GREMLIN Database
YUSQ - Probable tautomerase YusQ
UniProt: O32183 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (123)
Sequences: 851 (630)
Seq/√Len: 56.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_S47_E4.6761.00
45_Q50_E3.4661.00
63_T103_D3.1431.00
25_H29_I2.5411.00
32_I73_L2.5051.00
90_A104_V2.3291.00
85_L89_I2.2191.00
5_Q70_H2.0941.00
4_V24_I1.9821.00
7_H46_Y1.9051.00
11_G45_Q1.8721.00
6_I24_I1.8691.00
79_T114_E1.8200.99
26_Q92_R1.8130.99
20_L67_I1.7780.99
3_F42_V1.7670.99
89_I106_I1.7480.99
30_E88_S1.7420.99
78_T81_Q1.7380.99
73_L108_L1.6940.99
22_R39_Y1.6870.99
99_V104_V1.6620.99
17_L50_E1.6320.99
60_V120_N1.5450.98
21_S43_I1.5320.98
12_R16_W1.5320.98
16_W65_E1.5180.98
88_S92_R1.5180.98
21_S41_Q1.4990.98
14_E49_S1.4990.98
23_T27_S1.4470.97
87_R91_S1.4340.97
8_L17_L1.4160.97
76_S110_G1.4160.97
31_E88_S1.3800.96
89_I104_V1.3500.96
30_E92_R1.3420.96
26_Q30_E1.3010.95
7_H44_R1.3000.95
74_K118_F1.2610.94
23_T97_L1.2530.94
21_S39_Y1.2400.93
111_N115_D1.2360.93
12_R65_E1.2300.93
68_Y105_F1.2100.92
79_T83_K1.1890.92
91_S95_S1.1790.91
84_A87_R1.1760.91
19_K23_T1.1610.91
18_Q52_F1.1500.90
88_S91_S1.1480.90
75_Q113_D1.1100.89
70_H109_A1.0930.88
6_I43_I1.0850.87
82_K115_D1.0810.87
102_E120_N1.0770.87
20_L93_I1.0700.87
75_Q122_R1.0470.85
26_Q36_E1.0300.85
7_H42_V1.0210.84
5_Q44_R1.0210.84
63_T102_E1.0120.83
27_S89_I0.9940.82
94_H101_K0.9930.82
17_L45_Q0.9690.81
93_I97_L0.9680.81
6_I21_S0.9640.80
94_H100_R0.9550.80
110_G115_D0.9510.79
84_A88_S0.9410.79
56_F61_E0.9320.78
32_I81_Q0.9300.78
11_G16_W0.9180.77
48_K64_D0.9150.77
27_S92_R0.9050.76
91_S101_K0.8970.75
26_Q95_S0.8970.75
24_I43_I0.8940.75
25_H34_V0.8930.75
37_D54_D0.8860.74
66_L105_F0.8730.73
8_L43_I0.8600.72
117_S121_G0.8590.72
69_I93_I0.8530.72
54_D57_Y0.8480.71
13_S16_W0.8470.71
23_T96_E0.8470.71
72_T86_Y0.8350.70
24_I69_I0.8300.69
33_N81_Q0.8250.69
23_T92_R0.8190.68
71_F85_L0.8140.68
53_Y66_L0.8020.67
27_S85_L0.8000.67
25_H41_Q0.7970.66
2_P38_D0.7890.66
28_M34_V0.7860.65
7_H107_M0.7850.65
51_F66_L0.7790.65
100_R103_D0.7730.64
6_I69_I0.7700.64
112_Q115_D0.7700.64
10_S45_Q0.7660.63
14_E47_E0.7620.63
90_A106_I0.7430.61
72_T109_A0.7390.60
54_D62_R0.7380.60
34_V85_L0.7300.60
70_H107_M0.7190.58
98_G104_V0.7150.58
38_D118_F0.7150.58
8_L67_I0.7110.58
69_I76_S0.7100.57
72_T101_K0.7050.57
73_L76_S0.7030.57
28_M40_F0.7030.57
74_K115_D0.6960.56
60_V102_E0.6960.56
4_V69_I0.6920.55
29_I37_D0.6850.55
19_K97_L0.6840.55
18_Q22_R0.6780.54
74_K113_D0.6740.54
21_S40_F0.6720.53
19_K96_E0.6700.53
93_I104_V0.6690.53
92_R95_S0.6680.53
13_S17_L0.6640.52
46_Y50_E0.6640.52
40_F105_F0.6530.51
86_Y116_W0.6520.51
16_W97_L0.6480.51
74_K111_N0.6370.49
86_Y121_G0.6350.49
57_Y74_K0.6300.49
21_S25_H0.6250.48
37_D52_F0.6240.48
27_S34_V0.6230.48
17_L20_L0.6220.48
10_S50_E0.6190.48
9_R83_K0.6180.47
19_K98_G0.6170.47
3_F74_K0.6110.47
94_H106_I0.6080.46
69_I104_V0.6020.46
46_Y70_H0.6010.46
75_Q112_Q0.6010.46
32_I57_Y0.5990.45
39_Y52_F0.5980.45
107_M111_N0.5970.45
20_L99_V0.5900.44
42_V46_Y0.5790.43
106_I110_G0.5790.43
18_Q87_R0.5740.43
9_R64_D0.5740.43
14_E84_A0.5740.43
89_I92_R0.5720.42
15_V26_Q0.5680.42
74_K107_M0.5640.42
7_H41_Q0.5620.41
86_Y93_I0.5580.41
48_K96_E0.5530.40
26_Q96_E0.5500.40
25_H85_L0.5490.40
86_Y108_L0.5430.39
71_F77_R0.5420.39
4_V76_S0.5400.39
40_F111_N0.5380.39
41_Q111_N0.5370.39
39_Y55_P0.5360.39
68_Y104_V0.5340.38
21_S52_F0.5320.38
19_K67_I0.5310.38
96_E101_K0.5310.38
39_Y106_I0.5260.38
39_Y62_R0.5250.38
47_E50_E0.5240.37
23_T69_I0.5180.37
46_Y86_Y0.5160.37
14_E101_K0.5100.36
74_K110_G0.5090.36
21_S74_K0.5080.36
71_F113_D0.5050.35
66_L119_G0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aalA 3 0.9843 100 0.422 Contact Map
4lhpA 3 0.9843 100 0.444 Contact Map
3c6vA 3 0.937 99.9 0.461 Contact Map
4jcuA 3 0.9606 99.9 0.48 Contact Map
1mwwA 3 0.9449 99.9 0.484 Contact Map
3e6qA 4 0.9055 99.9 0.498 Contact Map
4lkbF 4 0.9449 99.9 0.512 Contact Map
1u9dA 3 0.8425 99.9 0.513 Contact Map
3t5sA 3 0.7559 99.9 0.524 Contact Map
2wkbA 3 0.9134 99.9 0.526 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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