GREMLIN Database
YUSI - Uncharacterized protein YusI
UniProt: O32175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (110)
Sequences: 2519 (1822)
Seq/√Len: 173.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E28_I3.1541.00
40_K84_E2.6021.00
47_Y83_L2.5431.00
34_A91_M2.2851.00
5_F18_K2.2341.00
98_T113_F2.2191.00
7_W30_E2.2181.00
100_D103_K2.1471.00
40_K44_K2.0221.00
9_P32_H1.9691.00
44_K83_L1.8101.00
32_H35_E1.7791.00
63_M67_E1.6161.00
64_K89_D1.6101.00
39_S42_E1.5951.00
20_W108_F1.5901.00
78_S81_E1.5021.00
45_A49_K1.4671.00
43_L87_A1.4101.00
4_T29_N1.4101.00
64_K68_L1.4021.00
20_W24_H1.3881.00
99_T104_V1.3811.00
6_Y31_I1.3771.00
5_F14_C1.3631.00
109_K112_Q1.3501.00
62_G91_M1.3471.00
9_P35_E1.3331.00
14_C33_I1.3101.00
18_K22_E1.3081.00
55_K60_T1.3061.00
48_E79_E1.3051.00
63_M66_R1.3011.00
52_L57_F1.2981.00
47_Y57_F1.2911.00
18_K30_E1.2621.00
56_K61_S1.2491.00
31_I37_P1.2281.00
76_H81_E1.2171.00
42_E99_T1.2121.00
58_F86_L1.2071.00
52_L106_V1.1911.00
70_L73_K1.1821.00
7_W18_K1.1571.00
31_I42_E1.1511.00
10_K15_R1.1451.00
111_D114_E1.1441.00
61_S109_K1.1351.00
64_K67_E1.1351.00
56_K106_V1.1251.00
40_K83_L1.1231.00
86_L92_L1.1211.00
42_E45_A1.1201.00
42_E46_L1.0831.00
14_C18_K1.0681.00
49_K104_V1.0681.00
112_Q115_E1.0661.00
9_P18_K1.0621.00
105_T113_F1.0370.99
53_D56_K1.0270.99
79_E83_L1.0230.99
54_L82_Q0.9990.99
20_W114_E0.9960.99
37_P93_I0.9880.99
74_L77_M0.9800.99
40_K80_D0.9790.99
29_N36_Q0.9760.99
47_Y53_D0.9620.99
8_Y14_C0.9500.99
111_D115_E0.9470.99
86_L93_I0.9450.99
44_K48_E0.9370.99
19_K23_E0.9300.99
46_L97_L0.9180.99
47_Y54_L0.9080.99
110_E114_E0.9070.99
97_L106_V0.9060.99
4_T31_I0.9020.98
5_F98_T0.8980.98
65_Y92_L0.8790.98
44_K79_E0.8770.98
98_T105_T0.8760.98
69_N73_K0.8760.98
53_D82_Q0.8710.98
43_L83_L0.8660.98
44_K80_D0.8630.98
73_K81_E0.8620.98
14_C92_L0.8590.98
46_L104_V0.8550.98
3_L26_K0.8490.98
77_M81_E0.8320.97
52_L56_K0.8320.97
24_H114_E0.8310.97
52_L104_V0.8300.97
3_L100_D0.8270.97
74_L82_Q0.8230.97
15_R19_K0.8210.97
47_Y79_E0.8190.97
73_K77_M0.8060.97
70_L74_L0.8020.97
31_I36_Q0.7920.97
17_A21_L0.7900.97
79_E82_Q0.7810.96
57_F106_V0.7800.96
73_K88_S0.7690.96
45_A99_T0.7450.95
84_E88_S0.7400.95
22_E27_E0.7380.95
41_E44_K0.7310.95
70_L75_Y0.7310.95
35_E62_G0.7270.95
31_I38_P0.7270.95
33_I97_L0.7070.94
19_K22_E0.7070.94
105_T112_Q0.7000.93
12_G19_K0.6950.93
68_L85_L0.6920.93
18_K28_I0.6870.93
33_I93_I0.6870.93
34_A64_K0.6860.93
5_F21_L0.6760.92
7_W32_H0.6690.92
8_Y91_M0.6680.92
58_F90_G0.6660.92
9_P14_C0.6620.91
38_P87_A0.6620.91
40_K87_A0.6610.91
62_G67_E0.6580.91
65_Y77_M0.6540.91
49_K102_E0.6500.91
12_G15_R0.6490.90
10_K32_H0.6440.90
99_T102_E0.6410.90
58_F82_Q0.6410.90
77_M82_Q0.6300.89
55_K82_Q0.6240.89
64_K91_M0.6210.88
38_P42_E0.6170.88
15_R18_K0.6150.88
5_F30_E0.6140.88
77_M85_L0.6090.87
82_Q86_L0.6070.87
67_E89_D0.6050.87
49_K103_K0.6040.87
57_F97_L0.5970.86
52_L97_L0.5940.86
6_Y42_E0.5850.85
17_A113_F0.5850.85
105_T109_K0.5820.85
8_Y34_A0.5810.85
6_Y37_P0.5690.84
54_L79_E0.5530.82
43_L93_I0.5520.82
17_A108_F0.5490.82
45_A48_E0.5420.81
33_I38_P0.5360.80
49_K100_D0.5330.80
81_E84_E0.5310.79
46_L99_T0.5310.79
59_N66_R0.5300.79
65_Y76_H0.5120.77
9_P91_M0.5090.76
69_N75_Y0.5070.76
20_W110_E0.5010.75
65_Y74_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fz4A 1 0.9915 100 0.264 Contact Map
3gkxA 2 0.9915 100 0.264 Contact Map
2kokA 1 0.9746 100 0.288 Contact Map
1z3eA 1 0.9831 100 0.296 Contact Map
1s3cA 2 0.9661 100 0.299 Contact Map
2mu0A 1 0.9746 100 0.305 Contact Map
3f0iA 1 0.9746 100 0.306 Contact Map
2m46A 1 0.9831 100 0.309 Contact Map
3rdwA 1 0.9576 100 0.309 Contact Map
1rw1A 1 0.9661 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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