FRLD - BACSU - GREMLIN Contacts

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FRLD - Fructosamine kinase FrlD

UniProt:	O32153	Sequences: MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIGIVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSRLRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCPYVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEADIIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGGSSEKTRIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	284 (260)
Sequences:	22413 (16618)
Seq/√Len:	1030.6

ECOLI - RBSK YDJH PSUK YEII FRLD SQUV YEGV KDGK K1PF PFKB INGK HLDE
BACSU - FRLD KDGK IOLC YDJE RBSK K1PF
HALSA - Q9HSM7 Q9HMJ3 Q9HP13
SULSO - KDGK Q981E2 Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
38_H	235_T	3.169	1.00
122_H	143_S	2.617	1.00
56_L	71_Q	2.611	1.00
196_R	202_I	2.511	1.00
41_S	65_N	2.503	1.00
203_L	247_L	2.458	1.00
4_I	118_H	2.430	1.00
236_A	241_Q	2.357	1.00
242_D	245_Y	2.282	1.00
201_A	229_F	2.253	1.00
48_N	73_H	2.220	1.00
134_P	161_Y	2.083	1.00
53_A	71_Q	2.073	1.00
45_I	72_A	2.029	1.00
33_A	38_H	2.027	1.00
185_H	204_S	2.005	1.00
169_G	196_R	1.983	1.00
5_A	30_A	1.937	1.00
143_S	234_L	1.921	1.00
236_A	249_Q	1.908	1.00
210_Y	244_T	1.907	1.00
136_L	140_V	1.906	1.00
35_R	62_E	1.892	1.00
120_L	141_P	1.843	1.00
228_S	253_T	1.820	1.00
31_V	62_E	1.798	1.00
141_P	163_T	1.790	1.00
60_K	66_A	1.781	1.00
241_Q	245_Y	1.776	1.00
166_F	230_I	1.771	1.00
133_L	142_V	1.751	1.00
178_G	209_V	1.727	1.00
32_L	231_A	1.724	1.00
201_A	251_A	1.692	1.00
163_T	190_K	1.686	1.00
203_L	210_Y	1.684	1.00
202_I	211_H	1.671	1.00
58_V	61_L	1.663	1.00
225_A	258_C	1.657	1.00
181_A	204_S	1.652	1.00
57_N	61_L	1.652	1.00
164_Y	191_M	1.640	1.00
233_F	246_A	1.615	1.00
130_E	157_R	1.612	1.00
215_V	252_E	1.606	1.00
244_T	248_R	1.604	1.00
56_L	60_K	1.602	1.00
183_T	187_Y	1.593	1.00
120_L	143_S	1.590	1.00
254_A	258_C	1.582	1.00
232_G	253_T	1.567	1.00
196_R	211_H	1.561	1.00
135_Q	139_L	1.536	1.00
193_C	233_F	1.533	1.00
33_A	235_T	1.512	1.00
20_F	54_H	1.510	1.00
120_L	234_L	1.493	1.00
131_N	134_P	1.490	1.00
191_M	205_A	1.484	1.00
9_N	44_G	1.478	1.00
145_D	195_T	1.476	1.00
196_R	199_Q	1.469	1.00
203_L	243_I	1.468	1.00
3_L	33_A	1.454	1.00
221_D	262_G	1.453	1.00
53_A	57_N	1.448	1.00
48_N	53_A	1.444	1.00
232_G	249_Q	1.441	1.00
212_Q	247_L	1.426	1.00
112_V	135_Q	1.422	1.00
141_P	164_Y	1.412	1.00
205_A	208_R	1.410	1.00
116_S	139_L	1.401	1.00
178_G	182_K	1.396	1.00
137_C	161_Y	1.394	1.00
131_N	135_Q	1.393	1.00
22_P	55_L	1.384	1.00
130_E	134_P	1.375	1.00
183_T	186_G	1.353	1.00
13_Y	18_E	1.351	1.00
137_C	163_T	1.323	1.00
182_K	186_G	1.323	1.00
162_V	165_A	1.319	1.00
212_Q	251_A	1.315	1.00
27_L	59_L	1.314	1.00
135_Q	138_G	1.313	1.00
215_V	248_R	1.299	1.00
39_E	65_N	1.294	1.00
146_F	167_F	1.271	1.00
56_L	69_I	1.254	1.00
52_A	76_N	1.248	1.00
217_A	259_G	1.247	1.00
58_V	62_E	1.236	1.00
141_P	190_K	1.230	1.00
22_P	58_V	1.217	1.00
48_N	71_Q	1.209	1.00
11_V	54_H	1.207	1.00
201_A	247_L	1.204	1.00
196_R	200_G	1.203	1.00
204_S	209_V	1.193	1.00
191_M	243_I	1.189	1.00
235_T	239_V	1.178	1.00
232_G	250_A	1.176	1.00
156_R	187_Y	1.175	1.00
191_M	237_F	1.161	1.00
182_K	204_S	1.156	1.00
236_A	246_A	1.156	1.00
233_F	237_F	1.150	1.00
195_T	229_F	1.147	1.00
166_F	195_T	1.144	1.00
256_K	260_V	1.144	1.00
54_H	57_N	1.144	1.00
245_Y	248_R	1.144	1.00
38_H	238_C	1.136	1.00
53_A	56_L	1.133	1.00
123_T	142_V	1.130	1.00
191_M	233_F	1.127	1.00
219_I	258_C	1.125	1.00
217_A	258_C	1.123	1.00
34_K	64_V	1.119	1.00
233_F	250_A	1.116	1.00
185_H	206_G	1.113	1.00
215_V	251_A	1.109	1.00
256_K	259_G	1.105	1.00
36_L	232_G	1.103	1.00
172_L	194_M	1.101	1.00
50_E	53_A	1.096	1.00
13_Y	20_F	1.091	1.00
33_A	40_S	1.078	1.00
122_H	234_L	1.077	1.00
182_K	209_V	1.072	1.00
57_N	60_K	1.069	1.00
164_Y	233_F	1.068	1.00
215_V	255_A	1.062	1.00
30_A	40_S	1.048	1.00
32_L	228_S	1.035	1.00
134_P	138_G	1.033	1.00
164_Y	237_F	1.031	1.00
105_L	108_Q	1.028	1.00
29_V	122_H	1.027	1.00
9_N	55_L	1.026	1.00
38_H	239_V	1.015	1.00
219_I	222_T	1.009	1.00
121_L	136_L	1.008	1.00
191_M	203_L	1.007	1.00
176_E	180_L	1.007	1.00
31_V	35_R	1.002	1.00
169_G	199_Q	0.998	1.00
34_K	63_Q	0.993	1.00
166_F	233_F	0.989	1.00
251_A	254_A	0.982	1.00
9_N	42_Y	0.974	1.00
41_S	114_F	0.973	1.00
179_E	182_K	0.972	1.00
41_S	118_H	0.970	1.00
228_S	257_T	0.966	1.00
45_I	109_E	0.964	1.00
233_F	243_I	0.963	1.00
33_A	231_A	0.958	1.00
144_F	162_V	0.958	1.00
41_S	68_Y	0.951	1.00
246_A	250_A	0.949	1.00
248_R	252_E	0.948	1.00
121_L	140_V	0.947	1.00
54_H	58_V	0.945	1.00
214_I	251_A	0.936	1.00
36_L	253_T	0.933	1.00
22_P	54_H	0.933	1.00
107_F	110_K	0.924	1.00
46_V	56_L	0.924	1.00
49_D	76_N	0.923	1.00
56_L	66_A	0.921	1.00
236_A	239_V	0.921	1.00
46_V	52_A	0.913	1.00
118_H	140_V	0.910	1.00
181_A	194_M	0.907	1.00
6_V	121_L	0.905	1.00
13_Y	78_M	0.903	1.00
228_S	267_G	0.899	1.00
241_Q	249_Q	0.898	1.00
152_D	156_R	0.897	1.00
122_H	230_I	0.894	1.00
106_A	109_E	0.893	1.00
179_E	183_T	0.893	1.00
145_D	166_F	0.893	1.00
46_V	69_I	0.892	1.00
168_S	171_D	0.890	1.00
219_I	259_G	0.889	1.00
34_K	39_E	0.886	1.00
235_T	249_Q	0.884	1.00
172_L	180_L	0.883	1.00
128_R	132_D	0.883	1.00
66_A	69_I	0.879	1.00
13_Y	51_A	0.869	1.00
15_Q	92_V	0.866	1.00
9_N	27_L	0.865	1.00
208_R	244_T	0.865	1.00
237_F	246_A	0.862	1.00
160_P	188_G	0.862	1.00
169_G	173_S	0.861	1.00
199_Q	211_H	0.860	1.00
5_A	26_A	0.860	1.00
47_G	76_N	0.859	1.00
4_I	43_I	0.841	1.00
14_Y	21_Y	0.840	1.00
190_K	206_G	0.834	1.00
115_I	118_H	0.832	1.00
123_T	133_L	0.831	1.00
109_E	131_N	0.827	1.00
29_V	230_I	0.825	1.00
229_F	251_A	0.821	1.00
242_D	246_A	0.821	1.00
212_Q	248_R	0.818	1.00
167_F	172_L	0.816	1.00
202_I	209_V	0.804	1.00
113_S	116_S	0.801	1.00
55_L	76_N	0.801	1.00
220_I	261_Y	0.800	1.00
217_A	255_A	0.799	1.00
145_D	167_F	0.796	1.00
212_Q	244_T	0.794	1.00
46_V	71_Q	0.793	1.00
177_C	180_L	0.792	1.00
200_G	214_I	0.791	1.00
27_L	264_F	0.789	1.00
3_L	238_C	0.788	1.00
90_I	93_R	0.781	1.00
252_E	256_K	0.772	1.00
10_V	77_G	0.770	1.00
159_C	162_V	0.770	1.00
92_V	96_K	0.768	1.00
45_I	70_R	0.768	1.00
205_A	243_I	0.767	1.00
56_L	70_R	0.762	1.00
228_S	232_G	0.761	1.00
157_R	160_P	0.759	1.00
232_G	236_A	0.757	1.00
107_F	131_N	0.757	1.00
123_T	129_L	0.757	1.00
89_R	93_R	0.756	1.00
178_G	181_A	0.755	1.00
125_V	144_F	0.754	1.00
182_K	185_H	0.752	1.00
34_K	40_S	0.748	1.00
30_A	42_Y	0.747	1.00
41_S	67_D	0.745	1.00
210_Y	247_L	0.743	1.00
4_I	41_S	0.739	1.00
20_F	51_A	0.738	1.00
11_V	20_F	0.732	1.00
112_V	139_L	0.731	1.00
143_S	166_F	0.728	1.00
228_S	254_A	0.728	1.00
11_V	51_A	0.727	1.00
134_P	157_R	0.726	1.00
251_A	255_A	0.725	1.00
120_L	238_C	0.725	1.00
103_L	108_Q	0.723	1.00
49_D	52_A	0.723	1.00
218_D	259_G	0.712	1.00
130_E	161_Y	0.708	1.00
81_V	91_F	0.708	1.00
181_A	192_V	0.704	1.00
31_V	264_F	0.702	1.00
68_Y	114_F	0.699	1.00
156_R	160_P	0.699	1.00
132_D	136_L	0.697	1.00
6_V	132_D	0.694	1.00
178_G	204_S	0.691	1.00
105_L	111_D	0.691	1.00
82_T	92_V	0.690	1.00
25_N	147_S	0.684	1.00
36_L	249_Q	0.683	1.00
154_Y	157_R	0.683	1.00
181_A	185_H	0.681	1.00
103_L	107_F	0.680	1.00
107_F	111_D	0.679	1.00
229_F	250_A	0.678	1.00
58_V	264_F	0.675	1.00
229_F	247_L	0.675	1.00
205_A	210_Y	0.675	1.00
92_V	95_N	0.671	1.00
143_S	164_Y	0.670	1.00
160_P	187_Y	0.668	1.00
200_G	211_H	0.668	1.00
229_F	254_A	0.666	1.00
178_G	211_H	0.665	1.00
198_G	216_E	0.665	1.00
185_H	205_A	0.664	1.00
51_A	78_M	0.657	1.00
90_I	94_S	0.657	1.00
153_D	156_R	0.657	1.00
115_I	140_V	0.656	1.00
36_L	235_T	0.656	1.00
193_C	203_L	0.653	1.00
181_A	209_V	0.646	1.00
44_G	69_I	0.645	1.00
81_V	223_L	0.640	1.00
109_E	112_V	0.637	1.00
224_G	267_G	0.636	1.00
30_A	64_V	0.636	1.00
241_Q	246_A	0.634	1.00
121_L	132_D	0.628	1.00
114_F	118_H	0.627	1.00
3_L	120_L	0.625	1.00
177_C	181_A	0.623	1.00
133_L	161_Y	0.622	1.00
82_T	90_I	0.622	1.00
19_T	261_Y	0.620	1.00
50_E	54_H	0.619	1.00
143_S	230_I	0.618	1.00
177_C	196_R	0.615	1.00
180_L	183_T	0.614	1.00
4_I	114_F	0.611	1.00
105_L	109_E	0.610	1.00
108_Q	111_D	0.608	1.00
180_L	184_A	0.607	1.00
39_E	119_D	0.602	1.00
13_Y	80_I	0.600	1.00
112_V	116_S	0.599	1.00
27_L	42_Y	0.598	1.00
254_A	257_T	0.597	1.00
104_R	108_Q	0.594	1.00
77_G	82_T	0.589	1.00
178_G	202_I	0.589	1.00
84_D	88_D	0.587	1.00
5_A	33_A	0.585	1.00
193_C	229_F	0.584	1.00
108_Q	131_N	0.583	1.00
224_G	266_Y	0.581	1.00
201_A	212_Q	0.580	1.00
3_L	38_H	0.579	1.00
119_D	140_V	0.579	1.00
33_A	234_L	0.578	1.00
93_R	98_G	0.577	1.00
129_L	132_D	0.576	1.00
48_N	74_G	0.575	1.00
103_L	106_A	0.574	1.00
79_A	93_R	0.574	1.00
245_Y	249_Q	0.573	1.00
172_L	184_A	0.573	1.00
8_D	147_S	0.572	1.00
105_L	128_R	0.569	1.00
185_H	207_D	0.566	1.00
170_S	174_E	0.566	1.00
106_A	110_K	0.565	1.00
50_E	57_N	0.562	1.00
223_L	263_A	0.561	1.00
247_L	251_A	0.560	1.00
22_P	264_F	0.559	1.00
145_D	227_D	0.557	1.00
231_A	235_T	0.557	1.00
130_E	133_L	0.551	1.00
90_I	96_K	0.550	1.00
112_V	138_G	0.549	1.00
165_A	192_V	0.546	1.00
25_N	126_Y	0.543	1.00
142_V	162_V	0.541	1.00
128_R	131_N	0.541	1.00
166_F	193_C	0.541	1.00
23_G	28_N	0.541	1.00
53_A	60_K	0.539	1.00
237_F	240_K	0.538	1.00
153_D	157_R	0.537	1.00
36_L	231_A	0.535	1.00
185_H	192_V	0.534	1.00
12_D	23_G	0.533	1.00
105_L	110_K	0.530	1.00
185_H	189_A	0.529	1.00
243_I	246_A	0.528	1.00
39_E	238_C	0.528	1.00
169_G	197_G	0.527	1.00
88_D	94_S	0.525	1.00
212_Q	215_V	0.521	1.00
68_Y	71_Q	0.520	1.00
8_D	126_Y	0.518	1.00
198_G	219_I	0.517	1.00
67_D	114_F	0.517	1.00
34_K	62_E	0.515	1.00
136_L	142_V	0.515	1.00
29_V	33_A	0.514	1.00
129_L	136_L	0.514	1.00
5_A	42_Y	0.512	1.00
18_E	78_M	0.511	1.00
172_L	177_C	0.506	1.00
181_A	184_A	0.504	1.00
163_T	191_M	0.503	1.00
120_L	164_Y	0.502	1.00
193_C	247_L	0.501	1.00
9_N	59_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rbcA	2	0.9824	100	0.215	Contact Map
3pl2A	2	0.9754	100	0.224	Contact Map
3iq0A	2	0.9754	100	0.224	Contact Map
3ljsA	2	0.9754	100	0.226	Contact Map
2qcvA	3	0.9754	100	0.227	Contact Map
2v78A	5	0.9718	100	0.231	Contact Map
1tyyA	2	0.9472	100	0.232	Contact Map
2dcnA	5	0.9648	100	0.232	Contact Map
3h49A	2	0.9648	100	0.233	Contact Map
3hj6A	2	0.8662	100	0.235	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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