GREMLIN Database
SUFU - Zinc-dependent sulfurtransferase SufU
UniProt: O32163 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (137)
Sequences: 1728 (1065)
Seq/√Len: 91.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_D57_E4.6561.00
83_K87_T3.8591.00
24_N81_K3.5231.00
84_D87_T3.3711.00
75_M116_L3.3331.00
26_G60_K2.4571.00
23_R78_Q2.4201.00
50_K58_D2.3891.00
35_D46_R2.3831.00
59_A80_I2.3111.00
50_K57_E2.2411.00
27_V48_T2.1201.00
28_L60_K2.1031.00
56_V88_A1.9931.00
73_A132_S1.9421.00
35_D44_R1.9351.00
48_T60_K1.9341.00
58_D81_K1.9271.00
24_N77_T1.9181.00
27_V62_E1.9101.00
30_D50_K1.8701.00
51_L85_I1.8131.00
89_L137_E1.7131.00
97_D102_K1.6651.00
80_I136_L1.6471.00
90_S94_I1.5901.00
80_I88_A1.5361.00
31_S50_K1.5361.00
36_M135_A1.5231.00
85_I89_L1.5131.00
93_K97_D1.4981.00
18_H74_S1.4931.00
33_V48_T1.4791.00
68_I129_A1.4250.99
55_I84_D1.4010.99
89_L141_A1.3760.99
34_V47_L1.3350.99
61_F77_T1.3310.99
85_I140_V1.3040.99
12_R16_M1.3010.99
51_L54_D1.2960.99
49_M59_A1.2890.99
54_D86_E1.2710.99
90_S109_D1.2660.99
14_V115_A1.1740.98
24_N58_D1.1580.97
96_S134_K1.1520.97
32_I139_G1.1500.97
37_N44_R1.1480.97
87_T90_S1.1100.97
56_V136_L1.0760.96
43_D128_C1.0720.96
94_I109_D1.0710.96
76_M133_W1.0670.96
137_E141_A1.0570.96
89_L140_V1.0510.95
59_A77_T1.0500.95
99_M126_I1.0500.95
74_S77_T1.0490.95
34_V138_K1.0410.95
26_G62_E1.0370.95
103_E106_D1.0220.95
17_D23_R1.0170.95
23_R74_S1.0100.94
27_V60_K0.9980.94
44_R64_E0.9880.94
31_S51_L0.9840.94
94_I107_S0.9710.93
136_L140_V0.9680.93
25_K70_M0.9520.92
51_L140_V0.9470.92
106_D109_D0.9430.92
22_P74_S0.9390.92
119_V129_A0.9290.91
25_K63_G0.9120.91
40_T121_K0.9000.90
86_E89_L0.8990.90
79_A91_M0.8970.90
98_M104_Y0.8910.90
12_R20_K0.8890.90
49_M56_V0.8870.89
36_M67_S0.8810.89
18_H22_P0.8770.89
23_R77_T0.8740.89
15_I68_I0.8650.88
27_V33_V0.8630.88
24_N78_Q0.8570.88
33_V46_R0.8470.87
36_M134_K0.8440.87
95_F99_M0.8400.87
65_G127_K0.8330.86
38_N127_K0.8320.86
25_K62_E0.8160.85
113_I133_W0.8110.85
83_K91_M0.8090.85
72_S133_W0.8070.85
56_V80_I0.8060.84
32_I143_E0.8020.84
28_L48_T0.8010.84
14_V17_D0.8010.84
90_S93_K0.8000.84
11_Y42_G0.7980.84
54_D85_I0.7870.83
118_G121_K0.7850.83
71_A116_L0.7810.83
39_P42_G0.7780.82
24_N74_S0.7730.82
96_S137_E0.7680.81
38_N65_G0.7650.81
91_M109_D0.7570.81
9_T13_Q0.7550.80
99_M120_S0.7400.79
126_I135_A0.7360.79
109_D114_E0.7360.79
51_L139_G0.7330.78
18_H75_M0.7260.78
98_M117_Q0.7240.78
65_G69_S0.7240.78
72_S95_F0.7180.77
67_S75_M0.7150.77
94_I97_D0.7120.76
88_A136_L0.7070.76
36_M40_T0.7060.76
117_Q120_S0.7040.76
93_K137_E0.6980.75
30_D48_T0.6960.75
92_S96_S0.6940.75
138_K142_K0.6900.74
96_S130_T0.6890.74
51_L143_E0.6850.74
75_M113_I0.6770.73
49_M136_L0.6770.73
38_N43_D0.6700.72
57_E82_G0.6670.72
123_P127_K0.6590.71
72_S83_K0.6550.70
70_M130_T0.6540.70
46_R62_E0.6540.70
97_D103_E0.6540.70
118_G122_F0.6530.70
89_L93_K0.6500.70
92_S137_E0.6500.70
97_D106_D0.6480.69
8_D121_K0.6440.69
102_K120_S0.6410.69
34_V135_A0.6350.68
42_G133_W0.6320.67
58_D61_F0.6320.67
65_G128_C0.6320.67
22_P25_K0.6300.67
61_F69_S0.6270.67
9_T102_K0.6200.66
38_N128_C0.6200.66
43_D65_G0.6190.66
126_I130_T0.6190.66
101_G120_S0.6170.66
18_H115_A0.6170.66
69_S128_C0.6150.65
94_I104_Y0.6140.65
43_D69_S0.6110.65
40_T64_E0.6000.63
118_G123_P0.5970.63
26_G58_D0.5960.63
94_I105_D0.5950.63
37_N70_M0.5900.62
93_K100_Q0.5900.62
38_N69_S0.5830.61
7_L122_F0.5820.61
119_V124_A0.5810.61
76_M80_I0.5800.61
93_K141_A0.5750.60
49_M139_G0.5710.60
38_N42_G0.5700.60
130_T134_K0.5680.59
11_Y39_P0.5670.59
91_M95_F0.5640.59
105_D114_E0.5630.59
11_Y122_F0.5620.58
7_L37_N0.5610.58
120_S123_P0.5580.58
97_D101_G0.5580.58
100_Q126_I0.5540.57
30_D58_D0.5520.57
76_M132_S0.5450.56
11_Y123_P0.5430.56
86_E90_S0.5390.55
31_S58_D0.5390.55
72_S75_M0.5380.55
14_V126_I0.5320.54
34_V142_K0.5310.54
103_E107_S0.5280.54
98_M110_L0.5270.54
84_D88_A0.5260.54
99_M130_T0.5250.53
70_M135_A0.5250.53
52_D55_I0.5250.53
94_I106_D0.5190.53
17_D21_N0.5180.52
83_K111_G0.5150.52
31_S52_D0.5070.51
19_Y67_S0.5050.51
105_D117_Q0.5040.51
11_Y38_N0.5030.50
31_S53_G0.5000.50
47_L136_L0.5000.50
124_A127_K0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xjsA 1 1 100 0.152 Contact Map
1su0B 1 0.9252 100 0.169 Contact Map
2qq4A 5 0.932 100 0.196 Contact Map
2z7eA 5 0.8367 100 0.322 Contact Map
3lvlA 1 0.8095 100 0.331 Contact Map
4eb5C 1 0.8095 100 0.342 Contact Map
3g0mA 1 0.8231 79.9 0.909 Contact Map
1vqzA 1 0.7619 58.6 0.922 Contact Map
3a7rA 1 0.7823 52.7 0.925 Contact Map
2e5aA 1 0.6939 51.8 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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