_P49_D0.7070.60
201_D208_D0.7050.59
129_G209_F0.7040.59
150_S246_A0.7020.59
285_G289_I0.7010.59
56_D149_A0.6970.58
212_V268_T0.6970.58
163_L182_A0.6950.58
179_S204_M0.6920.58
214_K220_V0.6910.58
87_K90_L0.6890.58
277_P280_I0.6860.57
81_L202_V0.6840.57
126_T167_A0.6830.57
37_E74_I0.6810.57
202_V211_A0.6740.56
126_T146_A0.6680.55
239_F271_Q0.6680.55
156_T186_L0.6640.55
51_M84_T0.6640.55
91_E154_S0.6640.55
235_Q257_A0.6630.55
154_S173_S0.6630.55
106_N110_L0.6630.55
204_M224_L0.6620.55
160_I179_S0.6610.54
167_A186_L0.6610.54
242_N266_H0.6590.54
233_L242_N0.6570.54
117_D120_G0.6560.54
61_R111_I0.6550.54
142_S180_K0.6530.54
84_T93_T0.6530.54
51_M120_G0.6480.53
265_H269_G0.6470.53
147_V223_T0.6470.53
193_L199_S0.6450.53
73_G111_I0.6450.53
120_G124_V0.6440.53
150_S186_L0.6420.52
83_V112_V0.6400.52
240_A270_T0.6380.52
183_G210_N0.6340.51
56_D187_A0.6320.51
272_G276_H0.6290.51
191_A202_V0.6250.50
252_S255_S0.6200.50
134_A145_N0.6170.50
282_T285_G0.6170.50
146_A153_T0.6150.49
165_V193_L0.6130.49
206_S225_T0.6120.49
51_M90_L0.6110.49
55_S126_T0.6100.49
45_P120_G0.6090.49
54_E228_D0.6090.49
43_A83_V0.6070.48
143_G173_S0.6060.48
260_G269_G0.6060.48
121_D143_G0.6040.48
81_L94_V0.6000.48
45_P72_A0.6000.48
185_D201_D0.6000.48
143_G161_Q0.5960.47
271_Q276_H0.5920.47
219_P268_T0.5920.47
250_V264_Q0.5910.47
48_I65_E0.5860.46
187_A190_D0.5840.46
139_L212_V0.5840.46
101_F104_G0.5820.46
131_V148_S0.5810.45
250_V260_G0.5800.45
260_G268_T0.5800.45
213_L218_G0.5800.45
72_A78_S0.5780.45
133_V146_A0.5770.45
184_I195_H0.5760.45
182_A198_G0.5740.45
210_N230_N0.5710.44
239_F254_Y0.5700.44
43_A84_T0.5700.44
245_S254_Y0.5670.44
286_D289_I0.5670.44
68_S73_G0.5660.44
39_D74_I0.5660.44
177_T229_A0.5650.44
60_V126_T0.5650.44
262_K265_H0.5630.43
204_M225_T0.5620.43
60_V247_S0.5610.43
88_R92_L0.5580.43
81_L229_A0.5570.43
202_V209_F0.5570.43
52_V89_K0.5570.43
135_G176_N0.5520.42
77_D83_V0.5520.42
94_V97_K0.5510.42
52_V121_D0.5510.42
50_S121_D0.5500.42
190_D258_D0.5490.42
54_E96_E0.5490.42
78_S88_R0.5480.42
154_S157_D0.5480.42
114_L117_D0.5480.42
152_N286_D0.5460.42
133_V144_L0.5450.41
250_V267_I0.5440.41
37_E172_V0.5430.41
130_D249_D0.5420.41
52_V91_E0.5400.41
256_F260_G0.5390.41
199_S202_V0.5380.41
93_T153_T0.5360.41
104_G164_K0.5360.41
209_F261_H0.5360.41
79_G85_E0.5350.40
217_T234_P0.5340.40
63_I134_A0.5330.40
240_A251_S0.5330.40
93_T259_K0.5330.40
92_L112_V0.5300.40
145_N166_K0.5290.40
81_L254_Y0.5280.40
231_V266_H0.5280.40
49_D88_R0.5280.40
280_I289_I0.5270.40
76_G108_S0.5270.40
40_S74_I0.5260.39
238_S274_G0.5260.39
65_E69_D0.5250.39
243_A250_V0.5240.39
139_L273_S0.5240.39
184_I191_A0.5230.39
123_A217_T0.5230.39
188_S196_V0.5230.39
56_D205_T0.5230.39
238_S273_S0.5220.39
92_L139_L0.5210.39
183_G192_N0.5200.39
241_V289_I0.5200.39
191_A204_M0.5180.39
53_I265_H0.5180.39
180_K198_G0.5160.38
204_M212_V0.5160.38
42_S69_D0.5130.38
141_L145_N0.5120.38
185_D223_T0.5120.38
239_F278_I0.5120.38
182_A218_G0.5110.38
80_K88_R0.5100.38
60_V141_L0.5090.38
77_D85_E0.5080.38
74_I110_L0.5070.37
134_A144_L0.5060.37
153_T198_G0.5050.37
198_G210_N0.5050.37
92_L275_R0.5050.37
66_E108_S0.5040.37
223_T244_L0.5040.37
53_I63_I0.5030.37
245_S260_G0.5030.37
280_I284_S0.5030.37
62_I68_S0.5020.37
232_S237_G0.5020.37
122_L158_V0.5020.37
155_V173_S0.5010.37
38_A76_G0.5010.37
171_D286_D0.5010.37
123_A145_N0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lycA 2 0.8034 99.8 0.625 Contact Map
3jx8A 4 0.8103 99.8 0.629 Contact Map
4opwA 1 0.7931 99.7 0.684 Contact Map
3petA 2 0.7207 99.7 0.686 Contact Map
4yguA 3 0.5862 99.6 0.69 Contact Map
4qrkA 1 0.6759 99.4 0.733 Contact Map
4peuA 1 0.7172 63.2 0.927 Contact Map
1y0gA 2 0.569 7.6 0.955 Contact Map
5a2fA 1 0 7.5 0.955 Contact Map
4uu4A 1 0.4552 6.1 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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