GREMLIN Database
YURM - Probable ABC transporter permease protein YurM
UniProt: O32154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (255)
Sequences: 69713 (46004)
Seq/√Len: 2880.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_G209_R3.9131.00
95_M99_I3.2731.00
197_Y206_V3.1351.00
182_R186_L3.0101.00
92_S95_M2.6571.00
93_Y252_G2.5431.00
121_R193_E2.5121.00
184_Y218_I2.5071.00
59_A82_F2.5071.00
202_T205_G2.4931.00
196_A206_V2.4891.00
83_V87_N2.4651.00
103_L166_I2.4481.00
107_I170_A2.4201.00
193_E211_F2.4121.00
247_R255_Q2.4031.00
91_S95_M2.3991.00
203_S206_V2.3281.00
80_E83_V2.3121.00
105_C223_G2.2581.00
80_E84_S2.2071.00
181_I219_L2.1881.00
204_F208_F2.1791.00
263_D266_V2.1551.00
124_F127_K2.1181.00
201_C205_G2.0411.00
205_G208_F1.9981.00
177_T222_S1.9651.00
113_A207_F1.9511.00
196_A201_C1.9251.00
53_L57_M1.9181.00
192_L214_M1.9091.00
185_F215_S1.9041.00
120_S186_L1.8971.00
57_M61_K1.8941.00
160_N164_A1.8711.00
113_A215_S1.8531.00
131_L182_R1.8401.00
92_S96_N1.7731.00
109_V223_G1.7531.00
197_Y203_S1.7301.00
99_I103_L1.6961.00
193_E206_V1.6911.00
104_T230_T1.6671.00
101_T227_A1.6441.00
252_G256_F1.6421.00
113_A181_I1.6201.00
112_S177_T1.6111.00
115_A178_I1.6111.00
193_E197_Y1.5951.00
84_S266_V1.5651.00
119_L178_I1.5171.00
84_S87_N1.5171.00
190_K193_E1.5121.00
38_W42_F1.4881.00
126_G129_F1.4631.00
89_G92_S1.4531.00
177_T226_T1.4341.00
123_E127_K1.4261.00
56_V272_T1.4201.00
54_W58_S1.4101.00
50_Y54_W1.4031.00
234_F238_I1.3811.00
79_P83_V1.3721.00
221_T225_L1.3631.00
120_S182_R1.3611.00
162_Y246_L1.3551.00
236_F240_F1.3411.00
247_R252_G1.3401.00
110_F114_W1.3351.00
108_T226_T1.3311.00
116_A181_I1.3211.00
212_L219_L1.3181.00
100_V248_T1.3131.00
181_I222_S1.3091.00
185_F211_F1.3021.00
160_N163_W1.2931.00
190_K194_E1.2891.00
121_R190_K1.2801.00
78_H81_N1.2801.00
196_A210_I1.2661.00
191_E194_E1.2541.00
129_F132_V1.2441.00
113_A219_L1.2291.00
65_D76_S1.2091.00
234_F254_M1.2051.00
109_V219_L1.2021.00
96_N99_I1.2011.00
32_I36_S1.2011.00
106_V110_F1.2001.00
31_Y35_T1.1941.00
117_Y185_F1.1931.00
255_Q259_A1.1751.00
103_L106_V1.1751.00
168_P240_F1.1711.00
42_F46_I1.1701.00
188_I214_M1.1671.00
161_T164_A1.1651.00
33_G37_V1.1611.00
97_S249_I1.1551.00
283_L287_K1.1471.00
202_T206_V1.1461.00
35_T39_V1.1351.00
243_D246_L1.1321.00
256_F261_Q1.1321.00
241_I246_L1.1311.00
55_M272_T1.1221.00
216_V220_V1.1221.00
62_N65_D1.1181.00
84_S88_Q1.1001.00
30_W33_G1.0941.00
166_I170_A1.0931.00
287_K290_V1.0891.00
32_I35_T1.0631.00
129_F133_L1.0611.00
256_F263_D1.0611.00
181_I218_I1.0571.00
233_E236_F1.0571.00
54_W57_M1.0511.00
174_I178_I1.0501.00
86_W91_S1.0491.00
107_I166_I1.0451.00
103_L107_I1.0391.00
35_T38_W1.0371.00
193_E203_S1.0311.00
117_Y203_S1.0301.00
120_S185_F1.0241.00
247_R251_A1.0221.00
99_I162_Y1.0211.00
104_T108_T1.0131.00
104_T169_Y1.0121.00
117_Y207_F1.0101.00
180_L222_S1.0061.00
248_T251_A1.0051.00
214_M217_P0.9991.00
114_W118_G0.9931.00
252_G255_Q0.9781.00
98_V102_A0.9761.00
64_D67_F0.9601.00
106_V223_G0.9601.00
158_L163_W0.9551.00
206_V209_R0.9471.00
201_C206_V0.9431.00
30_W34_E0.9411.00
34_E38_W0.9341.00
37_V41_L0.9341.00
127_K186_L0.9281.00
165_L237_A0.9231.00
99_I102_A0.9201.00
82_F272_T0.9071.00
151_S155_S0.9021.00
58_S61_K0.8981.00
85_A273_I0.8971.00
128_G131_L0.8951.00
252_G270_G0.8941.00
284_L288_Y0.8891.00
238_I251_A0.8891.00
116_A120_S0.8891.00
45_L49_A0.8831.00
102_A106_V0.8791.00
104_T166_I0.8751.00
149_L240_F0.8751.00
94_F249_I0.8711.00
169_Y230_T0.8711.00
184_Y215_S0.8711.00
125_K128_G0.8621.00
233_E237_A0.8601.00
108_T112_S0.8571.00
94_F98_V0.8561.00
215_S218_I0.8551.00
112_S178_I0.8481.00
61_K65_D0.8451.00
119_L131_L0.8411.00
149_L168_P0.8401.00
107_I110_F0.8381.00
208_F212_L0.8371.00
63_S67_F0.8321.00
216_V219_L0.8321.00
206_V211_F0.8301.00
244_E247_R0.8281.00
254_M258_D0.8271.00
226_T230_T0.8261.00
135_L179_I0.8261.00
257_R267_L0.8261.00
251_A255_Q0.8261.00
237_A248_T0.8231.00
150_Y154_Q0.8231.00
177_T181_I0.8221.00
118_G124_F0.8221.00
181_I215_S0.8181.00
168_P236_F0.8141.00
47_A51_P0.8141.00
207_F212_L0.8111.00
95_M98_V0.8031.00
142_P172_Y0.8031.00
100_V169_Y0.8001.00
278_I282_F0.7991.00
280_I284_L0.7961.00
90_I270_G0.7961.00
59_A63_S0.7941.00
81_N265_G0.7911.00
216_V288_Y0.7901.00
160_N243_D0.7861.00
201_C209_R0.7861.00
58_S62_N0.7851.00
58_S268_L0.7841.00
203_S207_F0.7801.00
116_A178_I0.7691.00
108_T177_T0.7681.00
268_L272_T0.7631.00
73_L76_S0.7631.00
154_Q159_Y0.7611.00
192_L210_I0.7601.00
55_M268_L0.7561.00
103_L170_A0.7511.00
60_F77_W0.7501.00
116_A185_F0.7491.00
146_L239_I0.7481.00
109_V181_I0.7381.00
108_T230_T0.7381.00
84_S263_D0.7351.00
142_P235_M0.7341.00
108_T173_R0.7271.00
62_N76_S0.7251.00
256_F270_G0.7211.00
219_L222_S0.7211.00
93_Y96_N0.7201.00
115_A174_I0.7161.00
279_I283_L0.7151.00
101_T105_C0.7151.00
88_Q91_S0.7141.00
207_F211_F0.7141.00
79_P82_F0.7121.00
256_F266_V0.7081.00
146_L235_M0.7081.00
188_I215_S0.7081.00
119_L182_R0.7071.00
274_S278_I0.7041.00
60_F78_H0.7011.00
50_Y53_L0.6981.00
266_V270_G0.6971.00
36_S39_V0.6951.00
195_A199_D0.6931.00
119_L130_F0.6931.00
190_K197_Y0.6921.00
181_I185_F0.6881.00
155_S159_Y0.6861.00
105_C227_A0.6851.00
211_F214_M0.6791.00
218_I222_S0.6791.00
265_G268_L0.6791.00
100_V165_L0.6781.00
135_L138_L0.6781.00
55_M271_L0.6751.00
83_V86_W0.6741.00
112_S181_I0.6731.00
249_I274_S0.6721.00
285_M288_Y0.6701.00
91_S94_F0.6681.00
173_R226_T0.6681.00
45_L48_I0.6671.00
61_K74_P0.6661.00
169_Y172_Y0.6651.00
145_S171_A0.6631.00
36_S40_F0.6601.00
173_R229_H0.6591.00
100_V166_I0.6581.00
268_L271_L0.6581.00
100_V162_Y0.6541.00
77_W80_E0.6531.00
81_N84_S0.6491.00
105_C109_V0.6471.00
151_S154_Q0.6471.00
111_I174_I0.6461.00
233_E248_T0.6451.00
34_E37_V0.6451.00
195_A198_L0.6391.00
124_F130_F0.6391.00
283_L286_Q0.6381.00
65_D75_S0.6321.00
149_L152_I0.6311.00
165_L169_Y0.6311.00
41_L45_L0.6301.00
85_A270_G0.6291.00
115_A134_C0.6291.00
44_Y48_I0.6281.00
219_L223_G0.6281.00
111_I170_A0.6281.00
96_N246_L0.6271.00
235_M238_I0.6231.00
125_K129_F0.6211.00
85_A266_V0.6171.00
118_G122_F0.6161.00
39_V42_F0.6151.00
156_L159_Y0.6141.00
62_N75_S0.6131.00
93_Y249_I0.6121.00
165_L241_I0.6111.00
134_C175_P0.6101.00
100_V104_T0.6081.00
78_H82_F0.6071.00
180_L218_I0.6061.00
97_S250_P0.6051.00
132_V136_G0.6041.00
126_G130_F0.6031.00
250_P253_L0.6031.00
255_Q258_D0.6031.00
31_Y34_E0.6021.00
131_L179_I0.6001.00
253_L270_G0.5971.00
74_P77_W0.5941.00
62_N66_I0.5931.00
284_L287_K0.5901.00
76_S79_P0.5891.00
108_T170_A0.5871.00
264_W267_L0.5861.00
229_H232_N0.5861.00
82_F269_A0.5851.00
89_G252_G0.5851.00
250_P274_S0.5841.00
208_F211_F0.5831.00
230_T233_E0.5821.00
123_E128_G0.5821.00
223_G226_T0.5821.00
220_V223_G0.5821.00
101_T231_W0.5811.00
117_Y211_F0.5801.00
40_F44_Y0.5801.00
142_P146_L0.5791.00
206_V210_I0.5791.00
49_A53_L0.5771.00
280_I283_L0.5751.00
138_L175_P0.5741.00
101_T230_T0.5741.00
97_S231_W0.5731.00
116_A182_R0.5721.00
122_F203_S0.5711.00
146_L150_Y0.5711.00
128_G132_V0.5681.00
282_F286_Q0.5681.00
59_A269_A0.5661.00
264_W268_L0.5651.00
76_S80_E0.5641.00
143_Q239_I0.5641.00
130_F134_C0.5631.00
235_M239_I0.5631.00
46_I50_Y0.5591.00
241_I245_N0.5591.00
228_Y232_N0.5531.00
131_L186_L0.5501.00
271_L274_S0.5491.00
138_L176_F0.5471.00
51_P55_M0.5461.00
109_V113_A0.5461.00
104_T170_A0.5441.00
277_P280_I0.5421.00
133_L137_G0.5401.00
169_Y233_E0.5401.00
123_E190_K0.5381.00
172_Y175_P0.5351.00
137_G175_P0.5341.00
153_I159_Y0.5321.00
194_E197_Y0.5291.00
251_A254_M0.5261.00
115_A118_G0.5261.00
202_T208_F0.5251.00
38_W41_L0.5231.00
127_K131_L0.5221.00
188_I193_E0.5201.00
61_K76_S0.5191.00
89_G93_Y0.5151.00
43_L47_A0.5151.00
153_I164_A0.5141.00
58_S63_S0.5141.00
123_E126_G0.5101.00
57_M60_F0.5101.00
110_F113_A0.5081.00
226_T229_H0.5071.00
105_C230_T0.5071.00
92_S99_I0.5031.00
82_F86_W0.5001.00
109_V114_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.8867 100 0.323 Contact Map
4tquN 1 0.89 100 0.333 Contact Map
2onkC 2 0.8067 100 0.351 Contact Map
3d31C 2 0.7867 100 0.375 Contact Map
4tquM 1 0.86 100 0.394 Contact Map
3rlfF 1 0.9267 100 0.423 Contact Map
4ymuD 2 0.7133 99.9 0.532 Contact Map
3tuiA 2 0.6933 99.9 0.551 Contact Map
3fymA 1 0.03 12.9 0.95 Contact Map
2m8rA 1 0.1767 12 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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