GREMLIN Database
YUST - Uncharacterized HTH-type transcriptional regulator YusT
UniProt: O32186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (278)
Sequences: 78958 (57205)
Seq/√Len: 3430.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_K74_L3.6321.00
15_E24_Q3.3521.00
157_Y282_T2.6261.00
67_Y81_A2.5081.00
11_M24_Q2.4831.00
95_G140_L2.4751.00
158_P259_K2.2901.00
172_V181_K2.2391.00
158_P161_E2.2061.00
161_E259_K2.2061.00
91_P122_S2.1951.00
45_T60_S2.1861.00
223_V230_S2.1511.00
111_S284_V2.1471.00
10_Q69_N2.1131.00
8_V35_R2.1021.00
10_Q14_R2.0571.00
91_P120_Q2.0531.00
165_V234_R2.0511.00
67_Y74_L2.0401.00
163_E234_R2.0201.00
111_S280_S1.9891.00
161_E257_Q1.9881.00
224_T245_S1.9831.00
11_M15_E1.9681.00
20_K23_L1.9431.00
93_M122_S1.9301.00
11_M14_R1.9131.00
220_I240_H1.8931.00
13_A57_L1.8771.00
10_Q65_L1.8711.00
174_D177_E1.8601.00
168_S249_Y1.8591.00
8_V32_V1.8551.00
14_R69_N1.8421.00
224_T240_H1.8411.00
71_I75_L1.8371.00
65_L69_N1.8261.00
184_L228_G1.8121.00
165_V248_L1.7991.00
182_P210_I1.7261.00
13_A65_L1.7171.00
156_S261_E1.7041.00
63_L81_A1.6921.00
49_L56_T1.6741.00
134_K139_E1.6461.00
64_L78_A1.6431.00
15_E20_K1.6321.00
67_Y70_K1.5841.00
155_E266_K1.5591.00
18_I36_I1.5541.00
10_Q68_A1.5411.00
17_T20_K1.5361.00
5_D35_R1.5231.00
157_Y264_V1.5231.00
14_R24_Q1.5131.00
5_D42_E1.4931.00
5_D38_Q1.4921.00
278_M282_T1.4491.00
28_V31_N1.4391.00
112_Y277_F1.4371.00
102_A217_E1.4361.00
264_V278_M1.4331.00
9_F65_L1.4241.00
46_T49_L1.4241.00
11_M25_L1.4231.00
155_E264_V1.4221.00
67_Y77_E1.4221.00
51_H56_T1.4201.00
145_I263_I1.4131.00
8_V27_Y1.4031.00
134_K140_L1.3891.00
147_C261_E1.3851.00
74_L77_E1.3841.00
19_T29_Q1.3841.00
115_E280_S1.3771.00
112_Y119_V1.3741.00
93_M124_T1.3661.00
87_E118_N1.3621.00
126_G130_F1.3591.00
135_V143_A1.3581.00
71_I78_A1.3481.00
270_I274_L1.3371.00
276_T279_D1.3331.00
240_H245_S1.3231.00
193_R197_E1.3221.00
59_A62_K1.3191.00
64_L79_S1.3181.00
66_D70_K1.3171.00
89_S118_N1.3101.00
10_Q72_I1.3011.00
111_S115_E1.3011.00
262_F278_M1.3011.00
162_E235_T1.2961.00
168_S172_V1.2931.00
219_I230_S1.2931.00
136_L153_E1.2801.00
221_G224_T1.2751.00
67_Y78_A1.2701.00
181_K229_I1.2701.00
142_G262_F1.2661.00
170_A245_S1.2601.00
3_S75_L1.2581.00
158_P261_E1.2581.00
27_Y31_N1.2491.00
170_A247_R1.2471.00
168_S229_I1.2361.00
113_Y210_I1.2261.00
63_L66_D1.2201.00
142_G274_L1.2121.00
34_A38_Q1.2111.00
110_A225_A1.2071.00
234_R248_L1.2051.00
42_E79_S1.1991.00
9_F48_F1.1861.00
173_P181_K1.1851.00
110_A114_E1.1811.00
9_F13_A1.1651.00
63_L67_Y1.1651.00
113_Y182_P1.1571.00
156_S263_I1.1571.00
126_G134_K1.1351.00
107_K225_A1.1301.00
248_L251_L1.1121.00
234_R238_Q1.1101.00
238_Q242_A1.1021.00
34_A37_Q1.1021.00
70_K77_E1.1011.00
62_K66_D1.1001.00
116_H276_T1.0991.00
6_L68_A1.0941.00
122_S212_E1.0831.00
220_I224_T1.0821.00
157_Y278_M1.0811.00
11_M21_A1.0781.00
280_S284_V1.0711.00
182_P208_P1.0711.00
101_A125_T1.0651.00
167_V248_L1.0641.00
37_Q41_A1.0561.00
221_G225_A1.0561.00
239_K243_E1.0521.00
18_I55_M1.0501.00
124_T134_K1.0491.00
279_D282_T1.0481.00
71_I74_L1.0411.00
33_T37_Q1.0321.00
79_S83_S1.0291.00
9_F47_L1.0241.00
111_S114_E1.0231.00
35_R38_Q1.0201.00
136_L151_H1.0181.00
169_A226_G1.0161.00
163_E257_Q1.0151.00
12_V21_A1.0111.00
280_S283_P1.0101.00
275_R279_D1.0101.00
108_L281_F1.0041.00
265_R268_S1.0001.00
73_G77_E0.9991.00
112_Y280_S0.9911.00
92_L277_F0.9871.00
64_L68_A0.9801.00
184_L219_I0.9781.00
167_V237_V0.9761.00
185_V209_V0.9741.00
200_L205_V0.9731.00
213_F219_I0.9731.00
38_Q41_A0.9671.00
12_V18_I0.9651.00
4_G7_R0.9641.00
21_A32_V0.9591.00
57_L61_G0.9511.00
112_Y116_H0.9481.00
27_Y32_V0.9471.00
8_V25_L0.9451.00
13_A48_F0.9311.00
76_D79_S0.9301.00
194_E197_E0.9301.00
7_R76_D0.9291.00
20_K24_Q0.9261.00
75_L79_S0.9161.00
70_K73_G0.9161.00
168_S173_P0.9151.00
166_V229_I0.9131.00
9_F39_L0.9081.00
98_Q215_T0.9061.00
9_F57_L0.9061.00
213_F222_G0.9001.00
175_V253_E0.8961.00
115_E283_P0.8951.00
134_K137_R0.8941.00
76_D80_K0.8921.00
45_T82_L0.8901.00
16_G56_T0.8881.00
271_S274_L0.8871.00
147_C259_K0.8811.00
95_G143_A0.8801.00
108_L280_S0.8671.00
48_F55_M0.8661.00
240_H243_E0.8601.00
155_E158_P0.8581.00
60_S63_L0.8531.00
110_A227_L0.8471.00
66_D69_N0.8471.00
182_P209_V0.8441.00
199_W203_V0.8431.00
108_L284_V0.8421.00
60_S82_L0.8411.00
77_E81_A0.8401.00
140_L143_A0.8361.00
19_T23_L0.8351.00
95_G145_I0.8351.00
120_Q208_P0.8331.00
75_L78_A0.8311.00
90_G273_A0.8251.00
124_T140_L0.8241.00
25_L32_V0.8221.00
51_H54_G0.8211.00
196_L200_L0.8171.00
14_R65_L0.8141.00
29_Q33_T0.8131.00
272_S276_T0.8111.00
94_I142_G0.8111.00
174_D252_P0.8101.00
74_L78_A0.8081.00
113_Y227_L0.8071.00
119_V273_A0.8061.00
15_E21_A0.8051.00
16_G54_G0.8011.00
9_F64_L0.7991.00
194_E198_K0.7991.00
7_R11_M0.7991.00
13_A16_G0.7981.00
13_A61_G0.7951.00
270_I275_R0.7941.00
4_G35_R0.7801.00
12_V48_F0.7801.00
168_S247_R0.7791.00
167_V230_S0.7791.00
169_A227_L0.7791.00
169_A172_V0.7761.00
78_A82_L0.7761.00
3_S72_I0.7751.00
130_F134_K0.7741.00
62_K65_L0.7731.00
154_L263_I0.7721.00
176_E179_I0.7711.00
16_G62_K0.7701.00
69_N73_G0.7661.00
237_V240_H0.7621.00
222_G227_L0.7591.00
37_Q46_T0.7551.00
5_D8_V0.7541.00
163_E250_P0.7531.00
68_A71_I0.7511.00
279_D283_P0.7491.00
12_V32_V0.7471.00
90_G119_V0.7431.00
215_T218_A0.7411.00
138_Y265_R0.7401.00
18_I32_V0.7391.00
7_R10_Q0.7391.00
49_L58_S0.7381.00
96_C101_A0.7331.00
167_V232_L0.7331.00
276_T280_S0.7301.00
172_V182_P0.7301.00
12_V36_I0.7231.00
199_W202_S0.7201.00
142_G277_F0.7201.00
112_Y276_T0.7181.00
268_S271_S0.7171.00
115_E276_T0.7161.00
171_S226_G0.7111.00
141_D274_L0.7061.00
233_P236_V0.7061.00
59_A63_L0.7051.00
198_K202_S0.7031.00
60_S64_L0.7021.00
136_L154_L0.7001.00
187_S212_E0.7001.00
195_T199_W0.6981.00
197_E201_R0.6921.00
179_I205_V0.6911.00
93_M141_D0.6911.00
88_P116_H0.6871.00
174_D253_E0.6861.00
177_E180_T0.6831.00
102_A221_G0.6821.00
111_S283_P0.6821.00
64_L82_L0.6801.00
153_E266_K0.6781.00
31_N35_R0.6771.00
67_Y71_I0.6771.00
93_M140_L0.6721.00
57_L62_K0.6721.00
196_L199_W0.6631.00
166_V231_L0.6621.00
176_E203_V0.6601.00
198_K201_R0.6601.00
107_K110_A0.6571.00
9_F61_G0.6551.00
195_T198_K0.6551.00
23_L26_G0.6551.00
56_T62_K0.6531.00
49_L54_G0.6491.00
7_R72_I0.6471.00
77_E80_K0.6391.00
186_Y219_I0.6361.00
146_G258_M0.6341.00
40_E50_R0.6291.00
125_T214_G0.6281.00
163_E254_A0.6251.00
73_G76_D0.6241.00
183_I229_I0.6241.00
272_S275_R0.6231.00
172_V229_I0.6231.00
211_M222_G0.6211.00
120_Q212_E0.6211.00
170_A244_G0.6201.00
239_K242_A0.6191.00
183_I207_Q0.6181.00
166_V178_A0.6181.00
36_I40_E0.6151.00
107_K111_S0.6141.00
40_E45_T0.6131.00
105_L108_L0.6131.00
142_G278_M0.6101.00
224_T243_E0.6031.00
12_V17_T0.6021.00
171_S247_R0.6011.00
13_A62_K0.6001.00
4_G38_Q0.5991.00
72_I76_D0.5981.00
80_K84_S0.5971.00
180_T208_P0.5951.00
4_G8_V0.5941.00
43_L64_L0.5911.00
96_C105_L0.5881.00
193_R212_E0.5871.00
68_A72_I0.5821.00
92_L273_A0.5791.00
116_H119_V0.5781.00
187_S214_G0.5781.00
194_E199_W0.5781.00
92_L142_G0.5771.00
135_V154_L0.5761.00
264_V275_R0.5741.00
45_T49_L0.5741.00
21_A25_L0.5731.00
213_F218_A0.5721.00
45_T85_S0.5671.00
89_S120_Q0.5641.00
43_L82_L0.5641.00
197_E200_L0.5641.00
31_N34_A0.5641.00
48_F57_L0.5621.00
162_E258_M0.5621.00
166_V183_I0.5601.00
95_G124_T0.5581.00
63_L82_L0.5561.00
159_A262_F0.5551.00
277_F281_F0.5551.00
164_P231_L0.5531.00
98_Q127_H0.5531.00
95_G126_G0.5531.00
30_S34_A0.5441.00
28_V34_A0.5421.00
18_I29_Q0.5421.00
219_I223_V0.5411.00
135_V263_I0.5401.00
125_T215_T0.5371.00
81_A84_S0.5361.00
43_L46_T0.5351.00
147_C156_S0.5341.00
90_G118_N0.5341.00
80_K83_S0.5321.00
27_Y35_R0.5321.00
104_R108_L0.5321.00
200_L207_Q0.5321.00
46_T60_S0.5321.00
232_L237_V0.5301.00
84_S88_P0.5301.00
191_S194_E0.5301.00
16_G55_M0.5301.00
107_K221_G0.5281.00
110_A113_Y0.5241.00
100_T104_R0.5241.00
106_P110_A0.5241.00
57_L65_L0.5221.00
193_R199_W0.5221.00
160_F260_T0.5211.00
192_Y196_L0.5201.00
273_A276_T0.5201.00
78_A81_A0.5181.00
38_Q42_E0.5161.00
102_A215_T0.5161.00
245_S248_L0.5161.00
155_E267_D0.5151.00
216_L233_P0.5141.00
136_L139_E0.5141.00
96_C123_L0.5141.00
222_G228_G0.5121.00
120_Q210_I0.5091.00
274_L278_M0.5091.00
8_V36_I0.5091.00
18_I54_G0.5081.00
66_D81_A0.5081.00
217_E221_G0.5061.00
251_L254_A0.5061.00
179_I206_T0.5061.00
6_L64_L0.5021.00
109_L121_L0.5011.00
127_H130_F0.5011.00
18_I50_R0.5001.00
167_V246_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7458 100 0.092 Contact Map
2esnA 3 0.9695 100 0.093 Contact Map
3fxqA 3 0.9695 100 0.099 Contact Map
3fzvA 4 0.9458 100 0.107 Contact Map
1ixcA 4 0.9627 100 0.108 Contact Map
2h98A 2 0.6915 100 0.11 Contact Map
1al3A 1 0.7085 100 0.112 Contact Map
4x6gA 4 1 100 0.114 Contact Map
2h9bA 2 0.6915 100 0.117 Contact Map
3szpA 3 0.9559 100 0.129 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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