GREMLIN Database
FRLD - Fructosamine kinase FrlD
UniProt: O32153 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (260)
Sequences: 22413 (16618)
Seq/√Len: 1030.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_H235_T3.1691.00
122_H143_S2.6171.00
56_L71_Q2.6111.00
196_R202_I2.5111.00
41_S65_N2.5031.00
203_L247_L2.4581.00
4_I118_H2.4301.00
236_A241_Q2.3571.00
242_D245_Y2.2821.00
201_A229_F2.2531.00
48_N73_H2.2201.00
134_P161_Y2.0831.00
53_A71_Q2.0731.00
45_I72_A2.0291.00
33_A38_H2.0271.00
185_H204_S2.0051.00
169_G196_R1.9831.00
5_A30_A1.9371.00
143_S234_L1.9211.00
236_A249_Q1.9081.00
210_Y244_T1.9071.00
136_L140_V1.9061.00
35_R62_E1.8921.00
120_L141_P1.8431.00
228_S253_T1.8201.00
31_V62_E1.7981.00
141_P163_T1.7901.00
60_K66_A1.7811.00
241_Q245_Y1.7761.00
166_F230_I1.7711.00
133_L142_V1.7511.00
178_G209_V1.7271.00
32_L231_A1.7241.00
201_A251_A1.6921.00
163_T190_K1.6861.00
203_L210_Y1.6841.00
202_I211_H1.6711.00
58_V61_L1.6631.00
225_A258_C1.6571.00
181_A204_S1.6521.00
57_N61_L1.6521.00
164_Y191_M1.6401.00
233_F246_A1.6151.00
130_E157_R1.6121.00
215_V252_E1.6061.00
244_T248_R1.6041.00
56_L60_K1.6021.00
183_T187_Y1.5931.00
120_L143_S1.5901.00
254_A258_C1.5821.00
232_G253_T1.5671.00
196_R211_H1.5611.00
135_Q139_L1.5361.00
193_C233_F1.5331.00
33_A235_T1.5121.00
20_F54_H1.5101.00
120_L234_L1.4931.00
131_N134_P1.4901.00
191_M205_A1.4841.00
9_N44_G1.4781.00
145_D195_T1.4761.00
196_R199_Q1.4691.00
203_L243_I1.4681.00
3_L33_A1.4541.00
221_D262_G1.4531.00
53_A57_N1.4481.00
48_N53_A1.4441.00
232_G249_Q1.4411.00
212_Q247_L1.4261.00
112_V135_Q1.4221.00
141_P164_Y1.4121.00
205_A208_R1.4101.00
116_S139_L1.4011.00
178_G182_K1.3961.00
137_C161_Y1.3941.00
131_N135_Q1.3931.00
22_P55_L1.3841.00
130_E134_P1.3751.00
183_T186_G1.3531.00
13_Y18_E1.3511.00
137_C163_T1.3231.00
182_K186_G1.3231.00
162_V165_A1.3191.00
212_Q251_A1.3151.00
27_L59_L1.3141.00
135_Q138_G1.3131.00
215_V248_R1.2991.00
39_E65_N1.2941.00
146_F167_F1.2711.00
56_L69_I1.2541.00
52_A76_N1.2481.00
217_A259_G1.2471.00
58_V62_E1.2361.00
141_P190_K1.2301.00
22_P58_V1.2171.00
48_N71_Q1.2091.00
11_V54_H1.2071.00
201_A247_L1.2041.00
196_R200_G1.2031.00
204_S209_V1.1931.00
191_M243_I1.1891.00
235_T239_V1.1781.00
232_G250_A1.1761.00
156_R187_Y1.1751.00
191_M237_F1.1611.00
182_K204_S1.1561.00
236_A246_A1.1561.00
233_F237_F1.1501.00
195_T229_F1.1471.00
166_F195_T1.1441.00
256_K260_V1.1441.00
54_H57_N1.1441.00
245_Y248_R1.1441.00
38_H238_C1.1361.00
53_A56_L1.1331.00
123_T142_V1.1301.00
191_M233_F1.1271.00
219_I258_C1.1251.00
217_A258_C1.1231.00
34_K64_V1.1191.00
233_F250_A1.1161.00
185_H206_G1.1131.00
215_V251_A1.1091.00
256_K259_G1.1051.00
36_L232_G1.1031.00
172_L194_M1.1011.00
50_E53_A1.0961.00
13_Y20_F1.0911.00
33_A40_S1.0781.00
122_H234_L1.0771.00
182_K209_V1.0721.00
57_N60_K1.0691.00
164_Y233_F1.0681.00
215_V255_A1.0621.00
30_A40_S1.0481.00
32_L228_S1.0351.00
134_P138_G1.0331.00
164_Y237_F1.0311.00
105_L108_Q1.0281.00
29_V122_H1.0271.00
9_N55_L1.0261.00
38_H239_V1.0151.00
219_I222_T1.0091.00
121_L136_L1.0081.00
191_M203_L1.0071.00
176_E180_L1.0071.00
31_V35_R1.0021.00
169_G199_Q0.9981.00
34_K63_Q0.9931.00
166_F233_F0.9891.00
251_A254_A0.9821.00
9_N42_Y0.9741.00
41_S114_F0.9731.00
179_E182_K0.9721.00
41_S118_H0.9701.00
228_S257_T0.9661.00
45_I109_E0.9641.00
233_F243_I0.9631.00
33_A231_A0.9581.00
144_F162_V0.9581.00
41_S68_Y0.9511.00
246_A250_A0.9491.00
248_R252_E0.9481.00
121_L140_V0.9471.00
54_H58_V0.9451.00
214_I251_A0.9361.00
36_L253_T0.9331.00
22_P54_H0.9331.00
107_F110_K0.9241.00
46_V56_L0.9241.00
49_D76_N0.9231.00
56_L66_A0.9211.00
236_A239_V0.9211.00
46_V52_A0.9131.00
118_H140_V0.9101.00
181_A194_M0.9071.00
6_V121_L0.9051.00
13_Y78_M0.9031.00
228_S267_G0.8991.00
241_Q249_Q0.8981.00
152_D156_R0.8971.00
122_H230_I0.8941.00
106_A109_E0.8931.00
179_E183_T0.8931.00
145_D166_F0.8931.00
46_V69_I0.8921.00
168_S171_D0.8901.00
219_I259_G0.8891.00
34_K39_E0.8861.00
235_T249_Q0.8841.00
172_L180_L0.8831.00
128_R132_D0.8831.00
66_A69_I0.8791.00
13_Y51_A0.8691.00
15_Q92_V0.8661.00
9_N27_L0.8651.00
208_R244_T0.8651.00
237_F246_A0.8621.00
160_P188_G0.8621.00
169_G173_S0.8611.00
199_Q211_H0.8601.00
5_A26_A0.8601.00
47_G76_N0.8591.00
4_I43_I0.8411.00
14_Y21_Y0.8401.00
190_K206_G0.8341.00
115_I118_H0.8321.00
123_T133_L0.8311.00
109_E131_N0.8271.00
29_V230_I0.8251.00
229_F251_A0.8211.00
242_D246_A0.8211.00
212_Q248_R0.8181.00
167_F172_L0.8161.00
202_I209_V0.8041.00
113_S116_S0.8011.00
55_L76_N0.8011.00
220_I261_Y0.8001.00
217_A255_A0.7991.00
145_D167_F0.7961.00
212_Q244_T0.7941.00
46_V71_Q0.7931.00
177_C180_L0.7921.00
200_G214_I0.7911.00
27_L264_F0.7891.00
3_L238_C0.7881.00
90_I93_R0.7811.00
252_E256_K0.7721.00
10_V77_G0.7701.00
159_C162_V0.7701.00
92_V96_K0.7681.00
45_I70_R0.7681.00
205_A243_I0.7671.00
56_L70_R0.7621.00
228_S232_G0.7611.00
157_R160_P0.7591.00
232_G236_A0.7571.00
107_F131_N0.7571.00
123_T129_L0.7571.00
89_R93_R0.7561.00
178_G181_A0.7551.00
125_V144_F0.7541.00
182_K185_H0.7521.00
34_K40_S0.7481.00
30_A42_Y0.7471.00
41_S67_D0.7451.00
210_Y247_L0.7431.00
4_I41_S0.7391.00
20_F51_A0.7381.00
11_V20_F0.7321.00
112_V139_L0.7311.00
143_S166_F0.7281.00
228_S254_A0.7281.00
11_V51_A0.7271.00
134_P157_R0.7261.00
251_A255_A0.7251.00
120_L238_C0.7251.00
103_L108_Q0.7231.00
49_D52_A0.7231.00
218_D259_G0.7121.00
130_E161_Y0.7081.00
81_V91_F0.7081.00
181_A192_V0.7041.00
31_V264_F0.7021.00
68_Y114_F0.6991.00
156_R160_P0.6991.00
132_D136_L0.6971.00
6_V132_D0.6941.00
178_G204_S0.6911.00
105_L111_D0.6911.00
82_T92_V0.6901.00
25_N147_S0.6841.00
36_L249_Q0.6831.00
154_Y157_R0.6831.00
181_A185_H0.6811.00
103_L107_F0.6801.00
107_F111_D0.6791.00
229_F250_A0.6781.00
58_V264_F0.6751.00
229_F247_L0.6751.00
205_A210_Y0.6751.00
92_V95_N0.6711.00
143_S164_Y0.6701.00
160_P187_Y0.6681.00
200_G211_H0.6681.00
229_F254_A0.6661.00
178_G211_H0.6651.00
198_G216_E0.6651.00
185_H205_A0.6641.00
51_A78_M0.6571.00
90_I94_S0.6571.00
153_D156_R0.6571.00
115_I140_V0.6561.00
36_L235_T0.6561.00
193_C203_L0.6531.00
181_A209_V0.6461.00
44_G69_I0.6451.00
81_V223_L0.6401.00
109_E112_V0.6371.00
224_G267_G0.6361.00
30_A64_V0.6361.00
241_Q246_A0.6341.00
121_L132_D0.6281.00
114_F118_H0.6271.00
3_L120_L0.6251.00
177_C181_A0.6231.00
133_L161_Y0.6221.00
82_T90_I0.6221.00
19_T261_Y0.6201.00
50_E54_H0.6191.00
143_S230_I0.6181.00
177_C196_R0.6151.00
180_L183_T0.6141.00
4_I114_F0.6111.00
105_L109_E0.6101.00
108_Q111_D0.6081.00
180_L184_A0.6071.00
39_E119_D0.6021.00
13_Y80_I0.6001.00
112_V116_S0.5991.00
27_L42_Y0.5981.00
254_A257_T0.5971.00
104_R108_Q0.5941.00
77_G82_T0.5891.00
178_G202_I0.5891.00
84_D88_D0.5871.00
5_A33_A0.5851.00
193_C229_F0.5841.00
108_Q131_N0.5831.00
224_G266_Y0.5811.00
201_A212_Q0.5801.00
3_L38_H0.5791.00
119_D140_V0.5791.00
33_A234_L0.5781.00
93_R98_G0.5771.00
129_L132_D0.5761.00
48_N74_G0.5751.00
103_L106_A0.5741.00
79_A93_R0.5741.00
245_Y249_Q0.5731.00
172_L184_A0.5731.00
8_D147_S0.5721.00
105_L128_R0.5691.00
185_H207_D0.5661.00
170_S174_E0.5661.00
106_A110_K0.5651.00
50_E57_N0.5621.00
223_L263_A0.5611.00
247_L251_A0.5601.00
22_P264_F0.5591.00
145_D227_D0.5571.00
231_A235_T0.5571.00
130_E133_L0.5511.00
90_I96_K0.5501.00
112_V138_G0.5491.00
165_A192_V0.5461.00
25_N126_Y0.5431.00
142_V162_V0.5411.00
128_R131_N0.5411.00
166_F193_C0.5411.00
23_G28_N0.5411.00
53_A60_K0.5391.00
237_F240_K0.5381.00
153_D157_R0.5371.00
36_L231_A0.5351.00
185_H192_V0.5341.00
12_D23_G0.5331.00
105_L110_K0.5301.00
185_H189_A0.5291.00
243_I246_A0.5281.00
39_E238_C0.5281.00
169_G197_G0.5271.00
88_D94_S0.5251.00
212_Q215_V0.5211.00
68_Y71_Q0.5201.00
8_D126_Y0.5181.00
198_G219_I0.5171.00
67_D114_F0.5171.00
34_K62_E0.5151.00
136_L142_V0.5151.00
29_V33_A0.5141.00
129_L136_L0.5141.00
5_A42_Y0.5121.00
18_E78_M0.5111.00
172_L177_C0.5061.00
181_A184_A0.5041.00
163_T191_M0.5031.00
120_L164_Y0.5021.00
193_C247_L0.5011.00
9_N59_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 0.9824 100 0.215 Contact Map
3pl2A 2 0.9754 100 0.224 Contact Map
3iq0A 2 0.9754 100 0.224 Contact Map
3ljsA 2 0.9754 100 0.226 Contact Map
2qcvA 3 0.9754 100 0.227 Contact Map
2v78A 5 0.9718 100 0.231 Contact Map
1tyyA 2 0.9472 100 0.232 Contact Map
2dcnA 5 0.9648 100 0.232 Contact Map
3h49A 2 0.9648 100 0.233 Contact Map
3hj6A 2 0.8662 100 0.235 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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