GREMLIN Database
SUFD - FeS cluster assembly protein SufD
UniProt: O32165 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 437 (406)
Sequences: 3259 (1814)
Seq/√Len: 90.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_Q198_S4.7461.00
253_R257_S4.7381.00
164_K195_D4.6401.00
164_K194_E4.4051.00
193_A230_V4.3261.00
193_A197_S4.3041.00
226_D255_R4.1031.00
195_D226_D3.8711.00
399_P402_E3.7661.00
226_D254_G3.7481.00
227_N256_D3.7471.00
294_G327_A3.4781.00
116_F160_L3.4211.00
224_T228_A3.3801.00
195_D225_G3.2461.00
198_S229_S3.2281.00
256_D283_G3.1371.00
312_A343_K3.0621.00
224_T259_I3.0461.00
118_D121_T3.0221.00
282_D312_A3.0121.00
161_Y194_E3.0021.00
400_K404_E3.0011.00
196_H227_N2.9681.00
282_D311_K2.8111.00
224_T257_S2.7921.00
199_V230_V2.7731.00
292_V321_G2.7111.00
222_V230_V2.6861.00
132_K225_G2.6111.00
107_Q111_D2.5501.00
229_S258_K2.5111.00
25_A29_N2.5061.00
307_I338_E2.4841.00
193_A228_A2.4401.00
165_N196_H2.3491.00
150_H188_H2.3341.00
173_Q204_N2.3031.00
342_S371_E2.2771.00
285_Y314_E2.2521.00
115_I161_Y2.1991.00
280_Y309_F2.1741.00
343_K373_D2.1351.00
308_H315_G2.1311.00
328_S360_R2.1051.00
394_M400_K2.0851.00
328_S362_D2.0691.00
34_A151_A2.0571.00
36_E40_D2.0491.00
255_R282_D2.0431.00
224_T230_V2.0131.00
246_V250_G2.0131.00
193_A199_V1.9961.00
162_V199_V1.9961.00
326_S358_K1.9641.00
191_I201_Y1.9581.00
172_V199_V1.9311.00
347_E377_G1.9301.00
30_L151_A1.9251.00
258_K285_Y1.9241.00
323_M327_A1.9101.00
282_D310_G1.9101.00
55_N58_N1.9061.00
252_A280_Y1.9001.00
138_G223_I1.8871.00
214_A243_T1.8321.00
316_Y345_N1.7261.00
279_L313_S1.7081.00
78_E81_A1.6511.00
385_V407_V1.6491.00
224_T253_R1.6311.00
268_D271_T1.6251.00
27_L123_A1.5821.00
35_L39_E1.5701.00
294_G300_E1.5661.00
92_L104_S1.5641.00
251_A259_I1.5611.00
91_T96_R1.5591.00
115_I163_P1.5501.00
309_F338_E1.5491.00
29_N33_Q1.5401.00
28_K32_L1.5391.00
91_T95_Q1.5391.00
112_K169_E1.5071.00
114_V162_V1.5031.00
120_L156_G1.4901.00
118_D156_G1.4871.00
135_M221_E1.4791.00
255_R283_G1.4721.00
342_S373_D1.4630.99
297_E326_S1.4610.99
254_G257_S1.4480.99
284_T313_S1.4480.99
363_A380_A1.4390.99
310_G313_S1.4360.99
314_E345_N1.4240.99
278_N307_I1.4190.99
283_G312_A1.4160.99
161_Y192_V1.4060.99
232_Y259_I1.3970.99
337_I376_A1.3860.99
245_Y248_R1.3750.99
296_G325_D1.3720.99
284_T310_G1.3690.99
139_V219_I1.3400.99
254_G281_G1.3150.99
37_Q40_D1.3130.99
95_Q179_E1.3070.99
121_T125_E1.3060.99
350_S363_A1.3000.99
344_A374_V1.2980.99
290_T319_K1.2870.99
322_V412_L1.2850.99
162_V193_A1.2740.99
299_T330_I1.2720.99
329_S361_G1.2680.99
291_V412_L1.2670.99
340_G371_E1.2660.99
226_D256_D1.2620.98
33_Q36_E1.2480.98
36_E39_E1.2480.98
200_T231_T1.2330.98
176_Y205_Y1.2290.98
335_G346_A1.2280.98
323_M361_G1.2140.98
122_A159_F1.2140.98
200_T233_G1.2100.98
136_K223_I1.2010.98
332_N364_N1.1910.98
245_Y250_G1.1890.98
302_F319_K1.1840.98
133_Y192_V1.1760.98
227_N283_G1.1720.98
22_Q124_R1.1700.98
277_T286_G1.1690.98
26_W131_E1.1620.97
168_V199_V1.1550.97
87_N170_T1.1520.97
25_A28_K1.1460.97
135_M150_H1.1450.97
337_I344_A1.1360.97
253_R259_I1.1280.97
162_V168_V1.1180.97
111_D114_V1.1180.97
117_T121_T1.1170.97
270_D299_T1.1090.97
231_T260_E1.1080.97
37_Q41_L1.1030.96
127_S131_E1.1000.96
167_Q196_H1.0950.96
122_A130_V1.0940.96
150_H219_I1.0930.96
116_F172_V1.0870.96
197_S230_V1.0800.96
278_N309_F1.0780.96
165_N227_N1.0770.96
341_A344_A1.0720.96
264_G428_L1.0710.96
238_L245_Y1.0590.96
33_Q37_Q1.0470.95
352_V363_A1.0350.95
77_D81_A1.0300.95
254_G280_Y1.0290.95
91_T97_D1.0200.95
189_V220_S1.0190.94
43_M146_L1.0140.94
30_L33_Q1.0100.94
160_L172_V1.0090.94
135_M188_H1.0050.94
192_V223_I1.0030.94
117_T125_E0.9980.94
255_R281_G0.9970.94
230_V259_I0.9960.94
330_I364_N0.9880.94
191_I222_V0.9850.93
163_P166_V0.9830.93
203_E232_Y0.9810.93
144_H274_E0.9800.93
92_L95_Q0.9740.93
115_I159_F0.9740.93
273_S302_F0.9700.93
335_G344_A0.9670.93
303_T332_N0.9660.93
253_R277_T0.9640.93
188_H219_I0.9620.93
186_F217_N0.9620.93
176_Y203_E0.9600.93
262_A289_K0.9530.92
57_T270_D0.9450.92
311_K342_S0.9450.92
363_A382_V0.9440.92
419_L425_K0.9420.92
81_A84_D0.9410.92
176_Y189_V0.9400.92
232_Y261_W0.9360.92
336_K370_D0.9340.91
27_L154_V0.9340.91
398_I406_L0.9330.91
277_T288_T0.9330.91
279_L310_G0.9320.91
133_Y223_I0.9310.91
32_L36_E0.9250.91
164_K226_D0.9230.91
119_I123_A0.9220.91
246_V249_R0.9220.91
134_F154_V0.9190.91
250_G259_I0.9190.91
367_L376_A0.9140.91
337_I348_Q0.9130.91
194_E225_G0.9060.90
139_V142_D0.9030.90
422_E426_K0.9020.90
274_E303_T0.9020.90
57_T299_T0.9000.90
425_K429_V0.8960.90
177_V206_I0.8950.90
313_S344_A0.8940.90
307_I336_K0.8920.89
422_E425_K0.8890.89
348_Q376_A0.8840.89
369_I374_V0.8810.89
113_G166_V0.8780.89
133_Y190_L0.8730.88
42_P145_K0.8710.88
27_L134_F0.8690.88
345_N375_T0.8680.88
162_V197_S0.8670.88
37_Q141_V0.8650.88
134_F190_L0.8620.88
117_T122_A0.8610.88
269_G297_E0.8520.87
165_N195_D0.8510.87
99_T104_S0.8500.87
149_L422_E0.8490.87
114_V199_V0.8450.87
303_T352_V0.8450.87
246_V251_A0.8430.87
234_A238_L0.8420.87
323_M359_A0.8390.86
334_I368_L0.8350.86
348_Q367_L0.8320.86
353_L408_I0.8320.86
74_D78_E0.8300.86
267_N271_T0.8290.86
221_E250_G0.8250.85
299_T328_S0.8240.85
187_N218_I0.8230.85
326_S356_S0.8210.85
323_M329_S0.8210.85
29_N32_L0.8200.85
251_A277_T0.8190.85
337_I369_I0.8170.85
317_I335_G0.8160.85
346_A376_A0.8160.85
355_L391_Y0.8160.85
190_L223_I0.8160.85
38_A145_K0.8150.85
56_F146_L0.8140.85
371_E374_V0.8130.85
334_I366_I0.8110.85
295_R298_Q0.8090.84
366_I370_D0.8060.84
159_F192_V0.8060.84
283_G310_G0.8060.84
225_G254_G0.8050.84
274_E332_N0.8050.84
75_L80_K0.7950.83
100_P103_L0.7930.83
243_T247_N0.7930.83
216_F238_L0.7920.83
369_I376_A0.7830.82
324_K356_S0.7800.82
129_L161_Y0.7800.82
205_Y245_Y0.7800.82
295_R325_D0.7790.82
279_L383_G0.7780.82
254_G284_T0.7770.82
248_R251_A0.7740.82
353_L360_R0.7740.82
193_A224_T0.7730.82
151_A188_H0.7720.81
195_D227_N0.7720.81
135_M190_L0.7660.81
306_I315_G0.7640.81
304_T319_K0.7640.81
203_E234_A0.7630.81
76_T80_K0.7590.80
126_H129_L0.7560.80
309_F340_G0.7540.80
253_R284_T0.7510.80
421_I424_V0.7510.80
271_T300_E0.7510.80
163_P192_V0.7510.80
236_D267_N0.7490.79
393_L407_V0.7470.79
301_N332_N0.7460.79
93_Y99_T0.7440.79
55_N59_F0.7440.79
332_N366_I0.7420.79
280_Y310_G0.7410.79
304_T317_I0.7390.79
253_R286_G0.7370.78
112_K168_V0.7360.78
40_D70_S0.7360.78
351_R381_S0.7360.78
234_A247_N0.7330.78
188_H221_E0.7320.78
244_T247_N0.7300.78
343_K371_E0.7300.78
90_K96_R0.7290.78
337_I368_L0.7270.77
35_L153_L0.7240.77
236_D298_Q0.7230.77
45_K49_T0.7200.77
222_V259_I0.7190.77
113_G163_P0.7170.76
114_V168_V0.7100.76
366_I377_G0.7100.76
78_E83_I0.7090.76
129_L132_K0.7070.75
77_D80_K0.7060.75
252_A278_N0.7050.75
70_S73_E0.7030.75
114_V166_V0.7030.75
339_H358_K0.7020.75
273_S319_K0.7010.75
136_K221_E0.6980.75
337_I345_N0.6970.74
305_Q336_K0.6960.74
86_E89_D0.6940.74
190_L221_E0.6920.74
148_A221_E0.6920.74
310_G340_G0.6910.74
157_G189_V0.6890.74
76_T79_V0.6880.73
236_D268_D0.6870.73
191_I199_V0.6870.73
293_V324_K0.6850.73
130_V159_F0.6850.73
226_D283_G0.6850.73
290_T302_F0.6830.73
287_D316_Y0.6830.73
52_T55_N0.6830.73
413_A429_V0.6830.73
129_L163_P0.6810.73
129_L159_F0.6810.73
37_Q142_D0.6790.73
346_A352_V0.6790.73
122_A129_L0.6770.72
294_G323_M0.6730.72
380_A408_I0.6720.72
326_S359_A0.6710.72
93_Y176_Y0.6710.72
288_T306_I0.6680.71
119_I130_V0.6680.71
339_H370_D0.6660.71
204_N237_N0.6660.71
115_I126_H0.6650.71
43_M51_I0.6640.71
312_A342_S0.6640.71
59_F62_H0.6620.71
289_K418_E0.6610.70
178_H185_L0.6610.70
367_L374_V0.6590.70
334_I348_Q0.6580.70
317_I320_H0.6580.70
94_V103_L0.6570.70
234_A245_Y0.6560.70
321_G329_S0.6560.70
244_T248_R0.6530.70
151_A219_I0.6520.69
199_V224_T0.6520.69
181_N212_K0.6520.69
119_I134_F0.6520.69
245_Y249_R0.6520.69
80_K83_I0.6520.69
243_T246_V0.6510.69
332_N361_G0.6500.69
117_T159_F0.6500.69
376_A379_A0.6500.69
227_N255_R0.6500.69
249_R273_S0.6480.69
413_A417_N0.6480.69
52_T272_I0.6440.69
109_L168_V0.6430.68
288_T346_A0.6410.68
279_L284_T0.6400.68
398_I403_A0.6390.68
184_A320_H0.6370.68
319_K331_F0.6350.67
54_W57_T0.6350.67
337_I374_V0.6320.67
223_I252_A0.6320.67
23_E32_L0.6320.67
34_A148_A0.6310.67
369_I373_D0.6300.67
220_S232_Y0.6290.67
211_P241_G0.6280.67
69_L73_E0.6260.66
342_S372_D0.6250.66
80_K84_D0.6250.66
162_V201_Y0.6250.66
138_G252_A0.6240.66
256_D282_D0.6240.66
43_M59_F0.6240.66
108_E170_T0.6230.66
197_S228_A0.6220.66
311_K341_A0.6210.66
336_K368_L0.6200.66
226_D257_S0.6200.66
325_D356_S0.6200.66
245_Y251_A0.6180.65
370_D383_G0.6170.65
163_P194_E0.6170.65
92_L96_R0.6160.65
44_P57_T0.6160.65
90_K99_T0.6160.65
309_F336_K0.6130.65
284_T311_K0.6130.65
134_F188_H0.6120.65
38_A42_P0.6110.64
292_V302_F0.6110.64
261_W380_A0.6100.64
377_G383_G0.6100.64
236_D263_L0.6090.64
311_K317_I0.6090.64
50_K58_N0.6080.64
341_A371_E0.6080.64
339_H342_S0.6050.64
319_K350_S0.6040.64
393_L398_I0.6040.64
322_V353_L0.6020.63
146_L246_V0.6020.63
282_D343_K0.6020.63
364_N377_G0.6020.63
225_G257_S0.6010.63
293_V432_I0.6010.63
90_K104_S0.6010.63
160_L168_V0.5990.63
332_N352_V0.5970.63
259_I277_T0.5970.63
97_D172_V0.5960.63
303_T350_S0.5960.63
79_V82_L0.5960.63
248_R276_T0.5950.62
95_Q99_T0.5940.62
430_S433_E0.5940.62
31_R34_A0.5920.62
315_G335_G0.5910.62
385_V404_E0.5910.62
321_G350_S0.5900.62
376_A386_D0.5890.62
133_Y225_G0.5890.62
344_A376_A0.5870.61
173_Q382_V0.5870.61
423_G426_K0.5870.61
350_S379_A0.5860.61
244_T249_R0.5860.61
221_E281_G0.5840.61
317_I344_A0.5840.61
346_A350_S0.5840.61
126_H159_F0.5830.61
158_A189_V0.5820.61
308_H370_D0.5820.61
123_A130_V0.5790.60
30_L131_E0.5790.60
302_F363_A0.5790.60
35_L38_A0.5780.60
338_E371_E0.5770.60
94_V179_E0.5770.60
180_S183_T0.5770.60
119_I154_V0.5750.60
75_L85_I0.5740.60
236_D265_L0.5740.60
150_H217_N0.5740.60
308_H338_E0.5740.60
92_L175_V0.5720.59
49_T58_N0.5710.59
225_G228_A0.5690.59
22_Q25_A0.5680.59
303_T412_L0.5670.59
391_Y395_S0.5670.59
325_D359_A0.5640.58
205_Y234_A0.5640.58
31_R148_A0.5640.58
30_L34_A0.5630.58
299_T319_K0.5620.58
344_A368_L0.5610.58
283_G314_E0.5600.58
89_D170_T0.5600.58
119_I159_F0.5600.58
381_S412_L0.5600.58
303_T363_A0.5580.58
343_K372_D0.5570.57
416_V432_I0.5560.57
33_Q141_V0.5560.57
40_D136_K0.5550.57
344_A371_E0.5550.57
265_L273_S0.5550.57
168_V212_K0.5540.57
90_K95_Q0.5540.57
233_G420_P0.5540.57
220_S262_A0.5530.57
303_T346_A0.5530.57
149_L186_F0.5530.57
191_I384_R0.5530.57
70_S74_D0.5510.57
33_Q74_D0.5490.56
352_V384_R0.5490.56
112_K162_V0.5480.56
369_I372_D0.5470.56
360_R432_I0.5460.56
251_A288_T0.5460.56
247_N263_L0.5450.56
144_H248_R0.5450.56
337_I373_D0.5450.56
24_P28_K0.5420.55
255_R312_A0.5420.55
231_T420_P0.5420.55
265_L302_F0.5420.55
275_N319_K0.5410.55
126_H133_Y0.5410.55
111_D169_E0.5410.55
295_R324_K0.5400.55
23_E28_K0.5400.55
114_V355_L0.5400.55
67_E215_V0.5390.55
371_E376_A0.5390.55
149_L153_L0.5380.55
94_V177_V0.5370.55
265_L292_V0.5370.55
115_I133_Y0.5360.55
319_K332_N0.5360.55
136_K139_V0.5360.55
133_Y136_K0.5360.55
107_Q326_S0.5350.54
108_E169_E0.5350.54
170_T199_V0.5340.54
135_M138_G0.5340.54
22_Q37_Q0.5320.54
405_R433_E0.5320.54
352_V361_G0.5310.54
176_Y208_T0.5310.54
114_V172_V0.5310.54
316_Y337_I0.5290.54
133_Y159_F0.5280.53
45_K51_I0.5280.53
372_D375_T0.5280.53
298_Q325_D0.5270.53
24_P123_A0.5270.53
260_E287_D0.5270.53
247_N251_A0.5260.53
130_V190_L0.5250.53
135_M151_A0.5250.53
381_S416_V0.5250.53
342_S375_T0.5240.53
195_D257_S0.5240.53
37_Q42_P0.5230.53
393_L435_K0.5230.53
63_T316_Y0.5230.53
368_L371_E0.5220.53
38_A148_A0.5210.53
247_N250_G0.5210.53
174_A191_I0.5200.52
34_A141_V0.5200.52
165_N197_S0.5200.52
171_P353_L0.5200.52
285_Y316_Y0.5200.52
371_E379_A0.5190.52
145_K148_A0.5180.52
121_T124_R0.5180.52
174_A344_A0.5180.52
276_T307_I0.5170.52
93_Y96_R0.5170.52
158_A174_A0.5160.52
34_A152_A0.5160.52
292_V384_R0.5150.52
273_S383_G0.5140.52
240_S296_G0.5130.51
196_H229_S0.5130.51
95_Q208_T0.5130.51
178_H216_F0.5130.51
188_H383_G0.5120.51
399_P409_Y0.5120.51
284_T309_F0.5120.51
275_N278_N0.5110.51
175_V206_I0.5100.51
371_E381_S0.5100.51
277_T383_G0.5100.51
237_N431_V0.5100.51
109_L116_F0.5090.51
356_S359_A0.5080.51
73_E82_L0.5080.51
315_G346_A0.5080.51
168_V172_V0.5080.51
113_G164_K0.5070.51
303_T319_K0.5060.50
36_E181_N0.5050.50
332_N363_A0.5050.50
198_S231_T0.5040.50
108_E112_K0.5040.50
291_V318_L0.5040.50
164_K197_S0.5040.50
346_A367_L0.5030.50
99_T102_H0.5020.50
96_R369_I0.5010.50
352_V382_V0.5010.50
381_S414_P0.5010.50
235_V266_M0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.9291 100 0.181 Contact Map
4dn7A 2 0.9039 100 0.282 Contact Map
4xfmA 2 0.1556 36 0.972 Contact Map
3dqqA 2 0.167 26.2 0.974 Contact Map
4edgA 1 0.1785 19.7 0.975 Contact Map
1rq8A 1 0.1167 18.6 0.976 Contact Map
1ifyA 1 0.1121 17.8 0.976 Contact Map
1yzyA 1 0.1579 16.4 0.976 Contact Map
2ekkA 1 0.1076 16.3 0.976 Contact Map
1wjiA 1 0.1259 15.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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