GREMLIN Database
FADA - 3-ketoacyl-CoA thiolase
UniProt: O32177 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (374)
Sequences: 11842 (6229)
Seq/√Len: 322.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_D327_R3.4871.00
171_R175_N3.4811.00
3_E260_R3.3571.00
360_L372_G3.3361.00
262_K266_L3.2161.00
37_E40_K3.1721.00
5_V263_A3.0491.00
171_R174_Q2.8411.00
178_K182_E2.8251.00
97_I357_T2.8001.00
170_V224_A2.7811.00
298_A302_A2.7251.00
165_Q239_T2.6951.00
260_R264_D2.6431.00
298_A387_V2.6321.00
156_K235_S2.6151.00
181_A220_P2.5731.00
193_E209_Q2.5711.00
109_Y112_A2.5571.00
9_G358_L2.5181.00
38_T256_M2.3991.00
364_M369_E2.3971.00
262_K265_A2.2751.00
217_G247_Q2.2561.00
311_L338_V2.2401.00
31_G54_I2.2381.00
10_A41_R2.2101.00
276_S298_A2.2021.00
276_S302_A2.1701.00
271_L365_K2.1511.00
104_I257_L2.1211.00
227_L243_G2.0871.00
35_V71_I2.0531.00
180_L218_V2.0491.00
253_A354_T2.0071.00
177_A218_V1.9711.00
273_K389_E1.9701.00
104_I259_D1.9691.00
272_V361_I1.9531.00
186_K213_S1.9451.00
163_E167_A1.9421.00
33_I192_V1.9281.00
304_L371_F1.9111.00
35_V113_I1.8911.00
295_I375_T1.8881.00
195_T209_Q1.8541.00
339_N363_E1.8501.00
310_G369_E1.8441.00
258_M263_A1.8321.00
148_G234_F1.8171.00
100_A112_A1.7961.00
31_G71_I1.7261.00
363_E367_R1.7081.00
7_V258_M1.6761.00
304_L309_I1.6641.00
161_S164_D1.6591.00
180_L189_I1.6451.00
48_N266_L1.6431.00
309_I387_V1.6261.00
111_T258_M1.6171.00
304_L387_V1.6111.00
100_A257_L1.6101.00
177_A181_A1.6081.00
255_V354_T1.6071.00
54_I115_G1.6011.00
186_K214_Q1.5931.00
226_I229_T1.5921.00
45_Y48_N1.5861.00
119_S122_Q1.5791.00
326_I333_E1.5471.00
326_I336_V1.5391.00
312_F373_V1.5391.00
67_M117_A1.5341.00
258_M262_K1.5291.00
171_R333_E1.5271.00
157_K286_V1.5271.00
164_D167_A1.5041.00
37_E41_R1.4981.00
306_L312_F1.4951.00
309_I312_F1.4941.00
196_V210_F1.4941.00
170_V174_Q1.4911.00
294_A385_A1.4881.00
3_E273_K1.4881.00
193_E211_V1.4821.00
84_I99_Y1.4721.00
184_K339_N1.4651.00
38_T42_A1.4611.00
196_V209_Q1.4571.00
21_S212_F1.4481.00
91_S384_A1.4431.00
370_Q389_E1.4411.00
91_S378_I1.4391.00
373_V387_V1.4331.00
33_I190_V1.4311.00
184_K363_E1.4301.00
187_D365_K1.4281.00
180_L214_Q1.4251.00
167_A171_R1.4191.00
311_L363_E1.4131.00
363_E366_R1.4101.00
37_E190_V1.3981.00
8_S42_A1.3931.00
22_L212_F1.3831.00
133_N137_A1.3821.00
97_I255_V1.3781.00
357_T388_F1.3721.00
5_V258_M1.3711.00
110_D259_D1.3691.00
35_V77_L1.3631.00
332_D335_K1.3621.00
296_P328_E1.3591.00
79_Y283_P1.3391.00
8_S38_T1.3371.00
296_P300_K1.3271.00
29_D74_L1.3251.00
98_A386_G1.3191.00
338_V367_R1.2901.00
14_V345_L1.2821.00
4_A257_L1.2781.00
160_V165_Q1.2711.00
311_L367_R1.2691.00
282_V289_I1.2651.00
14_V351_C1.2641.00
36_K40_K1.2551.00
177_A221_Q1.2541.00
259_D262_K1.2511.00
94_L357_T1.2411.00
293_E296_P1.2361.00
54_I254_A1.2361.00
278_A298_A1.2351.00
355_K359_S1.2321.00
110_D262_K1.2201.00
174_Q178_K1.2181.00
309_I371_F1.2171.00
148_G233_A1.2131.00
295_I373_V1.2091.00
309_I373_V1.2061.00
275_R389_E1.2011.00
310_G335_K1.1981.00
160_V323_I1.1971.00
310_G364_M1.1911.00
338_V363_E1.1851.00
103_K109_Y1.1831.00
34_C254_A1.1781.00
360_L374_V1.1721.00
9_G362_H1.1681.00
149_H235_S1.1671.00
133_N136_L1.1661.00
358_L362_H1.1661.00
174_Q221_Q1.1591.00
278_A297_R1.1531.00
280_G293_E1.1461.00
289_I292_V1.1381.00
274_F386_G1.1381.00
32_A74_L1.1371.00
13_P212_F1.1331.00
12_T34_C1.1281.00
34_C37_E1.1241.00
170_V221_Q1.1111.00
184_K366_R1.1101.00
56_C59_P1.1061.00
150_T287_M1.1061.00
188_E359_S1.1041.00
331_I336_V1.0921.00
95_Q99_Y1.0861.00
171_R334_E1.0821.00
126_M134_L1.0811.00
276_S387_V1.0791.00
222_T227_L1.0731.00
261_E265_A1.0731.00
50_D109_Y1.0731.00
167_A224_A1.0721.00
39_L44_G1.0621.00
113_I256_M1.0611.00
297_R300_K1.0611.00
302_A387_V1.0571.00
15_G216_E1.0551.00
286_V289_I1.0461.00
49_I111_T1.0451.00
314_L375_T1.0431.00
275_R371_F1.0431.00
158_Y289_I1.0401.00
39_L77_L1.0381.00
271_L361_I1.0311.00
194_V197_T1.0251.00
100_A114_A1.0211.00
306_L309_I1.0171.00
176_A218_V1.0131.00
356_L374_V1.0101.00
371_F387_V1.0061.00
157_K285_E1.0041.00
14_V249_S1.0011.00
102_E108_A0.9981.00
98_A277_F0.9971.00
289_I324_Q0.9941.00
361_I365_K0.9931.00
5_V273_K0.9921.00
10_A190_V0.9901.00
35_V52_L0.9801.00
12_T33_I0.9781.00
7_V268_L0.9761.00
260_R273_K0.9741.00
342_A352_T0.9721.00
4_A259_D0.9661.00
187_D366_R0.9661.00
5_V260_R0.9651.00
96_S354_T0.9651.00
108_A301_L0.9651.00
253_A351_C0.9601.00
12_T192_V0.9601.00
158_Y286_V0.9591.00
133_N138_E0.9561.00
378_I384_A0.9501.00
258_M268_L0.9441.00
177_A220_P0.9411.00
111_T262_K0.9391.00
168_F322_A0.9381.00
339_N367_R0.9371.00
304_L308_D0.9331.00
166_D244_N0.9321.00
137_A140_A0.9321.00
48_N262_K0.9301.00
371_F389_E0.9271.00
154_V289_I0.9251.00
134_L137_A0.9241.00
125_M130_T0.9211.00
53_I112_A0.9201.00
38_T113_I0.9161.00
6_I388_F0.9121.00
187_D362_H0.9061.00
152_E235_S0.8981.00
133_N140_A0.8941.00
295_I385_A0.8941.00
25_V122_Q0.8911.00
33_I37_E0.8891.00
108_A277_F0.8871.00
326_I331_I0.8851.00
8_S41_R0.8851.00
180_L186_K0.8831.00
136_L141_P0.8821.00
296_P329_L0.8771.00
62_E122_Q0.8761.00
34_C252_A0.8751.00
194_V212_F0.8751.00
53_I96_S0.8671.00
292_V328_E0.8631.00
94_L374_V0.8631.00
282_V290_G0.8601.00
280_G297_R0.8571.00
305_Q308_D0.8541.00
295_I314_L0.8531.00
48_N265_A0.8531.00
319_A343_I0.8521.00
16_K217_G0.8521.00
282_V293_E0.8491.00
276_S301_L0.8491.00
4_A105_M0.8421.00
94_L386_G0.8381.00
357_T386_G0.8311.00
151_A240_V0.8291.00
158_Y328_E0.8291.00
170_V226_I0.8281.00
50_D110_D0.8281.00
164_D323_I0.8281.00
56_C63_Q0.8241.00
260_R263_A0.8231.00
26_R122_Q0.8221.00
135_A138_E0.8211.00
361_I388_F0.8191.00
269_A365_K0.8171.00
10_A37_E0.8171.00
173_H217_G0.8161.00
113_I254_A0.8161.00
73_A79_Y0.8161.00
49_I113_I0.8141.00
120_M349_L0.8141.00
52_L72_G0.8121.00
150_T288_G0.8121.00
19_K121_S0.8091.00
105_M108_A0.8091.00
182_E366_R0.8081.00
339_N366_R0.8071.00
51_D279_V0.8051.00
289_I328_E0.8051.00
53_I100_A0.7991.00
312_F375_T0.7961.00
155_A320_S0.7941.00
170_V223_T0.7931.00
34_C38_T0.7931.00
55_G92_S0.7911.00
173_H218_V0.7901.00
341_G344_A0.7881.00
77_L81_V0.7851.00
224_A228_S0.7761.00
136_L139_K0.7761.00
133_N139_K0.7721.00
311_L360_L0.7711.00
25_V33_I0.7711.00
132_P136_L0.7691.00
26_R29_D0.7671.00
154_V324_Q0.7651.00
48_N111_T0.7620.99
178_K181_A0.7600.99
88_R279_V0.7590.99
88_R95_Q0.7580.99
132_P135_A0.7570.99
54_I71_I0.7560.99
29_D32_A0.7550.99
307_Q335_K0.7550.99
152_E156_K0.7550.99
134_L138_E0.7530.99
46_E78_P0.7510.99
135_A140_A0.7510.99
352_T356_L0.7480.99
176_A345_L0.7470.99
50_D297_R0.7450.99
312_F331_I0.7420.99
175_N333_E0.7420.99
101_A274_F0.7410.99
49_I77_L0.7410.99
310_G371_F0.7410.99
110_D301_L0.7400.99
230_L243_G0.7370.99
146_S149_H0.7360.99
5_V266_L0.7340.99
5_V262_K0.7340.99
13_P33_I0.7330.99
66_N382_M0.7330.99
114_A255_V0.7290.99
298_A309_I0.7290.99
102_E106_L0.7260.99
54_I68_A0.7260.99
10_A38_T0.7250.99
51_D88_R0.7250.99
253_A358_L0.7230.99
261_E264_D0.7230.99
271_L362_H0.7220.99
174_Q177_A0.7200.99
97_I257_L0.7190.99
100_A109_Y0.7170.99
323_I327_R0.7170.99
258_M266_L0.7170.99
299_L306_L0.7170.99
152_E238_G0.7140.99
32_A36_K0.7120.99
321_Q325_V0.7110.99
25_V119_S0.7100.99
72_G83_A0.7080.99
310_G370_Q0.7080.99
298_A373_V0.7060.99
39_L49_I0.7060.99
7_V263_A0.7060.99
135_A139_K0.7020.99
59_P85_T0.6990.99
9_G361_I0.6970.99
53_I84_I0.6970.99
297_R301_L0.6910.99
180_L220_P0.6900.99
176_A344_A0.6840.99
275_R302_A0.6840.99
86_V99_Y0.6830.99
372_G388_F0.6830.99
13_P213_S0.6820.99
39_L43_G0.6820.99
364_M388_F0.6810.99
364_M372_G0.6790.99
6_I257_L0.6790.99
103_K108_A0.6780.99
13_P189_I0.6770.99
47_G80_T0.6760.99
175_N178_K0.6760.99
288_G321_Q0.6750.99
181_A214_Q0.6750.99
10_A34_C0.6740.99
4_A104_I0.6730.99
322_A326_I0.6700.99
84_I95_Q0.6700.99
283_P286_V0.6700.99
167_A333_E0.6700.99
36_K76_G0.6690.99
14_V355_K0.6680.99
168_F341_G0.6660.99
314_L325_V0.6650.99
235_S238_G0.6640.99
36_K75_A0.6600.99
279_V384_A0.6570.98
99_Y102_E0.6560.98
173_H221_Q0.6550.98
77_L113_I0.6530.98
98_A384_A0.6500.98
345_L359_S0.6500.98
23_A121_S0.6490.98
351_C354_T0.6480.98
178_K184_K0.6460.98
132_P137_A0.6460.98
82_P279_V0.6450.98
170_V222_T0.6440.98
222_T243_G0.6420.98
255_V358_L0.6410.98
299_L302_A0.6410.98
8_S271_L0.6400.98
292_V296_P0.6350.98
295_I329_L0.6350.98
52_L113_I0.6340.98
72_G77_L0.6340.98
71_I117_A0.6340.98
152_E240_V0.6330.98
275_R387_V0.6310.98
27_P117_A0.6300.98
352_T374_V0.6290.98
3_E389_E0.6290.98
9_G255_V0.6280.98
173_H177_A0.6270.98
311_L369_E0.6270.98
257_L274_F0.6260.98
75_A78_P0.6250.98
217_G249_S0.6250.98
136_L146_S0.6240.98
223_T226_I0.6240.98
50_D112_A0.6220.98
94_L384_A0.6190.98
274_F388_F0.6180.98
95_Q279_V0.6170.98
274_F277_F0.6150.98
378_I382_M0.6150.98
39_L46_E0.6140.98
307_Q330_G0.6120.98
176_A180_L0.6090.98
125_M129_V0.6070.97
30_L192_V0.6040.97
158_Y324_Q0.6040.97
312_F335_K0.6040.97
53_I99_Y0.6020.97
52_L77_L0.5960.97
173_H223_T0.5960.97
357_T374_V0.5950.97
4_A101_A0.5950.97
295_I306_L0.5940.97
148_G238_G0.5930.97
151_A155_A0.5930.97
62_E126_M0.5920.97
150_T321_Q0.5920.97
95_Q98_A0.5890.97
36_K46_E0.5890.97
56_C67_M0.5880.97
5_V259_D0.5880.97
95_Q103_K0.5880.97
222_T226_I0.5870.97
32_A75_A0.5860.97
170_V227_L0.5860.97
341_G352_T0.5840.97
185_F345_L0.5840.97
31_G115_G0.5830.97
188_E362_H0.5830.97
173_H343_I0.5830.97
275_R304_L0.5830.97
99_Y103_K0.5820.97
10_A42_A0.5810.97
306_L331_I0.5810.97
134_L139_K0.5810.97
314_L322_A0.5800.97
97_I114_A0.5790.97
58_T123_V0.5770.97
188_E355_K0.5760.97
42_A256_M0.5760.97
3_E105_M0.5760.97
53_I86_V0.5740.96
10_A13_P0.5740.96
214_Q218_V0.5720.96
102_E105_M0.5710.96
308_D371_F0.5710.96
263_A266_L0.5680.96
356_L376_M0.5680.96
151_A320_S0.5670.96
31_G117_A0.5670.96
154_V320_S0.5670.96
278_A302_A0.5640.96
358_L361_I0.5630.96
15_G22_L0.5620.96
13_P214_Q0.5620.96
111_T266_L0.5610.96
378_I383_G0.5610.96
324_Q328_E0.5600.96
78_P81_V0.5590.96
282_V288_G0.5590.96
24_T122_Q0.5580.96
168_F323_I0.5570.96
10_A362_H0.5570.96
282_V286_V0.5560.96
94_L376_M0.5560.96
28_D63_Q0.5550.96
145_M285_E0.5550.96
105_M277_F0.5520.96
35_V72_G0.5520.96
295_I298_A0.5510.96
291_P377_C0.5510.96
52_L81_V0.5500.96
183_G186_K0.5500.96
41_R362_H0.5500.96
68_A85_T0.5490.95
175_N336_V0.5490.95
65_L89_Y0.5480.95
33_I36_K0.5480.95
149_H153_Q0.5470.95
92_S350_G0.5450.95
163_E224_A0.5450.95
240_V245_S0.5440.95
35_V39_L0.5430.95
304_L370_Q0.5410.95
173_H247_Q0.5410.95
147_M150_T0.5410.95
134_L140_A0.5410.95
21_S216_E0.5380.95
39_L42_A0.5380.95
150_T153_Q0.5370.95
160_V327_R0.5370.95
59_P63_Q0.5370.95
52_L71_I0.5360.95
365_K368_N0.5340.95
311_L339_N0.5340.95
169_A227_L0.5330.95
156_K237_D0.5320.95
163_E228_S0.5310.95
8_S256_M0.5310.95
368_N371_F0.5300.95
35_V254_A0.5300.95
174_Q224_A0.5290.94
136_L140_A0.5280.94
167_A228_S0.5280.94
272_V388_F0.5270.94
115_G254_A0.5270.94
184_K367_R0.5260.94
300_K305_Q0.5260.94
221_Q226_I0.5250.94
57_A89_Y0.5240.94
141_P144_Y0.5240.94
110_D265_A0.5230.94
12_T30_L0.5220.94
157_K289_I0.5210.94
326_I332_D0.5200.94
314_L326_I0.5190.94
82_P281_G0.5190.94
260_R270_P0.5190.94
234_F238_G0.5180.94
50_D82_P0.5180.94
64_G70_N0.5170.94
259_D263_A0.5140.94
288_G325_V0.5120.94
66_N83_A0.5120.94
71_I75_A0.5110.93
314_L321_Q0.5100.93
148_G235_S0.5080.93
28_D74_L0.5080.93
322_A336_V0.5040.93
139_K349_L0.5040.93
16_K219_R0.5020.93
150_T154_V0.5020.93
295_I325_V0.5010.93
168_F175_N0.5000.93
95_Q102_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wu9A 2 0.9923 100 0.265 Contact Map
3ss6A 4 0.9693 100 0.289 Contact Map
2vu1A 4 0.9693 100 0.29 Contact Map
1ulqA 4 0.9719 100 0.294 Contact Map
3svkA 2 0.8824 100 0.297 Contact Map
4n46A 4 0.9719 100 0.298 Contact Map
2iikA 2 0.9795 100 0.299 Contact Map
4c2jA 4 0.9642 100 0.3 Contact Map
4e1lA 4 0.9642 100 0.304 Contact Map
2ib8A 4 0.9668 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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