METP - BACSU - GREMLIN Contacts

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METP - Methionine import system permease protein MetP

UniProt:	O32168	Sequences: MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLFLTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALVIGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAIALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNIIDKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	222 (197)
Sequences:	71110 (43587)
Seq/√Len:	3105.4

ECOLI - METI POTH YEHY MALF YDCV MODB PSTC YECS POTC CYST YCJO PSTA CYSW POTI YCJP POTB THIP YEHW YNJC UGPA TAUC YDCU SSUC MALG GLNP PROW UGPE PHNE HISM HISQ GLTJ GLTK ARTQ YHDY ARTM
BACSU - METP GANP TCYB MDXF TCYL YXEN YTEP LPLB AMYD ARAP YQGI ARTQ YURN YQGH OPUCD AMYC OPUBD OPUAB OPUCB YVGM MDXG YTLD SSUC GANQ YCKA OPUBB GLNP ARAQ YESQ YURM YESP YTCP LPLC GLNM TCYM
HALSA - Q9HML6 Q9HP02 Q9HS11 Q9HPK3 Q9HR05 Q9HP01 Q9HMT4 Q9HHQ7 Q9HNI9 Q9HHQ6 Q9HS12 Q9HML7
SULSO - Q97UZ0 Q97YY2 Q97ZC1 Q97UF3 Q97YY3 Q97VC0 Q97UF4 Q97ZT6 Q97ZT7 Q97Z98 Q97UY9 Q97ZC2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_Y	23_Y	3.420	1.00
137_T	141_K	3.350	1.00
129_K	138_I	3.338	1.00
128_A	138_I	2.943	1.00
31_F	102_V	2.732	1.00
134_K	137_T	2.677	1.00
27_I	98_L	2.526	1.00
135_T	138_I	2.476	1.00
136_S	140_F	2.468	1.00
114_E	118_R	2.398	1.00
125_I	143_L	2.219	1.00
116_A	150_A	2.185	1.00
124_V	146_E	2.165	1.00
125_I	138_I	2.136	1.00
15_W	19_Y	2.117	1.00
16_N	19_Y	2.085	1.00
23_Y	94_P	1.990	1.00
210_I	214_L	1.977	1.00
97_A	169_A	1.971	1.00
55_K	58_N	1.958	1.00
180_L	183_V	1.877	1.00
125_I	129_K	1.836	1.00
137_T	140_F	1.835	1.00
16_N	20_E	1.794	1.00
113_V	151_L	1.790	1.00
133_A	137_T	1.781	1.00
39_L	110_A	1.748	1.00
89_G	92_L	1.727	1.00
37_V	147_S	1.676	1.00
37_V	113_V	1.665	1.00
156_T	212_G	1.648	1.00
20_E	23_Y	1.639	1.00
34_V	38_I	1.609	1.00
129_K	135_T	1.600	1.00
23_Y	27_I	1.594	1.00
36_G	109_Y	1.594	1.00
29_L	155_I	1.586	1.00
62_A	114_E	1.571	1.00
43_L	110_A	1.561	1.00
109_Y	158_T	1.555	1.00
128_A	133_A	1.554	1.00
71_I	76_L	1.531	1.00
40_G	113_V	1.504	1.00
180_L	184_E	1.502	1.00
179_N	183_V	1.488	1.00
13_E	16_N	1.473	1.00
39_L	106_A	1.464	1.00
25_T	159_A	1.431	1.00
17_A	180_L	1.409	1.00
181_A	197_A	1.407	1.00
135_T	139_I	1.403	1.00
90_T	93_G	1.394	1.00
134_K	138_I	1.390	1.00
56_A	59_S	1.349	1.00
166_T	170_G	1.336	1.00
109_Y	154_G	1.313	1.00
128_A	142_V	1.312	1.00
33_F	155_I	1.309	1.00
54_N	58_N	1.290	1.00
179_N	182_Y	1.266	1.00
31_F	98_L	1.263	1.00
178_G	181_A	1.255	1.00
190_N	193_V	1.251	1.00
42_L	61_I	1.246	1.00
153_S	157_V	1.241	1.00
117_L	147_S	1.236	1.00
122_K	125_I	1.225	1.00
41_L	117_L	1.222	1.00
85_K	88_V	1.216	1.00
122_K	126_E	1.209	1.00
80_L	100_A	1.199	1.00
56_A	60_V	1.189	1.00
184_E	188_S	1.189	1.00
30_L	34_V	1.182	1.00
206_F	210_I	1.166	1.00
123_G	126_E	1.158	1.00
98_L	102_V	1.154	1.00
101_L	162_L	1.143	1.00
35_I	106_A	1.130	1.00
89_G	93_G	1.127	1.00
187_Q	190_N	1.121	1.00
55_K	59_S	1.109	1.00
148_M	152_I	1.103	1.00
100_A	172_I	1.091	1.00
144_I	151_L	1.079	1.00
60_V	64_V	1.075	1.00
106_A	110_A	1.073	1.00
183_V	187_Q	1.071	1.00
27_I	30_L	1.057	1.00
57_V	60_V	1.052	1.00
29_L	159_A	1.045	1.00
117_L	143_L	1.042	1.00
52_W	125_I	1.038	1.00
27_I	31_F	1.032	1.00
95_N	99_P	1.031	1.00
92_L	95_N	1.023	1.00
60_V	63_A	1.022	1.00
113_V	154_G	1.019	1.00
176_G	179_N	1.011	1.00
176_G	180_L	1.006	1.00
210_I	213_D	0.990	1.00
120_V	146_E	0.987	1.00
65_V	110_A	0.985	1.00
181_A	184_E	0.975	1.00
35_I	102_V	0.974	1.00
95_N	98_L	0.967	1.00
29_L	162_L	0.962	1.00
113_V	147_S	0.962	1.00
32_A	105_S	0.961	1.00
28_S	32_A	0.959	1.00
23_Y	95_N	0.958	1.00
185_G	191_A	0.956	1.00
94_P	98_L	0.955	1.00
38_I	42_L	0.954	1.00
73_F	104_G	0.952	1.00
32_A	158_T	0.952	1.00
32_A	109_Y	0.945	1.00
207_I	211_I	0.945	1.00
41_L	139_I	0.943	1.00
28_S	162_L	0.941	1.00
192_D	195_F	0.940	1.00
54_N	59_S	0.938	1.00
185_G	188_S	0.937	1.00
28_S	101_L	0.937	1.00
133_A	141_K	0.935	1.00
211_I	214_L	0.933	1.00
176_G	181_A	0.927	1.00
40_G	117_L	0.926	1.00
109_Y	113_V	0.919	1.00
193_V	197_A	0.905	1.00
188_S	191_A	0.904	1.00
138_I	141_K	0.899	1.00
58_N	62_A	0.899	1.00
30_L	155_I	0.891	1.00
146_E	149_P	0.890	1.00
139_I	144_I	0.886	1.00
58_N	118_R	0.883	1.00
28_S	102_V	0.872	1.00
150_A	154_G	0.872	1.00
27_I	102_V	0.869	1.00
66_N	111_R	0.866	1.00
204_I	207_I	0.865	1.00
202_L	206_F	0.864	1.00
97_A	101_L	0.860	1.00
40_G	110_A	0.856	1.00
31_F	34_V	0.852	1.00
36_G	110_A	0.850	1.00
176_G	182_Y	0.841	1.00
205_V	209_Q	0.837	1.00
11_L	15_W	0.836	1.00
33_F	113_V	0.826	1.00
19_Y	22_L	0.822	1.00
169_A	176_G	0.820	1.00
26_L	30_L	0.817	1.00
23_Y	26_L	0.816	1.00
105_S	158_T	0.801	1.00
193_V	196_V	0.800	1.00
37_V	151_L	0.797	1.00
12_T	16_N	0.795	1.00
24_M	101_L	0.794	1.00
59_S	62_A	0.794	1.00
139_I	143_L	0.791	1.00
84_T	96_A	0.790	1.00
209_Q	213_D	0.789	1.00
20_E	174_S	0.788	1.00
76_L	104_G	0.787	1.00
15_W	18_T	0.782	1.00
165_S	169_A	0.781	1.00
112_L	154_G	0.781	1.00
194_T	198_T	0.780	1.00
143_L	146_E	0.780	1.00
196_V	200_F	0.779	1.00
140_F	143_L	0.776	1.00
100_A	168_I	0.775	1.00
140_F	144_I	0.773	1.00
192_D	196_V	0.772	1.00
207_I	210_I	0.771	1.00
184_E	190_N	0.771	1.00
133_A	138_I	0.762	1.00
25_T	163_I	0.756	1.00
33_F	151_L	0.756	1.00
178_G	182_Y	0.746	1.00
37_V	139_I	0.741	1.00
22_L	26_L	0.737	1.00
18_T	204_I	0.736	1.00
61_I	65_V	0.733	1.00
185_G	194_T	0.732	1.00
73_F	167_A	0.731	1.00
203_I	207_I	0.729	1.00
54_N	57_V	0.727	1.00
36_G	113_V	0.722	1.00
21_T	163_I	0.722	1.00
35_I	38_I	0.719	1.00
195_F	199_V	0.712	1.00
53_Q	56_A	0.711	1.00
204_I	209_Q	0.709	1.00
180_L	197_A	0.707	1.00
158_T	162_L	0.706	1.00
28_S	98_L	0.699	1.00
59_S	63_A	0.696	1.00
127_A	130_S	0.694	1.00
167_A	170_G	0.689	1.00
111_R	114_E	0.688	1.00
36_G	40_G	0.682	1.00
195_F	198_T	0.675	1.00
124_V	142_V	0.664	1.00
43_L	114_E	0.661	1.00
24_M	94_P	0.658	1.00
120_V	147_S	0.658	1.00
138_I	143_L	0.656	1.00
148_M	151_L	0.655	1.00
20_E	94_P	0.654	1.00
176_G	183_V	0.653	1.00
122_K	129_K	0.653	1.00
17_A	20_E	0.652	1.00
76_L	80_L	0.648	1.00
77_I	169_A	0.644	1.00
200_F	204_I	0.642	1.00
32_A	102_V	0.641	1.00
69_R	107_P	0.639	1.00
116_A	147_S	0.637	1.00
161_A	164_G	0.635	1.00
177_L	184_E	0.632	1.00
34_V	37_V	0.630	1.00
64_V	68_F	0.626	1.00
24_M	97_A	0.625	1.00
194_T	197_A	0.624	1.00
91_I	95_N	0.617	1.00
125_I	135_T	0.616	1.00
105_S	162_L	0.615	1.00
121_D	124_V	0.612	1.00
74_L	171_A	0.611	1.00
52_W	55_K	0.611	1.00
76_L	103_I	0.607	1.00
32_A	36_G	0.603	1.00
66_N	69_R	0.598	1.00
165_S	168_I	0.594	1.00
158_T	161_A	0.594	1.00
20_E	176_G	0.591	1.00
12_T	15_W	0.590	1.00
182_Y	186_Y	0.588	1.00
160_I	164_G	0.584	1.00
177_L	183_V	0.583	1.00
81_L	85_K	0.583	1.00
13_E	180_L	0.582	1.00
113_V	117_L	0.580	1.00
208_I	212_G	0.579	1.00
73_F	165_S	0.578	1.00
166_T	182_Y	0.577	1.00
185_G	189_N	0.574	1.00
211_I	215_I	0.574	1.00
77_I	81_L	0.573	1.00
185_G	190_N	0.573	1.00
134_K	140_F	0.569	1.00
126_E	129_K	0.569	1.00
101_L	169_A	0.569	1.00
25_T	29_L	0.557	1.00
147_S	150_A	0.556	1.00
29_L	109_Y	0.555	1.00
57_V	61_I	0.555	1.00
25_T	166_T	0.553	1.00
18_T	22_L	0.553	1.00
43_L	62_A	0.552	1.00
176_G	184_E	0.551	1.00
53_Q	58_N	0.550	1.00
18_T	177_L	0.548	1.00
151_L	154_G	0.546	1.00
199_V	203_I	0.545	1.00
154_G	158_T	0.541	1.00
82_G	86_F	0.539	1.00
29_L	34_V	0.537	1.00
175_G	179_N	0.535	1.00
151_L	155_I	0.532	1.00
200_F	203_I	0.531	1.00
198_T	201_I	0.530	1.00
177_L	180_L	0.528	1.00
72_P	76_L	0.528	1.00
182_Y	185_G	0.528	1.00
127_A	131_M	0.526	1.00
27_I	94_P	0.525	1.00
16_N	23_Y	0.524	1.00
109_Y	155_I	0.523	1.00
175_G	183_V	0.520	1.00
29_L	33_F	0.516	1.00
105_S	161_A	0.516	1.00
102_V	106_A	0.515	1.00
138_I	142_V	0.515	1.00
119_E	150_A	0.515	1.00
186_Y	191_A	0.515	1.00
104_G	168_I	0.514	1.00
24_M	176_G	0.506	1.00
101_L	165_S	0.505	1.00
62_A	111_R	0.504	1.00
30_L	33_F	0.502	1.00
38_I	41_L	0.502	1.00
178_G	184_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.9414	100	0.261	Contact Map
3d31C	2	0.9234	100	0.264	Contact Map
4tquM	1	0.964	100	0.289	Contact Map
3rlfF	1	0.9144	100	0.292	Contact Map
3tuiA	2	0.973	100	0.322	Contact Map
4ymuD	2	0.955	100	0.344	Contact Map
3rlfG	1	0.964	99.9	0.366	Contact Map
4tquN	1	0.9279	99.9	0.396	Contact Map
3zdqA	2	0.4009	12.3	0.933	Contact Map
4mrsA	2	0.4099	10.6	0.935	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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