GREMLIN Database
PROD1 - Proline dehydrogenase 1
UniProt: O32179 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (280)
Sequences: 2805 (1756)
Seq/√Len: 104.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_R149_E5.7191.00
81_Q118_V5.4241.00
169_R209_L4.4971.00
196_K200_D3.9351.00
109_L145_Q3.6541.00
204_Q229_F3.4431.00
73_A114_A3.3221.00
207_I219_V3.3201.00
219_V230_T3.2971.00
157_I164_A3.0971.00
74_E78_K2.7631.00
36_T39_S2.6881.00
77_K118_V2.6791.00
128_I143_Y2.6491.00
118_V121_Q2.6331.00
35_D39_S2.6151.00
117_S121_Q2.6101.00
208_K233_L2.6061.00
116_L126_V2.4571.00
50_S258_K2.4181.00
168_I206_L2.3901.00
70_N111_H2.3101.00
159_A206_L2.2691.00
207_I230_T2.2651.00
148_Q172_R2.2641.00
193_F202_H2.2581.00
99_I115_I2.2521.00
137_E141_S2.2211.00
84_A122_Y2.1331.00
197_R201_L2.1301.00
113_R117_S2.0911.00
81_Q122_Y2.0661.00
204_Q225_D2.0651.00
165_A205_S2.0321.00
127_T156_V2.0251.00
66_E70_N1.9931.00
106_E110_T1.9861.00
70_N74_E1.9571.00
75_E273_Y1.9241.00
244_F265_Y1.9241.00
75_E78_K1.9121.00
234_V244_F1.9061.00
66_E111_H1.8871.00
212_L237_H1.7751.00
77_K114_A1.7551.00
109_L142_I1.7531.00
105_E141_S1.7521.00
80_I124_V1.7421.00
118_V122_Y1.7341.00
208_K212_L1.6631.00
165_A169_R1.6371.00
260_L267_M1.6221.00
208_K229_F1.5801.00
270_Y280_Y1.5711.00
130_M139_T1.5411.00
157_I168_I1.5221.00
195_D198_G1.4871.00
117_S150_F1.4821.00
165_A202_H1.4731.00
109_L146_C1.4461.00
95_K98_S1.4361.00
163_R167_D1.4211.00
66_E107_L1.4151.00
38_E78_K1.4131.00
224_D256_R1.4041.00
143_Y155_T1.4021.00
221_T226_I1.3751.00
246_F265_Y1.3621.00
165_A209_L1.3601.00
52_L258_K1.3571.00
198_G201_L1.3500.99
97_T135_H1.3480.99
194_P198_G1.3370.99
53_C266_R1.3280.99
166_E169_R1.3260.99
204_Q226_I1.3090.99
38_E82_A1.3080.99
34_G39_S1.3000.99
43_T46_R1.2860.99
91_E127_T1.2830.99
115_I126_V1.2690.99
65_S68_E1.2670.99
193_F198_G1.2670.99
74_E77_K1.2650.99
257_Q267_M1.2150.99
221_T227_I1.2080.99
109_L149_E1.2070.99
77_K81_Q1.2010.99
232_Q236_E1.1920.99
25_R29_R1.1850.99
181_V184_A1.1790.99
73_A111_H1.1720.99
202_H206_L1.1690.99
144_R170_K1.1600.98
211_L237_H1.1580.98
91_E125_A1.1560.98
44_V56_I1.1560.98
95_K185_Y1.1390.98
233_L237_H1.1270.98
73_A77_K1.1190.98
258_K262_K1.1010.98
229_F233_L1.0980.98
57_D270_Y1.0900.98
44_V54_A1.0890.98
37_I82_A1.0760.97
93_S270_Y1.0740.97
212_L233_L1.0700.97
231_K246_F1.0580.97
80_I92_L1.0530.97
105_E138_Q1.0460.97
112_L146_C1.0400.97
82_A86_H1.0390.97
233_L236_E1.0340.97
109_L113_R1.0300.97
162_Y194_P1.0250.97
91_E177_N1.0220.97
208_K236_E1.0190.96
256_R259_E1.0140.96
186_K194_P1.0120.96
112_L128_I1.0090.96
132_D135_H1.0090.96
77_K115_I1.0030.96
80_I122_Y1.0000.96
199_T290_A1.0000.96
86_H89_N0.9980.96
218_A247_Q0.9960.96
26_L35_D0.9950.96
46_R49_R0.9850.96
155_T178_L0.9830.96
97_T101_L0.9760.95
48_N54_A0.9690.95
127_T177_N0.9680.95
106_E145_Q0.9670.95
104_S107_L0.9640.95
81_Q121_Q0.9610.95
211_L234_V0.9560.95
57_D129_D0.9530.95
76_C92_L0.9520.95
178_L210_Q0.9510.95
71_Q75_E0.9410.94
291_N294_F0.9390.94
91_E95_K0.9300.94
164_A167_D0.9260.94
209_L213_S0.9220.94
216_Y244_F0.9190.94
81_Q84_A0.9190.94
52_L261_A0.9180.94
31_F184_A0.9070.93
231_K265_Y0.9060.93
180_L206_L0.9050.93
136_Y181_V0.9050.93
259_E263_E0.9040.93
136_Y163_R0.8990.93
45_K86_H0.8990.93
164_A206_L0.8950.93
117_S149_E0.8930.93
113_R150_F0.8900.93
45_K49_R0.8840.92
199_T288_R0.8840.92
78_K81_Q0.8810.92
67_K71_Q0.8800.92
133_Y161_L0.8800.92
180_L210_Q0.8800.92
49_R67_K0.8790.92
207_I233_L0.8750.92
201_L204_Q0.8720.92
23_G26_L0.8710.92
116_L153_L0.8650.92
165_A206_L0.8620.91
143_Y153_L0.8600.91
66_E104_S0.8590.91
186_K192_A0.8580.91
100_G107_L0.8570.91
245_E268_R0.8520.91
240_P243_Q0.8510.91
62_Y132_D0.8500.91
42_K45_K0.8490.91
48_N90_S0.8430.91
127_T218_A0.8420.90
61_E184_A0.8410.90
37_I75_E0.8400.90
73_A115_I0.8380.90
147_K172_R0.8340.90
52_L267_M0.8320.90
231_K263_E0.8300.90
132_D188_S0.8300.90
147_K176_P0.8250.90
160_Y202_H0.8160.89
71_Q74_E0.8140.89
37_I78_K0.8140.89
278_F289_P0.8130.89
113_R146_C0.8090.89
41_V82_A0.8040.88
111_H114_A0.8030.88
124_V153_L0.7990.88
145_Q148_Q0.7970.88
58_Y273_Y0.7950.88
29_R236_E0.7940.88
59_L93_S0.7920.88
57_D95_K0.7900.87
230_T234_V0.7900.87
278_F286_A0.7870.87
61_E95_K0.7870.87
129_D283_R0.7850.87
168_I209_L0.7840.87
83_I92_L0.7830.87
54_A271_V0.7790.87
79_A273_Y0.7770.87
96_L142_I0.7770.87
225_D228_A0.7750.86
66_E101_L0.7740.86
129_D158_Q0.7700.86
138_Q142_I0.7690.86
157_I178_L0.7670.86
210_Q217_T0.7630.86
72_V76_C0.7630.86
30_R252_I0.7620.85
201_L205_S0.7550.85
120_K151_E0.7540.85
280_Y284_R0.7490.85
162_Y193_F0.7450.84
61_E270_Y0.7340.83
225_D229_F0.7300.83
249_L270_Y0.7290.83
283_R287_E0.7290.83
133_Y188_S0.7270.83
101_L138_Q0.7220.82
144_R174_L0.7200.82
44_V48_N0.7180.82
161_L192_A0.7180.82
232_Q235_A0.7140.82
81_Q85_E0.7140.82
290_A294_F0.7080.81
203_F226_I0.7060.81
180_L207_I0.7040.81
177_N218_A0.6940.80
202_H205_S0.6940.80
196_K226_I0.6920.80
74_E114_A0.6920.80
281_F288_R0.6900.79
223_D226_I0.6890.79
143_Y176_P0.6890.79
82_A85_E0.6890.79
36_T275_T0.6880.79
156_V181_V0.6840.79
258_K261_A0.6840.79
170_K215_N0.6830.79
235_A238_Q0.6810.78
140_L167_D0.6810.78
117_S120_K0.6800.78
141_S145_Q0.6780.78
63_A69_A0.6780.78
283_R288_R0.6690.77
52_L269_V0.6670.77
22_Y27_G0.6670.77
146_C153_L0.6660.77
63_A68_E0.6620.76
272_P280_Y0.6590.76
157_I167_D0.6590.76
51_G56_I0.6590.76
70_N110_T0.6580.76
272_P283_R0.6570.76
229_F232_Q0.6560.76
144_R148_Q0.6550.76
106_E109_L0.6550.76
40_A56_I0.6550.76
133_Y191_V0.6540.76
206_L210_Q0.6530.76
95_K129_D0.6520.75
107_L110_T0.6510.75
180_L219_V0.6500.75
179_R182_K0.6500.75
246_F260_L0.6460.75
114_A118_V0.6460.75
23_G27_G0.6450.75
56_I90_S0.6450.75
175_K243_Q0.6430.74
41_V56_I0.6420.74
22_Y26_L0.6410.74
105_E189_A0.6410.74
39_S42_K0.6410.74
81_Q230_T0.6390.74
227_I260_L0.6390.74
228_A231_K0.6380.74
59_L277_W0.6350.73
61_E249_L0.6340.73
187_E286_A0.6290.73
144_R157_I0.6260.72
181_V199_T0.6250.72
227_I246_F0.6250.72
96_L112_L0.6230.72
193_F199_T0.6230.72
195_D201_L0.6210.72
94_L126_V0.6200.72
168_I181_V0.6190.72
211_L230_T0.6190.72
41_V88_L0.6170.71
40_A44_V0.6170.71
260_L265_Y0.6150.71
117_S148_Q0.6150.71
121_Q151_E0.6140.71
261_A267_M0.6110.71
67_K106_E0.6100.70
77_K145_Q0.6080.70
223_D277_W0.6070.70
221_T230_T0.6070.70
95_K247_Q0.6050.70
203_F230_T0.6040.70
48_N51_G0.6020.69
136_Y139_T0.6010.69
84_A118_V0.6010.69
61_E287_E0.6000.69
133_Y163_R0.5980.69
105_E145_Q0.5970.69
214_G243_Q0.5960.69
53_C89_N0.5960.69
31_F281_F0.5930.68
199_T223_D0.5930.68
28_A277_W0.5920.68
105_E142_I0.5910.68
61_E129_D0.5910.68
74_E81_Q0.5900.68
158_Q249_L0.5880.68
53_C86_H0.5880.68
193_F205_S0.5860.67
74_E106_E0.5850.67
135_H139_T0.5850.67
57_D93_S0.5840.67
252_I281_F0.5830.67
52_L254_P0.5830.67
49_R71_Q0.5820.67
71_Q262_K0.5810.67
67_K205_S0.5810.67
187_E192_A0.5780.66
248_M254_P0.5780.66
57_D61_E0.5780.66
252_I288_R0.5770.66
72_V252_I0.5760.66
236_E240_P0.5740.66
119_A126_V0.5730.66
92_L116_L0.5720.66
55_T93_S0.5720.66
127_T279_S0.5710.65
133_Y279_S0.5670.65
154_G179_R0.5660.65
130_M248_M0.5660.65
136_Y199_T0.5650.65
129_D160_Y0.5650.65
181_V276_D0.5640.64
93_S247_Q0.5640.64
58_Y75_E0.5640.64
114_A263_E0.5630.64
156_V161_L0.5630.64
70_N78_K0.5620.64
18_F276_D0.5620.64
234_V239_I0.5600.64
160_Y283_R0.5600.64
224_D228_A0.5570.64
160_Y199_T0.5570.64
166_E178_L0.5570.64
211_L233_L0.5560.63
207_I229_F0.5560.63
250_Y286_A0.5560.63
184_A287_E0.5550.63
284_R287_E0.5540.63
185_Y247_Q0.5520.63
73_A126_V0.5520.63
181_V200_D0.5510.63
97_T146_C0.5510.63
187_E289_P0.5510.63
91_E124_V0.5510.63
98_S101_L0.5480.62
55_T268_R0.5470.62
40_A59_L0.5450.62
95_K156_V0.5440.62
33_A43_T0.5430.62
94_L98_S0.5410.61
184_A249_L0.5400.61
165_A275_T0.5350.60
184_A222_H0.5350.60
286_A289_P0.5350.60
125_A177_N0.5350.60
90_S95_K0.5350.60
239_I242_S0.5330.60
19_A23_G0.5290.60
58_Y281_F0.5290.60
129_D185_Y0.5280.59
46_R50_S0.5270.59
252_I290_A0.5260.59
237_H241_A0.5250.59
94_L261_A0.5240.59
94_L112_L0.5240.59
200_D225_D0.5240.59
34_G51_G0.5230.59
29_R85_E0.5220.59
165_A193_F0.5220.59
21_A25_R0.5200.58
57_D272_P0.5200.58
234_V255_E0.5180.58
231_K244_F0.5160.58
137_E163_R0.5160.58
113_R145_Q0.5140.57
257_Q269_V0.5130.57
78_K82_A0.5130.57
216_Y266_R0.5110.57
272_P279_S0.5110.57
31_F295_V0.5080.57
47_L250_Y0.5080.57
66_E110_T0.5070.56
169_R212_L0.5060.56
223_D252_I0.5030.56
248_M257_Q0.5030.56
124_V127_T0.5030.56
116_L146_C0.5020.56
220_A246_F0.5020.56
200_D252_I0.5020.56
110_T113_R0.5000.55
57_D185_Y0.5000.55
220_A282_M0.5000.55
282_M286_A0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ekgA 2 0.947 100 0.087 Contact Map
4h6qA 1 0.9139 100 0.089 Contact Map
4nm9A 2 0.957 100 0.161 Contact Map
3hazA 3 0.9735 100 0.165 Contact Map
3e2qA 2 0.9603 100 0.168 Contact Map
4o8aA 2 0.9503 100 0.171 Contact Map
3canA 2 0.3808 49.1 0.96 Contact Map
1k77A 1 0.755 37.9 0.962 Contact Map
3cqjA 2 0.7881 27 0.965 Contact Map
1i60A 1 0.7616 26 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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