GREMLIN Database
FRLB - Fructosamine deglycase FrlB
UniProt: O32157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (302)
Sequences: 5364 (3173)
Seq/√Len: 182.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_D74_K4.6361.00
105_A118_A4.0701.00
94_A117_E3.7451.00
179_A308_E3.1551.00
29_F39_M3.1501.00
134_N137_Y3.1131.00
172_E176_K2.9351.00
97_R119_Q2.7411.00
80_C145_F2.7261.00
228_A258_E2.6311.00
171_Y300_R2.5971.00
138_G206_V2.5171.00
26_H56_D2.5131.00
39_M80_C2.5091.00
187_K312_E2.4861.00
79_L93_A2.4771.00
95_F98_G2.4491.00
210_Y302_L2.4341.00
247_I262_L2.2661.00
42_S145_F2.2101.00
211_S223_S2.2081.00
24_I76_L2.1991.00
156_K159_Q2.1261.00
25_D72_G2.1091.00
311_E317_L2.1071.00
81_S114_L2.0331.00
154_N157_F2.0261.00
178_E181_N1.9881.00
163_G290_K1.9461.00
124_Y140_L1.9401.00
36_S40_Y1.9331.00
173_K176_K1.9181.00
77_V101_A1.9101.00
190_E312_E1.9101.00
76_L104_I1.8961.00
93_A114_L1.8941.00
188_A271_K1.8371.00
252_D291_G1.8081.00
150_V160_A1.8051.00
59_S227_H1.7761.00
166_Q170_V1.7641.00
138_G299_N1.7391.00
43_K47_D1.7241.00
208_Y225_A1.6961.00
107_T115_A1.6921.00
28_F75_S1.6881.00
95_F99_K1.6691.00
102_L120_Y1.6661.00
85_N113_P1.6591.00
26_H54_N1.6391.00
91_K94_A1.6181.00
115_A121_V1.6061.00
45_V146_G1.5911.00
46_F55_S1.5891.00
216_M224_H1.5821.00
27_V76_L1.5751.00
248_L302_L1.5721.00
170_V297_V1.5621.00
110_P123_Q1.5591.00
34_G134_N1.5401.00
58_Y66_R1.5381.00
72_G75_S1.5261.00
204_Y208_Y1.5251.00
163_G170_V1.5151.00
43_K56_D1.5011.00
180_D183_K1.4991.00
308_E312_E1.4831.00
162_E165_D1.4801.00
166_Q169_A1.4741.00
183_K308_E1.4701.00
249_L262_L1.4551.00
185_F273_T1.4551.00
193_S240_D1.4481.00
71_L101_A1.4421.00
183_K187_K1.4351.00
77_V96_A1.4321.00
30_V77_V1.4301.00
46_F149_Q1.4281.00
103_T118_A1.4181.00
48_R67_N1.4071.00
286_D298_L1.4051.00
278_A282_F1.4051.00
181_N184_Q1.4021.00
193_S242_S1.3971.00
249_L255_R1.3841.00
29_F55_S1.3781.00
52_S70_Q1.3731.00
278_A288_S1.3711.00
28_F63_F1.3701.00
79_L103_T1.3611.00
174_A297_V1.3541.00
46_F152_E1.3521.00
87_P91_K1.3411.00
169_A172_E1.3211.00
27_V78_I1.3151.00
151_L154_N1.2931.00
26_H72_G1.2791.00
167_L296_L1.2741.00
30_V63_F1.2721.00
263_T266_K1.2601.00
280_Y283_T1.2591.00
253_E291_G1.2501.00
52_S67_N1.2461.00
246_I305_Y1.2451.00
174_A178_E1.2421.00
96_A101_A1.2321.00
40_Y208_Y1.2271.00
111_E115_A1.2231.00
189_H305_Y1.2211.00
26_H75_S1.2081.00
179_A183_K1.2061.00
210_Y248_L1.1841.00
304_S308_E1.1781.00
142_Q296_L1.1781.00
162_E166_Q1.1731.00
206_V299_N1.1681.00
209_S213_C1.1651.00
49_E292_Y1.1651.00
232_F264_F1.1651.00
105_A114_L1.1641.00
150_V157_F1.1631.00
255_R259_E1.1621.00
245_F265_S1.1591.00
156_K160_A1.1511.00
97_R103_T1.1391.00
159_Q290_K1.1281.00
150_V153_N1.1241.00
102_L119_Q1.1231.00
63_F71_L1.1211.00
161_I165_D1.1191.00
106_M145_F1.1161.00
105_A121_V1.1111.00
29_F78_I1.1101.00
184_Q187_K1.1091.00
250_G298_L1.1031.00
203_N294_A1.1031.00
18_D102_L1.1001.00
23_T74_K1.0941.00
40_Y57_L1.0931.00
127_G136_N1.0921.00
239_I245_F1.0911.00
79_L89_T1.0831.00
194_I222_H1.0791.00
310_A315_H1.0731.00
198_M231_Y1.0731.00
316_P319_H1.0681.00
170_V173_K1.0581.00
97_R117_E1.0531.00
305_Y309_L1.0301.00
143_I296_L1.0301.00
265_S270_K1.0291.00
193_S313_R1.0241.00
157_F161_I1.0200.99
245_F270_K1.0160.99
197_T215_L1.0110.99
240_D321_R1.0110.99
156_K290_K1.0100.99
124_Y141_Y1.0090.99
159_Q163_G1.0040.99
90_V94_A1.0000.99
307_D311_E1.0000.99
93_A118_A0.9950.99
195_I215_L0.9890.99
75_S101_A0.9790.99
178_E182_A0.9780.99
170_V289_V0.9770.99
203_N298_L0.9680.99
197_T246_I0.9630.99
25_D75_S0.9600.99
138_G205_G0.9600.99
207_A248_L0.9540.99
79_L96_A0.9500.99
32_C60_A0.9460.99
110_P121_V0.9440.99
133_I218_M0.9440.99
32_C86_T0.9420.99
186_A305_Y0.9370.99
262_L272_L0.9320.99
110_P125_D0.9320.99
36_S59_S0.9300.99
198_M265_S0.9290.99
24_I75_S0.9190.99
262_L274_V0.9170.99
106_M144_V0.9150.99
248_L298_L0.9120.99
47_D66_R0.9110.99
275_L286_D0.9090.99
158_E162_E0.9050.99
64_I91_K0.9040.99
78_I104_I0.9020.99
31_A35_S0.9000.99
264_F268_Y0.8980.99
251_L255_R0.8960.99
220_W321_R0.8920.99
111_E116_Q0.8910.99
94_A98_G0.8870.99
24_I102_L0.8850.99
167_L297_V0.8840.99
42_S149_Q0.8810.99
153_N157_F0.8810.99
277_A288_S0.8730.98
163_G166_Q0.8720.98
32_C230_E0.8700.98
210_Y299_N0.8640.98
195_I221_I0.8600.98
122_A144_V0.8570.98
275_L301_V0.8560.98
278_A283_T0.8540.98
279_S283_T0.8410.98
125_D128_D0.8390.98
196_Y243_V0.8380.98
149_Q153_N0.8350.98
90_V113_P0.8290.98
148_L152_E0.8260.98
247_I258_E0.8250.98
192_E271_K0.8240.98
50_S149_Q0.8190.98
241_E269_G0.8190.98
34_G209_S0.8180.98
265_S272_L0.8130.97
93_A103_T0.8130.97
239_I270_K0.8120.97
251_L277_A0.8110.97
19_L22_K0.8090.97
169_A173_K0.8080.97
201_G254_T0.8060.97
185_F189_H0.8030.97
139_V296_L0.8020.97
170_V174_A0.8010.97
23_T102_L0.7980.97
198_M247_I0.7970.97
37_A208_Y0.7960.97
122_A148_L0.7950.97
189_H195_I0.7910.97
221_I309_L0.7850.97
203_N248_L0.7840.97
231_Y236_F0.7840.97
103_T119_Q0.7830.97
231_Y265_S0.7790.97
309_L313_R0.7770.97
226_I235_P0.7770.97
107_T143_I0.7750.97
182_A305_Y0.7740.97
35_S107_T0.7660.96
276_D282_F0.7590.96
160_A293_L0.7590.96
30_V79_L0.7590.96
43_K57_L0.7580.96
194_I243_V0.7570.96
213_C237_E0.7550.96
78_I148_L0.7530.96
249_L258_E0.7490.96
289_V293_L0.7460.96
276_D279_S0.7460.96
281_D284_A0.7420.96
279_S282_F0.7420.96
82_H108_F0.7400.96
209_S303_R0.7380.96
45_V149_Q0.7370.96
38_I145_F0.7300.95
37_A40_Y0.7280.95
34_G213_C0.7270.95
249_L259_E0.7260.95
31_A57_L0.7240.95
192_E244_P0.7170.95
113_P117_E0.7150.95
275_L298_L0.7140.95
106_M124_Y0.7120.95
291_G294_A0.7110.95
184_Q188_A0.7100.95
139_V303_R0.7100.95
29_F57_L0.7090.95
67_N95_F0.7070.94
49_E149_Q0.7050.94
129_E135_T0.7030.94
115_A123_Q0.7020.94
48_R292_Y0.7020.94
259_E263_T0.6950.94
22_K102_L0.6910.94
195_I246_I0.6880.94
50_S53_I0.6870.94
88_E229_G0.6870.94
297_V300_R0.6860.94
79_L114_L0.6840.93
134_N237_E0.6840.93
159_Q162_E0.6830.93
36_S57_L0.6820.93
67_N99_K0.6820.93
278_A281_D0.6820.93
82_H129_E0.6820.93
126_W140_L0.6760.93
163_G293_L0.6760.93
41_P206_V0.6760.93
290_K293_L0.6750.93
52_S55_S0.6740.93
182_A301_V0.6700.93
255_R279_S0.6690.93
28_F77_V0.6670.93
232_F236_F0.6670.93
221_I313_R0.6640.92
146_G160_A0.6620.92
111_E121_V0.6580.92
141_Y145_F0.6550.92
220_W237_E0.6530.92
289_V297_V0.6530.92
91_K95_F0.6520.92
186_A312_E0.6500.92
59_S229_G0.6480.91
197_T210_Y0.6460.91
261_A264_F0.6440.91
280_Y284_A0.6430.91
276_D280_Y0.6430.91
29_F46_F0.6420.91
171_Y296_L0.6420.91
27_V53_I0.6410.91
104_I122_A0.6400.91
274_V282_F0.6370.91
42_S46_F0.6370.91
110_P115_A0.6370.91
320_R323_M0.6330.90
47_D54_N0.6320.90
130_A319_H0.6320.90
28_F56_D0.6320.90
209_S318_S0.6300.90
203_N250_G0.6280.90
61_N229_G0.6260.90
34_G235_P0.6240.90
175_L300_R0.6200.90
27_V55_S0.6200.90
68_P95_F0.6180.89
52_S68_P0.6150.89
249_L274_V0.6130.89
206_V248_L0.6130.89
34_G138_G0.6120.89
45_V292_Y0.6120.89
183_K312_E0.6110.89
139_V300_R0.6110.89
263_T267_K0.6100.89
180_D184_Q0.6080.89
40_Y205_G0.6080.89
108_F134_N0.6070.89
61_N200_S0.6070.89
54_N70_Q0.6060.89
188_A273_T0.6060.89
264_F267_K0.6050.88
158_E166_Q0.6040.88
82_H134_N0.6040.88
82_H136_N0.6040.88
67_N253_E0.6020.88
41_P205_G0.6010.88
88_E232_F0.6000.88
219_Q315_H0.6000.88
147_T161_I0.6000.88
182_A304_S0.5990.88
173_K178_E0.5980.88
94_A116_Q0.5980.88
129_E136_N0.5980.88
115_A118_A0.5950.88
255_R276_D0.5950.88
79_L118_A0.5940.88
279_S288_S0.5920.87
166_Q289_V0.5920.87
112_S115_A0.5910.87
289_V294_A0.5910.87
275_L302_L0.5870.87
232_F324_W0.5840.87
114_L121_V0.5840.87
121_V124_Y0.5820.86
187_K190_E0.5790.86
150_V154_N0.5780.86
45_V202_A0.5760.86
160_A163_G0.5750.86
46_F148_L0.5740.86
36_S60_A0.5720.86
49_E150_V0.5710.85
174_A182_A0.5690.85
114_L118_A0.5680.85
111_E123_Q0.5670.85
43_K55_S0.5670.85
135_T209_S0.5640.85
18_D24_I0.5630.85
29_F145_F0.5610.84
30_V92_A0.5590.84
30_V96_A0.5570.84
157_F160_A0.5570.84
268_Y324_W0.5500.83
232_F268_Y0.5430.82
205_G235_P0.5430.82
294_A298_L0.5430.82
109_K124_Y0.5420.82
147_T151_L0.5400.82
139_V171_Y0.5400.82
147_T150_V0.5390.82
143_I167_L0.5380.82
131_L137_Y0.5380.82
236_F264_F0.5370.82
131_L235_P0.5350.82
94_A113_P0.5350.82
86_T220_W0.5350.82
257_L260_R0.5340.81
175_L304_S0.5340.81
40_Y43_K0.5340.81
27_V46_F0.5340.81
88_E134_N0.5330.81
48_R156_K0.5320.81
108_F136_N0.5320.81
297_V301_V0.5310.81
135_T303_R0.5300.81
49_E153_N0.5290.81
304_S307_D0.5290.81
190_E309_L0.5290.81
160_A290_K0.5280.81
167_L293_L0.5260.80
100_G111_E0.5260.80
18_D22_K0.5250.80
259_E266_K0.5250.80
37_A209_S0.5240.80
236_F268_Y0.5230.80
88_E213_C0.5230.80
266_K272_L0.5220.80
310_A317_L0.5190.80
107_T112_S0.5190.80
252_D288_S0.5190.80
209_S212_I0.5190.80
82_H127_G0.5180.79
251_L278_A0.5180.79
142_Q146_G0.5180.79
24_I74_K0.5160.79
32_C62_E0.5160.79
34_G96_A0.5160.79
132_A136_N0.5150.79
215_L221_I0.5150.79
197_T228_A0.5140.79
222_H238_I0.5140.79
181_N185_F0.5140.79
309_L312_E0.5140.79
38_I142_Q0.5130.79
59_S230_E0.5120.79
189_H246_I0.5110.79
126_W136_N0.5100.78
140_L143_I0.5100.78
138_G141_Y0.5090.78
18_D120_Y0.5070.78
318_S323_M0.5060.78
64_I95_F0.5060.78
49_E156_K0.5060.78
63_F96_A0.5060.78
211_S225_A0.5050.78
210_Y306_A0.5050.78
166_Q288_S0.5030.77
34_G212_I0.5030.77
186_A308_E0.5020.77
141_Y236_F0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3euaA 2 0.9939 100 0.216 Contact Map
3fj1A 2 0.9512 100 0.22 Contact Map
2zj3A 2 0.9817 100 0.222 Contact Map
1moqA 2 0.9817 100 0.225 Contact Map
2a3nA 2 0.9787 100 0.227 Contact Map
2pocA 4 0.9512 100 0.227 Contact Map
3fkjA 2 0.9939 100 0.228 Contact Map
2amlA 2 0.9878 100 0.233 Contact Map
3hbaA 2 0.8994 100 0.234 Contact Map
3tbfA 2 0.9573 100 0.237 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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