GREMLIN Database
METP - Methionine import system permease protein MetP
UniProt: O32168 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (197)
Sequences: 71110 (43587)
Seq/√Len: 3105.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_Y23_Y3.4201.00
137_T141_K3.3501.00
129_K138_I3.3381.00
128_A138_I2.9431.00
31_F102_V2.7321.00
134_K137_T2.6771.00
27_I98_L2.5261.00
135_T138_I2.4761.00
136_S140_F2.4681.00
114_E118_R2.3981.00
125_I143_L2.2191.00
116_A150_A2.1851.00
124_V146_E2.1651.00
125_I138_I2.1361.00
15_W19_Y2.1171.00
16_N19_Y2.0851.00
23_Y94_P1.9901.00
210_I214_L1.9771.00
97_A169_A1.9711.00
55_K58_N1.9581.00
180_L183_V1.8771.00
125_I129_K1.8361.00
137_T140_F1.8351.00
16_N20_E1.7941.00
113_V151_L1.7901.00
133_A137_T1.7811.00
39_L110_A1.7481.00
89_G92_L1.7271.00
37_V147_S1.6761.00
37_V113_V1.6651.00
156_T212_G1.6481.00
20_E23_Y1.6391.00
34_V38_I1.6091.00
129_K135_T1.6001.00
23_Y27_I1.5941.00
36_G109_Y1.5941.00
29_L155_I1.5861.00
62_A114_E1.5711.00
43_L110_A1.5611.00
109_Y158_T1.5551.00
128_A133_A1.5541.00
71_I76_L1.5311.00
40_G113_V1.5041.00
180_L184_E1.5021.00
179_N183_V1.4881.00
13_E16_N1.4731.00
39_L106_A1.4641.00
25_T159_A1.4311.00
17_A180_L1.4091.00
181_A197_A1.4071.00
135_T139_I1.4031.00
90_T93_G1.3941.00
134_K138_I1.3901.00
56_A59_S1.3491.00
166_T170_G1.3361.00
109_Y154_G1.3131.00
128_A142_V1.3121.00
33_F155_I1.3091.00
54_N58_N1.2901.00
179_N182_Y1.2661.00
31_F98_L1.2631.00
178_G181_A1.2551.00
190_N193_V1.2511.00
42_L61_I1.2461.00
153_S157_V1.2411.00
117_L147_S1.2361.00
122_K125_I1.2251.00
41_L117_L1.2221.00
85_K88_V1.2161.00
122_K126_E1.2091.00
80_L100_A1.1991.00
56_A60_V1.1891.00
184_E188_S1.1891.00
30_L34_V1.1821.00
206_F210_I1.1661.00
123_G126_E1.1581.00
98_L102_V1.1541.00
101_L162_L1.1431.00
35_I106_A1.1301.00
89_G93_G1.1271.00
187_Q190_N1.1211.00
55_K59_S1.1091.00
148_M152_I1.1031.00
100_A172_I1.0911.00
144_I151_L1.0791.00
60_V64_V1.0751.00
106_A110_A1.0731.00
183_V187_Q1.0711.00
27_I30_L1.0571.00
57_V60_V1.0521.00
29_L159_A1.0451.00
117_L143_L1.0421.00
52_W125_I1.0381.00
27_I31_F1.0321.00
95_N99_P1.0311.00
92_L95_N1.0231.00
60_V63_A1.0221.00
113_V154_G1.0191.00
176_G179_N1.0111.00
176_G180_L1.0061.00
210_I213_D0.9901.00
120_V146_E0.9871.00
65_V110_A0.9851.00
181_A184_E0.9751.00
35_I102_V0.9741.00
95_N98_L0.9671.00
29_L162_L0.9621.00
113_V147_S0.9621.00
32_A105_S0.9611.00
28_S32_A0.9591.00
23_Y95_N0.9581.00
185_G191_A0.9561.00
94_P98_L0.9551.00
38_I42_L0.9541.00
73_F104_G0.9521.00
32_A158_T0.9521.00
32_A109_Y0.9451.00
207_I211_I0.9451.00
41_L139_I0.9431.00
28_S162_L0.9411.00
192_D195_F0.9401.00
54_N59_S0.9381.00
185_G188_S0.9371.00
28_S101_L0.9371.00
133_A141_K0.9351.00
211_I214_L0.9331.00
176_G181_A0.9271.00
40_G117_L0.9261.00
109_Y113_V0.9191.00
193_V197_A0.9051.00
188_S191_A0.9041.00
138_I141_K0.8991.00
58_N62_A0.8991.00
30_L155_I0.8911.00
146_E149_P0.8901.00
139_I144_I0.8861.00
58_N118_R0.8831.00
28_S102_V0.8721.00
150_A154_G0.8721.00
27_I102_V0.8691.00
66_N111_R0.8661.00
204_I207_I0.8651.00
202_L206_F0.8641.00
97_A101_L0.8601.00
40_G110_A0.8561.00
31_F34_V0.8521.00
36_G110_A0.8501.00
176_G182_Y0.8411.00
205_V209_Q0.8371.00
11_L15_W0.8361.00
33_F113_V0.8261.00
19_Y22_L0.8221.00
169_A176_G0.8201.00
26_L30_L0.8171.00
23_Y26_L0.8161.00
105_S158_T0.8011.00
193_V196_V0.8001.00
37_V151_L0.7971.00
12_T16_N0.7951.00
24_M101_L0.7941.00
59_S62_A0.7941.00
139_I143_L0.7911.00
84_T96_A0.7901.00
209_Q213_D0.7891.00
20_E174_S0.7881.00
76_L104_G0.7871.00
15_W18_T0.7821.00
165_S169_A0.7811.00
112_L154_G0.7811.00
194_T198_T0.7801.00
143_L146_E0.7801.00
196_V200_F0.7791.00
140_F143_L0.7761.00
100_A168_I0.7751.00
140_F144_I0.7731.00
192_D196_V0.7721.00
207_I210_I0.7711.00
184_E190_N0.7711.00
133_A138_I0.7621.00
25_T163_I0.7561.00
33_F151_L0.7561.00
178_G182_Y0.7461.00
37_V139_I0.7411.00
22_L26_L0.7371.00
18_T204_I0.7361.00
61_I65_V0.7331.00
185_G194_T0.7321.00
73_F167_A0.7311.00
203_I207_I0.7291.00
54_N57_V0.7271.00
36_G113_V0.7221.00
21_T163_I0.7221.00
35_I38_I0.7191.00
195_F199_V0.7121.00
53_Q56_A0.7111.00
204_I209_Q0.7091.00
180_L197_A0.7071.00
158_T162_L0.7061.00
28_S98_L0.6991.00
59_S63_A0.6961.00
127_A130_S0.6941.00
167_A170_G0.6891.00
111_R114_E0.6881.00
36_G40_G0.6821.00
195_F198_T0.6751.00
124_V142_V0.6641.00
43_L114_E0.6611.00
24_M94_P0.6581.00
120_V147_S0.6581.00
138_I143_L0.6561.00
148_M151_L0.6551.00
20_E94_P0.6541.00
176_G183_V0.6531.00
122_K129_K0.6531.00
17_A20_E0.6521.00
76_L80_L0.6481.00
77_I169_A0.6441.00
200_F204_I0.6421.00
32_A102_V0.6411.00
69_R107_P0.6391.00
116_A147_S0.6371.00
161_A164_G0.6351.00
177_L184_E0.6321.00
34_V37_V0.6301.00
64_V68_F0.6261.00
24_M97_A0.6251.00
194_T197_A0.6241.00
91_I95_N0.6171.00
125_I135_T0.6161.00
105_S162_L0.6151.00
121_D124_V0.6121.00
74_L171_A0.6111.00
52_W55_K0.6111.00
76_L103_I0.6071.00
32_A36_G0.6031.00
66_N69_R0.5981.00
165_S168_I0.5941.00
158_T161_A0.5941.00
20_E176_G0.5911.00
12_T15_W0.5901.00
182_Y186_Y0.5881.00
160_I164_G0.5841.00
177_L183_V0.5831.00
81_L85_K0.5831.00
13_E180_L0.5821.00
113_V117_L0.5801.00
208_I212_G0.5791.00
73_F165_S0.5781.00
166_T182_Y0.5771.00
185_G189_N0.5741.00
211_I215_I0.5741.00
77_I81_L0.5731.00
185_G190_N0.5731.00
134_K140_F0.5691.00
126_E129_K0.5691.00
101_L169_A0.5691.00
25_T29_L0.5571.00
147_S150_A0.5561.00
29_L109_Y0.5551.00
57_V61_I0.5551.00
25_T166_T0.5531.00
18_T22_L0.5531.00
43_L62_A0.5521.00
176_G184_E0.5511.00
53_Q58_N0.5501.00
18_T177_L0.5481.00
151_L154_G0.5461.00
199_V203_I0.5451.00
154_G158_T0.5411.00
82_G86_F0.5391.00
29_L34_V0.5371.00
175_G179_N0.5351.00
151_L155_I0.5321.00
200_F203_I0.5311.00
198_T201_I0.5301.00
177_L180_L0.5281.00
72_P76_L0.5281.00
182_Y185_G0.5281.00
127_A131_M0.5261.00
27_I94_P0.5251.00
16_N23_Y0.5241.00
109_Y155_I0.5231.00
175_G183_V0.5201.00
29_L33_F0.5161.00
105_S161_A0.5161.00
102_V106_A0.5151.00
138_I142_V0.5151.00
119_E150_A0.5151.00
186_Y191_A0.5151.00
104_G168_I0.5141.00
24_M176_G0.5061.00
101_L165_S0.5051.00
62_A111_R0.5041.00
30_L33_F0.5021.00
38_I41_L0.5021.00
178_G184_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9414 100 0.261 Contact Map
3d31C 2 0.9234 100 0.264 Contact Map
4tquM 1 0.964 100 0.289 Contact Map
3rlfF 1 0.9144 100 0.292 Contact Map
3tuiA 2 0.973 100 0.322 Contact Map
4ymuD 2 0.955 100 0.344 Contact Map
3rlfG 1 0.964 99.9 0.366 Contact Map
4tquN 1 0.9279 99.9 0.396 Contact Map
3zdqA 2 0.4009 12.3 0.933 Contact Map
4mrsA 2 0.4099 10.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.