GREMLIN Database
SUFB - FeS cluster assembly protein SufB
UniProt: O32162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (414)
Sequences: 3187 (1763)
Seq/√Len: 86.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_K224_S5.1281.00
278_C282_A4.8631.00
190_K221_E4.7571.00
219_V256_C4.4201.00
190_K220_D4.3651.00
219_V223_A4.2061.00
252_K280_E4.1951.00
221_E252_K3.9011.00
252_K279_E3.7321.00
253_G281_N3.7041.00
424_S427_E3.6701.00
250_V254_G3.5221.00
319_A352_G3.4041.00
143_F186_I3.3501.00
221_E251_K3.3341.00
337_N368_G3.3251.00
224_S255_Y3.3071.00
276_T284_M3.2471.00
187_Y220_D3.2021.00
307_E337_N3.1861.00
281_N308_G3.1411.00
145_D148_S3.0891.00
425_E429_T3.0291.00
225_V256_C2.9771.00
250_V284_M2.9731.00
250_V282_A2.8651.00
307_E336_P2.8101.00
222_E253_G2.8091.00
248_I256_C2.7771.00
159_E251_K2.7701.00
255_Y283_T2.7291.00
45_Q49_D2.6601.00
332_I363_G2.4921.00
317_A346_S2.4891.00
219_V254_G2.4081.00
277_V305_K2.3771.00
367_E396_N2.3711.00
191_G222_E2.3581.00
368_G398_N2.3571.00
305_K334_L2.3411.00
142_V187_Y2.3331.00
56_E60_N2.3041.00
199_Q230_G2.2731.00
310_R339_S2.2671.00
351_G383_K2.2281.00
333_H340_S2.2201.00
176_N214_R2.2091.00
54_S177_S2.1861.00
353_K385_T2.1601.00
353_K387_D2.1181.00
419_M425_E2.0851.00
280_E307_E2.0561.00
283_T310_R2.0301.00
219_V225_V2.0301.00
348_S352_G2.0261.00
74_N77_E2.0251.00
50_F177_S2.0161.00
164_V249_I1.9971.00
250_V256_C1.9701.00
240_S268_V1.9321.00
217_I227_Y1.9271.00
188_V225_V1.9241.00
372_N402_E1.9031.00
307_E335_A1.9001.00
250_V278_C1.8351.00
198_L225_V1.7921.00
47_M150_L1.7141.00
145_D182_G1.7081.00
293_S296_T1.6801.00
304_L338_T1.6701.00
334_L363_G1.6421.00
139_Q195_E1.6261.00
341_T370_R1.6191.00
98_E101_Q1.5981.00
49_D53_K1.5771.00
142_V189_P1.5751.00
55_L59_Y1.5701.00
319_A325_Q1.5521.00
322_G351_G1.5471.00
147_D182_G1.5451.00
120_S127_V1.5431.00
303_I332_I1.5281.00
309_A335_A1.5161.00
367_E398_N1.5061.00
48_L52_L1.5031.00
308_G337_N1.4941.00
165_I245_V1.4760.99
280_E308_G1.4650.99
162_A247_E1.4580.99
410_V432_I1.4490.99
369_A399_I1.4380.99
335_A338_T1.4310.99
309_A338_T1.4220.99
362_F401_L1.4050.99
258_Y284_M1.4020.99
57_H60_N1.3950.99
141_I188_V1.3860.99
187_Y218_I1.3800.99
321_K350_Q1.3620.99
375_C388_T1.3500.99
339_S370_R1.3480.99
279_E305_K1.3400.99
315_S344_S1.3190.99
163_K249_I1.3100.99
148_S152_E1.3080.99
354_V386_S1.2870.98
53_K56_E1.2860.98
252_K281_N1.2810.98
388_T405_A1.2760.98
46_W158_R1.2720.98
56_E59_Y1.2610.98
42_E151_K1.2560.98
112_E196_T1.2510.98
324_H355_T1.2480.98
154_E158_R1.2390.98
316_I437_I1.2370.98
278_C284_M1.2340.98
360_V371_S1.2300.98
149_A185_F1.2300.98
117_A128_V1.2270.98
362_F369_A1.2150.98
226_H257_R1.2120.98
357_R389_I1.2060.98
188_V219_V1.1990.98
279_E306_G1.1980.98
223_A256_C1.1960.98
193_K222_E1.1950.98
120_S205_N1.1920.98
327_A344_S1.1840.97
63_M172_F1.1830.97
226_H259_T1.1830.97
202_F231_C1.1740.97
57_H61_M1.1660.97
162_A176_N1.1610.97
53_K57_H1.1540.97
264_W270_N1.1470.97
160_H218_I1.1430.97
302_C311_G1.1410.97
444_L449_A1.1410.97
123_Y128_V1.1400.97
303_I334_L1.1350.97
348_S386_S1.1320.97
50_F53_K1.1260.96
194_V225_V1.1230.96
347_I437_I1.1190.96
186_I198_L1.1190.96
365_K396_N1.1080.96
366_A369_A1.1020.96
189_P192_V1.0900.96
45_Q48_L1.0810.96
76_D324_H1.0740.95
176_N245_V1.0650.95
203_R232_T1.0620.95
355_T389_I1.0560.95
394_I399_I1.0540.95
295_L324_H1.0530.95
256_C284_M1.0470.95
279_E282_A1.0440.95
144_K148_S1.0430.95
253_G308_G1.0370.94
287_I314_L1.0300.94
57_H167_P1.0300.94
141_I192_V1.0290.94
423_I431_M1.0280.94
449_A453_N1.0270.94
118_G123_Y1.0260.94
278_C302_C1.0240.94
251_K279_E1.0220.94
218_I249_I1.0220.94
97_E101_Q1.0180.94
144_K152_E1.0170.94
191_G253_G1.0140.94
299_Y328_G1.0090.94
162_A214_R1.0040.93
144_K149_A1.0040.93
361_H395_L1.0020.93
138_A141_I1.0000.93
47_M180_W0.9980.93
360_V369_A0.9960.93
298_K327_A0.9910.93
277_V303_I0.9880.93
289_G452_M0.9870.93
280_E306_G0.9870.93
142_V185_F0.9840.93
76_D295_L0.9810.93
377_T388_T0.9790.93
212_F243_S0.9790.93
336_P367_E0.9780.92
229_E258_Y0.9760.92
308_G335_A0.9670.92
392_N401_L0.9650.92
146_T150_L0.9620.92
143_F198_L0.9580.92
52_L56_E0.9550.92
257_R285_E0.9520.91
62_P171_K0.9500.91
388_T407_V0.9490.91
214_R245_V0.9490.91
124_E127_V0.9490.91
302_C313_T0.9390.91
140_G192_V0.9380.91
220_D251_K0.9360.91
160_H249_I0.9300.90
304_L335_A0.9270.90
247_E275_R0.9260.90
258_Y286_W0.9230.90
342_I360_V0.9210.90
278_C311_G0.9160.90
117_A120_S0.9160.90
332_I361_H0.9150.90
58_F171_K0.9090.89
188_V194_V0.9040.89
373_I392_N0.9030.89
161_W180_W0.9000.89
202_F229_E0.8990.89
104_D113_Q0.8980.89
338_T369_A0.8950.89
215_T246_V0.8880.88
177_S214_R0.8880.88
362_F373_I0.8880.88
149_A157_F0.8860.88
161_W216_L0.8860.88
47_M161_W0.8850.88
122_Q125_S0.8830.88
362_F393_E0.8820.88
328_G357_R0.8820.88
73_L76_D0.8820.88
260_T272_V0.8720.87
380_M416_F0.8690.87
348_S354_V0.8670.87
359_I393_E0.8640.87
394_I398_N0.8640.87
65_Q68_G0.8630.87
373_I401_L0.8620.87
118_G121_A0.8580.87
320_G350_Q0.8580.87
351_G384_S0.8560.86
170_N299_Y0.8530.86
95_V100_K0.8500.86
219_V250_V0.8450.86
217_I248_I0.8450.86
324_H353_K0.8450.86
294_K322_G0.8440.86
160_H216_L0.8430.86
202_F215_T0.8410.85
392_N399_I0.8360.85
213_E244_A0.8340.85
108_I111_A0.8330.85
153_N185_F0.8270.84
216_L249_I0.8220.84
74_N78_I0.8210.84
49_D52_L0.8200.84
231_C270_N0.8200.84
396_N399_I0.8190.84
216_L247_E0.8160.84
57_H168_T0.8130.83
418_L432_I0.8110.83
190_K252_K0.8100.83
75_F172_F0.8100.83
189_P218_I0.8070.83
309_A336_P0.8070.83
141_I194_V0.8060.83
296_T325_Q0.8050.83
370_R400_S0.8040.83
349_K381_D0.8000.82
153_N156_I0.8000.82
188_V223_A0.8000.82
260_T270_N0.7990.82
320_G323_Q0.7970.82
357_R391_Y0.7960.82
391_Y395_L0.7950.82
221_E253_G0.7910.82
359_I391_Y0.7910.82
260_T264_W0.7900.82
71_N297_M0.7890.82
253_G280_E0.7870.81
362_F370_R0.7830.81
292_G296_T0.7810.81
117_A121_A0.7790.81
342_I345_K0.7780.81
391_Y402_E0.7760.81
299_Y357_R0.7750.80
334_L365_K0.7740.80
204_I211_Q0.7720.80
116_L121_A0.7710.80
123_Y127_V0.7690.80
362_F394_I0.7680.80
191_G221_E0.7680.80
229_E260_T0.7640.79
146_T157_F0.7580.79
378_L433_V0.7560.79
348_S384_S0.7560.79
329_A342_I0.7560.79
185_F218_I0.7550.79
368_G396_N0.7540.79
304_L408_S0.7510.78
54_S174_A0.7510.78
162_A216_L0.7490.78
170_N273_T0.7470.78
319_A348_S0.7470.78
351_G381_D0.7470.78
329_A344_S0.7450.78
163_K247_E0.7450.78
262_Q323_Q0.7450.78
121_A124_E0.7420.77
305_K335_A0.7390.77
328_G377_T0.7390.77
51_R174_A0.7360.77
217_I225_V0.7360.77
50_F158_R0.7330.77
347_I378_L0.7290.76
330_K361_H0.7290.76
172_F271_L0.7250.76
214_R247_E0.7210.75
335_A365_K0.7200.75
122_Q129_Y0.7190.75
99_I103_F0.7170.75
313_T331_M0.7160.75
367_E397_D0.7160.75
378_L385_T0.7150.75
104_D282_A0.7140.75
125_S128_V0.7110.74
369_A401_L0.7100.74
394_I401_L0.7090.74
119_V123_Y0.7090.74
118_G202_F0.7070.74
423_I428_A0.7070.74
410_V429_T0.7060.74
337_N367_E0.7050.74
120_S124_E0.7040.74
54_S167_P0.7040.74
248_I284_M0.7040.74
402_E408_S0.7020.74
175_L447_E0.7020.74
197_P378_L0.7020.74
55_L179_V0.7010.73
162_A177_S0.7000.73
350_Q381_D0.7000.73
240_S264_W0.7000.73
273_T301_A0.6990.73
314_L443_E0.6990.73
298_K344_S0.6980.73
177_S245_V0.6980.73
276_T302_C0.6910.72
118_G128_V0.6880.72
396_N406_K0.6840.72
366_A396_N0.6840.72
318_L349_K0.6830.71
274_K298_K0.6830.71
251_K282_A0.6820.71
207_E238_T0.6810.71
96_P140_G0.6800.71
257_R445_P0.6800.71
252_K282_A0.6770.71
359_I373_I0.6770.71
280_E337_N0.6760.71
364_R383_K0.6750.71
126_E198_L0.6740.70
357_R386_S0.6730.70
100_K103_F0.6700.70
371_S401_L0.6690.70
242_H264_W0.6690.70
252_K308_G0.6690.70
364_R395_L0.6660.70
326_D357_R0.6640.69
318_L456_I0.6630.69
438_E453_N0.6620.69
406_K439_P0.6600.69
362_F399_I0.6600.69
276_T282_A0.6600.69
278_C309_A0.6590.69
346_S354_V0.6580.69
160_H185_F0.6580.69
371_S377_T0.6570.69
144_K153_N0.6550.68
95_V103_F0.6550.68
121_A127_V0.6530.68
189_P220_D0.6530.68
302_C408_S0.6530.68
274_K300_P0.6520.68
78_I81_Y0.6510.68
157_F185_F0.6500.68
237_T267_N0.6500.68
344_S356_Y0.6500.68
312_M341_T0.6490.68
304_L309_A0.6490.68
381_D384_S0.6460.67
331_M340_S0.6450.67
334_L361_H0.6440.67
66_W77_E0.6430.67
262_Q292_G0.6420.67
401_L404_E0.6410.67
313_T371_S0.6400.66
418_L423_I0.6390.66
53_K167_P0.6390.66
119_V205_N0.6380.66
156_I159_E0.6370.66
176_N243_S0.6370.66
389_I402_E0.6350.66
111_A114_K0.6350.66
139_Q194_V0.6340.66
447_E450_V0.6340.66
368_G397_D0.6340.66
262_Q288_D0.6320.66
315_S327_A0.6310.65
121_A128_V0.6300.65
120_S128_V0.6300.65
149_A153_N0.6290.65
188_V227_Y0.6290.65
333_H363_G0.6290.65
114_K196_T0.6280.65
367_E400_S0.6280.65
183_G215_T0.6270.65
149_A156_I0.6260.65
284_M302_C0.6240.65
395_L408_S0.6240.65
369_A396_N0.6230.64
275_R405_A0.6220.64
394_I397_D0.6210.64
246_V258_Y0.6200.64
371_S375_C0.6190.64
146_T185_F0.6190.64
364_R367_E0.6190.64
43_E52_L0.6180.64
308_G339_S0.6180.64
214_R408_S0.6150.63
150_L157_F0.6150.63
156_I185_F0.6140.63
310_R341_T0.6120.63
115_Y128_V0.6120.63
174_A247_E0.6090.63
262_Q293_S0.6080.63
43_E48_L0.6070.62
307_E368_G0.6060.62
71_N74_N0.6050.62
225_V250_V0.6050.62
150_L161_W0.6040.62
132_M139_Q0.6020.62
45_Q85_S0.6010.62
210_G345_K0.6010.62
246_V287_I0.6010.62
318_L459_E0.6010.62
138_A195_E0.6000.62
58_F62_P0.5990.61
54_S57_H0.5980.61
249_I277_V0.5980.61
119_V127_V0.5970.61
272_V288_D0.5970.61
108_I217_I0.5960.61
50_F54_S0.5960.61
376_D406_K0.5960.61
406_K437_I0.5950.61
42_E45_Q0.5950.61
132_M137_E0.5930.61
353_K384_S0.5920.61
346_S375_C0.5920.61
249_I279_E0.5910.60
140_G189_P0.5900.60
119_V128_V0.5900.60
266_N321_K0.5890.60
57_H62_P0.5890.60
408_S411_S0.5880.60
156_I187_Y0.5880.60
438_E442_K0.5870.60
454_R457_K0.5870.60
401_L411_S0.5860.60
184_S215_T0.5850.60
324_H344_S0.5850.60
336_P342_I0.5850.60
377_T409_K0.5840.59
452_M460_M0.5840.59
379_I389_I0.5840.59
149_A183_G0.5810.59
108_I113_Q0.5810.59
169_D275_R0.5800.59
231_C260_T0.5780.59
204_I242_H0.5760.58
94_E98_E0.5760.58
336_P366_A0.5750.58
328_G437_I0.5740.58
328_G388_T0.5740.58
262_Q290_N0.5730.58
223_A254_G0.5680.57
217_I409_K0.5680.57
358_G393_E0.5680.57
227_Y246_V0.5670.57
56_E207_E0.5670.57
80_Y203_R0.5660.57
186_I255_Y0.5650.57
141_I225_V0.5650.57
252_K309_A0.5650.57
193_K310_R0.5640.57
153_N160_H0.5620.57
58_F174_A0.5620.57
298_K408_S0.5610.56
320_G349_K0.5580.56
259_T445_P0.5580.56
199_Q407_V0.5580.56
171_K174_A0.5580.56
405_A433_V0.5570.56
403_H417_Y0.5570.56
279_E309_A0.5570.56
343_V374_E0.5560.56
142_V160_H0.5560.56
204_I268_V0.5550.56
116_L120_S0.5550.56
146_T180_W0.5530.55
328_G371_S0.5530.55
62_P71_N0.5530.55
328_G375_C0.5520.55
42_E57_H0.5510.55
175_L212_F0.5500.55
357_R377_T0.5500.55
333_H395_L0.5490.55
230_G263_N0.5480.55
300_P303_I0.5480.55
327_A388_T0.5470.55
288_D300_P0.5460.54
160_H247_E0.5460.54
290_N298_K0.5460.54
309_A334_L0.5450.54
206_S209_M0.5440.54
231_C242_H0.5440.54
141_I230_G0.5440.54
375_C404_E0.5430.54
44_P150_L0.5420.54
396_N404_E0.5420.54
195_E217_I0.5410.54
291_I459_E0.5410.54
197_P226_H0.5410.54
389_I397_D0.5390.54
71_N367_E0.5390.54
285_E312_M0.5390.54
103_F121_A0.5380.53
277_V302_C0.5380.53
418_L459_E0.5370.53
297_M404_E0.5360.53
51_R54_S0.5360.53
175_L179_V0.5350.53
399_I421_R0.5350.53
121_A125_S0.5340.53
247_E306_G0.5330.53
362_F397_D0.5320.53
52_L91_S0.5320.53
193_K255_Y0.5320.53
191_G334_L0.5310.52
300_P433_V0.5300.52
161_W292_G0.5300.52
160_H251_K0.5280.52
281_N307_E0.5280.52
251_K254_G0.5280.52
72_S269_Y0.5270.52
342_I369_A0.5260.52
97_E100_K0.5250.52
242_H270_N0.5250.52
393_E396_N0.5250.52
254_G282_A0.5250.52
416_F420_S0.5250.52
124_E205_N0.5240.51
137_E140_G0.5240.51
441_T456_I0.5230.51
202_F414_Q0.5230.51
340_S360_V0.5220.51
317_A409_K0.5220.51
248_I276_T0.5200.51
96_P99_I0.5200.51
127_V228_V0.5190.51
333_H393_E0.5190.51
396_N401_L0.5180.51
350_Q380_M0.5180.51
371_S392_N0.5180.51
342_I373_I0.5180.51
220_D223_A0.5180.51
301_A330_K0.5170.51
299_Y373_I0.5170.51
297_M396_N0.5160.50
132_M141_I0.5160.50
328_G344_S0.5160.50
350_Q384_S0.5160.50
345_K456_I0.5150.50
54_S178_A0.5150.50
103_F106_L0.5150.50
104_D107_G0.5140.50
94_E100_K0.5130.50
59_Y150_L0.5130.50
119_V203_R0.5130.50
397_D400_S0.5120.50
233_A240_S0.5120.50
98_E208_N0.5120.50
297_M326_D0.5110.50
93_D424_S0.5110.50
323_Q350_Q0.5110.50
377_T389_I0.5100.50
50_F167_P0.5100.50
120_S130_H0.5100.50
356_Y389_I0.5100.50
290_N317_A0.5100.50
273_T299_Y0.5090.49
186_I239_N0.5090.49
201_Y234_P0.5080.49
379_I386_S0.5080.49
86_E241_L0.5080.49
361_H393_E0.5070.49
434_M457_K0.5070.49
322_G350_Q0.5070.49
270_N296_T0.5070.49
281_N458_F0.5060.49
340_S371_S0.5060.49
195_E226_H0.5060.49
221_E282_A0.5050.49
49_D60_N0.5050.49
55_L148_S0.5050.49
83_K331_M0.5050.49
271_L297_M0.5050.49
317_A327_A0.5040.49
169_D173_A0.5040.49
53_K168_T0.5040.49
82_V341_T0.5030.49
350_Q458_F0.5020.49
91_S447_E0.5010.48
207_E236_Y0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.8796 100 0.236 Contact Map
4dn7A 2 0.871 100 0.31 Contact Map
4xfmA 2 0.1527 63.9 0.969 Contact Map
3dqqA 2 0.1634 43.4 0.972 Contact Map
1yzyA 1 0.1548 33.8 0.974 Contact Map
1rq8A 1 0.1183 24.8 0.976 Contact Map
3uknA 2 0.1118 24.5 0.976 Contact Map
4xg0A 2 0.157 18.7 0.977 Contact Map
1ifyA 1 0.0925 17.4 0.977 Contact Map
4edgA 1 0.1742 16.8 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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