LIAG - BACSU - GREMLIN Contacts

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LIAG - Protein LiaG

UniProt:	O32200	Sequences: MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASASPRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFLNGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRIQDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTGPVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRHPIDIKTDSGDLAIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (246)
Sequences:	1116 (947)
Seq/√Len:	60.4

BACSU - LIAG YVLB
HALSA - Q9HNB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_S	205_T	3.954	1.00
169_S	206_S	3.766	1.00
188_S	206_S	3.621	1.00
206_S	226_S	3.354	1.00
150_S	169_S	3.251	1.00
150_S	188_S	3.221	1.00
169_S	188_S	3.168	1.00
168_S	187_A	3.167	1.00
187_A	205_T	3.042	1.00
127_S	149_A	2.985	1.00
128_S	150_S	2.911	1.00
205_T	225_T	2.900	1.00
149_A	168_S	2.791	1.00
150_S	206_S	2.785	1.00
187_A	225_T	2.736	1.00
128_S	169_S	2.692	1.00
149_A	225_T	2.657	1.00
72_A	112_V	2.647	1.00
226_S	247_S	2.628	1.00
188_S	226_S	2.553	1.00
149_A	187_A	2.542	1.00
127_S	168_S	2.530	1.00
150_S	226_S	2.426	1.00
127_S	205_T	2.401	1.00
128_S	188_S	2.375	1.00
149_A	205_T	2.281	1.00
206_S	284_S	2.211	1.00
152_N	190_D	2.192	1.00
128_S	226_S	2.179	1.00
226_S	284_S	2.154	1.00
128_S	206_S	2.116	1.00
225_T	283_D	2.069	1.00
167_A	172_V	2.042	1.00
188_S	247_S	2.001	1.00
169_S	226_S	1.998	1.00
168_S	283_D	1.961	1.00
205_T	283_D	1.957	1.00
169_S	284_S	1.945	1.00
168_S	225_T	1.861	1.00
246_A	283_D	1.851	1.00
150_S	247_S	1.802	1.00
228_D	286_D	1.800	1.00
127_S	187_A	1.726	0.99
127_S	225_T	1.689	0.99
225_T	246_A	1.681	0.99
150_S	284_S	1.670	0.99
149_A	283_D	1.659	0.99
169_S	247_S	1.643	0.99
206_S	247_S	1.643	0.99
57_S	128_S	1.604	0.99
171_D	228_D	1.602	0.99
53_I	112_V	1.593	0.99
171_D	208_D	1.534	0.98
229_A	280_I	1.526	0.98
130_D	171_D	1.520	0.98
65_E	113_R	1.512	0.98
208_D	228_D	1.511	0.98
190_D	228_D	1.500	0.98
128_S	284_S	1.488	0.98
174_I	177_T	1.480	0.98
128_S	247_S	1.461	0.98
188_S	284_S	1.458	0.98
152_N	228_D	1.451	0.98
187_A	283_D	1.441	0.98
208_D	286_D	1.437	0.98
126_T	129_G	1.405	0.97
187_A	246_A	1.405	0.97
130_D	152_N	1.399	0.97
130_D	208_D	1.367	0.97
148_S	186_L	1.351	0.96
67_R	71_S	1.344	0.96
59_D	130_D	1.338	0.96
171_D	190_D	1.337	0.96
250_V	287_L	1.335	0.96
193_L	196_V	1.322	0.96
71_S	113_R	1.304	0.96
269_G	272_G	1.299	0.96
85_E	90_L	1.284	0.95
57_S	188_S	1.273	0.95
247_S	284_S	1.267	0.95
59_D	190_D	1.266	0.95
222_V	280_I	1.263	0.95
171_D	249_D	1.252	0.94
280_I	287_L	1.231	0.94
276_H	280_I	1.211	0.93
50_S	89_K	1.207	0.93
189_G	227_G	1.191	0.93
63_I	111_I	1.171	0.92
190_D	208_D	1.157	0.92
59_D	129_G	1.134	0.91
126_T	131_V	1.130	0.91
127_S	283_D	1.113	0.90
57_S	150_S	1.106	0.90
249_D	286_D	1.096	0.89
57_S	226_S	1.091	0.89
167_A	204_M	1.088	0.89
149_A	246_A	1.065	0.88
83_V	92_L	1.052	0.87
58_K	108_S	1.048	0.87
37_E	76_G	1.047	0.87
59_D	152_N	1.038	0.87
129_G	177_T	1.028	0.86
245_S	248_G	1.027	0.86
238_S	272_G	1.026	0.86
165_V	174_I	1.018	0.86
111_I	115_P	1.010	0.85
66_E	116_Y	1.008	0.85
133_V	139_L	1.005	0.85
153_T	165_V	0.993	0.84
56_D	127_S	0.988	0.84
151_G	189_G	0.985	0.84
146_A	155_V	0.983	0.84
85_E	88_R	0.980	0.83
221_S	279_D	0.978	0.83
110_L	115_P	0.968	0.83
200_L	203_K	0.968	0.83
140_A	159_R	0.966	0.83
148_S	167_A	0.950	0.81
228_D	249_D	0.947	0.81
159_R	178_V	0.939	0.81
161_Q	180_K	0.933	0.80
59_D	228_D	0.933	0.80
51_M	85_E	0.931	0.80
48_I	90_L	0.930	0.80
55_S	58_K	0.926	0.80
122_L	194_V	0.925	0.80
168_S	246_A	0.922	0.80
186_L	191_A	0.919	0.79
243_A	287_L	0.919	0.79
186_L	204_M	0.919	0.79
57_S	206_S	0.916	0.79
205_T	246_A	0.906	0.78
63_I	113_R	0.902	0.78
231_V	278_I	0.899	0.78
52_V	123_A	0.895	0.77
127_S	246_A	0.895	0.77
166_K	203_K	0.893	0.77
59_D	286_D	0.892	0.77
148_S	204_M	0.892	0.77
130_D	286_D	0.890	0.77
202_V	222_V	0.888	0.77
141_L	144_L	0.885	0.77
131_V	146_A	0.882	0.76
55_S	110_L	0.879	0.76
148_S	224_L	0.878	0.76
152_N	208_D	0.878	0.76
209_F	229_A	0.855	0.74
169_S	172_V	0.848	0.74
122_L	133_V	0.847	0.73
130_D	228_D	0.840	0.73
165_V	172_V	0.828	0.72
45_P	70_I	0.828	0.72
65_E	71_S	0.820	0.71
142_S	161_Q	0.820	0.71
96_E	112_V	0.817	0.71
157_D	176_N	0.816	0.71
204_M	209_F	0.803	0.69
170_G	227_G	0.802	0.69
126_T	148_S	0.802	0.69
65_E	116_Y	0.799	0.69
62_I	114_L	0.794	0.69
186_L	224_L	0.792	0.68
190_D	286_D	0.791	0.68
176_N	195_H	0.788	0.68
170_G	189_G	0.787	0.68
222_V	229_A	0.785	0.68
240_A	277_P	0.779	0.67
241_V	269_G	0.778	0.67
155_V	242_N	0.775	0.67
227_G	248_G	0.774	0.67
43_A	74_I	0.769	0.66
222_V	281_K	0.763	0.65
242_N	279_D	0.763	0.65
258_D	269_G	0.762	0.65
213_L	220_V	0.761	0.65
234_P	254_Y	0.760	0.65
172_V	186_L	0.757	0.65
54_E	112_V	0.756	0.65
144_L	152_N	0.750	0.64
152_N	171_D	0.749	0.64
40_S	73_G	0.749	0.64
151_G	227_G	0.746	0.64
70_I	90_L	0.739	0.63
152_N	169_S	0.736	0.63
51_M	92_L	0.730	0.62
151_G	248_G	0.727	0.62
147_V	203_K	0.725	0.61
76_G	110_L	0.724	0.61
57_S	169_S	0.723	0.61
269_G	276_H	0.722	0.61
155_V	158_V	0.721	0.61
74_I	112_V	0.720	0.61
51_M	114_L	0.716	0.61
199_S	219_P	0.714	0.60
189_G	248_G	0.713	0.60
197_S	209_F	0.711	0.60
130_D	190_D	0.711	0.60
201_D	245_S	0.711	0.60
154_S	158_V	0.708	0.60
45_P	49_D	0.707	0.60
201_D	208_D	0.705	0.59
129_G	209_F	0.704	0.59
150_S	246_A	0.702	0.59
285_G	289_I	0.701	0.59
56_D	149_A	0.697	0.58
212_V	268_T	0.697	0.58
163_L	182_A	0.695	0.58
179_S	204_M	0.692	0.58
214_K	220_V	0.691	0.58
87_K	90_L	0.689	0.58
277_P	280_I	0.686	0.57
81_L	202_V	0.684	0.57
126_T	167_A	0.683	0.57
37_E	74_I	0.681	0.57
202_V	211_A	0.674	0.56
126_T	146_A	0.668	0.55
239_F	271_Q	0.668	0.55
156_T	186_L	0.664	0.55
51_M	84_T	0.664	0.55
91_E	154_S	0.664	0.55
235_Q	257_A	0.663	0.55
154_S	173_S	0.663	0.55
106_N	110_L	0.663	0.55
204_M	224_L	0.662	0.55
160_I	179_S	0.661	0.54
167_A	186_L	0.661	0.54
242_N	266_H	0.659	0.54
233_L	242_N	0.657	0.54
117_D	120_G	0.656	0.54
61_R	111_I	0.655	0.54
142_S	180_K	0.653	0.54
84_T	93_T	0.653	0.54
51_M	120_G	0.648	0.53
265_H	269_G	0.647	0.53
147_V	223_T	0.647	0.53
193_L	199_S	0.645	0.53
73_G	111_I	0.645	0.53
120_G	124_V	0.644	0.53
150_S	186_L	0.642	0.52
83_V	112_V	0.640	0.52
240_A	270_T	0.638	0.52
183_G	210_N	0.634	0.51
56_D	187_A	0.632	0.51
272_G	276_H	0.629	0.51
191_A	202_V	0.625	0.50
252_S	255_S	0.620	0.50
134_A	145_N	0.617	0.50
282_T	285_G	0.617	0.50
146_A	153_T	0.615	0.49
165_V	193_L	0.613	0.49
206_S	225_T	0.612	0.49
51_M	90_L	0.611	0.49
55_S	126_T	0.610	0.49
45_P	120_G	0.609	0.49
54_E	228_D	0.609	0.49
43_A	83_V	0.607	0.48
143_G	173_S	0.606	0.48
260_G	269_G	0.606	0.48
121_D	143_G	0.604	0.48
81_L	94_V	0.600	0.48
45_P	72_A	0.600	0.48
185_D	201_D	0.600	0.48
143_G	161_Q	0.596	0.47
271_Q	276_H	0.592	0.47
219_P	268_T	0.592	0.47
250_V	264_Q	0.591	0.47
48_I	65_E	0.586	0.46
187_A	190_D	0.584	0.46
139_L	212_V	0.584	0.46
101_F	104_G	0.582	0.46
131_V	148_S	0.581	0.45
250_V	260_G	0.580	0.45
260_G	268_T	0.580	0.45
213_L	218_G	0.580	0.45
72_A	78_S	0.578	0.45
133_V	146_A	0.577	0.45
184_I	195_H	0.576	0.45
182_A	198_G	0.574	0.45
210_N	230_N	0.571	0.44
239_F	254_Y	0.570	0.44
43_A	84_T	0.570	0.44
245_S	254_Y	0.567	0.44
286_D	289_I	0.567	0.44
68_S	73_G	0.566	0.44
39_D	74_I	0.566	0.44
177_T	229_A	0.565	0.44
60_V	126_T	0.565	0.44
262_K	265_H	0.563	0.43
204_M	225_T	0.562	0.43
60_V	247_S	0.561	0.43
88_R	92_L	0.558	0.43
81_L	229_A	0.557	0.43
202_V	209_F	0.557	0.43
52_V	89_K	0.557	0.43
135_G	176_N	0.552	0.42
77_D	83_V	0.552	0.42
94_V	97_K	0.551	0.42
52_V	121_D	0.551	0.42
50_S	121_D	0.550	0.42
190_D	258_D	0.549	0.42
54_E	96_E	0.549	0.42
78_S	88_R	0.548	0.42
154_S	157_D	0.548	0.42
114_L	117_D	0.548	0.42
152_N	286_D	0.546	0.42
133_V	144_L	0.545	0.41
250_V	267_I	0.544	0.41
37_E	172_V	0.543	0.41
130_D	249_D	0.542	0.41
52_V	91_E	0.540	0.41
256_F	260_G	0.539	0.41
199_S	202_V	0.538	0.41
93_T	153_T	0.536	0.41
104_G	164_K	0.536	0.41
209_F	261_H	0.536	0.41
79_G	85_E	0.535	0.40
217_T	234_P	0.534	0.40
63_I	134_A	0.533	0.40
240_A	251_S	0.533	0.40
93_T	259_K	0.533	0.40
92_L	112_V	0.530	0.40
145_N	166_K	0.529	0.40
81_L	254_Y	0.528	0.40
231_V	266_H	0.528	0.40
49_D	88_R	0.528	0.40
280_I	289_I	0.527	0.40
76_G	108_S	0.527	0.40
40_S	74_I	0.526	0.39
238_S	274_G	0.526	0.39
65_E	69_D	0.525	0.39
243_A	250_V	0.524	0.39
139_L	273_S	0.524	0.39
184_I	191_A	0.523	0.39
123_A	217_T	0.523	0.39
188_S	196_V	0.523	0.39
56_D	205_T	0.523	0.39
238_S	273_S	0.522	0.39
92_L	139_L	0.521	0.39
183_G	192_N	0.520	0.39
241_V	289_I	0.520	0.39
191_A	204_M	0.518	0.39
53_I	265_H	0.518	0.39
180_K	198_G	0.516	0.38
204_M	212_V	0.516	0.38
42_S	69_D	0.513	0.38
141_L	145_N	0.512	0.38
185_D	223_T	0.512	0.38
239_F	278_I	0.512	0.38
182_A	218_G	0.511	0.38
80_K	88_R	0.510	0.38
60_V	141_L	0.509	0.38
77_D	85_E	0.508	0.38
74_I	110_L	0.507	0.37
134_A	144_L	0.506	0.37
153_T	198_G	0.505	0.37
198_G	210_N	0.505	0.37
92_L	275_R	0.505	0.37
66_E	108_S	0.504	0.37
223_T	244_L	0.504	0.37
53_I	63_I	0.503	0.37
245_S	260_G	0.503	0.37
280_I	284_S	0.503	0.37
62_I	68_S	0.502	0.37
232_S	237_G	0.502	0.37
122_L	158_V	0.502	0.37
155_V	173_S	0.501	0.37
38_A	76_G	0.501	0.37
171_D	286_D	0.501	0.37
123_A	145_N	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lycA	2	0.8034	99.8	0.625	Contact Map
3jx8A	4	0.8103	99.8	0.629	Contact Map
4opwA	1	0.7931	99.7	0.684	Contact Map
3petA	2	0.7207	99.7	0.686	Contact Map
4yguA	3	0.5862	99.6	0.69	Contact Map
4qrkA	1	0.6759	99.4	0.733	Contact Map
4peuA	1	0.7172	63.2	0.927	Contact Map
1y0gA	2	0.569	7.6	0.955	Contact Map
5a2fA	1	0	7.5	0.955	Contact Map
4uu4A	1	0.4552	6.1	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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