GREMLIN Database
CSSS - Sensor histidine kinase CssS
UniProt: O32193 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (433)
Sequences: 47899 (41935)
Seq/√Len: 2015.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
390_K444_T4.2091.00
391_N395_H4.0001.00
384_N448_A3.7531.00
424_K428_T3.7041.00
316_F350_G3.5941.00
435_S446_R3.4701.00
263_T283_I3.1751.00
388_T444_T3.1751.00
370_A392_D3.1441.00
401_L438_N2.9861.00
377_S388_T2.8971.00
339_E373_K2.8431.00
339_E375_E2.8091.00
386_V448_A2.7971.00
388_T446_R2.7931.00
350_G430_H2.7231.00
373_K392_D2.7161.00
315_M349_P2.6991.00
386_V446_R2.6641.00
379_K386_V2.6581.00
397_E400_M2.6011.00
358_L427_L2.5751.00
436_I445_Y2.5731.00
341_D377_S2.5701.00
375_E390_K2.5691.00
260_R288_L2.5401.00
423_V434_I2.5091.00
437_E446_R2.4951.00
437_E444_T2.4571.00
427_L432_A2.4341.00
267_K284_E2.4281.00
405_Y434_I2.4251.00
315_M347_L2.4051.00
377_S390_K2.3311.00
317_S320_E2.3271.00
267_K281_D2.3191.00
396_I404_L2.3191.00
218_D221_G2.2921.00
400_M403_S2.2851.00
379_K388_T2.2711.00
401_L436_I2.2571.00
438_N443_V2.2561.00
433_S448_A2.2181.00
324_E356_N2.1561.00
427_L447_I2.0971.00
337_S373_K2.0971.00
341_D375_E2.0851.00
314_D352_P2.0671.00
329_L360_E2.0661.00
260_R287_A2.0481.00
350_G355_W1.9851.00
403_S406_E1.9721.00
243_T247_N1.9421.00
238_D241_E1.9281.00
313_H349_P1.9161.00
358_L426_I1.9071.00
260_R291_E1.8831.00
398_D401_L1.8811.00
291_E295_K1.8771.00
358_L423_V1.8581.00
381_D386_V1.8571.00
435_S448_A1.8431.00
426_I430_H1.8191.00
217_K221_G1.8171.00
202_R207_D1.7951.00
364_E368_R1.7881.00
230_M234_L1.7831.00
400_M409_N1.7781.00
216_R221_G1.7481.00
27_V31_N1.7401.00
403_S409_N1.7381.00
396_I400_M1.7331.00
359_L387_I1.7141.00
351_D354_Q1.6881.00
428_T433_S1.6871.00
263_T284_E1.6671.00
396_I443_V1.6661.00
264_Q284_E1.6401.00
319_V323_E1.6341.00
231_R234_L1.6211.00
352_P356_N1.5911.00
391_N442_G1.5791.00
387_I447_I1.5691.00
267_K277_E1.5661.00
361_N423_V1.5481.00
262_Y279_T1.5311.00
370_A374_I1.5251.00
85_P89_E1.5231.00
405_Y436_I1.5161.00
400_M411_G1.5101.00
197_E222_K1.5071.00
235_V239_E1.5061.00
228_E231_R1.5031.00
375_E392_D1.4941.00
238_D242_R1.4701.00
239_E243_T1.4641.00
284_E288_L1.4611.00
369_Y410_K1.4591.00
331_W367_I1.4541.00
324_E352_P1.4341.00
259_I287_A1.4331.00
182_A186_A1.4311.00
406_E409_N1.4281.00
328_R356_N1.4251.00
427_L434_I1.4141.00
354_Q357_K1.4141.00
438_N441_T1.4091.00
358_L447_I1.4061.00
317_S347_L1.4031.00
259_I283_I1.4001.00
251_D357_K1.3781.00
326_I340_I1.3701.00
354_Q429_L1.3631.00
197_E201_K1.3621.00
266_I280_V1.3401.00
203_I231_R1.3281.00
384_N433_S1.3261.00
321_V325_V1.3251.00
260_R284_E1.3241.00
269_G276_L1.3221.00
258_V262_Y1.3191.00
401_L405_Y1.3191.00
200_V203_I1.3171.00
244_L248_I1.3101.00
220_I224_G1.3081.00
202_R210_D1.2971.00
237_K241_E1.2941.00
397_E440_K1.2921.00
258_V286_E1.2861.00
311_V351_D1.2851.00
319_V378_M1.2781.00
354_Q426_I1.2741.00
425_R428_T1.2711.00
436_I443_V1.2601.00
227_I230_M1.2571.00
59_G63_R1.2551.00
236_Q240_T1.2541.00
165_K169_F1.2341.00
241_E245_L1.2281.00
432_A449_V1.2281.00
200_V204_S1.2281.00
323_E340_I1.2221.00
292_K353_E1.2201.00
258_V261_G1.2171.00
207_D210_D1.2161.00
263_T287_A1.2161.00
266_I276_L1.2131.00
281_D285_C1.2041.00
405_Y445_Y1.1961.00
194_V197_E1.1821.00
390_K439_D1.1751.00
247_N407_P1.1661.00
231_R235_V1.1561.00
405_Y424_K1.1541.00
28_L32_T1.1501.00
404_L436_I1.1471.00
263_T267_K1.1461.00
295_K299_Y1.1351.00
391_N443_V1.1341.00
34_R38_T1.1311.00
261_G265_S1.1291.00
196_F200_V1.1291.00
262_Y282_V1.1271.00
325_V360_E1.1161.00
224_G228_E1.1111.00
398_D438_N1.1091.00
186_A190_S1.1061.00
211_P232_Q1.0921.00
220_I223_L1.0911.00
325_V329_L1.0911.00
216_R224_G1.0891.00
366_Q374_I1.0871.00
319_V342_V1.0821.00
243_T407_P1.0811.00
277_E281_D1.0811.00
313_H430_H1.0771.00
26_L30_S1.0761.00
217_K220_I1.0721.00
325_V356_N1.0701.00
361_N364_E1.0601.00
342_V378_M1.0591.00
271_F276_L1.0501.00
199_H212_V1.0501.00
311_V354_Q1.0491.00
331_W334_K1.0441.00
355_W430_H1.0431.00
407_P425_R1.0411.00
316_F321_V1.0391.00
260_R264_Q1.0341.00
396_I401_L1.0341.00
187_K191_R1.0341.00
235_V238_D1.0341.00
253_K295_K1.0181.00
336_L370_A1.0141.00
40_E44_T1.0121.00
320_E324_E1.0081.00
179_W183_I1.0071.00
381_D384_N1.0031.00
362_I423_V1.0011.00
322_T378_M0.9951.00
226_T229_E0.9891.00
298_L301_T0.9851.00
48_E51_V0.9841.00
155_Y159_L0.9821.00
362_I434_I0.9791.00
152_L156_R0.9791.00
229_E233_K0.9771.00
418_I422_I0.9731.00
359_L389_I0.9711.00
201_K222_K0.9701.00
31_N34_R0.9691.00
197_E226_T0.9681.00
396_I436_I0.9641.00
270_I276_L0.9641.00
53_T57_L0.9631.00
200_V227_I0.9621.00
296_D354_Q0.9591.00
278_N282_V0.9591.00
46_E50_H0.9581.00
41_T44_T0.9561.00
263_T280_V0.9541.00
49_Q53_T0.9521.00
329_L363_L0.9481.00
362_I445_Y0.9481.00
369_Y394_P0.9461.00
321_V350_G0.9451.00
42_Y46_E0.9451.00
286_E289_K0.9391.00
251_D361_N0.9391.00
200_V226_T0.9391.00
404_L445_Y0.9371.00
103_F107_V0.9371.00
360_E364_E0.9371.00
356_N360_E0.9291.00
7_A187_K0.9281.00
359_L363_L0.9281.00
269_G272_P0.9261.00
254_T258_V0.9231.00
30_S164_F0.9211.00
381_D448_A0.9151.00
165_K168_L0.9121.00
362_I447_I0.9101.00
251_D255_P0.9091.00
328_R360_E0.9091.00
281_D284_E0.9081.00
9_Q218_D0.9081.00
326_I330_K0.9081.00
137_G140_V0.9081.00
164_F168_L0.9071.00
353_E356_N0.9071.00
250_H254_T0.9061.00
84_L90_A0.9021.00
239_E242_R0.9011.00
282_V286_E0.8991.00
139_S142_G0.8971.00
396_I402_S0.8961.00
192_P196_F0.8931.00
424_K433_S0.8911.00
343_E379_K0.8901.00
292_K296_D0.8881.00
201_K205_E0.8871.00
395_H443_V0.8851.00
197_E200_V0.8831.00
318_I387_I0.8831.00
31_N35_D0.8821.00
180_I184_W0.8811.00
325_V328_R0.8791.00
237_K240_T0.8781.00
49_Q52_L0.8781.00
432_A447_I0.8751.00
427_L449_V0.8751.00
184_W188_Y0.8751.00
329_L364_E0.8711.00
127_G130_V0.8691.00
216_R220_I0.8631.00
82_V147_M0.8621.00
45_I49_Q0.8611.00
358_L430_H0.8581.00
312_Q351_D0.8491.00
323_E327_E0.8481.00
288_L291_E0.8451.00
425_R429_L0.8441.00
200_V223_L0.8431.00
325_V363_L0.8371.00
287_A291_E0.8371.00
245_L248_I0.8351.00
17_I21_I0.8311.00
199_H210_D0.8301.00
145_A149_S0.8281.00
217_K224_G0.8281.00
44_T47_N0.8281.00
423_V427_L0.8271.00
144_S148_L0.8271.00
250_H255_P0.8261.00
276_L279_T0.8261.00
221_G224_G0.8241.00
23_I27_V0.8231.00
246_Q249_S0.8201.00
273_K276_L0.8161.00
285_C324_E0.8161.00
363_L376_I0.8111.00
396_I438_N0.8111.00
221_G225_H0.8091.00
300_L421_S0.8091.00
313_H431_K0.8081.00
283_I287_A0.8081.00
272_P276_L0.8071.00
130_V133_V0.8041.00
38_T42_Y0.8021.00
357_K426_I0.8011.00
183_I187_K0.7991.00
376_I389_I0.7991.00
410_K415_E0.7951.00
192_P197_E0.7941.00
186_A189_L0.7941.00
299_Y357_K0.7941.00
253_K291_E0.7931.00
337_S340_I0.7921.00
202_R206_Q0.7921.00
140_V143_Q0.7911.00
160_A165_K0.7901.00
213_K228_E0.7861.00
132_F135_K0.7851.00
265_S269_G0.7851.00
388_T437_E0.7801.00
59_G62_E0.7781.00
278_N281_D0.7781.00
214_V225_H0.7761.00
233_K236_Q0.7741.00
324_E328_R0.7731.00
43_T46_E0.7721.00
327_E330_K0.7701.00
398_D402_S0.7701.00
40_E43_T0.7701.00
223_L227_I0.7681.00
189_L192_P0.7671.00
313_H350_G0.7651.00
192_P200_V0.7611.00
202_R205_E0.7611.00
212_V224_G0.7601.00
47_N50_H0.7581.00
211_P231_R0.7571.00
230_M233_K0.7561.00
335_E372_T0.7561.00
55_Y58_P0.7561.00
101_S104_I0.7551.00
121_Y125_V0.7531.00
188_Y191_R0.7531.00
60_S63_R0.7521.00
321_V328_R0.7521.00
211_P228_E0.7521.00
203_I230_M0.7521.00
210_D213_K0.7481.00
318_I385_I0.7471.00
45_I48_E0.7461.00
282_V285_C0.7441.00
391_N394_P0.7431.00
252_L290_L0.7411.00
362_I427_L0.7411.00
296_D357_K0.7371.00
322_T359_L0.7371.00
227_I231_R0.7331.00
289_K356_N0.7331.00
397_E411_G0.7321.00
126_N130_V0.7311.00
204_S229_E0.7281.00
198_K202_R0.7281.00
56_R60_S0.7271.00
422_I426_I0.7271.00
368_R415_E0.7261.00
201_K226_T0.7261.00
247_N251_D0.7251.00
128_E132_F0.7241.00
199_H202_R0.7241.00
194_V198_K0.7201.00
262_Y286_E0.7191.00
275_D278_N0.7191.00
371_E394_P0.7161.00
336_L340_I0.7151.00
252_L255_P0.7151.00
248_I297_L0.7131.00
236_Q239_E0.7121.00
30_S34_R0.7121.00
104_I107_V0.7111.00
279_T283_I0.7101.00
156_R160_A0.7101.00
36_F40_E0.7091.00
44_T48_E0.7061.00
354_Q430_H0.7041.00
318_I348_M0.7031.00
203_I206_Q0.7031.00
250_H361_N0.7021.00
331_W336_L0.6981.00
401_L437_E0.6981.00
304_D407_P0.6971.00
316_F352_P0.6961.00
275_D279_T0.6951.00
35_D38_T0.6951.00
398_D439_D0.6931.00
50_H54_E0.6931.00
52_L55_Y0.6921.00
79_V82_V0.6901.00
168_L172_A0.6901.00
214_V224_G0.6881.00
319_V345_D0.6871.00
311_V429_L0.6871.00
273_K277_E0.6871.00
196_F224_G0.6871.00
80_Q149_S0.6871.00
423_V426_I0.6861.00
299_Y354_Q0.6861.00
38_T41_T0.6861.00
80_Q93_D0.6841.00
214_V221_G0.6831.00
50_H53_T0.6831.00
41_T45_I0.6821.00
225_H229_E0.6811.00
406_E424_K0.6791.00
323_E326_I0.6791.00
39_N42_Y0.6781.00
100_S103_F0.6781.00
262_Y283_I0.6771.00
58_P61_I0.6761.00
210_D214_V0.6741.00
317_S345_D0.6741.00
222_K225_H0.6741.00
57_L61_I0.6721.00
204_S207_D0.6711.00
224_G227_I0.6711.00
378_M385_I0.6701.00
309_Q354_Q0.6691.00
195_S198_K0.6691.00
404_L409_N0.6671.00
119_K123_A0.6671.00
264_Q268_D0.6671.00
336_L367_I0.6661.00
262_Y266_I0.6661.00
400_M413_K0.6651.00
396_I445_Y0.6631.00
244_L251_D0.6631.00
290_L294_I0.6601.00
341_D379_K0.6591.00
37_F40_E0.6591.00
43_T47_N0.6581.00
343_E346_I0.6571.00
245_L249_S0.6551.00
212_V228_E0.6531.00
272_P275_D0.6531.00
332_A335_E0.6521.00
218_D222_K0.6521.00
256_V294_I0.6521.00
410_K414_G0.6521.00
219_E223_L0.6521.00
258_V282_V0.6511.00
298_L302_K0.6501.00
395_H442_G0.6491.00
321_V355_W0.6491.00
404_L421_S0.6491.00
248_I252_L0.6471.00
223_L226_T0.6471.00
35_D39_N0.6471.00
291_E294_I0.6451.00
320_E352_P0.6441.00
13_V17_I0.6431.00
178_S182_A0.6421.00
264_Q267_K0.6411.00
136_K139_S0.6411.00
322_T376_I0.6371.00
442_G445_Y0.6361.00
84_L147_M0.6351.00
201_K204_S0.6341.00
331_W338_W0.6341.00
326_I338_W0.6341.00
56_R59_G0.6331.00
346_I385_I0.6321.00
435_S447_I0.6311.00
71_T74_T0.6311.00
192_P218_D0.6301.00
267_K280_V0.6301.00
244_L249_S0.6291.00
257_M260_R0.6291.00
316_F349_P0.6291.00
329_L367_I0.6281.00
366_Q389_I0.6251.00
226_T230_M0.6211.00
228_E232_Q0.6201.00
166_Q169_F0.6191.00
265_S270_I0.6181.00
234_L237_K0.6181.00
7_A194_V0.6171.00
320_E323_E0.6161.00
195_S199_H0.6151.00
261_G287_A0.6141.00
133_V136_K0.6131.00
331_W335_E0.6111.00
323_E342_V0.6091.00
401_L445_Y0.6091.00
300_L407_P0.6091.00
378_M387_I0.6081.00
110_L113_K0.6081.00
343_E378_M0.6081.00
160_A164_F0.6071.00
405_Y408_F0.6071.00
286_E328_R0.6071.00
54_E57_L0.6061.00
222_K226_T0.6061.00
85_P88_E0.6061.00
54_E58_P0.6051.00
242_R304_D0.6051.00
233_K237_K0.6051.00
284_E287_A0.6051.00
104_I108_Y0.6041.00
265_S279_T0.6041.00
262_Y287_A0.6041.00
257_M261_G0.6041.00
193_L223_L0.6031.00
421_S425_R0.6021.00
346_I378_M0.6011.00
235_V241_E0.6001.00
47_N51_V0.6001.00
114_Q118_K0.6001.00
386_V435_S0.6001.00
131_F134_I0.6001.00
42_Y45_I0.5991.00
232_Q236_Q0.5971.00
252_L256_V0.5971.00
334_K367_I0.5971.00
16_G19_L0.5961.00
33_L36_F0.5951.00
290_L298_L0.5951.00
32_T36_F0.5941.00
251_D254_T0.5931.00
319_V344_E0.5931.00
36_F39_N0.5921.00
402_S406_E0.5901.00
244_L247_N0.5891.00
90_A93_D0.5881.00
191_R195_S0.5871.00
14_I17_I0.5871.00
397_E401_L0.5861.00
204_S233_K0.5841.00
374_I389_I0.5821.00
216_R223_L0.5811.00
354_Q358_L0.5811.00
434_I445_Y0.5801.00
125_V129_K0.5801.00
401_L443_V0.5801.00
217_K223_L0.5781.00
200_V230_M0.5771.00
366_Q370_A0.5761.00
216_R219_E0.5751.00
331_W374_I0.5741.00
166_Q170_I0.5721.00
357_K360_E0.5721.00
155_Y158_D0.5721.00
321_V356_N0.5721.00
27_V30_S0.5721.00
169_F173_V0.5701.00
82_V90_A0.5701.00
162_T165_K0.5691.00
15_S18_L0.5691.00
279_T282_V0.5691.00
85_P91_S0.5691.00
105_H109_K0.5671.00
297_L301_T0.5661.00
254_T261_G0.5651.00
39_N43_T0.5641.00
324_E327_E0.5641.00
257_M262_Y0.5631.00
114_Q117_K0.5621.00
32_T35_D0.5611.00
162_T166_Q0.5611.00
288_L292_K0.5601.00
192_P195_S0.5591.00
259_I263_T0.5591.00
348_M385_I0.5551.00
101_S105_H0.5531.00
24_L28_L0.5511.00
14_I182_A0.5511.00
317_S321_V0.5501.00
334_K370_A0.5481.00
193_L197_E0.5461.00
300_L425_R0.5461.00
196_F199_H0.5451.00
262_Y265_S0.5451.00
363_L367_I0.5431.00
251_D422_I0.5431.00
172_A176_L0.5381.00
100_S104_I0.5381.00
93_D96_L0.5361.00
326_I376_I0.5361.00
301_T305_Y0.5341.00
106_K109_K0.5341.00
117_K120_R0.5321.00
215_D218_D0.5321.00
144_S150_Y0.5321.00
198_K201_K0.5311.00
255_P290_L0.5311.00
19_L23_I0.5301.00
336_L392_D0.5301.00
193_L220_I0.5301.00
188_Y192_P0.5301.00
192_P216_R0.5291.00
280_V284_E0.5291.00
267_K270_I0.5291.00
136_K140_V0.5281.00
269_G279_T0.5271.00
152_L155_Y0.5271.00
78_S81_H0.5271.00
28_L31_N0.5271.00
311_V430_H0.5241.00
438_N444_T0.5241.00
81_H85_P0.5241.00
270_I273_K0.5231.00
266_I279_T0.5221.00
8_F12_V0.5221.00
251_D293_K0.5221.00
375_E378_M0.5211.00
193_L196_F0.5211.00
111_A114_Q0.5201.00
195_S213_K0.5201.00
363_L374_I0.5181.00
390_K441_T0.5181.00
7_A11_W0.5181.00
269_G273_K0.5181.00
368_R412_K0.5171.00
191_R194_V0.5171.00
225_H228_E0.5161.00
9_Q188_Y0.5151.00
301_T304_D0.5141.00
26_L171_I0.5141.00
199_H211_P0.5131.00
55_Y59_G0.5131.00
69_E72_A0.5111.00
71_T75_T0.5111.00
124_D128_E0.5111.00
243_T425_R0.5111.00
16_G23_I0.5101.00
427_L433_S0.5101.00
122_S125_V0.5101.00
297_L408_F0.5081.00
214_V217_K0.5071.00
408_F421_S0.5061.00
134_I137_G0.5061.00
285_C288_L0.5051.00
249_S255_P0.5041.00
304_D425_R0.5041.00
70_A73_P0.5031.00
129_K132_F0.5011.00
200_V206_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5876 100 0.356 Contact Map
4bixA 2 0.4922 100 0.389 Contact Map
4ctiA 2 0.5033 100 0.401 Contact Map
4q20A 2 0.4945 100 0.469 Contact Map
3a0rA 2 0.7162 100 0.483 Contact Map
4e01A 3 0.6208 100 0.484 Contact Map
4mpcA 2 0.6408 100 0.485 Contact Map
3jz3A 2 0.3437 100 0.491 Contact Map
4gczA 2 0.7783 100 0.494 Contact Map
2q8gA 2 0.6364 100 0.496 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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