GREMLIN Database
METN - Methionine import ATP-binding protein MetN
UniProt: O32169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (264)
Sequences: 27565 (18529)
Seq/√Len: 1140.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E210_R4.2501.00
6_D23_N3.8931.00
19_N22_Q3.7911.00
5_Q61_T3.3021.00
9_K50_L3.2431.00
205_R226_L3.2261.00
3_N27_S3.2231.00
4_L7_V3.0291.00
35_G208_C2.8181.00
8_S59_S2.7911.00
83_E160_K2.7821.00
186_I192_L2.6761.00
34_F212_A2.6661.00
29_K32_E2.4141.00
48_I163_L2.3751.00
10_V19_N2.3501.00
224_E227_D2.3451.00
7_V57_P2.2931.00
136_S140_Q2.2471.00
223_G227_D2.2471.00
48_I197_I2.2451.00
3_N63_E2.1851.00
22_Q218_K2.1671.00
96_S139_S2.1271.00
8_S23_N2.0941.00
212_A219_V2.0871.00
113_K116_E2.0701.00
9_K58_T2.0151.00
9_K55_E1.9391.00
184_S206_K1.8991.00
35_G204_I1.8981.00
8_S19_N1.8801.00
210_R222_E1.8601.00
227_D231_N1.8581.00
4_L26_L1.8491.00
49_R54_L1.8351.00
100_R104_M1.8311.00
28_I34_F1.8121.00
97_R105_F1.8031.00
6_D25_S1.7401.00
10_V58_T1.7151.00
5_Q63_E1.7031.00
97_R101_D1.6761.00
100_R134_E1.6691.00
26_L212_A1.6551.00
30_K160_K1.6441.00
198_T204_I1.6221.00
50_L57_P1.6111.00
98_T101_D1.5961.00
99_V141_L1.5961.00
120_R158_N1.5951.00
65_A160_K1.5901.00
120_R123_E1.5831.00
97_R102_N1.5151.00
133_K136_S1.4911.00
8_S22_Q1.4801.00
100_R135_K1.4741.00
124_L156_A1.4341.00
180_L206_K1.4051.00
210_R221_E1.4041.00
223_G228_V1.3751.00
123_E127_L1.3671.00
49_R55_E1.3641.00
278_Q282_T1.3601.00
4_L51_L1.3431.00
122_N134_E1.3381.00
138_P149_V1.3341.00
280_L284_M1.3291.00
52_N163_L1.3241.00
11_Y20_A1.2871.00
158_N192_L1.2821.00
128_V152_A1.2721.00
208_C211_V1.2611.00
227_D230_K1.2591.00
196_L208_C1.2581.00
5_Q25_S1.2501.00
141_L149_V1.2501.00
11_Y46_S1.2451.00
137_Y140_Q1.2431.00
229_F232_P1.2431.00
272_V275_S1.2421.00
116_E120_R1.2311.00
231_N234_E1.2291.00
125_I134_E1.2201.00
116_E119_K1.2171.00
85_S154_A1.2171.00
213_V232_P1.2081.00
104_M121_A1.1921.00
226_L230_K1.1851.00
21_V50_L1.1791.00
53_G56_K1.1741.00
102_N138_P1.1731.00
32_E209_N1.1721.00
237_T241_V1.1521.00
171_L179_I1.1521.00
34_F210_R1.1511.00
126_K131_E1.1501.00
124_L152_A1.1501.00
282_T285_I1.1371.00
10_V17_D1.1361.00
225_V229_F1.1291.00
42_A214_M1.1261.00
102_N153_R1.1181.00
213_V228_V1.1061.00
275_S279_P1.1001.00
268_Q272_V1.0951.00
114_K117_R1.0911.00
276_A279_P1.0871.00
238_K242_Q1.0791.00
255_Q259_D1.0751.00
119_K123_E1.0731.00
183_L194_I1.0701.00
85_S159_P1.0641.00
52_N86_M1.0601.00
278_Q285_I1.0541.00
268_Q271_F1.0491.00
274_E278_Q1.0441.00
113_K117_R1.0441.00
275_S278_Q1.0361.00
271_F275_S1.0351.00
21_V24_V1.0301.00
269_L272_V1.0251.00
264_G267_V1.0191.00
94_L97_R1.0151.00
180_L203_V1.0151.00
117_R121_A1.0151.00
101_D104_M1.0141.00
6_D59_S1.0121.00
87_I154_A1.0111.00
51_L195_V1.0091.00
212_A222_E1.0051.00
122_N130_L0.9921.00
98_T102_N0.9861.00
271_F274_E0.9831.00
118_I122_N0.9831.00
33_I194_I0.9741.00
5_Q27_S0.9691.00
28_I193_T0.9621.00
50_L62_V0.9621.00
277_E280_L0.9551.00
266_M270_T0.9551.00
104_M108_E0.9521.00
277_E285_I0.9491.00
272_V276_A0.9411.00
228_V232_P0.9391.00
106_P153_R0.9381.00
202_H206_K0.9311.00
104_M118_I0.9301.00
225_V228_V0.9281.00
124_L127_L0.9241.00
276_A280_L0.9221.00
278_Q284_M0.9221.00
7_V50_L0.9221.00
281_I285_I0.9211.00
229_F233_K0.9151.00
4_L62_V0.9151.00
265_K268_Q0.9151.00
161_V193_T0.9141.00
265_K270_T0.9101.00
39_Y42_A0.9081.00
267_V270_T0.8921.00
36_I47_L0.8911.00
127_L185_D0.8901.00
34_F222_E0.8891.00
258_L261_T0.8881.00
105_F108_E0.8861.00
284_M288_F0.8841.00
163_L195_V0.8821.00
215_E218_K0.8761.00
24_V47_L0.8721.00
26_L47_L0.8671.00
243_Q246_E0.8651.00
31_G193_T0.8631.00
109_I114_K0.8621.00
54_L88_F0.8601.00
36_I195_V0.8591.00
196_L207_I0.8581.00
122_N126_K0.8551.00
103_I125_I0.8521.00
255_Q258_L0.8451.00
103_I156_A0.8401.00
100_R121_A0.8361.00
34_F195_V0.8351.00
95_W139_S0.8321.00
282_T286_R0.8321.00
9_K46_S0.8301.00
50_L55_E0.8291.00
259_D262_A0.8281.00
87_I164_C0.8271.00
257_L260_D0.8261.00
89_Q143_G0.8241.00
123_E126_K0.8231.00
273_G277_E0.8221.00
284_M287_N0.8211.00
45_S49_R0.8131.00
96_S137_Y0.8091.00
181_D184_S0.8091.00
264_G268_Q0.8031.00
181_D185_D0.8021.00
176_T200_E0.8011.00
285_I288_F0.8001.00
236_M240_F0.7991.00
273_G276_A0.7981.00
23_N59_S0.7941.00
130_L133_K0.7851.00
239_R243_Q0.7811.00
251_K254_L0.7781.00
244_V248_E0.7731.00
104_M117_R0.7721.00
50_L58_T0.7721.00
131_E134_E0.7701.00
241_V245_T0.7691.00
278_Q281_I0.7681.00
93_L102_N0.7641.00
259_D263_S0.7621.00
236_M239_R0.7601.00
226_L229_F0.7581.00
99_V102_N0.7501.00
273_G278_Q0.7491.00
283_E286_R0.7451.00
168_T179_I0.7431.00
114_K118_I0.7431.00
234_E238_K0.7421.00
166_E199_H0.7421.00
277_E282_T0.7401.00
256_H259_D0.7361.00
261_T264_G0.7311.00
100_R103_I0.7291.00
23_N218_K0.7281.00
244_V247_P0.7261.00
230_K233_K0.7241.00
258_L262_A0.7241.00
266_M269_L0.7241.00
240_F243_Q0.7231.00
270_T274_E0.7231.00
250_T253_T0.7191.00
269_L273_G0.7181.00
108_E117_R0.7181.00
129_G178_S0.7161.00
263_S267_V0.7151.00
115_S119_K0.7141.00
215_E220_V0.7101.00
107_L110_A0.7081.00
151_I179_I0.7051.00
29_K210_R0.7051.00
279_P282_T0.7021.00
256_H260_D0.7001.00
274_E277_E0.6971.00
102_N105_F0.6951.00
164_C183_L0.6951.00
211_V225_V0.6931.00
230_K234_E0.6901.00
225_V236_M0.6891.00
85_S89_Q0.6881.00
267_V271_F0.6841.00
64_V82_H0.6831.00
28_I161_V0.6821.00
257_L261_T0.6811.00
265_K269_L0.6801.00
257_L262_A0.6771.00
182_L185_D0.6761.00
262_A275_S0.6721.00
183_L207_I0.6711.00
94_L102_N0.6701.00
254_L258_L0.6701.00
47_L214_M0.6701.00
276_A282_T0.6701.00
280_L283_E0.6701.00
83_E157_N0.6691.00
239_R242_Q0.6671.00
30_K65_A0.6671.00
102_N106_P0.6651.00
176_T203_V0.6631.00
177_D181_D0.6611.00
138_P146_K0.6601.00
251_K255_Q0.6591.00
254_L257_L0.6591.00
22_Q217_G0.6581.00
99_V149_V0.6571.00
272_V278_Q0.6571.00
277_E281_I0.6571.00
24_V219_V0.6541.00
270_T273_G0.6501.00
6_D9_K0.6481.00
268_Q275_S0.6471.00
164_C194_I0.6471.00
10_V22_Q0.6461.00
84_I161_V0.6441.00
240_F244_V0.6441.00
270_T278_Q0.6401.00
246_E249_E0.6391.00
234_E237_T0.6351.00
267_V272_V0.6341.00
252_E255_Q0.6341.00
248_E251_K0.6331.00
95_W146_K0.6301.00
260_D263_S0.6271.00
265_K271_F0.6261.00
65_A83_E0.6251.00
275_S282_T0.6251.00
87_I147_Q0.6251.00
266_M271_F0.6231.00
237_T240_F0.6221.00
119_K122_N0.6211.00
271_F276_A0.6201.00
122_N132_G0.6201.00
264_G269_L0.6191.00
7_V62_V0.6171.00
120_R124_L0.6161.00
219_V222_E0.6111.00
162_L192_L0.6111.00
168_T203_V0.6081.00
265_K273_G0.6081.00
265_K272_V0.6071.00
126_K132_G0.6061.00
238_K241_V0.6051.00
103_I107_L0.6051.00
11_Y55_E0.6051.00
161_V195_V0.6041.00
159_P186_I0.6031.00
279_P283_E0.6001.00
37_I213_V0.5991.00
65_A82_H0.5981.00
250_T254_L0.5971.00
117_R120_R0.5971.00
283_E287_N0.5961.00
103_I106_P0.5921.00
100_R122_N0.5921.00
98_T135_K0.5911.00
253_T256_H0.5901.00
134_E137_Y0.5901.00
253_T257_L0.5901.00
271_F278_Q0.5871.00
51_L163_L0.5851.00
186_I194_I0.5841.00
258_L264_G0.5831.00
57_P62_V0.5821.00
184_S207_I0.5771.00
21_V47_L0.5691.00
264_G271_F0.5691.00
274_E282_T0.5681.00
26_L34_F0.5661.00
91_F146_K0.5641.00
243_Q247_P0.5611.00
242_Q245_T0.5611.00
232_P237_T0.5611.00
112_V117_R0.5591.00
181_D206_K0.5581.00
98_T137_Y0.5571.00
262_A266_M0.5561.00
267_V275_S0.5551.00
277_E284_M0.5551.00
249_E252_E0.5541.00
124_L128_V0.5501.00
205_R224_E0.5481.00
281_I284_M0.5481.00
187_N194_I0.5471.00
268_Q273_G0.5461.00
104_M107_L0.5441.00
53_G64_V0.5411.00
33_I196_L0.5401.00
107_L156_A0.5401.00
218_K222_E0.5361.00
205_R225_V0.5351.00
241_V244_V0.5341.00
271_F281_I0.5331.00
280_L285_I0.5311.00
2_I51_L0.5301.00
203_V207_I0.5291.00
48_I52_N0.5291.00
2_I64_V0.5281.00
4_L47_L0.5281.00
272_V277_E0.5271.00
33_I209_N0.5261.00
107_L111_G0.5251.00
150_G153_R0.5231.00
263_S268_Q0.5231.00
36_I212_A0.5221.00
249_E254_L0.5221.00
8_S21_V0.5201.00
105_F109_I0.5181.00
9_K21_V0.5181.00
204_I208_C0.5181.00
136_S141_L0.5141.00
263_S266_M0.5141.00
273_G282_T0.5111.00
162_L194_I0.5111.00
86_M89_Q0.5111.00
46_S55_E0.5081.00
173_P177_D0.5061.00
2_I161_V0.5061.00
113_K120_R0.5051.00
274_E279_P0.5041.00
106_P109_I0.5041.00
261_T267_V0.5021.00
118_I121_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 1 100 0.178 Contact Map
4yerA 2 0.8299 100 0.204 Contact Map
4ymuJ 2 0.7009 100 0.238 Contact Map
4u00A 1 0.7009 100 0.238 Contact Map
2oljA 2 0.7009 100 0.239 Contact Map
1vplA 2 0.695 100 0.241 Contact Map
4rvcA 4 0.7009 100 0.242 Contact Map
1b0uA 2 0.7185 100 0.242 Contact Map
4huqB 1 0.7977 100 0.244 Contact Map
2it1A 1 0.8065 100 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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