GREMLIN Database
CSSR - Transcriptional regulatory protein CssR
UniProt: O32192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (202)
Sequences: 77783 (55955)
Seq/√Len: 3937.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_N31_S3.7391.00
15_N33_T3.3341.00
19_T31_S3.2001.00
8_V38_A2.7341.00
39_R66_E2.6851.00
36_E57_D2.5921.00
30_T46_P2.5871.00
35_G58_T2.4891.00
58_T66_E2.3981.00
43_T70_K2.3721.00
34_K57_D2.3541.00
4_T30_T2.1841.00
21_Y106_P2.0891.00
32_F41_K2.0411.00
25_E110_I2.0081.00
4_T28_N1.9791.00
19_T23_E1.9741.00
33_T37_D1.9221.00
88_R108_E1.9221.00
54_M82_R1.8951.00
51_L63_L1.8441.00
194_R197_D1.8361.00
159_K162_D1.7771.00
30_T41_K1.7761.00
64_I76_V1.7631.00
34_K37_D1.7471.00
78_F91_G1.7411.00
6_Y32_F1.7331.00
85_D105_L1.6811.00
66_E70_K1.6781.00
68_K97_N1.6691.00
78_F96_S1.6641.00
177_R197_D1.6251.00
58_T62_T1.6121.00
65_K94_L1.5821.00
35_G63_L1.5781.00
98_D112_R1.5741.00
166_L183_K1.5451.00
59_D62_T1.5351.00
136_S150_N1.5341.00
165_L169_H1.5271.00
3_Y117_L1.4931.00
22_L113_V1.4711.00
66_E69_A1.4551.00
42_M67_I1.4481.00
36_E58_T1.4451.00
82_R87_D1.4381.00
41_K46_P1.4221.00
64_I78_F1.4091.00
199_L202_R1.3911.00
62_T65_K1.3901.00
39_R63_L1.3891.00
49_W74_V1.3821.00
41_K44_P1.3721.00
176_S179_D1.3671.00
48_L113_V1.3551.00
12_D33_T1.3291.00
175_Y183_K1.3241.00
166_L170_H1.3041.00
97_N116_L1.2791.00
9_E15_N1.2731.00
97_N119_L1.2721.00
133_A138_R1.2711.00
53_I61_Y1.2691.00
77_I116_L1.2661.00
160_E206_K1.2641.00
10_D52_D1.2581.00
51_L64_I1.2561.00
39_R58_T1.2331.00
53_I78_F1.2121.00
71_D74_V1.2121.00
61_Y91_G1.2051.00
37_D41_K1.1931.00
32_F38_A1.1921.00
8_V55_L1.1791.00
140_A143_A1.1781.00
27_W114_Q1.1761.00
179_D183_K1.1711.00
37_D40_K1.1701.00
90_L94_L1.1631.00
84_A87_D1.1611.00
145_E153_I1.1611.00
6_Y46_P1.1601.00
138_R147_Y1.1571.00
36_E40_K1.1401.00
110_I114_Q1.1351.00
6_Y38_A1.1341.00
61_Y90_L1.1281.00
85_D89_V1.1041.00
25_E114_Q1.0911.00
40_K44_P1.0811.00
198_D201_R1.0751.00
171_K175_Y1.0731.00
6_Y41_K1.0671.00
178_E193_D1.0601.00
5_I27_W1.0601.00
38_A63_L1.0411.00
141_E165_L1.0351.00
93_E114_Q1.0341.00
48_L117_L1.0211.00
86_I90_L1.0201.00
26_G114_Q1.0191.00
108_E111_I1.0191.00
65_K90_L1.0191.00
139_V168_I1.0121.00
161_F165_L1.0091.00
89_V93_E1.0081.00
38_A42_M0.9981.00
162_D165_L0.9951.00
111_I115_K0.9941.00
49_W67_I0.9881.00
19_T29_I0.9831.00
16_E31_S0.9811.00
7_L18_L0.9811.00
194_R198_D0.9811.00
32_F37_D0.9791.00
166_L175_Y0.9771.00
39_R43_T0.9721.00
61_Y94_L0.9671.00
51_L76_V0.9671.00
12_D16_E0.9611.00
6_Y42_M0.9531.00
53_I59_D0.9501.00
88_R101_S0.9481.00
8_V49_W0.9471.00
3_Y27_W0.9471.00
131_E138_R0.9421.00
195_V199_L0.9321.00
18_L79_I0.9301.00
200_V204_R0.9231.00
50_I109_L0.9191.00
49_W76_V0.9191.00
13_N17_L0.9181.00
8_V32_F0.9091.00
158_S162_D0.9071.00
64_I96_S0.8951.00
62_T66_E0.8911.00
64_I94_L0.8831.00
85_D88_R0.8811.00
12_D15_N0.8791.00
77_I112_R0.8581.00
16_E19_T0.8501.00
51_L78_F0.8491.00
147_Y153_I0.8461.00
90_L93_E0.8461.00
7_L29_I0.8441.00
139_V161_F0.8431.00
53_I87_D0.8391.00
40_K43_T0.8361.00
27_W110_I0.8351.00
83_D101_S0.8321.00
175_Y179_D0.8311.00
55_L63_L0.8271.00
89_V107_R0.8261.00
116_L119_L0.8231.00
20_K24_N0.8231.00
193_D197_D0.8181.00
75_P97_N0.8161.00
4_T47_H0.8161.00
201_R205_R0.8151.00
166_L180_I0.8021.00
106_P110_I0.8021.00
108_E112_R0.8011.00
63_L67_I0.8001.00
18_L109_L0.7941.00
42_M74_V0.7941.00
144_R162_D0.7921.00
53_I82_R0.7901.00
4_T46_P0.7891.00
58_T63_L0.7891.00
42_M71_D0.7871.00
14_L104_F0.7871.00
87_D90_L0.7831.00
210_L213_E0.7821.00
194_R201_R0.7791.00
115_K118_Q0.7781.00
202_R205_R0.7781.00
65_K69_A0.7771.00
178_E182_L0.7711.00
42_M46_P0.7691.00
35_G39_R0.7621.00
8_V63_L0.7561.00
50_I79_I0.7551.00
92_L112_R0.7521.00
16_E20_K0.7521.00
117_L120_V0.7511.00
105_L108_E0.7451.00
136_S149_E0.7431.00
137_Y149_E0.7401.00
86_I107_R0.7391.00
157_T206_K0.7371.00
54_M81_A0.7311.00
35_G57_D0.7221.00
163_L167_F0.7191.00
120_V124_A0.7181.00
50_I113_V0.7171.00
104_F109_L0.7111.00
79_I104_F0.7081.00
144_R161_F0.7071.00
168_I171_K0.6971.00
17_L21_Y0.6901.00
3_Y121_Y0.6901.00
177_R193_D0.6881.00
93_E111_I0.6841.00
149_E208_P0.6801.00
179_D182_L0.6791.00
67_I72_P0.6771.00
131_E140_A0.6741.00
204_R209_E0.6741.00
39_R42_M0.6741.00
167_F171_K0.6721.00
67_I76_V0.6691.00
7_L19_T0.6681.00
7_L31_S0.6641.00
198_D202_R0.6621.00
107_R111_I0.6601.00
147_Y151_G0.6591.00
91_G96_S0.6591.00
21_Y110_I0.6571.00
42_M49_W0.6561.00
115_K120_V0.6561.00
112_R116_L0.6561.00
43_T66_E0.6551.00
166_L169_H0.6531.00
15_N19_T0.6471.00
133_A136_S0.6431.00
98_D115_K0.6381.00
9_E55_L0.6351.00
157_T160_E0.6331.00
169_H183_K0.6301.00
75_P119_L0.6281.00
77_I98_D0.6281.00
73_D123_E0.6271.00
61_Y87_D0.6261.00
45_S71_D0.6261.00
85_D107_R0.6241.00
197_D200_V0.6231.00
11_E14_L0.6221.00
50_I77_I0.6211.00
75_P117_L0.6211.00
39_R70_K0.6191.00
53_I91_G0.6181.00
3_Y47_H0.6181.00
164_L214_T0.6171.00
35_G55_L0.6141.00
130_N142_D0.6131.00
68_K75_P0.6101.00
23_E29_I0.6061.00
5_I22_L0.6061.00
88_R105_L0.6031.00
73_D122_K0.5961.00
208_P211_K0.5941.00
14_L17_L0.5931.00
114_Q118_Q0.5931.00
137_Y146_V0.5901.00
11_E81_A0.5901.00
75_P123_E0.5871.00
51_L55_L0.5851.00
5_I48_L0.5831.00
43_T71_D0.5811.00
104_F108_E0.5811.00
64_I68_K0.5811.00
80_S88_R0.5791.00
22_L27_W0.5791.00
143_A147_Y0.5771.00
52_D102_K0.5771.00
21_Y25_E0.5771.00
167_F200_V0.5771.00
111_I114_Q0.5731.00
75_P120_V0.5681.00
191_G196_V0.5671.00
192_T195_V0.5661.00
211_K214_T0.5661.00
68_K74_V0.5641.00
42_M63_L0.5621.00
51_L67_I0.5571.00
141_E169_H0.5461.00
159_K199_L0.5451.00
34_K55_L0.5441.00
37_D57_D0.5431.00
139_V165_L0.5421.00
86_I89_V0.5351.00
10_D80_S0.5331.00
162_D166_L0.5241.00
8_V35_G0.5241.00
160_E163_L0.5211.00
23_E28_N0.5191.00
140_A145_E0.5181.00
7_L15_N0.5151.00
32_F35_G0.5151.00
149_E209_E0.5141.00
149_E152_N0.5111.00
89_V92_L0.5101.00
67_I74_V0.5081.00
5_I113_V0.5081.00
17_L20_K0.5071.00
107_R110_I0.5071.00
115_K119_L0.5061.00
169_H175_Y0.5051.00
20_K23_E0.5031.00
126_P129_K0.5021.00
177_R181_L0.5011.00
81_A103_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r0jA 2 0.9644 100 0.18 Contact Map
2gwrA 1 0.9644 100 0.194 Contact Map
2oqrA 2 0.9778 100 0.195 Contact Map
1ys7A 2 0.9867 100 0.205 Contact Map
1kgsA 1 0.9511 100 0.212 Contact Map
1p2fA 1 0.9422 100 0.224 Contact Map
4kfcA 2 0.9689 100 0.227 Contact Map
4b09A 2 0.9111 100 0.23 Contact Map
2hqrA 2 0.9378 100 0.245 Contact Map
3q9sA 1 0.9067 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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