GREMLIN Database
METQ - Methionine-binding lipoprotein MetQ
UniProt: O32167 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (258)
Sequences: 3629 (2508)
Seq/√Len: 156.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_T173_K3.5951.00
255_K259_D3.3511.00
34_V63_K3.1811.00
132_T181_K3.1661.00
102_K237_K3.0951.00
134_I197_G3.0271.00
236_R239_E3.0041.00
131_A198_D2.9431.00
36_A80_V2.9241.00
259_D263_K2.8831.00
88_I92_E2.8391.00
52_L256_K2.8021.00
32_E59_T2.5461.00
93_Q97_E2.5321.00
129_D177_N2.5201.00
119_K193_E2.4971.00
132_T179_E2.4301.00
106_A245_I2.3381.00
121_Y128_P2.3271.00
107_G249_M2.3271.00
54_K59_T2.1601.00
239_E242_S2.1551.00
32_E61_K2.1451.00
122_K126_D2.1121.00
104_V237_K2.0881.00
48_E257_I2.0881.00
135_L142_Q2.0651.00
128_P131_A2.0601.00
94_E101_Y2.0381.00
34_V61_K2.0311.00
136_T145_M2.0301.00
133_I199_A2.0171.00
76_A102_K1.9991.00
168_L182_K1.9961.00
147_A150_E1.9831.00
56_K247_A1.9801.00
95_M101_Y1.9291.00
259_D262_E1.8251.00
133_I178_L1.8011.00
116_I199_A1.7891.00
103_L234_A1.7761.00
82_A235_V1.7521.00
47_K50_E1.7521.00
152_A220_E1.7031.00
212_L217_D1.6791.00
154_L178_L1.6661.00
127_L199_A1.6651.00
151_N223_S1.6071.00
243_A247_A1.6031.00
78_K236_R1.5921.00
73_K77_D1.5901.00
121_Y198_D1.5711.00
255_K258_K1.5581.00
237_K240_E1.5311.00
213_N217_D1.5281.00
88_I105_N1.5271.00
108_A230_A1.5241.00
58_Y247_A1.5121.00
82_A248_L1.4961.00
115_G221_V1.4171.00
135_L180_F1.4131.00
44_E264_K1.4071.00
246_K250_E1.4061.00
156_T172_K1.4051.00
115_G218_A1.4041.00
48_E51_P1.4021.00
158_D172_K1.3811.00
171_I180_F1.3631.00
69_K90_Y1.3581.00
249_M253_H1.3471.00
158_D170_D1.3421.00
127_L131_A1.3311.00
31_K244_K1.3301.00
48_E52_L1.3281.00
73_K94_E1.3241.00
104_V240_E1.3101.00
52_L257_I1.3041.00
52_L55_E1.3011.00
52_L251_V1.2961.00
129_D176_K1.2951.00
76_A101_Y1.2861.00
161_V166_A1.2861.00
56_K250_E1.2861.00
233_I249_M1.2721.00
242_S245_I1.2701.00
134_I191_A1.2641.00
260_F264_K1.2571.00
88_I232_I1.2381.00
241_D246_K1.2301.00
43_A64_V1.2271.00
123_S126_D1.2151.00
73_K98_N1.2031.00
124_L220_E1.2001.00
138_N141_E1.1951.00
47_K62_V1.1901.00
75_L80_V1.1711.00
33_I244_K1.1551.00
44_E265_Y1.1501.00
48_E260_F1.1461.00
106_A249_M1.1451.00
193_E196_E1.1351.00
197_G200_V1.1351.00
157_L172_K1.1251.00
105_N232_I1.1231.00
36_A75_L1.1221.00
33_I58_Y1.1121.00
58_Y244_K1.1020.99
95_M237_K1.0990.99
20_C23_N1.0950.99
37_A46_L1.0950.99
120_T198_D1.0850.99
121_Y131_A1.0820.99
124_L127_L1.0780.99
235_V239_E1.0770.99
116_I201_F1.0690.99
92_E96_K1.0690.99
150_E156_T1.0580.99
78_K238_G1.0570.99
95_M102_K1.0540.99
42_H110_H1.0530.99
88_I108_A1.0460.99
188_T200_V1.0440.99
70_M73_K1.0330.99
143_G166_A1.0270.99
183_V191_A1.0200.99
84_Y109_V1.0160.99
72_N86_Q1.0030.99
235_V238_G0.9900.99
82_A245_I0.9890.99
223_S226_N0.9880.99
95_M103_L0.9850.99
13_F16_V0.9840.99
36_A65_L0.9810.99
75_L236_R0.9700.99
50_E54_K0.9650.99
35_V46_L0.9630.99
37_A43_A0.9610.99
12_V15_G0.9540.99
93_Q96_K0.9520.98
106_A235_V0.9480.98
48_E256_K0.9430.98
91_L95_M0.9430.98
247_A250_E0.9380.98
95_M104_V0.9350.98
68_Y185_P0.9300.98
91_L232_I0.9250.98
150_E154_L0.9250.98
158_D161_V0.9250.98
16_V19_A0.9240.98
44_E47_K0.9230.98
34_V81_D0.9190.98
83_N86_Q0.9150.98
53_L58_Y0.9080.98
65_L74_A0.9070.98
174_N178_L0.9050.98
114_F201_F0.9040.98
199_A219_I0.9020.98
142_Q168_L0.9010.98
49_A52_L0.8960.98
183_V188_T0.8910.98
51_P55_E0.8860.98
107_G233_I0.8830.98
51_P54_K0.8750.97
91_L234_A0.8700.97
116_I124_L0.8680.97
93_Q140_A0.8660.97
67_D70_M0.8650.97
73_K76_A0.8620.97
105_N108_A0.8620.97
84_Y252_L0.8610.97
30_K59_T0.8580.97
107_G253_H0.8560.97
94_E98_N0.8550.97
121_Y199_A0.8540.97
112_E205_N0.8530.97
238_G242_S0.8450.97
33_I248_L0.8350.97
247_A251_V0.8340.97
213_N266_D0.8280.96
84_Y110_H0.8260.96
98_N101_Y0.8190.96
214_P218_A0.8180.96
189_A210_N0.8130.96
42_H112_E0.8100.96
52_L254_S0.8060.96
53_L251_V0.8020.96
118_S121_Y0.7960.95
258_K262_E0.7960.95
48_E251_V0.7920.95
207_A212_L0.7880.95
11_L14_A0.7870.95
109_V252_L0.7840.95
72_N85_F0.7810.95
168_L180_F0.7770.95
127_L154_L0.7760.95
20_C24_N0.7710.95
65_L80_V0.7700.95
17_M20_C0.7690.95
214_P221_V0.7690.95
31_K58_Y0.7690.95
14_A18_A0.7660.94
12_V16_V0.7630.94
34_V75_L0.7630.94
50_E59_T0.7610.94
46_L84_Y0.7610.94
192_Y200_V0.7600.94
224_T227_N0.7590.94
187_L191_A0.7570.94
213_N218_A0.7570.94
72_N83_N0.7510.94
94_E103_L0.7490.94
134_I188_T0.7460.94
203_N231_N0.7440.94
11_L15_G0.7440.94
49_A251_V0.7420.93
262_E271_P0.7410.93
109_V253_H0.7410.93
190_K193_E0.7370.93
218_A221_V0.7360.93
105_N249_M0.7300.93
142_Q182_K0.7280.93
162_E166_A0.7270.93
167_T170_D0.7260.93
191_A196_E0.7260.93
214_P217_D0.7240.93
87_H140_A0.7240.93
185_P203_N0.7230.93
159_S162_E0.7230.93
138_N185_P0.7200.92
30_K244_K0.7130.92
75_L239_E0.7120.92
143_G147_A0.7100.92
42_H84_Y0.7090.92
130_G177_N0.7050.92
46_L60_L0.7030.91
145_M201_F0.7030.91
56_K251_V0.7020.91
68_Y71_Y0.6930.91
109_V249_M0.6920.91
105_N234_A0.6910.91
112_E269_V0.6890.91
174_N177_N0.6890.91
73_K101_Y0.6870.91
85_F90_Y0.6860.90
187_L190_K0.6830.90
148_M152_A0.6830.90
127_L198_D0.6830.90
151_N226_N0.6800.90
84_Y112_E0.6790.90
168_L172_K0.6760.90
68_Y75_L0.6700.89
43_A47_K0.6690.89
223_S227_N0.6640.89
205_N209_Q0.6630.89
63_K75_L0.6610.89
215_K218_A0.6590.89
233_I252_L0.6580.89
204_V268_A0.6580.89
172_K175_P0.6580.89
255_K262_E0.6540.88
53_L60_L0.6520.88
11_L16_V0.6440.87
147_A151_N0.6430.87
68_Y203_N0.6430.87
134_I183_V0.6420.87
155_I180_F0.6420.87
122_K217_D0.6410.87
50_E62_V0.6410.87
192_Y197_G0.6400.87
186_E206_Y0.6380.87
106_A234_A0.6370.87
52_L56_K0.6360.87
40_T44_E0.6340.87
39_K64_V0.6340.87
127_L133_I0.6330.87
154_L199_A0.6320.87
10_L14_A0.6280.86
235_V242_S0.6240.86
162_E165_D0.6230.86
116_I220_E0.6230.86
121_Y127_L0.6220.86
89_P228_P0.6210.86
27_E30_K0.6200.85
28_S31_K0.6180.85
68_Y231_N0.6180.85
118_S126_D0.6150.85
192_Y212_L0.6150.85
6_L16_V0.6130.85
87_H138_N0.6090.84
146_L155_I0.6090.84
147_A166_A0.6060.84
40_T265_Y0.6060.84
260_F263_K0.6050.84
104_V235_V0.6040.84
150_E162_E0.6020.84
42_H46_L0.6020.84
46_L252_L0.6010.84
87_H91_L0.5970.83
263_K266_D0.5950.83
242_S246_K0.5870.82
36_A74_A0.5850.82
136_T185_P0.5840.82
71_Y75_L0.5810.82
141_E145_M0.5750.81
258_K271_P0.5720.81
90_Y94_E0.5710.80
168_L179_E0.5700.80
76_A94_E0.5660.80
91_L103_L0.5650.80
125_K152_A0.5640.80
181_K197_G0.5640.80
137_N184_A0.5630.80
87_H141_E0.5590.79
192_Y202_I0.5580.79
109_V112_E0.5570.79
250_E253_H0.5540.78
260_F265_Y0.5530.78
184_A189_A0.5520.78
116_I127_L0.5520.78
68_Y138_N0.5510.78
18_A21_G0.5510.78
185_P189_A0.5490.78
136_T201_F0.5480.78
239_E245_I0.5480.78
23_N29_G0.5480.78
146_L157_L0.5470.78
147_A164_V0.5450.77
47_K64_V0.5450.77
35_V61_K0.5450.77
150_E159_S0.5420.77
149_L201_F0.5410.77
92_E95_M0.5410.77
142_Q185_P0.5400.77
114_F204_V0.5390.77
235_V240_E0.5380.76
136_T141_E0.5380.76
178_L199_A0.5380.76
96_K165_D0.5350.76
150_E160_K0.5340.76
121_Y124_L0.5340.76
87_H232_I0.5340.76
138_N145_M0.5330.76
112_E204_V0.5320.76
124_L219_I0.5300.75
83_N90_Y0.5270.75
113_P203_N0.5260.75
131_A174_N0.5260.75
89_P227_N0.5250.75
94_E100_D0.5250.75
97_E165_D0.5250.75
46_L62_V0.5230.74
189_A206_Y0.5230.74
153_G156_T0.5230.74
90_Y209_Q0.5230.74
31_K59_T0.5210.74
205_N208_I0.5210.74
112_E231_N0.5200.74
7_G14_A0.5170.74
69_K98_N0.5170.74
50_E61_K0.5160.73
19_A22_S0.5160.73
130_G179_E0.5150.73
67_D71_Y0.5150.73
60_L248_L0.5150.73
69_K73_K0.5140.73
33_I60_L0.5140.73
13_F17_M0.5130.73
150_E172_K0.5120.73
114_F203_N0.5120.73
45_I260_F0.5110.73
33_I245_I0.5110.73
6_L9_L0.5100.73
111_L227_N0.5090.72
106_A240_E0.5090.72
84_Y233_I0.5070.72
49_A257_I0.5070.72
174_N180_F0.5060.72
140_A145_M0.5050.72
122_K125_K0.5040.72
122_K156_T0.5040.72
31_K247_A0.5030.72
220_E223_S0.5030.72
7_G10_L0.5030.72
121_Y178_L0.5020.71
161_V170_D0.5010.71
113_P228_P0.5010.71
189_A202_I0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qhqA 1 0.865 100 0.404 Contact Map
3ir1A 3 0.8686 100 0.466 Contact Map
4ntlA 1 0.8759 100 0.478 Contact Map
4oteA 4 0.8759 100 0.487 Contact Map
3up9A 1 0.8613 100 0.488 Contact Map
1xs5A 1 0.8723 100 0.507 Contact Map
4k3fA 1 0.8759 100 0.51 Contact Map
3tqwA 1 0.854 100 0.514 Contact Map
3gxaA 3 0.8686 100 0.516 Contact Map
4q5tA 1 0.8905 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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