GREMLIN Database
LIAF - Protein LiaF
UniProt: O32199 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (193)
Sequences: 703 (596)
Seq/√Len: 42.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_I173_I6.7931.00
127_I148_I5.2761.00
150_D175_N4.9571.00
175_N196_D3.6271.00
127_I173_I3.3851.00
127_I194_I3.2481.00
129_E175_N3.2211.00
129_E150_D3.0561.00
173_I194_I3.0321.00
150_D196_D2.9481.00
139_L142_L2.8621.00
171_G176_V2.7451.00
147_F172_V2.7091.00
53_V57_F2.6681.00
174_G195_G2.6161.00
12_A87_Y2.4131.00
155_L178_I2.4071.00
20_L25_I2.4051.00
11_I82_L2.3341.00
180_V186_V2.1230.99
145_S170_S2.0500.99
58_A154_D2.0140.99
129_E196_D1.9900.99
35_F39_G1.9890.99
160_I165_S1.9540.99
8_G90_I1.8500.99
36_L58_A1.8150.98
35_F40_Y1.7740.98
142_L167_I1.7040.97
186_V200_I1.6900.97
62_F188_V1.6420.97
32_P39_G1.5980.96
15_G39_G1.5050.95
128_G149_G1.5020.95
144_V169_I1.4890.94
31_W79_A1.4800.94
30_F61_L1.4610.94
28_L38_A1.4430.93
15_G83_I1.4150.93
125_F146_G1.4060.92
15_G86_G1.3880.92
35_F54_M1.3590.91
28_L46_S1.3380.90
139_L165_S1.3360.90
128_G195_G1.3310.90
15_G58_A1.3200.90
63_L69_I1.3120.90
39_G79_A1.3100.90
78_F81_F1.2900.89
76_Y80_A1.2660.88
119_H138_D1.2650.88
69_I180_V1.2240.86
126_F172_V1.2190.86
73_L76_Y1.2160.86
58_A62_F1.2040.85
19_F80_A1.2020.85
8_G86_G1.1980.85
175_N200_I1.1880.84
133_M154_D1.1870.84
99_N102_Q1.1560.83
34_F38_A1.1430.82
175_N199_L1.1410.82
146_G171_G1.1350.81
19_F34_F1.1140.80
35_F38_A1.1090.80
6_L41_F1.1090.80
137_F141_D1.1050.80
149_G174_G1.0980.79
16_I188_V1.0920.79
36_L55_Y1.0910.79
172_V193_F1.0740.78
141_D174_G1.0740.78
51_G58_A1.0580.77
63_L154_D1.0520.76
141_D199_L1.0380.75
61_L83_I1.0370.75
60_F186_V1.0360.75
28_L101_K1.0160.74
143_N168_V1.0150.74
180_V188_V1.0140.74
52_S83_I0.9970.72
81_F88_R0.9960.72
12_A19_F0.9870.72
87_Y90_I0.9830.71
79_A83_I0.9810.71
139_L206_G0.9760.71
152_K194_I0.9730.70
39_G42_L0.9680.70
126_F147_F0.9660.70
15_G79_A0.9600.69
39_G80_A0.9560.69
161_P164_E0.9480.68
36_L39_G0.9440.68
124_S145_S0.9380.68
143_N151_I0.9230.66
25_I153_I0.9210.66
146_G151_I0.9180.66
33_L41_F0.9150.66
13_L28_L0.9050.65
28_L194_I0.9000.64
132_M184_L0.8990.64
54_M58_A0.8990.64
137_F156_S0.8990.64
67_F74_F0.8980.64
11_I205_S0.8970.64
159_M183_D0.8960.64
22_I82_L0.8900.63
11_I112_E0.8870.63
31_W36_L0.8840.63
17_S59_A0.8740.62
13_L63_L0.8730.62
10_I93_K0.8660.61
180_V189_S0.8620.61
54_M188_V0.8610.61
39_G58_A0.8590.61
160_I163_G0.8590.61
82_L179_Y0.8550.60
7_L156_S0.8540.60
139_L158_A0.8520.60
39_G54_M0.8480.60
167_I178_I0.8430.59
48_D76_Y0.8370.59
126_F166_T0.8330.58
85_A89_L0.8310.58
82_L148_I0.8290.58
19_F79_A0.8240.57
35_F42_L0.8170.57
142_L150_D0.8100.56
139_L150_D0.8050.56
80_A83_I0.8050.56
164_E184_L0.8010.55
124_S170_S0.7980.55
8_G22_I0.7960.55
158_A161_P0.7910.54
37_I203_K0.7840.54
137_F154_D0.7780.53
155_L167_I0.7770.53
137_F159_M0.7760.53
42_L53_V0.7750.53
39_G51_G0.7750.53
5_Q180_V0.7720.53
15_G62_F0.7700.52
34_F90_I0.7690.52
19_F22_I0.7670.52
8_G163_G0.7670.52
150_D182_S0.7650.52
139_L155_L0.7650.52
80_A142_L0.7460.50
6_L176_V0.7440.50
89_L95_I0.7410.50
32_P35_F0.7340.49
13_L45_Y0.7330.49
18_M192_V0.7310.49
39_G154_D0.7300.49
168_V171_G0.7280.48
79_A82_L0.7190.48
17_S81_F0.7180.47
67_F77_A0.7160.47
29_L93_K0.7160.47
135_Q157_K0.7140.47
130_L178_I0.7140.47
5_Q9_L0.7140.47
40_Y46_S0.7120.47
95_I186_V0.7100.47
11_I85_A0.7100.47
30_F39_G0.7070.46
149_G195_G0.7060.46
48_D87_Y0.7050.46
44_K183_D0.7030.46
34_F116_D0.7010.46
12_A195_G0.6970.45
126_F174_G0.6940.45
37_I59_A0.6940.45
8_G12_A0.6900.45
115_K187_A0.6890.45
20_L184_L0.6840.44
85_A178_I0.6820.44
59_A178_I0.6720.43
19_F189_S0.6720.43
34_F114_P0.6700.43
119_H205_S0.6670.43
139_L184_L0.6580.42
192_V197_I0.6520.41
9_L13_L0.6510.41
137_F160_I0.6460.41
9_L52_S0.6450.41
40_Y117_V0.6440.41
43_K90_I0.6420.40
77_A117_V0.6410.40
9_L57_F0.6390.40
60_F87_Y0.6380.40
87_Y98_P0.6380.40
152_K179_Y0.6370.40
86_G90_I0.6370.40
170_S191_A0.6360.40
76_Y185_E0.6360.40
127_I206_G0.6350.40
33_L78_F0.6340.40
16_I201_G0.6320.39
152_K178_I0.6200.38
44_K91_K0.6160.38
155_L166_T0.6150.38
97_E100_E0.6120.38
26_G37_I0.6120.38
50_L95_I0.6110.38
31_W83_I0.6090.37
36_L79_A0.6080.37
92_G193_F0.6060.37
155_L164_E0.6050.37
42_L46_S0.6030.37
164_E183_D0.6000.37
40_Y188_V0.5990.36
58_A63_L0.5990.36
158_A190_S0.5970.36
161_P169_I0.5970.36
136_P165_S0.5950.36
154_D176_V0.5920.36
69_I161_P0.5920.36
140_N144_V0.5910.36
55_Y158_A0.5910.36
37_I115_K0.5910.36
43_K51_G0.5890.36
19_F44_K0.5890.36
103_V115_K0.5860.35
84_Y187_A0.5850.35
68_S73_L0.5840.35
129_E163_G0.5830.35
12_A24_G0.5810.35
147_F193_F0.5790.35
16_I174_G0.5780.35
87_Y117_V0.5740.34
8_G70_T0.5710.34
22_I155_L0.5710.34
34_F62_F0.5680.34
66_L76_Y0.5680.34
146_G176_V0.5670.34
171_G192_V0.5660.34
136_P157_K0.5660.34
32_P80_A0.5660.34
180_V197_I0.5630.33
126_F193_F0.5620.33
93_K164_E0.5620.33
43_K87_Y0.5620.33
11_I16_I0.5610.33
30_F34_F0.5610.33
66_L177_D0.5600.33
180_V196_D0.5580.33
79_A86_G0.5560.33
112_E115_K0.5550.33
155_L165_S0.5530.33
39_G86_G0.5530.33
147_F153_I0.5530.33
196_D200_I0.5510.32
34_F96_F0.5510.32
16_I29_L0.5490.32
120_P140_N0.5480.32
33_L55_Y0.5470.32
12_A94_P0.5440.32
10_I128_G0.5440.32
98_P115_K0.5430.32
148_I194_I0.5430.32
141_D175_N0.5400.31
153_I169_I0.5390.31
11_I19_F0.5390.31
77_A81_F0.5340.31
121_D184_L0.5340.31
15_G32_P0.5310.31
5_Q47_R0.5310.31
150_D199_L0.5310.31
14_F177_D0.5300.31
158_A183_D0.5290.31
128_G151_I0.5280.30
81_F96_F0.5260.30
93_K156_S0.5250.30
50_L127_I0.5250.30
135_Q201_G0.5230.30
116_D198_N0.5210.30
87_Y91_K0.5200.30
169_I198_N0.5190.30
176_V180_V0.5170.30
73_L102_Q0.5150.29
30_F44_K0.5140.29
47_R55_Y0.5130.29
79_A167_I0.5120.29
141_D165_S0.5090.29
147_F197_I0.5020.28
22_I79_A0.5010.28
13_L182_S0.5000.28
123_R195_G0.5000.28
75_G87_Y0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qrkA 1 0.751 99.4 0.758 Contact Map
3giaA 1 0.4357 27 0.946 Contact Map
3l1lA 2 0.4315 13.9 0.953 Contact Map
4i0uA 4 0.2448 13.2 0.953 Contact Map
2rddB 1 0.1452 9.4 0.956 Contact Map
4ev6A 3 0.2531 8.4 0.957 Contact Map
1wazA 1 0.1909 7.8 0.958 Contact Map
2i68A 2 0.2407 7.7 0.958 Contact Map
4tphA 2 0.3651 6.8 0.959 Contact Map
4mndA 2 0.3693 6.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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