GREMLIN Database
YUSE - Thioredoxin-like protein YusE
UniProt: O32171 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 106 (97)
Sequences: 9055 (5924)
Seq/√Len: 601.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_V60_A2.9011.00
10_D62_A2.4201.00
38_V89_V2.3371.00
72_L82_R2.2111.00
88_S91_Y2.0881.00
42_M93_Y1.9861.00
6_E58_T1.9821.00
42_M89_V1.9491.00
52_N55_Y1.9241.00
26_C29_C1.8721.00
17_Y47_A1.8521.00
6_E59_F1.8461.00
72_L79_M1.7831.00
63_Y74_F1.7681.00
4_L49_Y1.7411.00
43_L93_Y1.7391.00
79_M82_R1.7321.00
15_D47_A1.6911.00
20_Y50_Q1.6881.00
35_M38_V1.6351.00
36_L48_F1.6221.00
39_V48_F1.5981.00
18_L36_L1.5851.00
93_Y97_K1.5271.00
12_I47_A1.5031.00
35_M89_V1.4891.00
16_V73_L1.4841.00
43_L97_K1.4651.00
17_Y49_Y1.4611.00
91_Y94_E1.4591.00
24_P52_N1.4421.00
5_Q8_E1.4421.00
18_L71_F1.4201.00
6_E56_S1.4051.00
86_F91_Y1.3731.00
83_G87_H1.3711.00
8_E12_I1.3681.00
53_V68_V1.2901.00
12_I17_Y1.2631.00
39_V93_Y1.2321.00
83_G95_L1.2161.00
20_Y33_S1.1721.00
73_L99_K1.1291.00
81_E95_L1.1271.00
19_L74_F1.1271.00
89_V93_Y1.0891.00
51_N59_F1.0881.00
39_V43_L1.0781.00
57_P61_K1.0501.00
78_K81_E1.0461.00
32_A35_M1.0111.00
3_E50_Q0.9961.00
33_S37_T0.9901.00
39_V89_V0.9821.00
71_F92_L0.9741.00
73_L95_L0.9681.00
32_A71_F0.9561.00
46_V96_I0.9501.00
36_L71_F0.9501.00
5_Q56_S0.9461.00
37_T50_Q0.9441.00
32_A92_L0.9371.00
16_V75_K0.9131.00
51_N60_A0.8921.00
22_Y50_Q0.8901.00
87_H91_Y0.8771.00
4_L12_I0.8751.00
39_V92_L0.8741.00
33_S50_Q0.8721.00
90_S94_E0.8481.00
73_L96_I0.8251.00
14_D17_Y0.7981.00
35_M88_S0.7971.00
14_D76_G0.7881.00
21_L63_Y0.7871.00
35_M39_V0.7771.00
18_L48_F0.7701.00
20_Y32_A0.7701.00
94_E97_K0.7661.00
45_D97_K0.7461.00
75_K80_V0.7341.00
20_Y28_T0.7231.00
77_G81_E0.7191.00
24_P54_N0.7161.00
9_L21_L0.7141.00
32_A36_L0.7121.00
41_E44_P0.7111.00
31_L86_F0.7071.00
15_D45_D0.7001.00
40_K48_F0.6991.00
43_L46_V0.6941.00
58_T62_A0.6901.00
75_K78_K0.6871.00
81_E99_K0.6841.00
15_D76_G0.6801.00
87_H95_L0.6801.00
16_V76_G0.6801.00
8_E49_Y0.6791.00
24_P30_Q0.6741.00
59_F62_A0.6741.00
3_E55_Y0.6611.00
95_L99_K0.6611.00
65_I70_C0.6591.00
32_A87_H0.6581.00
18_L73_L0.6341.00
38_V41_E0.6331.00
25_F30_Q0.6271.00
8_E11_H0.6261.00
27_G30_Q0.6231.00
31_L35_M0.6221.00
18_L96_I0.6181.00
28_T67_S0.6121.00
58_T61_K0.6111.00
4_L19_L0.6081.00
42_M97_K0.6081.00
57_P60_A0.6051.00
9_L63_Y0.5991.00
27_G31_L0.5991.00
3_E49_Y0.5961.00
28_T31_L0.5951.00
66_E82_R0.5951.00
56_S59_F0.5951.00
74_F79_M0.5861.00
9_L59_F0.5801.00
22_Y52_N0.5761.00
23_T26_C0.5721.00
83_G86_F0.5711.00
18_L92_L0.5601.00
25_F68_V0.5500.99
60_A63_Y0.5430.99
36_L39_V0.5420.99
23_T34_K0.5410.99
81_E98_Q0.5400.99
96_I99_K0.5300.99
54_N57_P0.5260.99
61_K66_E0.5230.99
59_F63_Y0.5230.99
51_N56_S0.5190.99
83_G91_Y0.5190.99
29_C34_K0.5190.99
9_L19_L0.5140.99
21_L65_I0.5120.99
90_S93_Y0.5110.99
36_L96_I0.5060.99
22_Y68_V0.5050.99
28_T87_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r2jA 2 0.9906 99.8 0.17 Contact Map
3f8uA 2 1 99.8 0.173 Contact Map
2b5eA 1 1 99.8 0.176 Contact Map
3apoA 1 0.9245 99.8 0.184 Contact Map
4ekzA 1 1 99.8 0.202 Contact Map
3us3A 2 0.9906 99.8 0.213 Contact Map
3ed3A 1 1 99.8 0.216 Contact Map
1sjiA 2 0.9906 99.8 0.217 Contact Map
4tveA 1 1 99.7 0.243 Contact Map
4tw5A 3 1 99.7 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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