GREMLIN Database
YURK - Uncharacterized HTH-type transcriptional regulator YurK
UniProt: O32152 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (195)
Sequences: 25513 (19795)
Seq/√Len: 1417.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_S31_A4.0401.00
21_D26_V3.9231.00
19_T60_E3.3521.00
15_K56_D3.2961.00
21_D42_K3.2851.00
64_I74_K2.8361.00
14_L45_V2.6751.00
36_E47_R2.6631.00
186_N189_Y2.6481.00
17_I21_D2.5301.00
65_R71_T2.4881.00
66_Q69_K2.3691.00
14_L43_Y2.2921.00
15_K60_E2.2811.00
20_D24_K2.1601.00
32_K72_F2.1421.00
112_S115_I2.0911.00
8_T16_Q2.0351.00
17_I43_Y1.9891.00
15_K19_T1.9581.00
105_S191_Q1.8991.00
69_K72_F1.8431.00
58_V65_R1.8251.00
134_L142_T1.8021.00
52_K55_L1.7661.00
19_T23_K1.7521.00
37_N41_T1.7181.00
10_L13_Q1.6851.00
121_I125_S1.6851.00
38_E42_K1.6731.00
17_I20_D1.6031.00
191_Q194_E1.6001.00
21_D27_Y1.5921.00
58_V63_L1.5921.00
191_Q195_S1.5861.00
115_I137_D1.5821.00
19_T62_Y1.5521.00
35_T38_E1.5481.00
39_L50_V1.5331.00
66_Q72_F1.5261.00
13_Q17_I1.5241.00
63_L71_T1.4891.00
22_I73_V1.4751.00
36_E51_R1.4691.00
54_I63_L1.4651.00
181_N189_Y1.4481.00
130_L146_T1.4351.00
131_K134_L1.4161.00
27_Y73_V1.4011.00
55_L65_R1.3951.00
109_I187_V1.3901.00
189_Y193_E1.3851.00
64_I72_F1.3771.00
111_A116_A1.3731.00
122_Q125_S1.3621.00
100_K135_Y1.3441.00
11_Y56_D1.3401.00
45_V50_V1.3311.00
91_F139_Q1.3211.00
98_K102_H1.3101.00
38_E41_T1.2821.00
56_D59_E1.2671.00
8_T13_Q1.2661.00
192_Q196_K1.2631.00
29_P75_S1.2501.00
179_T183_K1.2451.00
102_H135_Y1.2441.00
111_A115_I1.2381.00
55_L59_E1.2331.00
21_D25_G1.2301.00
9_P12_I1.2251.00
55_L58_V1.2101.00
187_V191_Q1.2081.00
115_I147_H1.1901.00
130_L134_L1.1901.00
23_K62_Y1.1701.00
129_E145_V1.1621.00
143_F147_H1.1391.00
109_I129_E1.1131.00
66_Q70_G1.1081.00
54_I71_T1.1081.00
32_K70_G1.1011.00
104_L108_I1.1011.00
56_D60_E1.0951.00
140_P151_D1.0801.00
176_V180_H1.0741.00
91_F95_T1.0641.00
21_D43_Y1.0521.00
27_Y31_A1.0441.00
107_D129_E1.0421.00
116_A183_K1.0391.00
12_I56_D1.0361.00
127_V131_K1.0211.00
120_Q123_P1.0191.00
143_F194_E1.0141.00
180_H184_L1.0101.00
12_I16_Q1.0081.00
167_H171_K1.0031.00
89_S93_E0.9991.00
116_A119_L0.9961.00
97_K101_H0.9891.00
189_Y192_Q0.9751.00
133_I145_V0.9701.00
177_V193_E0.9551.00
131_K145_V0.9541.00
195_S199_D0.9521.00
132_R182_T0.9451.00
11_Y15_K0.9401.00
166_M170_L0.9331.00
10_L49_T0.9321.00
168_D172_Q0.9201.00
165_S168_D0.9151.00
52_K56_D0.9131.00
113_K117_E0.9081.00
68_G71_T0.9071.00
111_A185_L0.9041.00
131_K135_Y0.9021.00
105_S129_E0.9001.00
16_Q19_T0.8961.00
30_T64_I0.8911.00
116_A179_T0.8891.00
124_E127_V0.8871.00
96_G100_K0.8821.00
184_L189_Y0.8821.00
32_K35_T0.8821.00
201_D204_D0.8811.00
18_I39_L0.8791.00
118_K131_K0.8771.00
108_I150_L0.8661.00
39_L54_I0.8661.00
46_S49_T0.8641.00
171_K177_V0.8571.00
105_S131_K0.8561.00
157_D160_I0.8541.00
8_T12_I0.8531.00
142_T146_T0.8451.00
100_K138_D0.8431.00
97_K199_D0.8331.00
36_E65_R0.8311.00
94_S110_P0.8281.00
54_I58_V0.8161.00
105_S187_V0.8141.00
40_C50_V0.8071.00
188_V194_E0.8041.00
29_P74_K0.8041.00
126_P150_L0.7991.00
113_K116_A0.7921.00
180_H183_K0.7901.00
190_A200_C0.7831.00
30_T75_S0.7801.00
128_V132_R0.7791.00
136_N142_T0.7771.00
114_P118_K0.7721.00
17_I42_K0.7681.00
166_M169_I0.7631.00
11_Y52_K0.7611.00
129_E175_K0.7581.00
131_K193_E0.7581.00
188_V191_Q0.7571.00
33_L63_L0.7531.00
158_T161_A0.7491.00
90_E93_E0.7461.00
156_I159_F0.7441.00
121_I124_E0.7431.00
26_V42_K0.7421.00
125_S151_D0.7401.00
188_V192_Q0.7381.00
96_G99_P0.7361.00
16_Q20_D0.7341.00
130_L149_P0.7311.00
88_Y92_M0.7301.00
120_Q124_E0.7271.00
108_I126_P0.7271.00
106_H109_I0.7251.00
105_S188_V0.7211.00
112_S116_A0.7211.00
102_H105_S0.7171.00
128_V179_T0.7171.00
144_E147_H0.7171.00
92_M136_N0.7091.00
14_L17_I0.7091.00
21_D24_K0.7091.00
87_G90_E0.7071.00
27_Y33_L0.7051.00
123_P127_V0.7041.00
90_E94_S0.7011.00
192_Q195_S0.7001.00
14_L50_V0.6981.00
95_T144_E0.6901.00
156_I160_I0.6821.00
41_T44_N0.6791.00
178_P194_E0.6781.00
43_Y50_V0.6771.00
18_I27_Y0.6731.00
151_D154_P0.6671.00
193_E196_K0.6671.00
177_V180_H0.6671.00
34_P42_K0.6661.00
84_A139_Q0.6661.00
115_I118_K0.6651.00
194_E197_Y0.6581.00
145_V149_P0.6581.00
169_I172_Q0.6571.00
101_H104_L0.6561.00
116_A185_L0.6541.00
178_P193_E0.6521.00
101_H195_S0.6511.00
140_P143_F0.6501.00
37_N40_C0.6481.00
181_N186_N0.6471.00
110_P126_P0.6471.00
176_V179_T0.6441.00
40_C43_Y0.6421.00
101_H191_Q0.6421.00
159_F162_D0.6391.00
149_P152_L0.6381.00
39_L43_Y0.6351.00
36_E71_T0.6251.00
129_E132_R0.6231.00
112_S119_L0.6231.00
101_H105_S0.6221.00
172_Q200_C0.6211.00
165_S169_I0.6171.00
200_C204_D0.6161.00
97_K195_S0.6121.00
136_N141_L0.5991.00
7_S13_Q0.5971.00
111_A127_V0.5961.00
98_K191_Q0.5951.00
108_I128_V0.5931.00
54_I65_R0.5891.00
177_V189_Y0.5871.00
130_L142_T0.5851.00
105_S109_I0.5831.00
104_L133_I0.5831.00
150_L154_P0.5801.00
190_A204_D0.5751.00
50_V63_L0.5721.00
14_L18_I0.5701.00
106_H110_P0.5691.00
126_P149_P0.5671.00
97_K137_D0.5661.00
115_I119_L0.5641.00
58_V71_T0.5641.00
105_S108_I0.5641.00
111_A135_Y0.5621.00
153_F156_I0.5601.00
111_A119_L0.5591.00
153_F157_D0.5591.00
135_Y138_D0.5581.00
94_S106_H0.5561.00
15_K53_A0.5531.00
152_L155_G0.5531.00
190_A195_S0.5521.00
195_S203_G0.5511.00
49_T53_A0.5511.00
100_K103_V0.5511.00
14_L53_A0.5491.00
196_K200_C0.5491.00
32_K69_K0.5471.00
119_L131_K0.5471.00
35_T68_G0.5461.00
189_Y204_D0.5451.00
175_K197_Y0.5431.00
97_K100_K0.5431.00
40_C48_I0.5401.00
49_T52_K0.5391.00
127_V130_L0.5371.00
190_A203_G0.5371.00
194_E198_L0.5311.00
20_D23_K0.5311.00
48_I52_K0.5291.00
107_D111_A0.5281.00
77_K80_R0.5271.00
102_H133_I0.5261.00
40_C47_R0.5261.00
115_I134_L0.5251.00
133_I149_P0.5131.00
12_I15_K0.5121.00
118_K134_L0.5111.00
72_F75_S0.5091.00
67_Q70_G0.5081.00
37_N47_R0.5071.00
34_P49_T0.5071.00
93_E96_G0.5071.00
151_D155_G0.5071.00
102_H106_H0.5051.00
103_V107_D0.5051.00
98_K141_L0.5041.00
20_D26_V0.5031.00
106_H112_S0.5001.00
190_A194_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9959 100 0.128 Contact Map
2ra5A 2 0.6116 100 0.153 Contact Map
3f8mA 2 0.9421 100 0.173 Contact Map
3edpA 2 0.9132 100 0.19 Contact Map
3eetA 2 0.9545 100 0.2 Contact Map
3bwgA 2 0.9421 100 0.208 Contact Map
1hw1A 2 0.8099 100 0.451 Contact Map
4p96A 2 0.8926 99.9 0.459 Contact Map
3c7jA 4 0.8512 99.9 0.466 Contact Map
3f8lA 2 0.6694 99.9 0.467 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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