GREMLIN Database
GCSH - Glycine cleavage system H protein
UniProt: O32174 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (121)
Sequences: 3759 (2315)
Seq/√Len: 210.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_T119_Q3.9981.00
93_S96_E3.3981.00
75_T104_E3.2991.00
56_F101_I2.9841.00
24_R102_V2.8141.00
78_E102_V2.6441.00
29_H32_Q2.1631.00
93_S97_K2.0531.00
18_V23_A2.0171.00
23_A105_P2.0111.00
73_N110_E1.9781.00
49_E106_S1.8911.00
115_M123_M1.8891.00
22_K102_V1.8681.00
117_A121_E1.8541.00
49_E75_T1.8011.00
50_I70_A1.7731.00
86_S89_F1.7021.00
17_K24_R1.6971.00
109_S112_E1.6721.00
107_D110_E1.6481.00
7_L17_K1.6391.00
21_E104_E1.5461.00
7_L95_Y1.5441.00
52_A113_K1.5121.00
57_G68_L1.4861.00
72_I105_P1.4851.00
29_H33_S1.4841.00
90_V100_M1.4811.00
6_D17_K1.4791.00
58_S65_V1.4501.00
51_K54_E1.4371.00
45_E48_A1.4021.00
82_D86_S1.3861.00
11_G123_M1.3751.00
22_K104_E1.3601.00
55_P67_E1.3581.00
82_D97_K1.3371.00
51_K73_N1.3031.00
56_F68_L1.2831.00
83_L100_M1.2741.00
89_F98_A1.2711.00
47_G75_T1.2671.00
16_V23_A1.2571.00
32_Q91_N1.2291.00
43_L79_V1.2121.00
58_S62_V1.2001.00
30_F34_E1.1791.00
82_D89_F1.1661.00
50_I56_F1.1241.00
22_K77_V1.1051.00
19_E24_R1.0971.00
18_V105_P1.0911.00
74_G103_V1.0901.00
5_K118_E1.0861.00
52_A110_E1.0861.00
14_E62_V1.0821.00
81_E84_D1.0671.00
86_S92_E1.0631.00
25_I101_I1.0611.00
119_Q122_E1.0391.00
42_E58_S1.0381.00
8_R111_I1.0281.00
77_V104_E1.0101.00
41_V83_L0.9821.00
46_V79_V0.9821.00
39_V62_V0.9781.00
8_R112_E0.9541.00
118_E121_E0.9501.00
43_L100_M0.9400.99
48_A54_E0.9300.99
10_S16_V0.9270.99
78_E81_E0.9140.99
89_F92_E0.9100.99
72_I103_V0.9080.99
16_V72_I0.9030.99
19_E22_K0.9010.99
95_Y117_A0.9000.99
5_K121_E0.8960.99
10_S14_E0.8800.99
18_V111_I0.8770.99
19_E102_V0.8680.99
27_I59_V0.8530.99
89_F97_K0.8470.99
23_A72_I0.8450.99
41_V59_V0.8400.99
68_L101_I0.8340.99
82_D85_D0.8260.99
105_P108_A0.8220.99
4_P117_A0.8210.99
70_A103_V0.8150.98
10_S28_T0.8100.98
15_W26_G0.8040.98
73_N106_S0.8010.98
12_E69_Y0.7930.98
39_V65_V0.7840.98
37_D88_E0.7830.98
9_Y95_Y0.7820.98
58_S67_E0.7800.98
29_H95_Y0.7510.97
83_L89_F0.7430.97
13_H36_G0.7400.97
88_E92_E0.7400.97
107_D111_I0.7360.97
8_R116_T0.7340.97
106_S110_E0.7290.97
35_L66_S0.7290.97
32_Q95_Y0.7160.97
115_M119_Q0.7120.96
12_E64_T0.7060.96
81_E85_D0.7050.96
46_V78_E0.7020.96
38_I59_V0.6990.96
25_I103_V0.6950.96
44_P79_V0.6780.95
4_P9_Y0.6650.95
63_K66_S0.6650.95
23_A111_I0.6640.95
34_E61_S0.6560.94
11_G119_Q0.6360.93
31_A66_S0.6330.93
22_K78_E0.6320.93
50_I73_N0.6290.93
50_I76_V0.6270.93
4_P28_T0.6260.93
108_A111_I0.6260.93
118_E122_E0.6240.93
68_L100_M0.6210.93
9_Y28_T0.6170.92
12_E53_D0.6150.92
93_S98_A0.6130.92
92_E97_K0.6120.92
14_E39_V0.6110.92
14_E69_Y0.6080.92
27_I31_A0.6050.92
60_E63_K0.6040.92
29_H91_N0.6040.92
44_P76_V0.6010.91
38_I91_N0.5980.91
41_V87_P0.5960.91
34_E66_S0.5960.91
47_G77_V0.5940.91
6_D117_A0.5920.91
45_E85_D0.5920.91
44_P61_S0.5910.91
35_L64_T0.5840.90
38_I57_G0.5840.90
8_R18_V0.5830.90
46_V81_E0.5730.89
25_I71_P0.5730.89
39_V60_E0.5700.89
22_K105_P0.5660.89
61_S64_T0.5640.89
11_G113_K0.5580.88
108_A112_E0.5570.88
30_F124_T0.5570.88
14_E31_A0.5510.87
23_A110_E0.5490.87
55_P64_T0.5430.87
35_L120_Y0.5430.87
38_I58_S0.5430.87
28_T94_P0.5410.86
55_P84_D0.5390.86
10_S114_L0.5380.86
48_A51_K0.5360.86
55_P58_S0.5330.86
70_A76_V0.5240.85
14_E25_I0.5230.85
40_F60_E0.5220.84
76_V101_I0.5220.84
57_G101_I0.5160.84
66_S69_Y0.5150.84
38_I56_F0.5130.83
14_E64_T0.5110.83
18_V108_A0.5090.83
40_F66_S0.5070.83
37_D62_V0.5060.83
48_A85_D0.5060.83
8_R37_D0.5050.83
7_L117_A0.5040.82
9_Y117_A0.5040.82
31_A62_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgbA 1 0.9843 100 0.126 Contact Map
3mxuA 3 0.9764 100 0.169 Contact Map
3tzuA 2 0.9528 100 0.203 Contact Map
1hpcA 2 1 100 0.207 Contact Map
3a7lA 1 1 100 0.216 Contact Map
3wdnA 1 0.9685 100 0.24 Contact Map
1onlA 1 0.9921 100 0.25 Contact Map
1zkoA 2 0.9921 100 0.27 Contact Map
5a35A 1 0.8819 100 0.311 Contact Map
1k8mA 1 0.6772 96.6 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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