GREMLIN Database
YUSR - Short-chain dehydrogenase/reductase homolog YusR
UniProt: O32184 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (126)
Sequences: 60038 (34278)
Seq/√Len: 3053.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_A64_R3.6091.00
25_N52_T3.4921.00
46_S50_G3.2721.00
8_A55_L3.1471.00
69_A120_I2.9391.00
12_V59_L2.9281.00
98_A115_S2.8251.00
119_Q122_T2.7221.00
106_L121_I2.4311.00
74_A99_E2.3231.00
27_G49_H2.3101.00
32_I122_T2.2811.00
52_T67_G2.1751.00
2_K6_F2.1171.00
74_A79_A1.9171.00
49_H120_I1.8901.00
4_M48_V1.8191.00
106_L123_I1.7691.00
96_C102_D1.7051.00
14_F18_S1.6971.00
27_G67_G1.6601.00
26_V107_I1.5571.00
22_A114_E1.4701.00
55_L65_V1.4571.00
67_G120_I1.4481.00
68_V107_I1.4411.00
8_A25_N1.3921.00
22_A66_S1.3601.00
116_L121_I1.3541.00
41_Y45_K1.3281.00
85_M89_I1.3221.00
4_M25_N1.2961.00
52_T65_V1.2881.00
73_V98_A1.2751.00
86_K90_G1.2661.00
74_A85_M1.2481.00
109_S116_L1.2451.00
86_K89_I1.2421.00
8_A23_I1.2391.00
23_I65_V1.2191.00
87_S90_G1.2131.00
39_M58_A1.2001.00
8_A51_L1.1991.00
31_G49_H1.1821.00
60_A117_T1.1731.00
82_E86_K1.1611.00
82_E85_M1.1481.00
106_L109_S1.1401.00
32_I49_H1.1261.00
28_S41_Y1.1241.00
101_D105_K1.1231.00
14_F17_K1.1161.00
73_V103_V1.1091.00
2_K5_F1.1061.00
6_F10_A1.0881.00
32_I69_A1.0781.00
42_A50_G1.0731.00
5_F51_L1.0601.00
108_C111_I1.0511.00
96_C114_E1.0401.00
94_L117_T1.0401.00
115_S125_S1.0091.00
15_M20_D1.0041.00
10_A13_P0.9951.00
24_V111_I0.9931.00
20_D64_R0.9791.00
7_C11_V0.9781.00
92_L115_S0.9521.00
34_G50_G0.9491.00
89_I97_I0.9441.00
56_A118_G0.9261.00
64_R114_E0.9251.00
116_L123_I0.9251.00
16_K59_L0.9191.00
11_V15_M0.9171.00
102_D114_E0.9151.00
49_H53_K0.9151.00
12_V16_K0.9071.00
49_H69_A0.9021.00
11_V14_F0.8921.00
46_S53_K0.8731.00
105_K114_E0.8541.00
24_V107_I0.8521.00
72_A78_W0.8461.00
5_F9_R0.8381.00
25_N48_V0.8261.00
27_G69_A0.8251.00
32_I120_I0.8191.00
39_M51_L0.8171.00
42_A54_S0.8161.00
49_H67_G0.8131.00
4_M7_C0.8041.00
37_S58_A0.8031.00
110_L116_L0.8001.00
15_M18_S0.7981.00
83_E86_K0.7911.00
104_A108_C0.7901.00
10_A14_F0.7831.00
50_G53_K0.7761.00
25_N65_V0.7711.00
99_E114_E0.7631.00
105_K112_E0.7451.00
8_A11_V0.7401.00
116_L119_Q0.7331.00
106_L116_L0.7301.00
30_A42_A0.7241.00
43_V51_L0.7171.00
98_A125_S0.7171.00
103_V123_I0.7101.00
30_A35_A0.7031.00
59_L65_V0.7001.00
6_F9_R0.6941.00
5_F40_P0.6921.00
4_M8_A0.6911.00
92_L127_Q0.6851.00
85_M97_I0.6851.00
22_A111_I0.6821.00
56_A117_T0.6781.00
100_P104_A0.6741.00
108_C112_E0.6691.00
70_P103_V0.6691.00
102_D115_S0.6631.00
60_A94_L0.6571.00
15_M21_G0.6551.00
30_A38_S0.6531.00
2_K40_P0.6531.00
83_E87_S0.6531.00
96_C115_S0.6501.00
69_A122_T0.6481.00
119_Q124_D0.6471.00
109_S112_E0.6461.00
35_A38_S0.6441.00
50_G54_S0.6441.00
16_K19_K0.6411.00
55_L59_L0.6401.00
105_K108_C0.6391.00
68_V103_V0.6321.00
46_S49_H0.6311.00
33_T127_Q0.6311.00
68_V106_L0.6291.00
117_T126_G0.6261.00
18_S21_G0.6241.00
94_L115_S0.6231.00
66_S119_Q0.6231.00
39_M54_S0.6221.00
65_V117_T0.6221.00
72_A92_L0.6211.00
78_W97_I0.6201.00
105_K109_S0.6191.00
60_A93_L0.6151.00
76_R79_A0.6141.00
54_S58_A0.6071.00
42_A46_S0.6041.00
12_V15_M0.6031.00
13_P16_K0.6021.00
7_C10_A0.5981.00
66_S110_L0.5921.00
74_A97_I0.5891.00
40_P44_S0.5841.00
57_H93_L0.5781.00
28_S45_K0.5771.00
61_P95_Q0.5681.00
33_T57_H0.5661.00
13_P17_K0.5601.00
84_K88_M0.5601.00
29_I127_Q0.5581.00
41_Y44_S0.5561.00
78_W81_R0.5551.00
8_A59_L0.5461.00
91_S127_Q0.5461.00
31_G42_A0.5441.00
4_M51_L0.5441.00
64_R94_L0.5381.00
105_K113_Q0.5381.00
27_G48_V0.5341.00
66_S116_L0.5341.00
29_I122_T0.5261.00
84_K87_S0.5211.00
79_A85_M0.5191.00
72_A97_I0.5181.00
31_G46_S0.5171.00
39_M43_V0.5171.00
72_A88_M0.5131.00
102_D105_K0.5101.00
38_S81_R0.5081.00
103_V107_I0.5071.00
51_L55_L0.5021.00
110_L121_I0.5011.00
26_V68_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2et6A 1 0.9302 100 0.206 Contact Map
3lt0A 4 0.9767 100 0.207 Contact Map
1vl8A 4 1 100 0.207 Contact Map
3wtcA 4 1 100 0.208 Contact Map
1zemA 4 0.9767 100 0.21 Contact Map
4qedA 4 1 100 0.211 Contact Map
4o0lA 4 1 100 0.213 Contact Map
2z1nA 4 0.9612 100 0.213 Contact Map
1ae1A 4 1 100 0.214 Contact Map
4weoA 4 0.938 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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