GREMLIN Database
FADN - Probable 3-hydroxyacyl-CoA dehydrogenase
UniProt: O32178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 789 (771)
Sequences: 763 (496)
Seq/√Len: 17.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_D323_G5.6281.00
416_E427_K5.5231.00
153_K178_E4.9741.00
577_A594_A4.9171.00
493_L510_I4.7781.00
754_E758_E4.4561.00
535_V582_M4.2791.00
523_G685_A4.2661.00
154_A180_D4.2601.00
108_V114_V4.0201.00
11_L91_L3.9841.00
104_I126_R3.9741.00
615_I736_L3.9551.00
482_S496_H3.9321.00
94_D97_K3.8371.00
559_R563_E3.8271.00
490_V685_A3.7561.00
598_Q671_S3.7051.00
671_S680_D3.6501.00
728_H770_E3.5451.00
515_E567_K3.5381.00
296_I300_A3.4431.00
79_S660_E3.1490.99
87_T97_K3.1100.99
596_R684_L3.1000.99
158_G174_I3.0740.99
409_K435_E3.0200.99
52_K57_V3.0130.99
11_L122_V2.9640.99
361_W414_K2.9560.99
126_R155_H2.8860.98
381_D384_A2.8690.98
491_A521_Y2.8410.98
248_S253_T2.8140.98
598_Q680_D2.8080.98
309_G313_Y2.8020.98
516_E520_N2.7810.98
542_I768_S2.7410.98
693_W696_P2.7080.98
289_D293_K2.6980.98
577_A591_C2.6880.98
779_H783_K2.6730.97
310_K313_Y2.6150.97
57_V60_R2.6060.97
728_H731_K2.5810.97
267_R271_D2.5780.97
230_Y355_R2.5170.96
648_M725_I2.4880.96
475_I491_A2.4750.96
69_L72_Q2.4560.96
720_K727_E2.4320.95
97_K100_E2.3620.95
95_A121_L2.3440.94
8_A24_L2.3380.94
129_G155_H2.3320.94
32_L97_K2.3010.94
224_E227_K2.2770.94
376_G385_I2.2590.93
600_A674_Q2.2590.93
701_V705_G2.2490.93
475_I521_Y2.2100.92
77_L86_I2.2000.92
189_A193_N2.1810.92
27_I672_V2.1750.92
474_V477_K2.1750.92
239_T250_T2.1650.92
705_G708_G2.1600.92
476_A512_K2.1460.91
249_A253_T2.1450.91
52_K60_R2.1380.91
91_L95_A2.1360.91
716_A730_F2.0980.90
352_S357_G2.0950.90
480_G505_D2.0680.90
53_D57_V2.0670.90
82_N85_Y2.0470.89
302_Q306_K2.0290.89
103_W133_S2.0260.89
108_V118_I2.0250.89
433_G438_Y2.0150.88
634_D638_A2.0100.88
34_L89_G2.0030.88
198_G391_W1.9970.88
117_K120_A1.9920.88
762_E766_S1.9750.87
720_K730_F1.9730.87
30_P85_Y1.9680.87
54_S58_R1.9670.87
309_G312_I1.9670.87
766_S769_G1.9660.87
13_S107_V1.9350.86
497_S535_V1.9350.86
123_D149_S1.9300.86
361_W365_S1.9300.86
413_E417_Q1.9300.86
234_E355_R1.9240.86
735_K766_S1.9140.86
168_L394_G1.9130.86
489_D689_Y1.9080.85
499_S535_V1.9040.85
192_E676_H1.9030.85
118_I121_L1.9010.85
569_K623_E1.9000.85
424_G428_E1.8960.85
526_I568_I1.8950.85
555_D559_R1.8930.85
634_D637_N1.8780.85
568_I595_A1.8740.84
238_I359_L1.8670.84
52_K58_R1.8610.84
230_Y359_L1.8590.84
41_L60_R1.8580.84
254_L262_F1.8410.83
150_D153_K1.8370.83
91_L122_V1.8320.83
488_D682_K1.8030.82
119_F144_M1.8020.82
643_F646_I1.7910.82
409_K413_E1.7870.81
7_K100_E1.7790.81
501_A535_V1.7780.81
517_T573_K1.7780.81
766_S770_E1.7740.81
487_G682_K1.7620.80
598_Q669_Q1.7550.80
390_K401_E1.7340.79
56_E60_R1.7310.79
41_L52_K1.7020.78
514_L526_I1.7010.78
54_S60_R1.6980.78
731_K770_E1.6940.78
9_A98_L1.6920.78
779_H787_L1.6910.78
365_S420_A1.6860.77
120_A148_R1.6860.77
595_A693_W1.6810.77
310_K314_E1.6780.77
490_V523_G1.6770.77
78_T601_S1.6770.77
142_Q177_K1.6640.76
133_S157_L1.6500.76
332_A352_S1.6450.76
263_A291_L1.6410.75
143_E146_E1.6410.75
37_V58_R1.6260.75
406_I411_S1.6230.75
127_K130_S1.6200.74
256_V394_G1.6180.74
40_D57_V1.6140.74
561_F618_G1.6130.74
38_P41_L1.6120.74
117_K121_L1.6110.74
227_K362_N1.6100.74
433_G437_F1.6010.73
9_A101_A1.5940.73
408_L430_L1.5920.73
569_K622_K1.5850.73
295_W302_Q1.5830.73
126_R130_S1.5670.72
123_D148_R1.5600.71
726_S729_D1.5420.71
656_Q659_R1.5270.70
132_V152_F1.5210.69
369_L422_M1.5110.69
23_H26_N1.5110.69
134_S141_V1.5100.69
434_N439_I1.5050.69
294_G300_A1.5050.69
591_C594_A1.5000.68
522_K690_D1.5000.68
53_D60_R1.4990.68
82_N656_Q1.4930.68
225_M251_F1.4690.67
15_V261_T1.4680.67
652_S658_A1.4560.66
238_I360_L1.4540.66
615_I763_A1.4530.66
95_A118_I1.4450.65
123_D152_F1.4450.65
569_K626_I1.4420.65
527_G678_L1.4310.65
669_Q684_L1.4300.65
542_I617_G1.4280.64
599_A664_L1.4230.64
414_K418_L1.4210.64
59_S62_S1.4130.64
558_I765_L1.4100.63
346_M402_M1.4080.63
500_N528_N1.4070.63
642_T646_I1.3930.62
216_Y366_Q1.3890.62
727_E772_K1.3750.61
518_E572_A1.3730.61
610_S736_L1.3700.61
210_A379_A1.3670.61
69_L73_K1.3540.60
288_N292_E1.3540.60
142_Q176_I1.3530.60
682_K686_A1.3530.60
465_L529_Q1.3500.60
104_I155_H1.3480.60
60_R64_Q1.3470.60
477_K496_H1.3460.60
440_K470_E1.3430.60
599_A655_A1.3410.59
59_S69_L1.3380.59
495_F528_N1.3360.59
97_K127_K1.3320.59
439_I442_N1.3310.59
703_V706_E1.3310.59
256_V298_S1.3290.59
545_E550_N1.3280.59
339_A344_A1.3270.59
706_E744_K1.3270.59
580_F677_L1.3260.59
645_T661_M1.3180.58
243_I360_L1.3170.58
147_G152_F1.3170.58
54_S57_V1.3170.58
104_I125_H1.3070.57
522_K689_Y1.3010.57
565_M590_A1.2990.57
495_F500_N1.2970.57
623_E626_I1.2950.57
248_S393_F1.2940.57
645_T663_I1.2920.56
387_Q390_K1.2910.56
55_S59_S1.2890.56
132_V148_R1.2880.56
126_R129_G1.2810.56
623_E627_N1.2790.56
622_K626_I1.2770.56
148_R152_F1.2760.56
213_I371_S1.2700.55
341_G344_A1.2680.55
78_T672_V1.2660.55
171_L191_G1.2620.55
636_M640_M1.2580.54
116_K147_G1.2560.54
713_L734_K1.2520.54
412_A415_L1.2510.54
372_A423_P1.2420.53
104_I122_V1.2390.53
491_A517_T1.2380.53
71_K74_P1.2330.53
365_S414_K1.2290.53
650_K657_E1.2280.53
96_E99_K1.2260.52
692_G696_P1.2170.52
248_S252_R1.2150.52
15_V23_H1.2120.52
123_D126_R1.2110.52
566_M622_K1.2050.51
8_A29_I1.2040.51
58_R62_S1.2030.51
11_L23_H1.2000.51
144_M261_T1.2000.51
727_E730_F1.1980.51
702_K705_G1.1930.50
279_E282_R1.1880.50
475_I483_L1.1870.50
593_P622_K1.1860.50
532_N535_V1.1830.50
490_V690_D1.1820.50
69_L77_L1.1780.50
103_W159_T1.1780.50
510_I514_L1.1770.49
253_T262_F1.1760.49
480_G503_G1.1710.49
480_G561_F1.1650.49
6_R417_Q1.1650.49
242_L360_L1.1590.48
579_P603_A1.1560.48
493_L524_L1.1500.48
62_S69_L1.1500.48
308_E311_T1.1460.48
245_R253_T1.1450.48
101_A130_S1.1440.47
482_S485_D1.1400.47
365_S418_L1.1400.47
547_Q778_Q1.1400.47
592_L652_S1.1390.47
130_S155_H1.1380.47
291_L301_G1.1370.47
566_M623_E1.1360.47
771_A775_A1.1340.47
591_C605_M1.1330.47
361_W418_L1.1330.47
481_A509_M1.1310.47
218_L254_L1.1310.47
534_C588_T1.1300.47
169_K198_G1.1290.47
184_L201_T1.1280.46
487_G686_A1.1230.46
596_R669_Q1.1230.46
248_S281_F1.1190.46
263_A283_I1.1140.46
210_A367_T1.1120.46
703_V708_G1.1120.46
563_E754_E1.1110.45
720_K725_I1.1110.45
486_L492_L1.1100.45
92_E121_L1.1090.45
427_K431_D1.1080.45
309_G314_E1.1080.45
331_P334_E1.1050.45
157_L187_M1.1030.45
354_D357_G1.1010.45
603_A652_S1.0980.45
499_S534_C1.0960.45
433_G436_T1.0960.45
627_N665_K1.0960.45
11_L125_H1.0950.44
60_R69_L1.0950.44
37_V41_L1.0930.44
53_D93_D1.0910.44
438_Y443_G1.0850.44
262_F393_F1.0800.44
133_S159_T1.0790.44
53_D56_E1.0770.43
751_V755_Y1.0710.43
551_F769_G1.0700.43
38_P60_R1.0680.43
253_T281_F1.0660.43
23_H349_L1.0650.43
286_F290_M1.0620.43
610_S732_I1.0580.42
617_G621_N1.0550.42
489_D685_A1.0540.42
662_N722_S1.0540.42
217_G253_T1.0540.42
315_L320_L1.0520.42
104_I130_S1.0470.42
207_N268_N1.0470.42
628_H632_G1.0450.41
438_Y442_N1.0410.41
501_A506_I1.0390.41
527_G580_F1.0380.41
40_D70_L1.0380.41
503_G561_F1.0380.41
644_E650_K1.0370.41
507_I564_T1.0350.41
243_I346_M1.0300.41
253_T393_F1.0280.40
316_D319_T1.0260.40
168_L256_V1.0250.40
468_L472_K1.0200.40
777_M781_L1.0170.40
365_S411_S1.0140.40
498_K534_C1.0140.40
641_K644_E1.0130.40
758_E762_E1.0120.40
625_Y740_I1.0070.39
397_L405_A1.0070.39
735_K770_E1.0040.39
476_A516_E1.0040.39
289_D292_E1.0030.39
489_D522_K1.0010.39
591_C597_I1.0010.39
54_S59_S0.9990.39
40_D53_D0.9980.39
98_L122_V0.9960.39
615_I739_V0.9920.38
332_A354_D0.9920.38
408_L426_I0.9920.38
410_Q414_K0.9900.38
133_S187_M0.9860.38
29_I85_Y0.9850.38
126_R151_D0.9840.38
59_S64_Q0.9770.38
514_L564_T0.9760.37
56_E64_Q0.9760.37
422_M722_S0.9750.37
287_M614_L0.9740.37
679_Y683_Q0.9710.37
542_I614_L0.9710.37
677_L680_D0.9710.37
109_V114_V0.9660.37
225_M253_T0.9650.37
486_L529_Q0.9620.37
203_K247_K0.9620.37
10_V14_G0.9590.36
37_V92_E0.9570.36
659_R667_T0.9530.36
150_D617_G0.9500.36
642_T740_I0.9490.36
5_I8_A0.9480.36
639_A712_L0.9470.36
242_L333_L0.9460.36
54_S62_S0.9430.36
705_G709_Y0.9420.36
478_N483_L0.9410.35
693_W705_G0.9400.35
353_D358_R0.9400.35
122_V132_V0.9390.35
257_V651_V0.9390.35
709_Y741_A0.9370.35
497_S506_I0.9370.35
330_S354_D0.9370.35
64_Q69_L0.9360.35
475_I478_N0.9340.35
374_L377_E0.9340.35
121_L153_K0.9330.35
758_E761_R0.9320.35
627_N630_R0.9310.35
169_K675_D0.9290.35
77_L83_T0.9270.35
56_E59_S0.9270.35
58_R69_L0.9260.35
53_D59_S0.9260.35
122_V125_H0.9260.35
598_Q684_L0.9250.35
235_V248_S0.9240.35
95_A316_D0.9230.34
702_K750_E0.9220.34
54_S61_L0.9160.34
534_C773_S0.9140.34
477_K482_S0.9130.34
54_S69_L0.9130.34
728_H772_K0.9110.34
53_D58_R0.9090.34
658_A664_L0.9090.34
765_L769_G0.9090.34
538_N541_M0.9060.34
57_V725_I0.9060.34
506_I569_K0.9060.34
383_H456_V0.8990.33
432_K438_Y0.8960.33
131_I554_V0.8940.33
652_S677_L0.8940.33
329_K334_E0.8940.33
429_M433_G0.8930.33
476_A513_G0.8920.33
19_G107_V0.8910.33
670_I680_D0.8900.33
732_I740_I0.8900.33
184_L259_L0.8890.33
63_R88_P0.8870.32
395_W561_F0.8850.32
621_N756_L0.8850.32
290_M295_W0.8850.32
70_L74_P0.8850.32
191_G199_V0.8840.32
33_L107_V0.8830.32
735_K763_A0.8800.32
30_P87_T0.8790.32
54_S64_Q0.8770.32
547_Q774_Q0.8770.32
305_Y541_M0.8760.32
422_M427_K0.8750.32
224_E366_Q0.8740.32
511_H567_K0.8730.32
207_N391_W0.8710.32
91_L118_I0.8710.32
514_L568_I0.8660.31
188_T201_T0.8650.31
104_I149_S0.8640.31
703_V745_V0.8630.31
483_L491_A0.8630.31
116_K278_K0.8620.31
81_K660_E0.8620.31
53_D64_Q0.8610.31
474_V482_S0.8600.31
717_E721_L0.8600.31
505_D508_Q0.8590.31
205_T378_I0.8580.31
222_V254_L0.8550.31
198_G213_I0.8550.31
725_I730_F0.8540.31
645_T648_M0.8530.31
522_K686_A0.8530.31
210_A592_L0.8530.31
59_S63_R0.8510.31
745_V748_G0.8510.31
228_G355_R0.8510.31
566_M569_K0.8500.31
550_N553_E0.8470.30
437_F442_N0.8470.30
117_K422_M0.8460.30
469_K529_Q0.8460.30
41_L53_D0.8450.30
6_R151_D0.8450.30
228_G362_N0.8440.30
447_Y727_E0.8430.30
248_S284_P0.8400.30
252_R301_G0.8380.30
24_L213_I0.8380.30
460_K465_L0.8380.30
438_Y441_E0.8370.30
385_I754_E0.8370.30
375_L422_M0.8360.30
439_I453_Y0.8360.30
630_R699_E0.8350.30
307_K312_I0.8320.30
341_G345_K0.8310.30
485_D682_K0.8310.30
669_Q680_D0.8300.30
241_P261_T0.8300.30
731_K772_K0.8290.29
469_K482_S0.8270.29
570_Y753_E0.8260.29
141_V145_A0.8250.29
122_V390_K0.8230.29
38_P58_R0.8230.29
575_V595_A0.8220.29
728_H773_S0.8220.29
68_K121_L0.8210.29
780_M787_L0.8200.29
491_A516_E0.8190.29
772_K775_A0.8180.29
146_E727_E0.8180.29
529_Q674_Q0.8160.29
71_K653_A0.8150.29
254_L393_F0.8130.29
649_A654_S0.8120.29
665_K668_D0.8100.29
593_P623_E0.8090.28
41_L55_S0.8090.28
158_G239_T0.8090.28
218_L262_F0.8090.28
120_A124_E0.8080.28
350_I406_I0.8080.28
305_Y495_F0.8070.28
81_K84_S0.8060.28
416_E426_I0.8050.28
218_L221_T0.8030.28
758_E769_G0.8030.28
437_F443_G0.8010.28
659_R664_L0.8010.28
702_K706_E0.7990.28
149_S152_F0.7990.28
460_K463_I0.7990.28
459_N676_H0.7970.28
228_G359_L0.7970.28
347_K410_Q0.7950.28
684_L687_S0.7950.28
650_K653_A0.7940.28
504_L508_Q0.7930.28
231_Q354_D0.7930.28
604_Y611_G0.7930.28
532_N582_M0.7910.28
277_E374_L0.7890.27
190_F599_A0.7870.27
739_V759_I0.7870.27
758_E766_S0.7850.27
390_K416_E0.7840.27
731_K735_K0.7830.27
70_L569_K0.7830.27
491_A513_G0.7800.27
464_H529_Q0.7800.27
718_Q722_S0.7790.27
8_A31_V0.7770.27
232_V317_P0.7760.27
123_D132_V0.7760.27
535_V545_E0.7750.27
69_L105_I0.7750.27
112_L143_E0.7740.27
287_M535_V0.7740.27
663_I747_F0.7730.27
394_G506_I0.7720.27
5_I605_M0.7690.26
108_V286_F0.7670.26
431_D436_T0.7670.26
229_G318_V0.7660.26
158_G250_T0.7650.26
104_I696_P0.7640.26
731_K766_S0.7640.26
671_S677_L0.7630.26
63_R70_L0.7630.26
121_L288_N0.7620.26
64_Q68_K0.7620.26
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763_A770_E0.5010.16
215_T254_L0.5010.16
642_T730_F0.5000.16
62_S68_K0.5000.16
263_A292_E0.5000.16
267_R597_I0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkA 2 0.4943 100 0.761 Contact Map
3zwcA 1 0.512 100 0.768 Contact Map
2wtbA 1 0.4778 100 0.769 Contact Map
3k6jA 1 0.4766 100 0.772 Contact Map
1zcjA 1 0.5108 100 0.774 Contact Map
4b3hA 1 0.4905 100 0.793 Contact Map
3mogA 3 0.5234 100 0.795 Contact Map
4j0eA 2 0.3663 100 0.83 Contact Map
1f0yA 2 0.3663 100 0.837 Contact Map
1zejA 2 0.3549 100 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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