GREMLIN Database
YURO - Uncharacterized ABC transporter extracellular-binding protein YurO
UniProt: O32156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (392)
Sequences: 30160 (24164)
Seq/√Len: 1220.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T66_Q3.7821.00
402_T405_Q3.5511.00
110_L318_P3.3711.00
232_V404_Q3.2071.00
157_D283_N3.2051.00
239_Q243_P3.1511.00
156_K285_G2.8791.00
33_T64_D2.8731.00
111_D139_K2.8621.00
236_E240_E2.8061.00
35_K66_Q2.8011.00
174_I240_E2.5341.00
50_E54_K2.4831.00
156_K160_Q2.4611.00
63_I320_E2.4281.00
404_Q408_K2.4011.00
169_T172_E2.3631.00
154_Y285_G2.3511.00
55_E58_K2.3391.00
56_F323_E2.2661.00
74_S77_D2.2361.00
408_K412_K2.2251.00
323_E326_Q2.2071.00
57_E64_D2.1781.00
135_T140_Q2.1371.00
159_F268_M2.1341.00
175_D179_K2.1301.00
229_E233_K2.1221.00
128_Q132_T2.1011.00
330_S333_M2.0951.00
31_K64_D2.0721.00
227_T408_K2.0711.00
411_Q415_K2.0681.00
113_S139_K2.0631.00
178_K182_E2.0421.00
317_H320_E2.0261.00
401_M409_A2.0171.00
35_K68_E2.0131.00
164_L176_V1.9951.00
51_E54_K1.9931.00
253_D256_Y1.9751.00
37_F82_M1.9561.00
125_Q349_G1.9391.00
55_E327_F1.9291.00
54_K58_K1.9201.00
395_Q400_D1.9121.00
157_D161_K1.8991.00
236_E403_P1.8801.00
172_E175_D1.8751.00
233_K236_E1.8241.00
90_D317_H1.8221.00
13_V16_L1.8171.00
175_D178_K1.7851.00
132_T135_T1.7551.00
319_K323_E1.7471.00
109_A310_M1.7351.00
57_E61_P1.7261.00
179_K183_H1.7251.00
32_V320_E1.7161.00
395_Q401_M1.7151.00
14_S17_T1.7121.00
115_Y322_M1.7091.00
365_Q369_D1.7021.00
55_E59_D1.6691.00
405_Q409_A1.6611.00
335_E339_K1.6471.00
396_M406_V1.6281.00
53_V57_E1.6261.00
232_V403_P1.6261.00
236_E404_Q1.6231.00
171_D174_I1.5881.00
54_K57_E1.5811.00
55_E336_K1.5801.00
92_Y312_S1.5711.00
216_E221_A1.5661.00
53_V324_F1.5581.00
142_G308_G1.5561.00
361_R365_Q1.5541.00
409_A413_A1.5541.00
134_F308_G1.5311.00
32_V317_H1.5261.00
387_D391_T1.5231.00
174_I241_L1.5081.00
152_F287_F1.5061.00
154_Y287_F1.4941.00
232_V236_E1.4861.00
83_L88_P1.4761.00
111_D114_S1.4701.00
156_K283_N1.4701.00
388_A413_A1.4661.00
408_K411_Q1.4591.00
405_Q408_K1.4571.00
158_I267_A1.4571.00
46_K50_E1.4531.00
216_E223_T1.4421.00
31_K62_D1.4391.00
315_T318_P1.4371.00
409_A412_K1.4261.00
174_I178_K1.4031.00
331_K335_E1.4031.00
158_I180_L1.4021.00
56_F327_F1.4021.00
171_D175_D1.3991.00
239_Q396_M1.3971.00
56_F63_I1.3951.00
180_L267_A1.3941.00
110_L313_S1.3941.00
260_Q265_K1.3841.00
51_E55_E1.3801.00
230_G233_K1.3591.00
311_I325_L1.3581.00
237_K240_E1.3571.00
237_K241_L1.3491.00
78_K82_M1.3421.00
56_F324_F1.3411.00
392_G401_M1.3411.00
261_F284_L1.3331.00
333_M336_K1.3301.00
396_M403_P1.3261.00
189_S266_S1.3241.00
38_H67_I1.3161.00
392_G409_A1.3071.00
162_L180_L1.3071.00
104_I141_Y1.2991.00
167_P172_E1.2881.00
177_S268_M1.2871.00
227_T411_Q1.2841.00
178_K244_Y1.2771.00
53_V67_I1.2691.00
151_S286_M1.2621.00
63_I323_E1.2551.00
315_T321_A1.2441.00
91_I325_L1.2431.00
217_K221_A1.2311.00
152_F268_M1.2231.00
362_E365_Q1.2191.00
327_F333_M1.2151.00
412_K415_K1.2041.00
320_E323_E1.2021.00
94_S310_M1.2001.00
174_I237_K1.1981.00
401_M406_V1.1931.00
168_K172_E1.1901.00
164_L179_K1.1901.00
134_F140_Q1.1861.00
11_A15_M1.1821.00
21_C25_S1.1781.00
171_D293_S1.1781.00
47_S50_E1.1771.00
392_G395_Q1.1751.00
90_D315_T1.1741.00
10_I16_L1.1671.00
336_K340_D1.1661.00
155_N282_V1.1641.00
71_L74_S1.1541.00
21_C24_Q1.1451.00
240_E243_P1.1351.00
32_V62_D1.1321.00
392_G410_V1.1311.00
121_D124_S1.1291.00
312_S315_T1.1261.00
110_L315_T1.1251.00
159_F164_L1.1221.00
324_F328_L1.1221.00
322_M326_Q1.1111.00
259_Q263_S1.1111.00
91_I321_A1.1081.00
391_T413_A1.1081.00
395_Q409_A1.1071.00
14_S18_I1.1061.00
155_N158_I1.1021.00
176_V179_K1.0941.00
107_N313_S1.0891.00
349_G352_T1.0891.00
347_V350_T1.0871.00
157_D282_V1.0861.00
216_E222_K1.0801.00
173_L177_S1.0791.00
10_I13_V1.0771.00
10_I14_S1.0651.00
324_F327_F1.0641.00
311_I322_M1.0631.00
160_Q166_P1.0631.00
158_I162_L1.0621.00
47_S51_E1.0611.00
365_Q368_V1.0601.00
34_L324_F1.0581.00
358_A361_R1.0581.00
114_S117_K1.0531.00
131_I135_T1.0511.00
9_I13_V1.0501.00
401_M405_Q1.0441.00
104_I136_Y1.0411.00
6_L13_V1.0411.00
233_K237_K1.0411.00
79_I92_Y1.0401.00
311_I321_A1.0391.00
185_Y265_K1.0351.00
232_V407_M1.0331.00
159_F176_V1.0301.00
206_N212_E1.0291.00
160_Q165_D1.0271.00
15_M18_I1.0251.00
56_F320_E1.0241.00
318_P322_M1.0191.00
117_K123_S1.0181.00
158_I161_K1.0171.00
88_P312_S1.0141.00
177_S244_Y1.0131.00
239_Q403_P1.0121.00
336_K339_K1.0111.00
256_Y259_Q1.0051.00
313_S318_P1.0031.00
17_T20_G1.0001.00
181_K187_P0.9971.00
65_I324_F0.9971.00
209_M233_K0.9961.00
385_V414_A0.9951.00
91_I324_F0.9911.00
36_F309_F0.9911.00
236_E239_Q0.9901.00
213_K217_K0.9881.00
83_L108_K0.9831.00
173_L268_M0.9811.00
37_F89_P0.9801.00
388_A391_T0.9781.00
53_V65_I0.9721.00
57_E62_D0.9671.00
229_E232_V0.9651.00
12_A15_M0.9551.00
164_L180_L0.9541.00
354_E357_T0.9541.00
176_V268_M0.9491.00
179_K182_E0.9491.00
162_L183_H0.9471.00
260_Q266_S0.9451.00
224_G415_K0.9431.00
235_L396_M0.9411.00
331_K349_G0.9391.00
291_E294_G0.9351.00
86_T314_R0.9341.00
52_V55_E0.9311.00
358_A362_E0.9301.00
271_A275_E0.9271.00
123_S131_I0.9271.00
92_Y310_M0.9251.00
128_Q348_Q0.9241.00
11_A17_T0.9221.00
9_I16_L0.9211.00
142_G310_M0.9201.00
9_I15_M0.9171.00
158_I185_Y0.9161.00
181_K244_Y0.9161.00
364_V368_V0.9141.00
384_E387_D0.9081.00
406_V410_V0.9051.00
125_Q347_V0.9031.00
131_I140_Q0.9031.00
78_K81_V0.8991.00
51_E336_K0.8991.00
122_W125_Q0.8971.00
59_D330_S0.8971.00
332_R335_E0.8961.00
278_L281_P0.8961.00
21_C26_S0.8911.00
392_G413_A0.8881.00
388_A410_V0.8871.00
81_V85_T0.8861.00
37_F70_V0.8841.00
113_S117_K0.8781.00
157_D160_Q0.8761.00
48_Y51_E0.8711.00
13_V17_T0.8701.00
407_M411_Q0.8691.00
391_T395_Q0.8681.00
402_T406_V0.8671.00
226_F231_Y0.8641.00
51_E340_D0.8641.00
11_A14_S0.8631.00
32_V63_I0.8531.00
388_A392_G0.8531.00
128_Q131_I0.8511.00
335_E353_E0.8511.00
34_L320_E0.8511.00
153_F271_A0.8501.00
154_Y166_P0.8481.00
110_L312_S0.8431.00
104_I109_A0.8391.00
6_L9_I0.8381.00
332_R336_K0.8381.00
31_K61_P0.8371.00
55_E332_R0.8361.00
362_E366_H0.8301.00
363_A366_H0.8301.00
36_F91_I0.8291.00
76_K99_F0.8271.00
115_Y319_K0.8231.00
162_L179_K0.8211.00
127_V348_Q0.8201.00
321_A325_L0.8201.00
166_P172_E0.8181.00
145_W309_F0.8181.00
392_G406_V0.8151.00
126_L329_T0.8101.00
177_S181_K0.8081.00
109_A141_Y0.8071.00
116_Y140_Q0.8071.00
113_S140_Q0.8061.00
224_G411_Q0.8041.00
174_I244_Y0.7981.00
7_F14_S0.7951.00
387_D390_L0.7911.00
206_N231_Y0.7891.00
335_E350_T0.7871.00
160_Q283_N0.7841.00
361_R364_V0.7831.00
12_A16_L0.7801.00
92_Y109_A0.7791.00
165_D168_K0.7791.00
57_E65_I0.7791.00
319_K322_M0.7781.00
70_V78_K0.7771.00
177_S187_P0.7761.00
10_I17_T0.7741.00
311_I315_T0.7721.00
6_L16_L0.7721.00
18_I21_C0.7711.00
121_D326_Q0.7701.00
113_S135_T0.7651.00
159_F180_L0.7651.00
55_E333_M0.7631.00
166_P287_F0.7631.00
110_L311_I0.7631.00
62_D323_E0.7621.00
82_M87_S0.7621.00
235_L406_V0.7611.00
9_I12_A0.7591.00
235_L407_M0.7581.00
6_L17_T0.7531.00
407_M410_V0.7501.00
34_L317_H0.7481.00
111_D141_Y0.7421.00
135_T138_N0.7411.00
186_T247_K0.7411.00
162_L267_A0.7401.00
59_D332_R0.7381.00
174_I177_S0.7371.00
366_H369_D0.7341.00
77_D81_V0.7341.00
391_T394_Q0.7341.00
166_P176_V0.7311.00
12_A17_T0.7291.00
110_L115_Y0.7271.00
389_Y410_V0.7271.00
114_S322_M0.7261.00
110_L114_S0.7261.00
259_Q262_K0.7231.00
7_F10_I0.7231.00
59_D327_F0.7221.00
26_S30_G0.7201.00
228_D231_Y0.7191.00
363_A367_I0.7121.00
162_L176_V0.7111.00
209_M237_K0.7101.00
225_E228_D0.7091.00
353_E356_A0.7081.00
176_V180_L0.7071.00
213_K216_E0.7051.00
114_S139_K0.7041.00
181_K186_T0.7041.00
228_D232_V0.7021.00
170_W237_K0.6951.00
255_E258_R0.6941.00
202_I206_N0.6921.00
8_L15_M0.6911.00
52_V327_F0.6911.00
83_L312_S0.6881.00
204_T207_Q0.6871.00
91_I309_F0.6841.00
350_T353_E0.6831.00
165_D176_V0.6821.00
6_L10_I0.6821.00
31_K63_I0.6811.00
155_N283_N0.6801.00
7_F13_V0.6781.00
123_S135_T0.6781.00
34_L321_A0.6781.00
43_E47_S0.6761.00
277_K281_P0.6751.00
52_V333_M0.6741.00
161_K185_Y0.6721.00
207_Q374_V0.6661.00
103_F109_A0.6651.00
100_A142_G0.6651.00
154_Y159_F0.6651.00
126_L131_I0.6641.00
101_F105_R0.6621.00
59_D62_D0.6621.00
121_D125_Q0.6621.00
7_F11_A0.6601.00
178_K181_K0.6601.00
37_F68_E0.6591.00
383_V387_D0.6581.00
406_V409_A0.6561.00
110_L322_M0.6541.00
180_L268_M0.6531.00
20_G23_S0.6531.00
318_P321_A0.6511.00
104_I107_N0.6501.00
59_D323_E0.6491.00
16_L19_A0.6471.00
212_E231_Y0.6471.00
403_P407_M0.6441.00
241_L244_Y0.6441.00
17_T21_C0.6441.00
129_S132_T0.6441.00
239_Q242_M0.6431.00
216_E225_E0.6431.00
396_M401_M0.6421.00
125_Q331_K0.6421.00
153_F286_M0.6391.00
260_Q263_S0.6381.00
7_F17_T0.6371.00
233_K292_I0.6371.00
386_A390_L0.6361.00
56_F61_P0.6351.00
164_L167_P0.6351.00
170_W174_I0.6341.00
238_L242_M0.6331.00
173_L188_I0.6301.00
57_E63_I0.6301.00
188_I191_G0.6291.00
88_P314_R0.6281.00
75_Y79_I0.6271.00
226_F414_A0.6271.00
257_V269_I0.6261.00
115_Y318_P0.6241.00
168_K291_E0.6201.00
161_K183_H0.6191.00
52_V328_L0.6191.00
255_E259_Q0.6191.00
331_K347_V0.6171.00
348_Q352_T0.6161.00
20_G24_Q0.6151.00
187_P191_G0.6151.00
223_T415_K0.6131.00
95_W98_E0.6131.00
309_F325_L0.6101.00
110_L314_R0.6091.00
114_S118_N0.6071.00
11_A16_L0.6071.00
94_S103_F0.6071.00
186_T189_S0.6071.00
43_E46_K0.6061.00
404_Q407_M0.6041.00
244_Y248_H0.6031.00
36_F67_I0.6021.00
159_F166_P0.5991.00
217_K223_T0.5981.00
360_Q363_A0.5951.00
127_V351_A0.5941.00
19_A23_S0.5921.00
8_L12_A0.5921.00
74_S78_K0.5921.00
177_S241_L0.5911.00
118_N319_K0.5881.00
68_E82_M0.5881.00
351_A354_E0.5881.00
34_L315_T0.5881.00
100_A104_I0.5861.00
100_A109_A0.5861.00
394_Q398_G0.5861.00
19_A22_S0.5851.00
403_P406_V0.5851.00
107_N110_L0.5841.00
102_K106_G0.5831.00
342_G346_A0.5821.00
8_L14_S0.5811.00
261_F282_V0.5801.00
280_E284_L0.5801.00
162_L185_Y0.5801.00
376_W382_D0.5791.00
35_K82_M0.5791.00
377_F382_D0.5781.00
366_H370_A0.5781.00
252_V260_Q0.5781.00
206_N234_A0.5781.00
155_N264_G0.5771.00
8_L11_A0.5771.00
52_V336_K0.5711.00
5_L12_A0.5711.00
156_K282_V0.5711.00
153_F276_I0.5711.00
187_P192_T0.5701.00
360_Q364_V0.5701.00
122_W326_Q0.5701.00
113_S322_M0.5681.00
167_P268_M0.5661.00
76_K102_K0.5661.00
152_F270_Y0.5641.00
205_L209_M0.5641.00
32_V61_P0.5631.00
5_L8_L0.5621.00
80_K102_K0.5621.00
131_I144_P0.5611.00
285_G362_E0.5601.00
21_C30_G0.5601.00
322_M325_L0.5591.00
36_F53_V0.5581.00
82_M89_P0.5561.00
56_F65_I0.5561.00
115_Y118_N0.5551.00
112_L325_L0.5551.00
246_N260_Q0.5551.00
392_G396_M0.5531.00
276_I280_E0.5531.00
228_D411_Q0.5511.00
180_L183_H0.5511.00
239_Q402_T0.5501.00
180_L185_Y0.5501.00
64_D67_I0.5491.00
15_M19_A0.5481.00
34_L90_D0.5471.00
184_G188_I0.5471.00
178_K240_E0.5471.00
5_L16_L0.5451.00
134_F142_G0.5451.00
68_E78_K0.5441.00
77_D80_K0.5431.00
35_K89_P0.5431.00
127_V130_Q0.5391.00
189_S192_T0.5371.00
187_P190_F0.5371.00
148_D307_E0.5371.00
22_S25_S0.5371.00
234_A238_L0.5361.00
117_K121_D0.5361.00
160_Q163_N0.5361.00
157_D264_G0.5351.00
326_Q330_S0.5321.00
309_F328_L0.5321.00
227_T407_M0.5301.00
35_K90_D0.5301.00
99_F102_K0.5291.00
68_E89_P0.5281.00
118_N322_M0.5271.00
76_K103_F0.5271.00
342_G345_S0.5271.00
9_I14_S0.5271.00
50_E67_I0.5261.00
231_Y411_Q0.5231.00
159_F267_A0.5221.00
203_G207_Q0.5221.00
18_I23_S0.5201.00
172_E176_V0.5201.00
188_I192_T0.5191.00
382_D386_A0.5191.00
6_L14_S0.5191.00
258_R271_A0.5181.00
8_L13_V0.5161.00
112_L322_M0.5161.00
165_D172_E0.5161.00
359_I362_E0.5151.00
49_F52_V0.5151.00
230_G234_A0.5151.00
153_F284_L0.5151.00
34_L91_I0.5151.00
125_Q348_Q0.5141.00
291_E300_E0.5141.00
213_K374_V0.5131.00
32_V323_E0.5131.00
39_R75_Y0.5131.00
353_E357_T0.5131.00
108_K111_D0.5121.00
61_P320_E0.5121.00
44_P47_S0.5101.00
257_V266_S0.5091.00
36_F93_F0.5081.00
232_V408_K0.5071.00
159_F165_D0.5071.00
143_V325_L0.5061.00
205_L234_A0.5061.00
148_D306_P0.5051.00
90_D316_K0.5031.00
381_V384_E0.5031.00
275_E279_V0.5021.00
363_A368_V0.5001.00
36_F324_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r2fA 1 0.8934 100 0.157 Contact Map
3uorA 1 0.8839 100 0.16 Contact Map
4r9fA 1 0.8768 100 0.163 Contact Map
3vxbA 1 0.8934 100 0.164 Contact Map
4r6kA 1 0.9005 100 0.171 Contact Map
4mfiA 1 0.8886 100 0.184 Contact Map
4g68A 1 0.8981 100 0.192 Contact Map
4c1uA 1 0.8981 100 0.194 Contact Map
4r6hA 1 0.8957 100 0.208 Contact Map
4ovjA 1 0.8886 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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