GREMLIN Database
YURR - Uncharacterized oxidoreductase YurR
UniProt: O32159 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (342)
Sequences: 26155 (18755)
Seq/√Len: 1014.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_A169_A5.0831.00
5_I188_V3.3221.00
3_S198_D3.1061.00
5_I197_A3.0111.00
32_R176_A2.9081.00
176_A191_D2.8871.00
70_K88_R2.8791.00
28_T172_I2.8711.00
232_E300_A2.6881.00
179_L189_Q2.6581.00
3_S26_R2.6471.00
125_S128_E2.6221.00
4_Y20_L2.5131.00
25_A354_L2.4821.00
5_I30_I2.3951.00
21_A167_R2.3911.00
64_G347_A2.3791.00
22_K75_Q2.3781.00
30_I195_F2.2421.00
21_A169_A2.1801.00
26_R170_T2.1461.00
19_H347_A2.1061.00
120_D147_G2.1051.00
4_Y25_A2.0991.00
128_E131_K2.0921.00
199_A329_Y2.0851.00
122_T128_E2.0601.00
16_T201_I2.0481.00
129_T142_S2.0201.00
226_A309_R1.9841.00
23_T354_L1.9671.00
18_Y163_A1.9521.00
14_A157_C1.9421.00
122_T146_S1.9381.00
351_K356_K1.9141.00
334_L345_L1.9091.00
14_A161_L1.9071.00
331_A345_L1.9051.00
71_D75_Q1.9011.00
5_I195_F1.8591.00
85_G155_A1.8461.00
23_T356_K1.8371.00
283_H287_S1.8301.00
105_E123_R1.8101.00
331_A349_L1.7971.00
187_G196_A1.7931.00
109_Y113_E1.7901.00
68_Y347_A1.7801.00
22_K167_R1.7731.00
19_H346_G1.7401.00
18_Y22_K1.7361.00
21_A164_A1.7171.00
35_P173_K1.7101.00
163_A166_K1.7101.00
329_Y353_V1.7081.00
329_Y349_L1.6961.00
208_A332_N1.6541.00
187_G194_Q1.6271.00
126_A130_K1.6211.00
163_A167_R1.6181.00
178_L191_D1.6131.00
201_I353_V1.6111.00
105_E109_Y1.5901.00
109_Y112_R1.5831.00
68_Y71_D1.5831.00
108_A112_R1.5831.00
19_H23_T1.5631.00
162_S165_E1.5491.00
12_L331_A1.5481.00
162_S166_K1.5431.00
12_L334_L1.5341.00
202_V208_A1.5301.00
34_E174_G1.5261.00
178_L189_Q1.5031.00
152_N155_A1.4981.00
232_E302_V1.4871.00
161_L165_E1.4871.00
199_A353_V1.4851.00
16_T331_A1.4751.00
64_G67_R1.4731.00
161_L171_V1.4701.00
231_F234_T1.4641.00
23_T350_A1.4551.00
19_H22_K1.4441.00
190_T195_F1.4391.00
34_E173_K1.4371.00
102_D105_E1.4351.00
9_A35_P1.4321.00
181_E186_T1.4301.00
28_T195_F1.4241.00
286_L290_L1.4221.00
3_S28_T1.4191.00
189_Q194_Q1.4181.00
202_V328_L1.4181.00
101_L105_E1.4151.00
3_S25_A1.4111.00
23_T351_K1.4081.00
9_A29_V1.4031.00
177_S188_V1.3891.00
190_T193_K1.3801.00
86_Y149_A1.3711.00
35_P161_L1.3701.00
202_V330_A1.3671.00
69_Y156_L1.3671.00
90_G144_H1.3411.00
5_I28_T1.3301.00
282_Q304_T1.3301.00
124_L128_E1.3201.00
67_R71_D1.3171.00
20_L350_A1.3141.00
172_I175_N1.3121.00
11_I342_G1.3121.00
7_V204_A1.3021.00
101_L141_E1.2911.00
4_Y199_A1.2901.00
279_A283_H1.2871.00
15_S19_H1.2871.00
30_I197_A1.2861.00
127_S131_K1.2711.00
322_V330_A1.2551.00
33_K37_Q1.2541.00
122_T144_H1.2541.00
197_A200_V1.2501.00
70_K74_H1.2421.00
347_A351_K1.2401.00
329_Y352_L1.2341.00
6_I17_A1.2301.00
346_G350_A1.2301.00
41_A305_R1.2271.00
204_A211_I1.2161.00
17_A27_V1.2071.00
331_A334_L1.1981.00
14_A164_A1.1981.00
204_A208_A1.1941.00
28_T170_T1.1931.00
175_N190_T1.1901.00
14_A29_V1.1901.00
71_D74_H1.1861.00
124_L132_L1.1841.00
348_E351_K1.1821.00
128_E132_L1.1811.00
90_G146_S1.1621.00
184_T187_G1.1571.00
182_N185_V1.1421.00
154_R158_R1.1331.00
95_H104_M1.1311.00
241_W244_V1.1301.00
56_Q60_Q1.1301.00
106_E109_Y1.1281.00
273_D276_R1.1271.00
98_A102_D1.1241.00
185_V196_A1.1241.00
18_Y167_R1.1231.00
66_A70_K1.1141.00
7_V200_V1.1061.00
108_A143_V1.1041.00
199_A321_A1.1011.00
101_L123_R1.0941.00
15_S160_L1.0871.00
108_A123_R1.0861.00
321_A326_Q1.0861.00
262_A289_A1.0851.00
182_N187_G1.0801.00
30_I172_I1.0781.00
9_A31_D1.0741.00
16_T203_T1.0491.00
17_A29_V1.0451.00
138_D141_E1.0451.00
63_K67_R1.0301.00
29_V171_V1.0201.00
211_I214_P1.0181.00
319_V345_L1.0171.00
210_E213_K1.0131.00
72_L76_L1.0121.00
288_K291_A1.0111.00
122_T132_L1.0111.00
65_G69_Y1.0091.00
20_L25_A1.0051.00
151_V156_L1.0031.00
16_T346_G1.0011.00
98_A141_E1.0001.00
120_D146_S0.9991.00
278_T281_G0.9981.00
102_D106_E0.9971.00
240_S243_V0.9931.00
156_L343_P0.9851.00
15_S342_G0.9801.00
151_V339_L0.9741.00
132_L144_H0.9681.00
259_R302_V0.9601.00
180_F200_V0.9581.00
202_V212_L0.9561.00
15_S346_G0.9551.00
159_S163_A0.9531.00
76_L163_A0.9511.00
287_S290_L0.9461.00
30_I190_T0.9461.00
64_G344_F0.9431.00
25_A199_A0.9421.00
30_I177_S0.9381.00
185_V198_D0.9381.00
64_G68_Y0.9341.00
82_S159_S0.9331.00
6_I16_T0.9331.00
287_S291_A0.9321.00
186_T328_L0.9321.00
199_A327_G0.9311.00
184_T326_Q0.9291.00
112_R121_I0.9281.00
92_I129_T0.9271.00
186_T327_G0.9231.00
36_G157_C0.9221.00
203_T331_A0.9211.00
97_D100_K0.9201.00
251_Y254_S0.9161.00
14_A171_V0.9151.00
27_V169_A0.9111.00
282_Q286_L0.9071.00
179_L214_P0.9041.00
17_A169_A0.9041.00
224_Q311_F0.8981.00
65_G68_Y0.8951.00
199_A202_V0.8911.00
69_Y342_G0.8911.00
159_S162_S0.8911.00
350_A353_V0.8901.00
156_L339_L0.8891.00
73_I84_T0.8781.00
23_T347_A0.8761.00
88_R147_G0.8761.00
83_D155_A0.8671.00
58_W62_A0.8601.00
250_Q254_S0.8581.00
227_Q267_E0.8581.00
32_R175_N0.8531.00
87_K150_R0.8511.00
290_L297_A0.8511.00
284_E288_K0.8511.00
321_A352_L0.8481.00
35_P171_V0.8481.00
23_T355_G0.8471.00
239_G242_P0.8471.00
321_A329_Y0.8461.00
232_E259_R0.8441.00
312_T333_G0.8441.00
242_P245_M0.8431.00
186_T200_V0.8411.00
230_H261_V0.8401.00
69_Y73_I0.8381.00
172_I195_F0.8381.00
175_N191_D0.8351.00
4_Y201_I0.8331.00
85_G152_N0.8331.00
17_A164_A0.8291.00
250_Q253_L0.8281.00
181_E185_V0.8271.00
230_H303_E0.8241.00
44_G153_G0.8211.00
225_K267_E0.8201.00
19_H68_Y0.8141.00
155_A158_R0.8131.00
231_F262_A0.8051.00
124_L129_T0.8031.00
11_I39_T0.8031.00
115_A120_D0.8021.00
164_A168_G0.8001.00
62_A66_A0.7981.00
175_N192_T0.7981.00
284_E287_S0.7961.00
41_A307_G0.7951.00
229_M301_A0.7941.00
29_V169_A0.7921.00
156_L160_L0.7921.00
18_Y160_L0.7891.00
221_V310_P0.7871.00
47_C337_S0.7851.00
200_V327_G0.7831.00
337_S340_T0.7791.00
38_A206_A0.7771.00
11_I157_C0.7771.00
127_S130_K0.7771.00
180_F188_V0.7711.00
95_H101_L0.7691.00
239_G243_V0.7671.00
175_N195_F0.7631.00
319_V323_P0.7601.00
15_S156_L0.7531.00
212_L330_A0.7481.00
104_M108_A0.7471.00
225_K306_V0.7441.00
69_Y343_P0.7431.00
130_K137_A0.7421.00
39_T42_A0.7421.00
164_A171_V0.7401.00
290_L298_D0.7361.00
16_T349_L0.7351.00
65_G344_F0.7351.00
157_C161_L0.7311.00
319_V349_L0.7301.00
92_I142_S0.7301.00
20_L353_V0.7291.00
16_T353_V0.7261.00
47_C340_T0.7181.00
267_E281_G0.7171.00
230_H259_R0.7151.00
231_F301_A0.7141.00
92_I124_L0.7121.00
325_V328_L0.7111.00
212_L215_L0.7101.00
7_V202_V0.7081.00
177_S180_F0.7051.00
252_I255_F0.7041.00
19_H350_A0.7041.00
312_T335_G0.7021.00
320_G323_P0.7021.00
312_T318_V0.7001.00
32_R207_W0.6991.00
165_E171_V0.6971.00
15_S343_P0.6961.00
322_V325_V0.6961.00
21_A26_R0.6951.00
73_I76_L0.6951.00
29_V161_L0.6941.00
238_T242_P0.6931.00
11_I339_L0.6931.00
223_F308_F0.6891.00
185_V200_V0.6891.00
57_D62_A0.6871.00
22_K163_A0.6851.00
108_A121_I0.6831.00
207_W210_E0.6821.00
350_A354_L0.6801.00
111_R116_P0.6791.00
129_T143_V0.6791.00
198_D327_G0.6791.00
238_T241_W0.6791.00
110_K113_E0.6771.00
126_A129_T0.6771.00
286_L304_T0.6771.00
176_A179_L0.6731.00
60_Q63_K0.6731.00
91_A148_A0.6721.00
103_K106_E0.6701.00
62_A65_G0.6691.00
46_V86_Y0.6671.00
201_I349_L0.6671.00
39_T157_C0.6651.00
321_A327_G0.6651.00
213_K218_H0.6641.00
69_Y72_L0.6611.00
3_S196_A0.6601.00
32_R37_Q0.6571.00
334_L342_G0.6561.00
26_R198_D0.6491.00
251_Y263_G0.6481.00
178_L190_T0.6481.00
145_I148_A0.6461.00
229_M285_V0.6451.00
3_S197_A0.6421.00
5_I200_V0.6411.00
344_F347_A0.6411.00
265_T309_R0.6401.00
165_E170_T0.6401.00
18_Y164_A0.6401.00
174_G192_T0.6391.00
283_H286_L0.6331.00
245_M248_S0.6321.00
180_F186_T0.6291.00
29_V164_A0.6291.00
12_L345_L0.6281.00
226_A265_T0.6261.00
92_I144_H0.6221.00
228_I305_R0.6211.00
351_K355_G0.6211.00
270_A273_D0.6191.00
241_W245_M0.6181.00
59_Y63_K0.6181.00
155_A159_S0.6171.00
82_S85_G0.6171.00
190_T194_Q0.6151.00
31_D173_K0.6141.00
69_Y76_L0.6141.00
112_R120_D0.6131.00
161_L173_K0.6101.00
53_R56_Q0.6081.00
68_Y343_P0.6081.00
280_G283_H0.6081.00
105_E108_A0.6081.00
160_L342_G0.6071.00
290_L296_L0.6061.00
288_K292_V0.6051.00
67_R70_K0.6001.00
106_E110_K0.5991.00
266_H336_A0.5991.00
28_T197_A0.5981.00
62_A68_Y0.5971.00
317_P320_G0.5961.00
310_P334_L0.5951.00
158_R162_S0.5951.00
240_S244_V0.5941.00
265_T281_G0.5941.00
181_E184_T0.5911.00
181_E325_V0.5881.00
60_Q64_G0.5881.00
344_F348_E0.5871.00
191_D194_Q0.5871.00
143_V146_S0.5871.00
111_R121_I0.5851.00
342_G346_G0.5851.00
125_S131_K0.5841.00
186_T189_Q0.5841.00
31_D34_E0.5831.00
62_A69_Y0.5821.00
244_V247_P0.5811.00
238_T244_V0.5801.00
19_H72_L0.5791.00
320_G330_A0.5781.00
43_A251_Y0.5771.00
62_A341_M0.5761.00
239_G244_V0.5751.00
206_A308_F0.5751.00
224_Q266_H0.5741.00
331_A346_G0.5721.00
129_T132_L0.5721.00
68_Y72_L0.5711.00
68_Y344_F0.5681.00
121_I145_I0.5671.00
21_A27_V0.5671.00
30_I175_N0.5661.00
123_R143_V0.5661.00
220_Q313_P0.5651.00
242_P247_P0.5631.00
343_P346_G0.5621.00
180_F215_L0.5601.00
181_E327_G0.5591.00
61_L65_G0.5591.00
229_M282_Q0.5581.00
61_L348_E0.5571.00
188_V200_V0.5571.00
46_V151_V0.5561.00
56_Q113_E0.5541.00
63_K66_A0.5541.00
208_A221_V0.5531.00
3_S195_F0.5511.00
125_S129_T0.5501.00
6_I27_V0.5501.00
334_L338_G0.5501.00
110_K114_D0.5481.00
187_G200_V0.5461.00
232_E235_D0.5461.00
227_Q306_V0.5441.00
48_P145_I0.5441.00
88_R149_A0.5441.00
5_I198_D0.5421.00
309_R334_L0.5411.00
181_E187_G0.5391.00
129_T139_G0.5371.00
57_D60_Q0.5361.00
201_I329_Y0.5351.00
135_I295_G0.5351.00
250_Q255_F0.5341.00
294_P297_A0.5331.00
351_K357_Q0.5321.00
242_P246_P0.5321.00
296_L299_A0.5321.00
42_A339_L0.5311.00
84_T159_S0.5291.00
25_A353_V0.5261.00
164_A167_R0.5261.00
130_K138_D0.5251.00
46_V340_T0.5241.00
175_N193_K0.5241.00
349_L352_L0.5241.00
261_V265_T0.5241.00
186_T325_V0.5231.00
254_S258_G0.5231.00
227_Q278_T0.5221.00
38_A309_R0.5221.00
240_S245_M0.5211.00
59_Y62_A0.5191.00
45_I148_A0.5191.00
9_A161_L0.5181.00
277_V304_T0.5161.00
58_W337_S0.5151.00
311_F336_A0.5151.00
289_A293_A0.5141.00
7_V177_S0.5141.00
286_L301_A0.5131.00
107_R110_K0.5131.00
221_V332_N0.5121.00
182_N196_A0.5121.00
189_Q192_T0.5121.00
227_Q281_G0.5111.00
180_F328_L0.5101.00
133_F136_L0.5101.00
111_R114_D0.5091.00
31_D171_V0.5091.00
153_G339_L0.5081.00
92_I132_L0.5071.00
71_D347_A0.5061.00
11_I156_L0.5051.00
43_A253_L0.5051.00
18_Y21_A0.5051.00
206_A223_F0.5051.00
202_V211_I0.5031.00
297_A300_A0.5031.00
58_W69_Y0.5031.00
252_I256_D0.5021.00
187_G190_T0.5021.00
65_G72_L0.5021.00
286_L298_D0.5011.00
38_A310_P0.5011.00
124_L142_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.9624 100 0.26 Contact Map
1y56B 1 0.9624 100 0.298 Contact Map
4x9mA 1 0.9785 100 0.303 Contact Map
3axbA 2 0.9597 100 0.306 Contact Map
1ryiA 4 0.9597 100 0.307 Contact Map
2gf3A 1 0.9677 100 0.311 Contact Map
2gagB 1 0.9651 100 0.313 Contact Map
3pvcA 1 0.9516 100 0.325 Contact Map
3ps9A 1 0.957 100 0.329 Contact Map
4rslA 1 0.9489 100 0.333 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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