GREMLIN Database
LIAS - Sensor histidine kinase LiaS
UniProt: O32198 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (307)
Sequences: 72767 (59808)
Seq/√Len: 3413.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_I337_Q3.6911.00
288_Q341_K3.3821.00
316_K320_S3.1931.00
327_E339_E3.1661.00
292_K337_Q3.0961.00
220_K253_G3.0361.00
292_K339_E2.9351.00
173_T194_V2.9041.00
295_D299_G2.7821.00
281_I292_K2.7801.00
290_R341_K2.6711.00
242_E279_T2.6371.00
277_K296_N2.5561.00
290_R339_E2.5491.00
284_I344_I2.5431.00
177_L195_E2.5421.00
283_G290_R2.5211.00
242_E277_K2.5091.00
328_V338_I2.5081.00
305_V330_S2.4901.00
273_S296_N2.4661.00
244_D281_I2.3661.00
301_K304_Q2.2811.00
253_G322_I2.2721.00
170_S199_G2.2651.00
329_I339_E2.2621.00
279_T294_I2.2351.00
285_K290_R2.2061.00
315_M326_A2.2041.00
177_L192_R2.1911.00
170_S198_A2.1811.00
283_G292_K2.1521.00
329_I337_Q2.1101.00
244_D279_T2.1021.00
304_Q307_A2.0911.00
331_V334_K2.0551.00
281_I294_I2.0181.00
325_V341_K2.0001.00
261_I319_A1.9461.00
319_A340_V1.8951.00
221_G224_E1.8721.00
170_S202_Q1.8581.00
184_D187_T1.8471.00
228_E259_F1.8331.00
319_A324_G1.8281.00
267_S271_R1.8211.00
156_R159_H1.7731.00
240_D277_K1.7721.00
300_F336_T1.7481.00
302_M305_V1.7471.00
276_S296_N1.7411.00
202_Q206_R1.7391.00
169_I198_A1.7301.00
233_F263_Q1.7161.00
327_E341_K1.7101.00
305_V328_V1.6951.00
174_S195_E1.6921.00
195_E199_G1.6921.00
330_S336_T1.6871.00
261_I315_M1.6271.00
261_I318_R1.6081.00
183_A187_T1.5891.00
300_F304_Q1.5821.00
273_S276_S1.5611.00
253_G258_L1.5511.00
262_V291_L1.5501.00
318_R322_I1.4971.00
176_V191_I1.4851.00
172_M190_R1.4731.00
121_V125_V1.4701.00
177_L188_V1.4671.00
125_V128_L1.4671.00
223_K227_T1.4601.00
320_S325_V1.4481.00
173_T195_E1.4241.00
254_V257_H1.4091.00
279_T296_N1.4041.00
149_E153_R1.4021.00
170_S195_E1.3771.00
273_S278_V1.3631.00
179_H187_T1.3611.00
121_V124_Q1.3321.00
269_V278_V1.3321.00
319_A326_A1.3181.00
114_L117_M1.3121.00
89_T94_N1.3121.00
105_D108_G1.3111.00
232_E259_F1.2961.00
145_S149_E1.2951.00
264_E315_M1.2941.00
301_K332_E1.2851.00
183_A186_K1.2831.00
172_M193_M1.2701.00
289_L344_I1.2641.00
330_S333_G1.2601.00
124_Q128_L1.2581.00
169_I194_V1.2421.00
69_G73_G1.2361.00
125_V129_Q1.2261.00
257_H321_E1.2231.00
291_L340_V1.2191.00
239_I243_W1.2161.00
261_I340_V1.2071.00
30_S34_F1.1951.00
122_E126_A1.1811.00
255_E259_F1.1801.00
168_A197_M1.1741.00
285_K341_K1.1641.00
223_K282_L1.1621.00
111_A115_N1.1611.00
173_T198_A1.1581.00
221_G250_I1.1521.00
120_R124_Q1.1521.00
227_T243_W1.1491.00
168_A172_M1.1471.00
257_H318_R1.1401.00
257_H260_R1.1341.00
192_R196_H1.1291.00
265_A338_I1.1291.00
330_S334_K1.1271.00
203_N256_D1.1261.00
118_A122_E1.1251.00
225_G229_L1.1181.00
104_D108_G1.1131.00
295_D335_G1.1121.00
84_I88_L1.1071.00
230_L243_W1.0981.00
249_A284_I1.0971.00
144_K147_I1.0961.00
94_N97_Y1.0871.00
294_I331_V1.0861.00
328_V336_T1.0811.00
193_M197_M1.0791.00
157_D260_R1.0681.00
150_E154_L1.0631.00
144_K148_S1.0601.00
258_L322_I1.0581.00
184_D188_V1.0501.00
324_G342_V1.0481.00
229_L263_Q1.0471.00
228_E255_E1.0391.00
317_E320_S1.0341.00
176_V187_T1.0341.00
189_K193_M1.0321.00
288_Q325_V1.0301.00
173_T177_L1.0281.00
249_A289_L1.0251.00
220_K225_G1.0241.00
170_S174_S1.0201.00
232_E263_Q1.0171.00
229_L233_F1.0061.00
245_I282_L1.0041.00
84_I109_L1.0031.00
103_G108_G0.9961.00
229_L259_F0.9961.00
259_F263_Q0.9951.00
197_M200_E0.9951.00
168_A171_M0.9921.00
221_G248_T0.9911.00
265_A315_M0.9911.00
223_K245_I0.9761.00
118_A121_V0.9711.00
123_L127_S0.9641.00
187_T190_R0.9631.00
66_F70_Y0.9581.00
317_E321_E0.9491.00
188_V192_R0.9451.00
246_Q283_G0.9381.00
207_A257_H0.9371.00
52_P56_I0.9321.00
324_G340_V0.9311.00
206_R210_L0.9281.00
113_Q116_E0.9231.00
223_K248_T0.9231.00
285_K288_Q0.9211.00
67_A71_M0.9201.00
122_E125_V0.9161.00
108_G111_A0.9151.00
73_G77_K0.9101.00
173_T191_I0.9091.00
272_H298_K0.9071.00
192_R195_E0.9041.00
225_G253_G0.9001.00
124_Q127_S0.8991.00
31_F35_Y0.8951.00
239_I273_S0.8941.00
263_Q267_S0.8931.00
119_K123_L0.8871.00
262_V266_L0.8861.00
295_D336_T0.8861.00
40_P43_L0.8851.00
118_A125_V0.8831.00
199_G202_Q0.8821.00
111_A114_L0.8821.00
153_R157_D0.8791.00
171_M175_A0.8791.00
87_I91_E0.8781.00
226_L282_L0.8761.00
236_K267_S0.8721.00
84_I113_Q0.8701.00
300_F305_V0.8701.00
264_E267_S0.8701.00
120_R123_L0.8691.00
233_F266_L0.8681.00
299_G336_T0.8681.00
147_I151_R0.8641.00
148_S152_Q0.8631.00
252_K345_F0.8621.00
256_D259_F0.8611.00
227_T231_D0.8571.00
110_A114_L0.8561.00
182_D187_T0.8541.00
287_S344_I0.8511.00
175_A179_H0.8481.00
189_K192_R0.8411.00
310_Y314_S0.8401.00
229_L232_E0.8331.00
89_T97_Y0.8321.00
302_M330_S0.8281.00
274_K298_K0.8241.00
194_V198_A0.8211.00
300_F338_I0.8181.00
319_A342_V0.8141.00
203_N207_A0.8131.00
266_L280_V0.8131.00
146_V149_E0.8121.00
240_D243_W0.8091.00
81_D84_I0.8081.00
71_M75_R0.8081.00
193_M196_H0.8081.00
143_K147_I0.8041.00
190_R193_M0.8011.00
288_Q344_I0.8001.00
88_L109_L0.7991.00
260_R263_Q0.7961.00
83_L87_I0.7961.00
198_A202_Q0.7951.00
221_G249_A0.7851.00
70_Y74_N0.7851.00
185_D188_V0.7841.00
224_E228_E0.7811.00
300_F306_K0.7771.00
230_L234_R0.7741.00
98_R119_K0.7731.00
88_L92_N0.7721.00
227_T245_I0.7701.00
316_K325_V0.7681.00
315_M319_A0.7671.00
220_K255_E0.7651.00
172_M197_M0.7621.00
179_H182_D0.7611.00
210_L260_R0.7591.00
159_H206_R0.7581.00
211_H313_N0.7571.00
222_L291_L0.7571.00
292_K329_I0.7561.00
73_G76_L0.7511.00
200_E259_F0.7491.00
229_L266_L0.7441.00
280_V293_V0.7431.00
164_Q168_A0.7411.00
231_D234_R0.7411.00
226_L262_V0.7331.00
100_P115_N0.7321.00
230_L233_F0.7301.00
120_R125_V0.7301.00
262_V293_V0.7261.00
257_H322_I0.7241.00
110_A115_N0.7231.00
228_E232_E0.7201.00
94_N98_R0.7201.00
314_S318_R0.7191.00
87_I113_Q0.7181.00
167_F171_M0.7171.00
300_F330_S0.7161.00
305_V338_I0.7151.00
177_L191_I0.7141.00
91_E116_E0.7111.00
32_M36_Y0.7101.00
326_A338_I0.7081.00
150_E157_D0.7081.00
96_A122_E0.7061.00
74_N78_T0.7021.00
265_A340_V0.6971.00
76_L79_R0.6921.00
207_A260_R0.6921.00
39_D43_L0.6901.00
84_I87_I0.6881.00
150_E156_R0.6881.00
265_A326_A0.6871.00
51_I55_L0.6851.00
143_K146_V0.6831.00
107_I110_A0.6801.00
230_L241_I0.6801.00
266_L278_V0.6791.00
88_L113_Q0.6751.00
237_Q270_F0.6711.00
37_R41_L0.6701.00
282_L291_L0.6691.00
196_H228_E0.6671.00
82_T86_S0.6671.00
269_V293_V0.6661.00
246_Q281_I0.6621.00
40_P44_L0.6591.00
209_L213_R0.6591.00
151_R156_R0.6591.00
227_T230_L0.6561.00
86_S99_I0.6561.00
93_G97_Y0.6561.00
202_Q205_M0.6551.00
246_Q282_L0.6541.00
87_I90_F0.6521.00
29_I33_M0.6511.00
225_G259_F0.6491.00
108_G112_D0.6481.00
151_R155_A0.6461.00
195_E198_A0.6451.00
288_Q343_P0.6451.00
233_F267_S0.6441.00
75_R79_R0.6441.00
265_A319_A0.6431.00
260_R318_R0.6421.00
87_I114_L0.6421.00
223_K247_D0.6381.00
191_I195_E0.6381.00
174_S178_E0.6321.00
90_F118_A0.6321.00
33_M37_R0.6311.00
168_A193_M0.6311.00
148_S215_V0.6311.00
313_N317_E0.6281.00
246_Q249_A0.6221.00
98_R115_N0.6211.00
52_P55_L0.6201.00
59_L63_T0.6181.00
282_L289_L0.6171.00
101_P112_D0.6161.00
150_E159_H0.6151.00
117_M121_V0.6141.00
214_P217_L0.6131.00
199_G203_N0.6091.00
210_L257_H0.6061.00
145_S148_S0.6061.00
225_G228_E0.6051.00
86_S89_T0.6041.00
53_F56_I0.6031.00
152_Q157_D0.6001.00
238_P275_A0.6001.00
86_S97_Y0.5991.00
175_A190_R0.5991.00
230_L280_V0.5971.00
179_H190_R0.5971.00
290_R327_E0.5971.00
55_L59_L0.5951.00
244_D283_G0.5941.00
167_F170_S0.5921.00
44_L48_W0.5921.00
226_L280_V0.5921.00
107_I111_A0.5921.00
147_I156_R0.5871.00
41_L45_S0.5851.00
34_F38_L0.5851.00
220_K252_K0.5831.00
268_N311_G0.5821.00
278_V293_V0.5811.00
186_K190_R0.5811.00
30_S33_M0.5801.00
172_M194_V0.5791.00
305_V329_I0.5781.00
85_E89_T0.5781.00
265_A293_V0.5751.00
261_I322_I0.5721.00
231_D235_K0.5721.00
294_I333_G0.5711.00
90_F117_M0.5701.00
331_V337_Q0.5691.00
258_L342_V0.5681.00
103_G106_E0.5681.00
242_E245_I0.5671.00
56_I60_I0.5671.00
101_P108_G0.5641.00
101_P111_A0.5631.00
83_L86_S0.5631.00
207_A256_D0.5621.00
300_F328_V0.5611.00
98_R118_A0.5601.00
176_V190_R0.5591.00
295_D298_K0.5591.00
77_K81_D0.5581.00
81_D85_E0.5551.00
89_T93_G0.5541.00
166_L205_M0.5541.00
187_T191_I0.5541.00
91_E94_N0.5531.00
174_S177_L0.5511.00
225_G258_L0.5491.00
232_E236_K0.5491.00
123_L126_A0.5471.00
172_M175_A0.5471.00
302_M331_V0.5471.00
97_Y100_P0.5471.00
223_K249_A0.5461.00
102_L106_E0.5431.00
115_N118_A0.5421.00
49_F52_P0.5401.00
302_M306_K0.5401.00
114_L118_A0.5401.00
330_S335_G0.5401.00
209_L212_L0.5391.00
166_L201_A0.5391.00
225_G230_L0.5391.00
43_L47_S0.5381.00
112_D116_E0.5381.00
239_I270_F0.5381.00
91_E95_F0.5381.00
103_G111_A0.5361.00
119_K122_E0.5351.00
164_Q171_M0.5341.00
233_F270_F0.5331.00
249_A282_L0.5321.00
197_M232_E0.5311.00
49_F53_F0.5301.00
236_K270_F0.5291.00
284_I289_L0.5281.00
201_A205_M0.5281.00
219_G257_H0.5251.00
233_F236_K0.5251.00
152_Q156_R0.5241.00
301_K305_V0.5241.00
186_K189_K0.5241.00
226_L230_L0.5231.00
315_M318_R0.5231.00
121_V128_L0.5201.00
80_I83_L0.5191.00
224_E227_T0.5181.00
197_M201_A0.5171.00
222_L289_L0.5161.00
103_G107_I0.5161.00
126_A129_Q0.5141.00
249_A252_K0.5141.00
226_L229_L0.5131.00
201_A204_E0.5121.00
112_D115_N0.5091.00
45_S48_W0.5081.00
89_T92_N0.5081.00
99_I115_N0.5081.00
324_G343_P0.5071.00
169_I173_T0.5071.00
269_V273_S0.5071.00
111_A117_M0.5061.00
79_R83_L0.5051.00
99_I111_A0.5051.00
326_A340_V0.5051.00
190_R194_V0.5051.00
154_L157_D0.5031.00
75_R78_T0.5011.00
88_L91_E0.5011.00
225_G255_E0.5011.00
151_R154_L0.5011.00
105_D111_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.7472 100 0.339 Contact Map
4bixA 2 0.5833 100 0.422 Contact Map
4ctiA 2 0.6194 100 0.439 Contact Map
4r39A 1 0.5722 100 0.493 Contact Map
2c2aA 2 0.5944 100 0.495 Contact Map
4q20A 2 0.5778 100 0.495 Contact Map
3jz3A 2 0.4194 100 0.496 Contact Map
4mpcA 2 0.8083 100 0.499 Contact Map
3d36A 2 0.5611 100 0.5 Contact Map
2q8gA 2 0.8139 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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