BSN2 - BACSU - GREMLIN Contacts

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BSN2 - Extracellular ribonuclease

UniProt:	O32150	Sequences: MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSGTGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKETDEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLRPADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEGDDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPFIDHPEWADEIWP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (229)
Sequences:	711 (491)
Seq/√Len:	32.4

ECOLI - END1
BACSU - BSN2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
246_L	283_A	4.933	1.00
256_D	260_K	4.052	1.00
247_E	251_Q	3.494	1.00
68_A	83_I	2.964	1.00
276_F	286_I	2.951	1.00
141_K	153_G	2.933	1.00
249_N	283_A	2.830	1.00
108_N	111_N	2.799	1.00
160_R	208_M	2.767	1.00
67_G	79_T	2.710	1.00
204_D	252_D	2.605	1.00
196_E	202_K	2.596	1.00
115_L	205_V	2.562	1.00
177_N	247_E	2.557	1.00
98_A	102_T	2.441	0.99
60_D	63_T	2.425	0.99
71_K	79_T	2.378	0.99
156_I	265_I	2.337	0.99
173_M	190_Y	2.266	0.99
138_V	205_V	2.237	0.99
102_T	156_I	2.222	0.99
199_D	202_K	2.189	0.99
250_K	284_D	2.161	0.99
105_D	111_N	2.139	0.99
81_H	85_S	2.120	0.98
126_N	164_V	2.085	0.98
68_A	71_K	2.067	0.98
200_D	255_D	2.065	0.98
209_L	227_L	2.022	0.98
157_H	208_M	1.946	0.97
214_V	276_F	1.940	0.97
63_T	66_E	1.906	0.97
131_G	184_K	1.847	0.96
98_A	156_I	1.805	0.96
256_D	259_R	1.799	0.96
90_L	98_A	1.798	0.96
246_L	250_K	1.771	0.95
99_L	159_L	1.758	0.95
123_K	126_N	1.750	0.95
118_N	198_R	1.694	0.94
69_E	112_V	1.688	0.94
239_H	243_S	1.682	0.94
132_D	164_V	1.676	0.94
165_Q	169_A	1.651	0.93
71_K	75_S	1.613	0.92
101_E	264_I	1.606	0.92
111_N	120_S	1.600	0.92
60_D	66_E	1.590	0.92
74_D	235_S	1.587	0.92
131_G	165_Q	1.585	0.92
81_H	218_G	1.538	0.90
266_Y	271_H	1.518	0.90
77_K	214_V	1.511	0.89
259_R	263_E	1.486	0.89
105_D	113_I	1.475	0.88
91_S	94_E	1.467	0.88
138_V	208_M	1.463	0.88
101_E	269_Y	1.461	0.88
188_N	195_W	1.439	0.87
95_V	159_L	1.427	0.87
139_W	212_M	1.375	0.84
79_T	82_R	1.361	0.84
143_H	174_D	1.360	0.84
263_E	267_E	1.356	0.84
123_K	132_D	1.339	0.83
61_T	66_E	1.339	0.83
153_G	159_L	1.334	0.83
143_H	209_L	1.333	0.82
170_R	175_F	1.328	0.82
102_T	269_Y	1.313	0.82
138_V	160_R	1.305	0.81
156_I	269_Y	1.292	0.80
185_A	189_Y	1.268	0.79
144_G	152_P	1.266	0.79
108_N	113_I	1.258	0.79
77_K	217_E	1.242	0.78
58_Y	61_T	1.241	0.78
246_L	249_N	1.226	0.77
105_D	120_S	1.216	0.76
58_Y	62_D	1.203	0.75
68_A	79_T	1.197	0.75
279_H	282_W	1.190	0.75
126_N	132_D	1.186	0.74
141_K	159_L	1.186	0.74
145_D	153_G	1.183	0.74
75_S	79_T	1.183	0.74
138_V	209_L	1.173	0.74
118_N	201_V	1.170	0.73
198_R	201_V	1.155	0.72
115_L	138_V	1.134	0.71
102_T	265_I	1.116	0.70
196_E	199_D	1.100	0.69
98_A	269_Y	1.097	0.68
165_Q	184_K	1.096	0.68
102_T	160_R	1.091	0.68
113_I	201_V	1.086	0.68
158_H	196_E	1.079	0.67
128_G	131_G	1.068	0.66
82_R	85_S	1.067	0.66
144_G	158_H	1.054	0.65
148_T	153_G	1.054	0.65
169_A	195_W	1.049	0.65
58_Y	63_T	1.049	0.65
282_W	285_E	1.043	0.64
210_F	283_A	1.027	0.63
139_W	240_G	1.021	0.63
228_N	233_N	1.020	0.63
65_Y	275_P	1.019	0.63
176_D	194_S	1.009	0.62
99_L	112_V	1.003	0.61
96_W	135_R	1.001	0.61
264_I	269_Y	0.999	0.61
76_L	286_I	0.981	0.60
215_R	253_P	0.978	0.59
123_K	164_V	0.966	0.58
150_K	154_T	0.964	0.58
182_Y	195_W	0.948	0.57
157_H	160_R	0.944	0.57
84_I	215_R	0.943	0.56
98_A	265_I	0.932	0.56
210_F	214_V	0.931	0.56
144_G	151_G	0.928	0.55
86_G	215_R	0.915	0.54
126_N	131_G	0.912	0.54
185_A	188_N	0.911	0.54
158_H	208_M	0.911	0.54
121_R	125_L	0.905	0.53
98_A	112_V	0.903	0.53
127_G	164_V	0.903	0.53
229_D	243_S	0.895	0.53
210_F	242_Q	0.892	0.52
138_V	141_K	0.891	0.52
87_H	216_Y	0.885	0.52
220_D	223_P	0.884	0.52
195_W	210_F	0.881	0.51
95_V	99_L	0.879	0.51
208_M	265_I	0.878	0.51
62_D	251_Q	0.877	0.51
224_D	227_L	0.875	0.51
226_E	229_D	0.872	0.51
74_D	78_S	0.871	0.51
61_T	83_I	0.865	0.50
191_D	194_S	0.864	0.50
160_R	205_V	0.855	0.49
115_L	160_R	0.854	0.49
258_E	277_I	0.853	0.49
119_E	122_S	0.852	0.49
139_W	144_G	0.851	0.49
245_L	249_N	0.836	0.48
147_G	151_G	0.833	0.47
200_D	204_D	0.832	0.47
75_S	247_E	0.823	0.47
141_K	212_M	0.819	0.46
78_S	282_W	0.816	0.46
60_D	279_H	0.813	0.46
140_A	239_H	0.812	0.46
144_G	170_R	0.811	0.46
216_Y	270_Q	0.810	0.46
125_L	132_D	0.805	0.45
139_W	143_H	0.805	0.45
99_L	144_G	0.801	0.45
87_H	283_A	0.798	0.45
124_N	131_G	0.791	0.44
135_R	154_T	0.791	0.44
263_E	266_Y	0.789	0.44
206_A	275_P	0.787	0.44
96_W	112_V	0.786	0.44
61_T	112_V	0.784	0.43
67_G	183_A	0.783	0.43
103_D	160_R	0.774	0.43
191_D	225_L	0.768	0.42
148_T	172_N	0.766	0.42
80_L	286_I	0.765	0.42
95_V	135_R	0.763	0.42
252_D	255_D	0.762	0.42
150_K	153_G	0.761	0.42
68_A	80_L	0.758	0.41
78_S	82_R	0.751	0.41
83_I	86_G	0.749	0.41
134_N	170_R	0.748	0.41
260_K	264_I	0.748	0.41
216_Y	272_N	0.742	0.40
119_E	171_G	0.739	0.40
62_D	282_W	0.736	0.40
164_V	171_G	0.731	0.39
106_P	120_S	0.730	0.39
113_I	120_S	0.730	0.39
107_R	111_N	0.726	0.39
66_E	267_E	0.720	0.38
199_D	254_V	0.714	0.38
213_A	287_W	0.714	0.38
124_N	164_V	0.712	0.38
95_V	161_P	0.711	0.38
114_L	121_R	0.709	0.37
103_D	106_P	0.707	0.37
91_S	154_T	0.707	0.37
104_E	200_D	0.702	0.37
71_K	251_Q	0.698	0.37
69_E	79_T	0.696	0.36
210_F	254_V	0.692	0.36
254_V	258_E	0.692	0.36
284_D	287_W	0.692	0.36
141_K	205_V	0.686	0.36
225_L	229_D	0.685	0.36
78_S	217_E	0.685	0.36
123_K	127_G	0.679	0.35
138_V	257_R	0.678	0.35
126_N	130_V	0.677	0.35
177_N	244_V	0.675	0.35
159_L	172_N	0.675	0.35
210_F	287_W	0.674	0.35
89_M	150_K	0.669	0.34
157_H	277_I	0.668	0.34
123_K	128_G	0.668	0.34
210_F	245_L	0.667	0.34
60_D	263_E	0.666	0.34
172_N	235_S	0.664	0.34
154_T	170_R	0.663	0.34
65_Y	206_A	0.663	0.34
64_Y	117_T	0.662	0.34
223_P	226_E	0.661	0.34
67_G	75_S	0.661	0.34
138_V	175_F	0.661	0.34
125_L	129_N	0.660	0.34
143_H	223_P	0.658	0.34
150_K	171_G	0.656	0.33
142_S	172_N	0.654	0.33
210_F	227_L	0.654	0.33
101_E	104_E	0.649	0.33
139_W	245_L	0.642	0.32
186_P	190_Y	0.633	0.32
85_S	254_V	0.633	0.32
258_E	272_N	0.633	0.32
215_R	272_N	0.631	0.32
67_G	71_K	0.631	0.32
86_G	94_E	0.630	0.32
186_P	189_Y	0.629	0.32
148_T	154_T	0.627	0.31
104_E	108_N	0.627	0.31
240_G	244_V	0.623	0.31
75_S	250_K	0.623	0.31
264_I	267_E	0.622	0.31
227_L	246_L	0.619	0.31
133_W	170_R	0.616	0.31
260_K	263_E	0.615	0.31
140_A	175_F	0.612	0.30
122_S	128_G	0.611	0.30
70_G	76_L	0.610	0.30
66_E	75_S	0.610	0.30
141_K	148_T	0.607	0.30
247_E	250_K	0.606	0.30
94_E	149_S	0.602	0.30
104_E	141_K	0.601	0.30
106_P	111_N	0.600	0.29
249_N	284_D	0.599	0.29
214_V	271_H	0.598	0.29
141_K	158_H	0.597	0.29
148_T	233_N	0.596	0.29
92_Y	137_H	0.594	0.29
101_E	171_G	0.594	0.29
114_L	178_G	0.592	0.29
121_R	163_D	0.591	0.29
245_L	270_Q	0.589	0.29
112_V	158_H	0.588	0.29
143_H	160_R	0.587	0.29
105_D	108_N	0.585	0.28
85_S	89_M	0.584	0.28
161_P	166_V	0.583	0.28
127_G	132_D	0.583	0.28
125_L	131_G	0.581	0.28
221_G	236_A	0.581	0.28
78_S	85_S	0.580	0.28
170_R	190_Y	0.580	0.28
175_F	209_L	0.579	0.28
205_V	209_L	0.579	0.28
213_A	217_E	0.578	0.28
183_A	189_Y	0.574	0.28
195_W	220_D	0.573	0.28
160_R	175_F	0.573	0.28
225_L	228_N	0.572	0.28
258_E	287_W	0.571	0.28
72_T	249_N	0.571	0.28
210_F	282_W	0.567	0.27
209_L	239_H	0.566	0.27
160_R	277_I	0.563	0.27
173_M	192_G	0.563	0.27
244_V	277_I	0.563	0.27
90_L	96_W	0.561	0.27
98_A	135_R	0.560	0.27
67_G	82_R	0.559	0.27
86_G	269_Y	0.554	0.26
139_W	201_V	0.552	0.26
99_L	161_P	0.552	0.26
121_R	131_G	0.548	0.26
74_D	234_G	0.548	0.26
264_I	271_H	0.547	0.26
266_Y	272_N	0.547	0.26
144_G	196_E	0.545	0.26
215_R	258_E	0.545	0.26
163_D	252_D	0.542	0.26
152_P	158_H	0.541	0.26
158_H	212_M	0.541	0.26
163_D	204_D	0.540	0.26
82_R	86_G	0.539	0.25
233_N	281_E	0.535	0.25
257_R	287_W	0.534	0.25
128_G	243_S	0.533	0.25
133_W	144_G	0.533	0.25
139_W	227_L	0.533	0.25
137_H	167_N	0.532	0.25
178_G	194_S	0.532	0.25
237_P	287_W	0.531	0.25
68_A	282_W	0.529	0.25
75_S	180_T	0.525	0.25
216_Y	253_P	0.523	0.24
134_N	162_A	0.523	0.24
62_D	148_T	0.523	0.24
201_V	252_D	0.522	0.24
78_S	214_V	0.521	0.24
70_G	147_G	0.521	0.24
185_A	193_D	0.519	0.24
88_T	247_E	0.519	0.24
80_L	83_I	0.518	0.24
58_Y	175_F	0.517	0.24
247_E	255_D	0.517	0.24
123_K	131_G	0.516	0.24
172_N	219_D	0.513	0.24
85_S	244_V	0.512	0.24
213_A	237_P	0.511	0.24
82_R	192_G	0.511	0.24
103_D	277_I	0.511	0.24
204_D	255_D	0.508	0.24
70_G	73_G	0.508	0.24
114_L	174_D	0.506	0.23
222_Y	227_L	0.506	0.23
153_G	243_S	0.505	0.23
112_V	175_F	0.505	0.23
139_W	198_R	0.505	0.23
163_D	166_V	0.503	0.23
94_E	98_A	0.503	0.23
121_R	184_K	0.502	0.23
117_T	197_P	0.501	0.23
227_L	239_H	0.501	0.23
83_I	238_Y	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pu3A	1	0.5833	100	0.487	Contact Map
4un4B	1	0.7951	70.7	0.957	Contact Map
3m7kA	2	0.4271	31.1	0.966	Contact Map
4h9dA	3	0.3368	25.7	0.968	Contact Map
4ogeA	1	0.7674	15.4	0.971	Contact Map
4p6kA	2	0.0521	7.4	0.975	Contact Map
4p1wA	1	0.1042	6.4	0.976	Contact Map
2mfqB	1	0.0799	4.2	0.978	Contact Map
4ph1A	1	0.0868	2.6	0.98	Contact Map
3zbiC	1	0.0972	2.2	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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