GREMLIN Database
SUFS - Cysteine desulfurase SufS
UniProt: O32164 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (335)
Sequences: 44139 (29804)
Seq/√Len: 1628.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_E140_K3.6351.00
313_R392_V3.4181.00
309_Y389_D3.4051.00
185_A195_I3.3831.00
309_Y385_E3.1201.00
180_P183_E2.9751.00
113_E160_T2.8201.00
156_R190_D2.8071.00
113_E138_T2.6921.00
156_R187_I2.6631.00
154_D157_E2.6261.00
209_D212_D2.6251.00
170_H202_S2.6091.00
351_E397_K2.4791.00
185_A189_H2.4771.00
118_Y143_P2.4321.00
73_K289_D2.4221.00
286_A289_D2.3361.00
317_L396_Q2.3281.00
188_A193_A2.2731.00
199_G218_F2.2651.00
313_R316_Q2.2411.00
220_L233_V2.2371.00
351_E394_A2.2151.00
313_R389_D2.1891.00
309_Y313_R2.1461.00
166_V188_A2.1361.00
154_D158_T2.1171.00
182_K186_K2.0641.00
113_E163_T2.0481.00
277_I280_G2.0121.00
390_K394_A2.0001.00
186_K190_D1.9291.00
42_D46_N1.9281.00
151_S154_D1.9271.00
189_H216_D1.9251.00
112_D164_K1.9221.00
308_A312_E1.9031.00
313_R396_Q1.9021.00
152_L183_E1.8861.00
321_T335_N1.8601.00
302_H306_L1.8571.00
305_K385_E1.8401.00
347_V398_T1.8291.00
188_A195_I1.7641.00
377_A391_L1.7601.00
90_K94_T1.7451.00
43_K47_Q1.7311.00
301_R305_K1.7251.00
156_R191_N1.7251.00
140_K158_T1.7171.00
165_I196_V1.6871.00
347_V350_A1.6841.00
183_E186_K1.6781.00
79_N209_D1.6771.00
113_E162_N1.6711.00
143_P154_D1.6591.00
168_V195_I1.6491.00
76_K292_E1.6451.00
182_K212_D1.6261.00
152_L187_I1.6011.00
197_V215_C1.5931.00
187_I191_N1.5861.00
96_L123_A1.5851.00
302_H305_K1.5801.00
316_Q396_Q1.5711.00
304_H308_A1.5611.00
142_I158_T1.5531.00
74_V233_V1.5501.00
159_V187_I1.5481.00
311_L332_V1.5381.00
297_D301_R1.5181.00
168_V184_M1.5111.00
384_T387_E1.5071.00
99_V217_F1.4851.00
340_H343_D1.4741.00
310_A379_F1.4631.00
112_D162_N1.4621.00
335_N373_A1.4581.00
153_E156_R1.4531.00
333_T374_T1.4461.00
153_E157_E1.4441.00
72_E76_K1.4431.00
116_I128_W1.4281.00
215_C218_F1.4161.00
323_Y335_N1.4041.00
69_G73_K1.4011.00
85_E238_K1.3931.00
307_A311_L1.3791.00
145_Q149_T1.3701.00
109_K112_D1.3691.00
385_E389_D1.3621.00
156_R160_T1.3621.00
394_A397_K1.3591.00
89_T95_S1.3561.00
156_R183_E1.3311.00
300_S304_H1.3261.00
309_Y388_I1.3141.00
155_V184_M1.3111.00
115_V158_T1.3071.00
73_K292_E1.3011.00
160_T163_T1.3011.00
321_T337_D1.2971.00
209_D213_L1.2961.00
100_A128_W1.2841.00
73_K285_G1.2811.00
295_G298_E1.2491.00
312_E315_R1.2491.00
40_T43_K1.2471.00
310_A388_I1.2341.00
89_T98_M1.2271.00
73_K76_K1.2261.00
118_Y141_Y1.2251.00
103_Y194_V1.2241.00
140_K160_T1.2201.00
92_T200_A1.2181.00
72_E75_R1.2101.00
343_D347_V1.2001.00
72_E83_M1.1881.00
115_V163_T1.1811.00
347_V351_E1.1761.00
152_L156_R1.1731.00
126_I129_Q1.1711.00
40_T286_A1.1651.00
41_L283_G1.1601.00
386_E389_D1.1521.00
68_E72_E1.1481.00
217_F236_G1.1451.00
187_I190_D1.1451.00
247_A251_G1.1441.00
166_V193_A1.1431.00
181_I197_V1.1391.00
390_K393_E1.1391.00
313_R317_L1.1371.00
65_D69_G1.1371.00
138_T160_T1.1321.00
224_K227_G1.1321.00
346_T350_A1.1311.00
116_I141_Y1.1271.00
145_Q151_S1.1261.00
393_E397_K1.1121.00
129_Q133_K1.1101.00
189_H195_I1.1081.00
289_D293_E1.1041.00
392_V396_Q1.0791.00
285_G289_D1.0761.00
298_E301_R1.0741.00
389_D393_E1.0671.00
170_H181_I1.0641.00
342_H346_T1.0601.00
125_I141_Y1.0591.00
81_K238_K1.0561.00
96_L196_V1.0551.00
298_E302_H1.0541.00
295_G299_I1.0531.00
196_V219_A1.0521.00
388_I392_V1.0511.00
309_Y312_E1.0501.00
348_L355_V1.0501.00
222_S284_L1.0491.00
330_G333_T1.0451.00
175_L369_L1.0431.00
306_L388_I1.0421.00
208_I212_D1.0411.00
313_R393_E1.0401.00
95_S219_A1.0351.00
84_A238_K1.0341.00
311_L315_R1.0281.00
101_L249_F1.0261.00
353_I390_K1.0111.00
147_D325_P1.0091.00
81_K237_K1.0031.00
179_N184_M0.9981.00
228_P283_G0.9961.00
155_V166_V0.9951.00
81_K85_E0.9941.00
250_G253_M0.9931.00
312_E316_Q0.9841.00
70_A285_G0.9831.00
216_D237_K0.9781.00
248_E251_G0.9771.00
159_V191_N0.9731.00
225_M284_L0.9731.00
305_K309_Y0.9651.00
86_I235_Y0.9541.00
66_G282_I0.9501.00
210_V213_L0.9461.00
96_L219_A0.9451.00
167_A196_V0.9441.00
185_A214_D0.9431.00
248_E253_M0.9401.00
345_A355_V0.9381.00
159_V193_A0.9381.00
108_L137_A0.9371.00
97_N101_L0.9361.00
203_T220_L0.9361.00
249_F253_M0.9321.00
153_E183_E0.9271.00
128_W139_L0.9251.00
168_V181_I0.9251.00
328_R331_L0.9241.00
48_Y62_R0.9241.00
310_A391_L0.9221.00
171_V202_S0.9181.00
344_V398_T0.9181.00
160_T191_N0.9181.00
353_I391_L0.9181.00
111_G164_K0.9131.00
159_V163_T0.9121.00
226_C380_Y0.9121.00
79_N211_Q0.9041.00
78_I220_L0.9031.00
170_H218_F0.9031.00
85_E239_A0.9001.00
247_A253_M0.9001.00
210_V214_D0.8961.00
125_I129_Q0.8931.00
75_R86_I0.8901.00
69_G285_G0.8861.00
355_V375_A0.8851.00
242_E245_E0.8831.00
81_K211_Q0.8811.00
130_Q249_F0.8801.00
194_V217_F0.8781.00
286_A290_F0.8681.00
353_I394_A0.8671.00
282_I285_G0.8651.00
329_A332_V0.8581.00
166_V184_M0.8561.00
346_T349_D0.8481.00
343_D346_T0.8471.00
77_F203_T0.8461.00
108_L112_D0.8421.00
115_V142_I0.8421.00
73_K290_F0.8411.00
43_K46_N0.8391.00
66_G69_G0.8391.00
116_I120_E0.8371.00
345_A357_A0.8361.00
142_I154_D0.8331.00
119_M179_N0.8331.00
99_V196_V0.8291.00
132_V137_A0.8271.00
334_F377_A0.8231.00
249_F252_E0.8191.00
116_I139_L0.8161.00
309_Y392_V0.8121.00
78_I235_Y0.8101.00
188_A191_N0.8081.00
68_E71_R0.8061.00
182_K208_I0.8051.00
140_K163_T0.8051.00
306_L385_E0.8011.00
159_V166_V0.7981.00
210_V235_Y0.7981.00
331_L334_F0.7981.00
247_A250_G0.7971.00
103_Y217_F0.7921.00
266_E269_W0.7911.00
81_K239_A0.7911.00
299_I302_H0.7851.00
86_I89_T0.7831.00
237_K240_L0.7831.00
80_A235_Y0.7781.00
329_A334_F0.7761.00
217_F240_L0.7751.00
171_V329_A0.7741.00
67_Y281_A0.7731.00
328_R332_V0.7721.00
310_A377_A0.7681.00
331_L335_N0.7681.00
329_A333_T0.7671.00
247_A252_E0.7661.00
168_V179_N0.7661.00
386_E390_K0.7661.00
183_E187_I0.7651.00
285_G288_I0.7601.00
310_A392_V0.7581.00
75_R80_A0.7581.00
314_F395_L0.7581.00
196_V217_F0.7561.00
155_V187_I0.7561.00
115_V140_K0.7551.00
41_L45_Y0.7541.00
332_V335_N0.7541.00
299_I381_L0.7531.00
322_V325_P0.7531.00
265_K269_W0.7521.00
126_I130_Q0.7521.00
170_H213_L0.7491.00
103_Y107_N0.7481.00
184_M195_I0.7481.00
241_L244_M0.7461.00
194_V216_D0.7451.00
189_H214_D0.7451.00
49_N52_V0.7451.00
344_V395_L0.7371.00
182_K213_L0.7371.00
307_A332_V0.7341.00
114_V165_I0.7321.00
124_N167_A0.7291.00
185_A213_L0.7281.00
171_V328_R0.7271.00
194_V240_L0.7261.00
302_H385_E0.7251.00
207_K297_D0.7231.00
77_F297_D0.7231.00
152_L155_V0.7221.00
299_I303_E0.7211.00
188_A192_G0.7181.00
165_I194_V0.7171.00
222_S231_V0.7171.00
383_N388_I0.7171.00
339_V343_D0.7151.00
114_V128_W0.7131.00
130_Q134_A0.7121.00
186_K189_H0.7121.00
169_S173_N0.7111.00
56_V60_G0.7061.00
70_A88_F0.7051.00
99_V103_Y0.7051.00
350_A358_G0.7041.00
70_A73_K0.7041.00
245_E249_F0.7021.00
248_E252_E0.7011.00
129_Q141_Y0.7001.00
233_V237_K0.7001.00
319_G337_D0.7001.00
246_P251_G0.6981.00
211_Q214_D0.6961.00
273_A276_P0.6961.00
306_L379_F0.6961.00
69_G72_E0.6951.00
170_H197_V0.6911.00
289_D292_E0.6901.00
43_K48_Y0.6901.00
328_R333_T0.6891.00
246_P249_F0.6871.00
280_G283_G0.6851.00
96_L167_A0.6851.00
228_P231_V0.6841.00
75_R83_M0.6821.00
178_V206_M0.6791.00
389_D392_V0.6791.00
240_L243_N0.6781.00
143_P158_T0.6761.00
81_K84_A0.6731.00
238_K242_E0.6721.00
303_E330_G0.6671.00
138_T162_N0.6671.00
355_V377_A0.6631.00
315_R325_P0.6621.00
393_E396_Q0.6611.00
314_F334_F0.6601.00
330_G334_F0.6601.00
323_Y374_T0.6541.00
58_T62_R0.6531.00
62_R65_D0.6511.00
77_F288_I0.6501.00
202_S218_F0.6471.00
73_K294_I0.6471.00
101_L135_T0.6471.00
222_S225_M0.6451.00
311_L322_V0.6441.00
317_L320_V0.6421.00
300_S303_E0.6411.00
246_P252_E0.6401.00
216_D221_S0.6391.00
383_N387_E0.6391.00
158_T161_S0.6381.00
100_A165_I0.6371.00
284_L288_I0.6321.00
69_G289_D0.6321.00
222_S227_G0.6311.00
64_T68_E0.6311.00
301_R304_H0.6311.00
287_A291_L0.6281.00
242_E246_P0.6271.00
322_V335_N0.6251.00
85_E237_K0.6241.00
291_L294_I0.6231.00
70_A289_D0.6221.00
356_R359_H0.6201.00
238_K241_L0.6191.00
391_L394_A0.6191.00
127_P130_Q0.6191.00
86_I233_V0.6181.00
199_G202_S0.6171.00
101_L130_Q0.6161.00
100_A167_A0.6161.00
185_A215_C0.6141.00
320_V325_P0.6131.00
305_K308_A0.6121.00
306_L310_A0.6111.00
310_A332_V0.6111.00
80_A85_E0.6101.00
185_A188_A0.6091.00
310_A314_F0.6061.00
308_A311_L0.6051.00
227_G231_V0.6041.00
344_V375_A0.6041.00
297_D300_S0.6041.00
93_T97_N0.6011.00
157_E161_S0.6011.00
74_V288_I0.6011.00
341_P357_A0.6001.00
317_L392_V0.5991.00
279_A282_I0.5961.00
207_K210_V0.5961.00
218_F221_S0.5941.00
119_M177_T0.5901.00
199_G203_T0.5891.00
236_G241_L0.5891.00
48_Y52_V0.5891.00
122_H126_I0.5891.00
168_V197_V0.5871.00
283_G287_A0.5861.00
216_D219_A0.5851.00
124_N127_P0.5851.00
156_R186_K0.5841.00
394_A398_T0.5831.00
379_F388_I0.5831.00
333_T336_L0.5811.00
187_I193_A0.5791.00
155_V159_V0.5781.00
266_E270_K0.5771.00
73_K77_F0.5771.00
118_Y144_L0.5721.00
380_Y383_N0.5721.00
74_V88_F0.5701.00
121_H173_N0.5701.00
181_I195_I0.5691.00
310_A313_R0.5691.00
329_A335_N0.5681.00
92_T96_L0.5671.00
145_Q154_D0.5661.00
219_A222_S0.5641.00
341_P345_A0.5611.00
67_Y278_I0.5591.00
233_V236_G0.5591.00
186_K214_D0.5591.00
323_Y333_T0.5581.00
87_I98_M0.5571.00
181_I185_A0.5551.00
149_T179_N0.5551.00
231_V280_G0.5511.00
241_L245_E0.5481.00
195_I215_C0.5471.00
246_P253_M0.5471.00
321_T324_G0.5461.00
61_T64_T0.5461.00
44_Y48_Y0.5451.00
311_L328_R0.5451.00
41_L44_Y0.5451.00
85_E89_T0.5451.00
161_S191_N0.5441.00
42_D45_Y0.5421.00
246_P250_G0.5421.00
391_L395_L0.5411.00
290_F293_E0.5401.00
306_L383_N0.5401.00
291_L295_G0.5391.00
227_G230_G0.5391.00
94_T97_N0.5391.00
226_C381_L0.5381.00
71_R88_F0.5371.00
111_G138_T0.5351.00
182_K207_K0.5341.00
45_Y279_A0.5341.00
203_T225_M0.5341.00
224_K376_R0.5321.00
160_T190_D0.5291.00
170_H208_I0.5291.00
354_A357_A0.5281.00
142_I155_V0.5261.00
152_L180_P0.5261.00
55_G60_G0.5251.00
332_V336_L0.5251.00
330_G335_N0.5231.00
339_V344_V0.5221.00
80_A218_F0.5221.00
70_A281_A0.5211.00
218_F222_S0.5201.00
294_I298_E0.5191.00
267_L271_F0.5191.00
268_P271_F0.5191.00
130_Q135_T0.5181.00
379_F383_N0.5171.00
40_T44_Y0.5161.00
132_V135_T0.5151.00
41_L280_G0.5141.00
278_I281_A0.5131.00
185_A197_V0.5111.00
40_T45_Y0.5111.00
328_R334_F0.5091.00
119_M144_L0.5071.00
101_L247_A0.5061.00
76_K79_N0.5041.00
306_L309_Y0.5011.00
355_V358_G0.5001.00
189_H193_A0.5001.00
218_F235_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kmjA 2 0.9926 100 0.302 Contact Map
4w91A 2 0.9926 100 0.321 Contact Map
4lw2A 2 0.9778 100 0.328 Contact Map
4q75A 2 1 100 0.33 Contact Map
1t3iA 2 0.9828 100 0.331 Contact Map
3e9kA 2 0.9458 100 0.352 Contact Map
3caiA 2 0.9261 100 0.369 Contact Map
1eluA 2 0.9113 100 0.376 Contact Map
4isyA 2 0.8892 100 0.386 Contact Map
3a9zA 2 0.8966 100 0.386 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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