GREMLIN Database
ALLC - Allantoate amidohydrolase
UniProt: O32149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 412 (396)
Sequences: 4196 (3086)
Seq/√Len: 155.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_A318_I4.0741.00
342_F354_E3.6591.00
50_M67_G3.5601.00
68_R122_E3.3951.00
253_L316_K3.0041.00
203_S353_E2.9321.00
379_S391_T2.9231.00
81_T103_A2.8961.00
347_E405_D2.8471.00
45_A49_E2.8321.00
81_T407_L2.7611.00
223_L248_I2.7331.00
343_E409_K2.6571.00
162_V167_A2.6351.00
98_Y396_L2.5981.00
15_Y108_K2.5841.00
40_M44_L2.5321.00
348_N405_D2.4951.00
47_K65_V2.3661.00
69_L117_P2.2261.00
47_K51_S2.2081.00
226_E239_K2.1871.00
38_E41_D2.1451.00
347_E409_K2.1181.00
69_L111_K2.1161.00
11_S105_L2.1111.00
341_A406_L2.0981.00
163_S166_T2.0971.00
73_Q118_K2.0791.00
72_T118_K2.0581.00
53_F104_M2.0471.00
247_R315_Q2.0271.00
211_T354_E2.0231.00
380_R390_Y2.0091.00
107_L123_A1.9821.00
106_A407_L1.9641.00
377_V391_T1.9551.00
273_E283_R1.9511.00
45_A48_T1.9401.00
37_K41_D1.9141.00
9_K397_E1.8991.00
109_Q113_T1.8961.00
383_V386_S1.8951.00
251_E308_L1.8851.00
222_T283_R1.8841.00
391_T396_L1.8701.00
18_W45_A1.8611.00
263_L301_F1.8521.00
167_A170_E1.8511.00
37_K170_E1.8411.00
14_D18_W1.8201.00
334_D371_P1.8131.00
247_R316_K1.8071.00
337_L373_C1.7881.00
65_V125_S1.7861.00
342_F346_L1.7841.00
119_K187_S1.7621.00
12_I400_V1.7591.00
311_G315_Q1.7461.00
220_L323_D1.7291.00
49_E52_S1.7271.00
390_Y393_A1.7121.00
224_E283_R1.7071.00
109_Q404_T1.6881.00
56_E70_S1.6791.00
46_V85_I1.6631.00
308_L311_G1.6511.00
271_T285_Q1.6511.00
12_I101_L1.6401.00
10_N14_D1.6301.00
78_V120_T1.6211.00
94_Y390_Y1.6171.00
110_L115_G1.6151.00
48_T52_S1.5891.00
44_L173_F1.5861.00
248_I309_I1.5631.00
295_Q330_P1.5611.00
379_S395_Q1.5541.00
302_H306_V1.5511.00
48_T51_S1.5461.00
80_V124_V1.5401.00
341_A375_L1.5311.00
224_E319_R1.5061.00
73_Q76_D1.5001.00
81_T106_A1.4841.00
18_W21_Q1.4801.00
223_L286_F1.4781.00
29_G32_R1.4621.00
344_T402_A1.4601.00
228_N233_T1.4561.00
13_T17_E1.4531.00
340_A409_K1.4521.00
190_V406_L1.4451.00
70_S120_T1.4421.00
139_W142_G1.4401.00
303_Q307_A1.4381.00
206_D351_S1.4321.00
55_L69_L1.4311.00
207_L402_A1.4291.00
50_M104_M1.4161.00
202_M237_W1.4161.00
46_V67_G1.4131.00
258_E304_D1.4121.00
47_K57_T1.4051.00
83_S100_V1.4051.00
109_Q401_R1.4041.00
23_G38_E1.4031.00
338_K354_E1.4001.00
76_D119_K1.3951.00
206_D395_Q1.3891.00
80_V186_I1.3891.00
111_K117_P1.3781.00
247_R254_L1.3661.00
102_A400_V1.3631.00
85_I125_S1.3621.00
72_T116_A1.3591.00
251_E254_L1.3571.00
306_V310_N1.3551.00
307_A311_G1.3441.00
62_V143_N1.3341.00
242_L270_I1.3331.00
55_L107_L1.3221.00
147_V368_R1.3201.00
230_A266_T1.3131.00
139_W164_L1.3031.00
81_T190_V1.3021.00
220_L285_Q1.3011.00
184_T190_V1.3001.00
110_L117_P1.2941.00
363_A372_A1.2911.00
187_S190_V1.2881.00
224_E321_V1.2881.00
184_T187_S1.2831.00
15_Y105_L1.2821.00
242_L284_V1.2791.00
87_T97_A1.2751.00
241_P284_V1.2751.00
245_S249_I1.2711.00
186_I190_V1.2651.00
20_A93_K1.2651.00
263_L292_H1.2641.00
222_T285_Q1.2621.00
243_A253_L1.2611.00
397_E401_R1.2531.00
248_I286_F1.2481.00
108_K112_E1.2421.00
39_W43_Q1.2391.00
133_R158_D1.2351.00
189_F363_A1.2311.00
256_S265_L1.2271.00
344_T409_K1.2251.00
47_K59_F1.2231.00
128_E131_G1.2181.00
222_T321_V1.2151.00
77_E119_K1.2141.00
15_Y49_E1.2081.00
380_R392_S1.1981.00
405_D409_K1.1961.00
249_I270_I1.1941.00
158_D162_V1.1901.00
22_Y45_A1.1841.00
242_L272_A1.1781.00
199_T234_S1.1781.00
247_R250_H1.1751.00
324_E327_R1.1721.00
346_L352_C1.1711.00
205_R353_E1.1641.00
243_A249_I1.1571.00
79_I188_A1.1501.00
107_L121_L1.1451.00
300_Q304_D1.1451.00
19_L42_A1.1421.00
234_S237_W1.1411.00
272_A284_V1.1351.00
245_S270_I1.1341.00
13_T393_A1.1291.00
166_T169_H1.1281.00
252_L265_L1.1151.00
107_L111_K1.1151.00
22_Y42_A1.1121.00
174_G177_V1.1020.99
69_L107_L1.1020.99
341_A373_C1.1000.99
17_E21_Q1.0920.99
206_D398_I1.0830.99
295_Q329_E1.0810.99
46_V50_M1.0790.99
226_E383_V1.0640.99
35_Y63_G1.0570.99
223_L245_S1.0490.99
223_L320_A1.0460.99
212_S293_Q1.0420.99
66_F80_V1.0330.99
178_F181_A1.0330.99
401_R405_D1.0310.99
379_S392_S1.0290.99
71_G120_T1.0280.99
98_Y192_L1.0280.99
66_F124_V1.0270.99
79_I119_K1.0260.99
18_W49_E1.0190.99
169_H175_K1.0150.99
233_T280_I1.0120.99
44_L47_K1.0090.99
53_F108_K1.0080.99
249_I267_C1.0060.99
33_L40_M1.0000.99
346_L351_S1.0000.99
46_V125_S0.9940.99
138_Y365_M0.9930.99
183_R186_I0.9930.99
377_V399_G0.9910.99
104_M123_A0.9890.99
23_G90_N0.9870.99
350_F398_I0.9860.99
149_S152_D0.9820.99
345_A402_A0.9820.99
254_L258_E0.9790.99
106_A404_T0.9760.99
157_R163_S0.9740.99
165_Q169_H0.9710.99
115_G408_Y0.9700.99
64_N140_G0.9700.99
239_K319_R0.9700.99
41_D44_L0.9630.99
299_E327_R0.9600.99
153_A399_G0.9580.99
37_K167_A0.9570.99
138_Y142_G0.9500.98
338_K373_C0.9500.98
392_S395_Q0.9480.98
46_V123_A0.9480.98
209_I341_A0.9430.98
309_I320_A0.9410.98
89_I276_V0.9410.98
64_N67_G0.9370.98
178_F182_Y0.9340.98
40_M171_S0.9290.98
39_W127_C0.9270.98
102_A192_L0.9270.98
344_T405_D0.9270.98
150_E154_K0.9270.98
186_I370_Y0.9220.98
245_S286_F0.9220.98
344_T348_N0.9200.98
13_T94_Y0.9140.98
21_Q24_A0.9110.98
343_E347_E0.9110.98
16_I20_A0.9080.98
219_Y302_H0.9070.98
9_K394_R0.9060.98
192_L399_G0.9060.98
400_V404_T0.9060.98
205_R351_S0.9050.98
335_E339_A0.8970.98
333_M372_A0.8960.98
102_A403_L0.8950.98
308_L312_I0.8930.98
348_N401_R0.8910.98
68_R78_V0.8860.98
23_G28_G0.8840.97
196_Q207_L0.8830.97
68_R120_T0.8800.97
339_A343_E0.8730.97
252_L286_F0.8660.97
19_L97_A0.8610.97
221_V288_I0.8580.97
338_K342_F0.8560.97
398_I401_R0.8530.97
67_G70_S0.8520.97
295_Q299_E0.8480.97
33_L36_T0.8480.97
190_V193_H0.8450.97
133_R365_M0.8440.97
69_L110_L0.8430.97
383_V388_K0.8420.97
394_R398_I0.8390.97
366_I370_Y0.8380.97
22_Y41_D0.8370.97
43_Q65_V0.8350.96
292_H297_V0.8340.96
166_T170_E0.8300.96
102_A399_G0.8300.96
221_V322_I0.8270.96
34_L39_W0.8210.96
44_L48_T0.8120.96
145_T369_R0.8100.96
14_D17_E0.8090.96
201_E381_G0.8070.96
272_A275_N0.8060.96
19_L46_V0.8050.96
228_N280_I0.8030.96
154_K165_Q0.8020.96
69_L116_A0.8000.96
138_Y141_S0.7990.95
85_I97_A0.7980.95
374_M384_S0.7960.95
145_T366_I0.7930.95
223_L318_I0.7920.95
340_A344_T0.7900.95
165_Q168_M0.7870.95
49_E53_F0.7840.95
77_E187_S0.7840.95
255_R304_D0.7830.95
288_I305_M0.7830.95
149_S153_A0.7810.95
263_L297_V0.7800.95
142_G148_F0.7790.95
35_Y127_C0.7790.95
164_L167_A0.7780.95
273_E285_Q0.7780.95
58_R66_F0.7760.95
196_Q199_T0.7670.94
143_N153_A0.7650.94
60_D64_N0.7650.94
186_I189_F0.7570.94
297_V300_Q0.7570.94
27_D32_R0.7570.94
17_E93_K0.7570.94
88_V126_L0.7550.94
55_L104_M0.7550.94
345_A352_C0.7530.94
303_Q306_V0.7520.94
187_S192_L0.7480.94
50_M57_T0.7480.94
245_S267_C0.7470.94
57_T65_V0.7460.94
340_A343_E0.7450.93
219_Y322_I0.7440.93
126_L189_F0.7430.93
27_D387_P0.7380.93
158_D356_V0.7370.93
221_V286_F0.7370.93
307_A310_N0.7370.93
299_E303_Q0.7360.93
183_R188_A0.7340.93
185_D188_A0.7330.93
199_T203_S0.7320.93
43_Q127_C0.7310.93
290_I301_F0.7310.93
269_K287_S0.7290.93
255_R308_L0.7290.93
222_T323_D0.7290.93
244_A312_I0.7280.93
70_S75_P0.7280.93
55_L111_K0.7270.93
207_L378_P0.7270.93
151_Q155_E0.7260.93
138_Y216_Q0.7260.93
338_K341_A0.7250.93
296_H299_E0.7250.93
19_L101_L0.7240.92
255_R258_E0.7230.92
227_C241_P0.7210.92
85_I100_V0.7210.92
193_H196_Q0.7190.92
152_D156_P0.7180.92
53_F111_K0.7180.92
58_R122_E0.7170.92
378_P395_Q0.7140.92
132_S279_V0.7130.92
186_I192_L0.7120.92
220_L325_Y0.7110.92
50_M107_L0.7100.92
71_G76_D0.7100.92
155_E354_E0.7100.92
209_I338_K0.7100.92
203_S206_D0.7090.92
61_D150_E0.7070.92
250_H253_L0.7060.92
151_Q154_K0.7040.91
128_E136_M0.7020.91
343_E346_L0.7000.91
155_E163_S0.6990.91
46_V100_V0.6990.91
66_F144_M0.6980.91
226_E381_G0.6970.91
40_M59_F0.6970.91
175_K178_F0.6970.91
185_D190_V0.6960.91
25_S28_G0.6960.91
346_L349_G0.6930.91
202_M236_K0.6910.91
221_V309_I0.6890.91
81_T121_L0.6890.91
366_I369_R0.6880.90
391_T395_Q0.6870.90
217_R302_H0.6830.90
392_S396_L0.6810.90
404_T408_Y0.6780.90
196_Q200_L0.6780.90
126_L366_I0.6770.90
191_E208_G0.6760.90
243_A316_K0.6750.90
349_G352_C0.6750.90
114_Y117_P0.6750.90
148_F153_A0.6740.90
67_G71_G0.6720.89
51_S56_E0.6720.89
265_L290_I0.6700.89
110_L116_A0.6690.89
232_T264_R0.6680.89
169_H174_G0.6670.89
223_L244_A0.6670.89
58_R68_R0.6660.89
246_S250_H0.6630.89
98_Y377_V0.6620.89
15_Y18_W0.6620.89
128_E139_W0.6610.89
269_K275_N0.6600.89
67_G123_A0.6570.88
82_G362_D0.6540.88
28_G32_R0.6530.88
214_A293_Q0.6520.88
105_L109_Q0.6520.88
151_Q156_P0.6510.88
232_T359_A0.6500.88
44_L59_F0.6500.88
339_A354_E0.6490.88
259_L300_Q0.6490.88
254_L308_L0.6490.88
26_A134_F0.6490.88
198_K202_M0.6460.87
55_L67_G0.6440.87
33_L132_S0.6430.87
196_Q210_V0.6420.87
190_V403_L0.6420.87
377_V396_L0.6410.87
128_E230_A0.6400.87
375_L399_G0.6380.87
184_T194_I0.6370.87
223_L309_I0.6340.86
113_T404_T0.6330.86
339_A342_F0.6290.86
19_L85_I0.6280.86
59_F65_V0.6280.86
162_V170_E0.6270.86
242_L245_S0.6270.86
182_Y186_I0.6270.86
163_S167_A0.6270.86
399_G403_L0.6250.86
63_G67_G0.6240.86
56_E68_R0.6210.85
234_S358_G0.6190.85
201_E205_R0.6170.85
57_T67_G0.6160.85
69_L115_G0.6160.85
109_Q112_E0.6140.85
401_R404_T0.6140.85
30_V33_L0.6130.85
105_L108_K0.6130.85
231_G268_G0.6120.85
255_R301_F0.6120.85
103_A123_A0.6100.84
199_T202_M0.6090.84
393_A397_E0.6070.84
226_E280_I0.6060.84
239_K244_A0.6050.84
247_R251_E0.6030.84
142_G365_M0.6010.83
246_S249_I0.6010.83
248_I320_A0.6000.83
252_L267_C0.5990.83
395_Q398_I0.5980.83
260_P294_H0.5980.83
46_V104_M0.5970.83
184_T188_A0.5970.83
306_V322_I0.5960.83
51_S57_T0.5960.83
11_S112_E0.5950.83
210_V215_G0.5940.83
12_I16_I0.5940.83
144_M366_I0.5940.83
335_E368_R0.5930.83
213_I216_Q0.5920.83
342_F352_C0.5910.82
67_G125_S0.5910.82
344_T406_L0.5900.82
31_T90_N0.5900.82
312_I316_K0.5870.82
215_G218_R0.5850.82
104_M107_L0.5850.82
228_N238_R0.5850.82
294_H297_V0.5830.82
360_G364_Q0.5830.82
190_V337_L0.5820.81
98_Y102_A0.5810.81
242_L281_P0.5810.81
241_P282_G0.5800.81
11_S14_D0.5790.81
20_A24_A0.5790.81
29_G33_L0.5760.81
16_I101_L0.5760.81
242_L249_I0.5750.81
171_S175_K0.5740.81
219_Y324_E0.5730.80
190_V407_L0.5720.80
252_L288_I0.5720.80
375_L403_L0.5710.80
390_Y396_L0.5710.80
339_A346_L0.5700.80
117_P121_L0.5700.80
49_E104_M0.5690.80
27_D33_L0.5690.80
30_V97_A0.5680.80
22_Y38_E0.5670.80
27_D30_V0.5670.80
300_Q303_Q0.5660.80
44_L51_S0.5660.80
62_V150_E0.5660.80
97_A125_S0.5650.80
350_F402_A0.5650.80
52_S108_K0.5640.79
185_D192_L0.5630.79
217_R298_L0.5610.79
293_Q356_V0.5610.79
62_V140_G0.5590.79
228_N383_V0.5580.79
65_V68_R0.5580.79
131_G230_A0.5570.79
204_G207_L0.5560.78
340_A406_L0.5560.78
117_P120_T0.5540.78
242_L246_S0.5540.78
239_K317_G0.5540.78
139_W156_P0.5530.78
156_P357_S0.5530.78
128_E135_P0.5520.78
15_Y45_A0.5500.78
162_V166_T0.5500.78
72_T75_P0.5500.78
336_R340_A0.5480.77
87_T93_K0.5480.77
206_D378_P0.5480.77
304_D307_A0.5470.77
65_V70_S0.5460.77
94_Y396_L0.5450.77
364_Q367_G0.5450.77
87_T396_L0.5440.77
113_T408_Y0.5440.77
235_M264_R0.5430.77
64_N71_G0.5420.77
243_A250_H0.5420.77
93_K97_A0.5420.77
113_T116_A0.5410.77
197_G201_E0.5410.77
111_K114_Y0.5400.76
64_N124_V0.5400.76
381_G384_S0.5380.76
197_G200_L0.5380.76
154_K174_G0.5370.76
195_E208_G0.5370.76
20_A23_G0.5370.76
72_T120_T0.5340.76
139_W153_A0.5330.76
164_L168_M0.5300.75
337_L406_L0.5290.75
247_R312_I0.5280.75
79_I187_S0.5280.75
204_G208_G0.5260.75
168_M171_S0.5250.74
81_T189_F0.5250.74
88_V276_V0.5220.74
277_A325_Y0.5220.74
27_D31_T0.5210.74
13_T397_E0.5200.74
228_N386_S0.5180.73
78_V122_E0.5180.73
195_E200_L0.5180.73
334_D339_A0.5160.73
167_A171_S0.5160.73
12_I396_L0.5160.73
221_V320_A0.5160.73
66_F122_E0.5140.73
131_G138_Y0.5120.73
276_V279_V0.5120.73
159_E271_T0.5120.73
73_Q116_A0.5100.72
348_N398_I0.5100.72
78_V144_M0.5090.72
143_N150_E0.5090.72
188_A193_H0.5080.72
207_L210_V0.5070.72
157_R166_T0.5060.72
141_S191_E0.5060.72
134_F158_D0.5060.72
39_W125_S0.5040.71
213_I364_Q0.5040.71
103_A106_A0.5040.71
19_L22_Y0.5030.71
268_G287_S0.5010.71
378_P382_G0.5010.71
20_A30_V0.5000.71
250_H316_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n5fA 2 0.9782 100 0.359 Contact Map
4pxdA 2 0.9927 100 0.362 Contact Map
4wjbA 2 0.9854 100 0.366 Contact Map
2v8hA 2 0.983 100 0.378 Contact Map
4pxeA 2 1 100 0.378 Contact Map
3khxA 1 0.8738 100 0.455 Contact Map
1lfwA 1 0.9539 100 0.463 Contact Map
3ifeA 2 0.8544 100 0.476 Contact Map
3pfoA 2 0.8398 100 0.48 Contact Map
3rzaA 2 0.8228 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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