GREMLIN Database
YUSP - Uncharacterized MFS-type transporter YusP
UniProt: O32182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 541 (422)
Sequences: 28288 (19845)
Seq/√Len: 966.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_N103_E5.3981.00
89_M177_G4.4361.00
87_I114_G3.8731.00
96_G171_Y3.5681.00
210_G243_I3.3461.00
206_T249_V3.2221.00
102_T106_I3.1791.00
94_L107_F3.1411.00
387_F395_V2.8991.00
348_L364_F2.8251.00
261_Y391_E2.8131.00
100_N103_E2.7611.00
77_R128_D2.6461.00
56_A109_G2.6271.00
209_V242_G2.6251.00
12_R134_Q2.6031.00
217_A236_F2.5761.00
214_L239_A2.5601.00
318_T370_L2.4861.00
202_A249_V2.4131.00
314_S366_A2.3941.00
300_S303_E2.3741.00
82_V185_A2.3491.00
82_V181_V2.2131.00
64_I113_I2.1821.00
164_L168_W2.1311.00
60_T109_G2.1111.00
182_I186_R2.1001.00
244_V248_I2.0901.00
91_A114_G2.0781.00
95_C107_F2.0661.00
233_L237_A2.0311.00
134_Q137_K2.0311.00
221_G227_W2.0271.00
388_S391_E2.0131.00
200_D203_G2.0121.00
259_P391_E1.9991.00
345_G368_I1.9811.00
280_I410_G1.9481.00
103_E107_F1.9441.00
276_F406_G1.9051.00
46_G49_M1.8791.00
91_A110_L1.8761.00
184_I188_L1.8421.00
160_I168_W1.7901.00
84_G117_I1.7851.00
91_A107_F1.7721.00
22_A81_Y1.7711.00
210_G239_A1.7711.00
93_A97_M1.7651.00
284_G414_L1.7451.00
165_N168_W1.7011.00
20_I145_I1.6811.00
253_A256_P1.6691.00
68_A117_I1.6681.00
213_S235_L1.6661.00
49_M101_M1.6621.00
324_Q328_K1.6621.00
213_S242_G1.6601.00
234_G238_L1.6451.00
101_M105_I1.6421.00
136_A327_Y1.6371.00
162_D302_S1.6351.00
73_D393_G1.6271.00
341_V371_G1.6251.00
36_A161_V1.6211.00
249_V253_A1.6201.00
292_F297_V1.6171.00
294_Q304_S1.6071.00
130_F138_F1.6001.00
82_V184_I1.5841.00
56_A105_I1.5831.00
95_C104_L1.5691.00
345_G371_G1.5691.00
246_F250_E1.5681.00
283_F407_G1.5641.00
24_F149_A1.5521.00
213_S238_L1.5461.00
78_R82_V1.5431.00
92_S173_N1.5411.00
198_N255_E1.5131.00
338_G374_L1.5091.00
263_F269_T1.4971.00
251_S261_Y1.4921.00
98_A103_E1.4901.00
210_G242_G1.4901.00
299_V307_I1.4851.00
201_I205_F1.4821.00
131_T134_Q1.4731.00
343_A347_L1.4731.00
217_A239_A1.4721.00
39_K42_G1.4671.00
15_L129_L1.4571.00
16_I130_F1.4541.00
132_G135_R1.4401.00
345_G364_F1.4401.00
86_I181_V1.4361.00
269_T273_L1.4281.00
220_F225_Y1.4241.00
29_D32_I1.4191.00
98_A107_F1.4181.00
357_S360_V1.4141.00
230_W234_G1.4091.00
303_E306_T1.3991.00
359_L363_S1.3981.00
247_I251_S1.3971.00
247_I260_M1.3881.00
57_Y115_G1.3881.00
248_I252_K1.3821.00
271_L383_L1.3801.00
63_T208_I1.3771.00
79_I190_G1.3741.00
71_L80_V1.3651.00
72_A77_R1.3621.00
340_L344_G1.3541.00
53_L104_L1.3351.00
333_P336_I1.3351.00
183_F187_G1.3331.00
83_S87_I1.3261.00
36_A169_V1.3221.00
127_G135_R1.3221.00
162_D300_S1.3221.00
216_L220_F1.3211.00
248_I251_S1.3171.00
93_A174_L1.3131.00
32_I169_V1.3121.00
203_G249_V1.3061.00
209_V213_S1.2991.00
239_A243_I1.2911.00
90_A94_L1.2891.00
94_L103_E1.2871.00
299_V303_E1.2741.00
64_I116_G1.2731.00
238_L242_G1.2691.00
18_G187_G1.2621.00
323_G327_Y1.2531.00
358_K362_T1.2471.00
78_R185_A1.2461.00
206_T242_G1.2461.00
41_V50_M1.2451.00
159_W163_S1.2381.00
72_A121_M1.2341.00
27_A146_Y1.2311.00
424_N428_D1.2201.00
206_T245_S1.2171.00
13_T17_T1.2171.00
89_M181_V1.2161.00
70_K74_L1.2131.00
20_I141_V1.1991.00
332_K336_I1.1961.00
322_G374_L1.1941.00
168_W175_P1.1921.00
12_R130_F1.1881.00
347_L350_T1.1861.00
259_P394_V1.1851.00
178_I182_I1.1771.00
314_S318_T1.1721.00
338_G375_V1.1711.00
217_A232_I1.1691.00
324_Q327_Y1.1671.00
18_G183_F1.1671.00
82_V86_I1.1591.00
102_T105_I1.1581.00
330_G333_P1.1571.00
347_L351_T1.1571.00
318_T373_G1.1551.00
174_L178_I1.1501.00
293_M307_I1.1431.00
97_M171_Y1.1381.00
303_E307_I1.1371.00
337_T374_L1.1331.00
363_S366_A1.1241.00
85_L180_A1.1151.00
311_M369_G1.1111.00
421_R425_L1.1111.00
29_D173_N1.1081.00
325_L329_I1.1061.00
359_L362_T1.1051.00
245_S248_I1.1031.00
236_F240_L1.1001.00
67_I204_I1.0991.00
21_I180_A1.0991.00
217_A235_L1.0921.00
240_L244_V1.0901.00
293_M361_A1.0871.00
89_M93_A1.0871.00
25_F177_G1.0841.00
243_I247_I1.0821.00
18_G180_A1.0781.00
160_I164_L1.0761.00
193_Q196_P1.0741.00
89_M174_L1.0721.00
203_G253_A1.0701.00
30_G58_L1.0691.00
265_N269_T1.0661.00
272_N402_F1.0611.00
225_Y231_Q1.0571.00
225_Y232_I1.0571.00
351_T364_F1.0531.00
205_F209_V1.0521.00
71_L75_L1.0501.00
425_L428_D1.0491.00
81_Y184_I1.0471.00
127_G392_L1.0451.00
87_I91_A1.0411.00
167_K171_Y1.0411.00
76_G79_I1.0401.00
55_T219_S1.0401.00
345_G367_I1.0391.00
261_Y264_K1.0331.00
77_R190_G1.0321.00
94_L97_M1.0291.00
342_M371_G1.0271.00
333_P337_T1.0261.00
73_D77_R1.0231.00
126_I142_F1.0181.00
133_K137_K1.0141.00
220_F224_D1.0141.00
60_T112_G1.0131.00
158_G301_A1.0071.00
14_L187_G1.0071.00
266_R270_F1.0061.00
360_V364_F1.0061.00
360_V363_S1.0051.00
425_L429_K1.0051.00
225_Y229_S1.0031.00
99_N102_T0.9951.00
353_D356_T0.9881.00
181_V185_A0.9821.00
421_R424_N0.9821.00
69_G73_D0.9801.00
383_L399_S0.9791.00
249_V252_K0.9781.00
52_W56_A0.9651.00
136_A323_G0.9641.00
156_I159_W0.9621.00
265_N391_E0.9621.00
122_A142_F0.9591.00
275_G399_S0.9591.00
228_D233_L0.9541.00
265_N388_S0.9531.00
338_G371_G0.9531.00
352_L356_T0.9521.00
56_A60_T0.9521.00
60_T64_I0.9511.00
79_I83_S0.9471.00
54_T287_T0.9461.00
268_F272_N0.9461.00
278_M375_V0.9451.00
83_S86_I0.9421.00
272_N398_S0.9401.00
348_L351_T0.9391.00
321_I324_Q0.9391.00
32_I157_G0.9381.00
311_M368_I0.9371.00
258_L398_S0.9371.00
232_I235_L0.9371.00
183_F186_R0.9331.00
95_C170_F0.9321.00
431_V434_L0.9321.00
223_K226_A0.9301.00
307_I358_K0.9291.00
318_T374_L0.9271.00
192_Q195_G0.9231.00
241_I245_S0.9181.00
73_D394_V0.9171.00
136_A140_G0.9121.00
198_N254_K0.9121.00
99_N107_F0.9111.00
268_F395_V0.9101.00
215_L408_T0.9071.00
91_A94_L0.9061.00
80_V117_I0.9031.00
276_F402_F0.9031.00
406_G410_G0.9031.00
26_S118_M0.9021.00
266_R269_T0.9021.00
19_L122_A0.9021.00
204_I208_I0.8991.00
231_Q234_G0.8981.00
160_I172_I0.8911.00
293_M297_V0.8871.00
337_T341_V0.8851.00
245_S249_V0.8841.00
40_I104_L0.8771.00
417_V421_R0.8741.00
37_M50_M0.8741.00
97_M107_F0.8731.00
80_V83_S0.8711.00
199_F204_I0.8701.00
209_V212_V0.8691.00
209_V238_L0.8681.00
428_D431_V0.8671.00
190_G193_Q0.8661.00
163_S302_S0.8651.00
288_F415_G0.8651.00
106_I110_L0.8631.00
53_L101_M0.8621.00
229_S232_I0.8621.00
33_V53_L0.8601.00
238_L245_S0.8601.00
39_K43_D0.8591.00
34_G54_T0.8581.00
318_T322_G0.8571.00
334_Q337_T0.8571.00
363_S367_I0.8551.00
49_M102_T0.8531.00
99_N167_K0.8501.00
320_I324_Q0.8501.00
265_N386_S0.8501.00
103_E106_I0.8491.00
244_V247_I0.8491.00
325_L334_Q0.8441.00
231_Q235_L0.8431.00
356_T360_V0.8421.00
430_L434_L0.8411.00
362_T366_A0.8391.00
318_T321_I0.8391.00
218_L221_G0.8381.00
63_T212_V0.8371.00
227_W232_I0.8351.00
326_V378_I0.8301.00
322_G373_G0.8291.00
28_L32_I0.8291.00
186_R189_Q0.8281.00
289_V365_M0.8281.00
106_I109_G0.8281.00
210_G247_I0.8271.00
313_I317_I0.8251.00
346_F368_I0.8231.00
351_T360_V0.8191.00
151_V312_M0.8181.00
40_I44_L0.8141.00
162_D301_A0.8131.00
75_L80_V0.8131.00
144_A148_L0.8131.00
294_Q301_A0.8131.00
93_A171_Y0.8031.00
66_P207_M0.8031.00
329_I334_Q0.8021.00
237_A241_I0.8001.00
208_I212_V0.8001.00
79_I82_V0.7951.00
310_P314_S0.7951.00
23_M146_Y0.7861.00
157_G161_V0.7851.00
331_I382_A0.7851.00
128_D392_L0.7841.00
211_V401_F0.7831.00
43_D167_K0.7801.00
428_D432_P0.7801.00
68_A84_G0.7761.00
159_W302_S0.7751.00
236_F239_A0.7751.00
267_T386_S0.7741.00
69_G397_S0.7701.00
293_M299_V0.7701.00
251_S260_M0.7681.00
346_F350_T0.7681.00
40_I50_M0.7641.00
306_T310_P0.7641.00
13_T130_F0.7641.00
268_F383_L0.7631.00
126_I138_F0.7601.00
344_G348_L0.7591.00
211_V405_I0.7591.00
85_L181_V0.7571.00
349_L352_L0.7571.00
336_I340_L0.7571.00
94_L110_L0.7561.00
276_F409_F0.7541.00
344_G347_L0.7541.00
339_M375_V0.7531.00
27_A149_A0.7531.00
430_L433_Y0.7501.00
264_K269_T0.7491.00
213_S239_A0.7491.00
158_G305_G0.7471.00
242_G245_S0.7461.00
125_V129_L0.7461.00
307_I310_P0.7451.00
36_A40_I0.7451.00
182_I185_A0.7451.00
234_G237_A0.7441.00
175_P179_I0.7431.00
203_G250_E0.7401.00
216_L235_L0.7381.00
86_I90_A0.7381.00
330_G334_Q0.7361.00
60_T113_I0.7361.00
429_K432_P0.7351.00
228_D231_Q0.7351.00
317_I320_I0.7341.00
202_A205_F0.7281.00
77_R124_I0.7261.00
337_T340_L0.7261.00
147_G315_M0.7251.00
274_I339_M0.7251.00
251_S264_K0.7251.00
291_F295_G0.7241.00
92_S111_Q0.7211.00
374_L378_I0.7181.00
380_T399_S0.7151.00
18_G184_I0.7121.00
107_F110_L0.7091.00
240_L243_I0.7071.00
22_A118_M0.7071.00
63_T204_I0.7071.00
58_L407_G0.7061.00
341_V367_I0.7061.00
95_C98_A0.7021.00
37_M54_T0.7001.00
89_M178_I0.6981.00
19_L129_L0.6971.00
204_I257_I0.6961.00
168_W171_Y0.6911.00
84_G114_G0.6911.00
339_M343_A0.6911.00
199_F203_G0.6891.00
191_R194_T0.6881.00
153_G157_G0.6871.00
124_I393_G0.6831.00
62_T408_T0.6821.00
263_F268_F0.6821.00
95_C111_Q0.6811.00
274_I379_L0.6811.00
175_P178_I0.6811.00
190_G194_T0.6791.00
290_P304_S0.6781.00
340_L343_A0.6781.00
226_A229_S0.6741.00
58_L408_T0.6731.00
140_G144_A0.6711.00
72_A124_I0.6711.00
207_M211_V0.6701.00
123_M142_F0.6701.00
413_M416_A0.6701.00
384_Q396_T0.6681.00
251_S254_K0.6671.00
329_I333_P0.6671.00
44_L101_M0.6641.00
135_R385_E0.6631.00
24_F145_I0.6611.00
62_T405_I0.6611.00
202_A206_T0.6601.00
108_R111_Q0.6591.00
287_T411_I0.6511.00
229_S233_L0.6481.00
139_Q381_L0.6481.00
120_P123_M0.6481.00
179_I183_F0.6471.00
207_M257_I0.6451.00
272_N399_S0.6451.00
176_V179_I0.6451.00
72_A393_G0.6411.00
267_T382_A0.6401.00
220_F232_I0.6401.00
210_G213_S0.6401.00
61_S404_S0.6391.00
154_P305_G0.6391.00
283_F286_I0.6391.00
348_L360_V0.6341.00
78_R190_G0.6321.00
202_A253_A0.6321.00
429_K433_Y0.6311.00
146_Y150_S0.6301.00
314_S370_L0.6281.00
341_V370_L0.6281.00
96_G167_K0.6261.00
292_F296_I0.6261.00
137_K324_Q0.6251.00
307_I362_T0.6241.00
25_F173_N0.6241.00
38_P42_G0.6231.00
124_I396_T0.6231.00
92_S174_L0.6221.00
40_I161_V0.6221.00
226_A232_I0.6211.00
13_T137_K0.6211.00
159_W164_L0.6211.00
267_T270_F0.6191.00
32_I172_I0.6181.00
246_F258_L0.6171.00
326_V381_L0.6171.00
229_S234_G0.6131.00
42_G45_G0.6121.00
352_L364_F0.6111.00
220_F231_Q0.6091.00
161_V165_N0.6091.00
336_I343_A0.6081.00
15_L18_G0.6071.00
369_G373_G0.6041.00
400_Q403_R0.6041.00
148_L152_I0.6041.00
29_D108_R0.6031.00
299_V358_K0.6021.00
210_G244_V0.6021.00
194_T197_I0.6021.00
139_Q143_G0.6011.00
338_G378_I0.6001.00
87_I113_I0.6001.00
77_R191_R0.5991.00
381_L385_E0.5991.00
19_L125_V0.5981.00
22_A85_L0.5961.00
210_G214_L0.5951.00
61_S115_G0.5931.00
68_A120_P0.5931.00
288_F418_M0.5931.00
40_I43_D0.5931.00
85_L177_G0.5921.00
216_L225_Y0.5911.00
97_M103_E0.5911.00
334_Q374_L0.5901.00
197_I255_E0.5891.00
129_L189_Q0.5891.00
342_M345_G0.5871.00
149_A154_P0.5861.00
223_K227_W0.5851.00
65_V400_Q0.5851.00
426_L429_K0.5841.00
149_A153_G0.5831.00
29_D172_I0.5821.00
73_D76_G0.5821.00
230_W233_L0.5811.00
70_K255_E0.5811.00
336_I339_M0.5791.00
275_G379_L0.5791.00
78_R189_Q0.5771.00
191_R196_P0.5771.00
221_G225_Y0.5771.00
416_A420_A0.5751.00
152_I156_I0.5751.00
57_Y88_F0.5741.00
77_R125_V0.5731.00
217_A221_G0.5721.00
133_K136_A0.5721.00
426_L434_L0.5711.00
321_I325_L0.5711.00
171_Y175_P0.5701.00
69_G393_G0.5681.00
137_K141_V0.5661.00
81_Y125_V0.5661.00
302_S306_T0.5661.00
314_S362_T0.5631.00
326_V330_G0.5621.00
171_Y174_L0.5621.00
145_I149_A0.5611.00
57_Y108_R0.5611.00
206_T210_G0.5581.00
221_G232_I0.5581.00
25_F85_L0.5561.00
64_I67_I0.5551.00
130_F134_Q0.5521.00
300_S304_S0.5501.00
364_F367_I0.5501.00
250_E253_A0.5491.00
285_A368_I0.5491.00
428_D434_L0.5471.00
427_T431_V0.5471.00
227_W233_L0.5471.00
152_I155_Q0.5461.00
256_P259_P0.5451.00
88_F114_G0.5451.00
348_L367_I0.5441.00
62_T404_S0.5431.00
309_T313_I0.5431.00
60_T114_G0.5411.00
335_I379_L0.5411.00
13_T138_F0.5411.00
250_E257_I0.5401.00
282_M372_M0.5381.00
384_Q392_L0.5371.00
306_T309_T0.5371.00
50_M291_F0.5371.00
220_F223_K0.5371.00
24_F152_I0.5361.00
173_N177_G0.5351.00
31_T150_S0.5351.00
273_L277_F0.5341.00
74_L198_N0.5341.00
269_T272_N0.5341.00
97_M167_K0.5321.00
16_I126_I0.5311.00
133_K327_Y0.5311.00
411_I415_G0.5301.00
27_A150_S0.5301.00
31_T153_G0.5301.00
24_F28_L0.5301.00
52_W59_L0.5301.00
41_V47_L0.5291.00
279_S403_R0.5281.00
135_R403_R0.5271.00
296_I354_L0.5271.00
75_L199_F0.5271.00
55_T415_G0.5261.00
34_G287_T0.5261.00
314_S317_I0.5261.00
309_T312_M0.5251.00
426_L433_Y0.5241.00
410_G413_M0.5241.00
392_L396_T0.5231.00
80_V121_M0.5231.00
43_D166_W0.5201.00
29_D92_S0.5201.00
366_A370_L0.5181.00
161_V301_A0.5181.00
426_L430_L0.5171.00
132_G136_A0.5161.00
14_L17_T0.5151.00
53_L56_A0.5151.00
127_G384_Q0.5151.00
160_I169_V0.5141.00
375_V379_L0.5131.00
375_V378_I0.5131.00
155_Q306_T0.5121.00
137_K327_Y0.5111.00
143_G319_S0.5111.00
239_A242_G0.5101.00
15_L125_V0.5091.00
25_F29_D0.5091.00
185_A189_Q0.5091.00
290_P308_M0.5081.00
232_I236_F0.5071.00
348_L363_S0.5061.00
206_T246_F0.5051.00
41_V46_G0.5041.00
207_M246_F0.5041.00
338_G345_G0.5031.00
127_G139_Q0.5011.00
50_M53_L0.5011.00
325_L328_K0.5001.00
206_T209_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.7652 100 0.465 Contact Map
4pypA 1 0.7634 100 0.48 Contact Map
3wdoA 1 0.8041 100 0.481 Contact Map
4j05A 3 0.7043 100 0.482 Contact Map
2gfpA 2 0.6913 100 0.501 Contact Map
4gc0A 1 0.8059 100 0.506 Contact Map
4zw9A 1 0.8022 100 0.516 Contact Map
3o7qA 1 0.7061 100 0.517 Contact Map
4tphA 2 0.7782 100 0.518 Contact Map
4ldsA 2 0.756 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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