GREMLIN Database
PUCG - Purine catabolism protein PucG
UniProt: O32148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (341)
Sequences: 38599 (25016)
Seq/√Len: 1354.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
301_A377_L3.7351.00
88_D113_H3.4601.00
305_G380_L3.2291.00
159_G169_F3.1511.00
301_A373_K3.1081.00
144_H176_T2.9751.00
154_P157_A2.9441.00
129_I164_T2.8301.00
52_M281_R2.7131.00
88_D111_N2.6691.00
183_K186_E2.6381.00
173_A192_A2.5881.00
93_I116_E2.5521.00
346_F385_A2.5251.00
278_E281_R2.5211.00
88_D133_K2.4871.00
309_M384_E2.4511.00
24_P28_R2.4471.00
129_I161_A2.4151.00
194_G208_P2.4001.00
305_G308_A2.3561.00
297_H373_K2.3541.00
127_D130_R2.3531.00
269_A272_M2.2911.00
55_E284_L2.2781.00
162_C167_A2.2591.00
156_K160_E2.1821.00
159_G163_R2.1731.00
140_V162_C2.1321.00
156_K186_E2.1071.00
312_R328_E2.0461.00
301_A305_G2.0171.00
305_G377_L2.0011.00
75_I98_G1.9401.00
300_A304_A1.9211.00
88_D137_P1.8951.00
160_E164_T1.8931.00
133_K136_K1.8831.00
163_R190_D1.8811.00
87_D138_K1.8801.00
364_I379_V1.8631.00
58_Q183_K1.8351.00
125_P161_A1.7761.00
127_D131_E1.7711.00
139_I170_I1.7461.00
124_D127_D1.7331.00
28_R32_T1.7311.00
116_E127_D1.7161.00
171_V189_I1.7091.00
52_M277_R1.7091.00
378_F382_G1.7051.00
87_D136_K1.6851.00
293_E297_H1.6831.00
314_F328_E1.6701.00
88_D136_K1.6591.00
302_L366_T1.6401.00
346_F382_G1.6391.00
113_H131_E1.6331.00
52_M284_L1.6181.00
189_I192_A1.6171.00
341_M345_Q1.6151.00
304_A308_A1.5991.00
69_G73_A1.5971.00
162_C169_F1.5801.00
27_L31_S1.5791.00
157_A160_E1.5791.00
30_M275_A1.5761.00
78_V191_A1.5741.00
129_I165_E1.5731.00
101_L105_A1.5431.00
126_E130_R1.5341.00
296_R300_A1.5341.00
125_P157_A1.5311.00
142_M158_I1.5281.00
51_E55_E1.5141.00
64_A213_E1.5121.00
373_K377_L1.5051.00
305_G384_E1.5021.00
294_R298_H1.4991.00
118_E122_V1.4931.00
68_D74_G1.4791.00
196_T276_L1.4771.00
289_E293_E1.4731.00
29_V278_E1.4691.00
305_G309_M1.4631.00
326_C361_I1.4601.00
334_D337_S1.4341.00
126_E129_I1.4301.00
372_R375_N1.4121.00
145_G321_M1.4101.00
292_F296_R1.4011.00
299_E303_A1.3941.00
142_M169_F1.3801.00
53_L208_P1.3761.00
163_R188_K1.3761.00
129_I133_K1.3741.00
384_E388_L1.3731.00
23_D282_L1.3721.00
60_K213_E1.3621.00
132_I161_A1.3531.00
44_G48_E1.3511.00
140_V167_A1.3321.00
75_I170_I1.3311.00
93_I114_M1.3111.00
374_E377_L1.3081.00
302_L376_V1.3071.00
161_A165_E1.3061.00
129_I157_A1.3021.00
307_K316_D1.2811.00
90_L131_E1.2811.00
48_E52_M1.2711.00
159_G188_K1.2541.00
304_A307_K1.2421.00
86_E138_K1.2321.00
337_S341_M1.2241.00
290_T293_E1.2191.00
305_G381_A1.2151.00
102_T105_A1.2111.00
115_L131_E1.2061.00
48_E277_R1.2031.00
341_M386_V1.1981.00
378_F381_A1.1941.00
49_T277_R1.1921.00
62_R213_E1.1911.00
28_R31_S1.1851.00
312_R331_G1.1791.00
191_A211_Y1.1761.00
60_K185_D1.1721.00
190_D212_N1.1701.00
200_L276_L1.1601.00
101_L104_I1.1541.00
308_A384_E1.1521.00
25_R282_L1.1461.00
90_L137_P1.1451.00
277_R281_R1.1441.00
162_C165_E1.1391.00
294_R297_H1.1361.00
111_N133_K1.1341.00
103_E106_E1.1341.00
71_S174_V1.1321.00
183_K187_W1.1321.00
58_Q185_D1.1311.00
381_A385_A1.1231.00
177_I194_G1.1151.00
84_E87_D1.1131.00
203_P275_A1.1111.00
303_A325_T1.1111.00
160_E188_K1.1081.00
52_M55_E1.1071.00
45_I274_Y1.1061.00
118_E124_D1.1061.00
25_R285_E1.1031.00
181_E289_E1.1031.00
161_A164_T1.1011.00
170_I193_I1.0971.00
29_V32_T1.0921.00
125_P129_I1.0891.00
128_I158_I1.0881.00
51_E54_R1.0881.00
155_L171_V1.0781.00
303_A307_K1.0761.00
22_V27_L1.0701.00
377_L381_A1.0701.00
74_G193_I1.0661.00
113_H133_K1.0641.00
91_I114_M1.0591.00
48_E281_R1.0591.00
43_T47_N1.0581.00
290_T294_R1.0571.00
336_E340_D1.0511.00
350_I362_W1.0471.00
342_L350_I1.0471.00
152_I180_C1.0431.00
25_R278_E1.0381.00
82_V168_L1.0351.00
141_A170_I1.0331.00
380_L384_E1.0331.00
144_H192_A1.0321.00
327_V364_I1.0321.00
184_V210_T1.0261.00
142_M155_L1.0181.00
163_R169_F1.0181.00
17_P324_V1.0161.00
201_S367_M1.0141.00
170_I191_A1.0091.00
348_I379_V1.0051.00
281_R285_E1.0021.00
104_I107_R0.9891.00
298_H373_K0.9831.00
340_D344_A0.9831.00
176_T192_A0.9781.00
143_V147_T0.9691.00
348_I382_G0.9661.00
291_R294_R0.9651.00
341_M346_F0.9591.00
46_M273_L0.9571.00
104_I108_Y0.9551.00
145_G176_T0.9521.00
348_I378_F0.9501.00
102_T106_E0.9501.00
286_E290_T0.9501.00
168_L191_A0.9451.00
65_Y210_T0.9441.00
298_H376_V0.9391.00
302_L379_V0.9371.00
316_D319_C0.9371.00
182_V185_D0.9331.00
191_A215_V0.9321.00
299_E325_T0.9311.00
382_G385_A0.9311.00
340_D345_Q0.9271.00
302_L364_I0.9271.00
56_L177_I0.9261.00
132_I137_P0.9211.00
120_G316_D0.9201.00
133_K165_E0.9191.00
75_I193_I0.9151.00
366_T376_V0.9131.00
309_M380_L0.9061.00
181_E292_F0.9051.00
82_V191_A0.9001.00
278_E282_L0.8891.00
94_Y153_H0.8861.00
303_A313_L0.8841.00
80_A255_E0.8751.00
350_I364_I0.8751.00
88_D135_V0.8731.00
162_C166_D0.8691.00
306_I327_V0.8681.00
370_S375_N0.8671.00
16_T20_V0.8601.00
339_R352_S0.8601.00
302_L325_T0.8581.00
56_L280_V0.8531.00
16_T370_S0.8531.00
379_V383_L0.8521.00
128_I140_V0.8451.00
125_P128_I0.8421.00
133_K137_P0.8391.00
196_T202_V0.8351.00
276_L280_V0.8281.00
68_D77_A0.8251.00
53_L280_V0.8251.00
374_E378_F0.8231.00
337_S340_D0.8191.00
275_A279_G0.8161.00
16_T21_E0.8141.00
57_F194_G0.8121.00
301_A304_A0.8101.00
59_T64_A0.8071.00
91_I95_G0.8071.00
196_T206_M0.8051.00
145_G322_P0.8051.00
314_F326_C0.8041.00
16_T367_M0.8031.00
105_A110_A0.8031.00
212_N215_V0.8021.00
159_G187_W0.8021.00
47_N51_E0.8021.00
297_H301_A0.8011.00
173_A176_T0.7971.00
140_V158_I0.7961.00
57_F184_V0.7961.00
311_L329_I0.7941.00
49_T52_M0.7921.00
60_K64_A0.7881.00
309_M381_A0.7871.00
89_V102_T0.7801.00
118_E127_D0.7801.00
113_H137_P0.7791.00
90_L113_H0.7791.00
100_L114_M0.7771.00
17_P365_G0.7761.00
287_G290_T0.7741.00
83_I110_A0.7721.00
321_M324_V0.7671.00
168_L215_V0.7611.00
338_V386_V0.7601.00
144_H187_W0.7601.00
25_R28_R0.7591.00
314_F361_I0.7591.00
103_E107_R0.7521.00
291_R295_H0.7521.00
116_E131_E0.7461.00
57_F210_T0.7451.00
160_E163_R0.7421.00
181_E184_V0.7411.00
168_L190_D0.7401.00
206_M272_M0.7371.00
200_L280_V0.7351.00
132_I167_A0.7321.00
376_V380_L0.7301.00
16_T369_Y0.7301.00
92_P95_G0.7281.00
381_A384_E0.7271.00
301_A380_L0.7231.00
51_E62_R0.7201.00
254_L257_Y0.7191.00
24_P27_L0.7181.00
79_L101_L0.7141.00
182_V186_E0.7131.00
181_E186_E0.7121.00
73_A77_A0.7121.00
156_K187_W0.7111.00
177_I200_L0.7111.00
49_T273_L0.7101.00
59_T210_T0.7101.00
198_K363_R0.7081.00
213_E217_D0.7061.00
66_P77_A0.7041.00
142_M171_V0.7041.00
99_Y141_A0.7001.00
144_H155_L0.6991.00
302_L380_L0.6981.00
26_V279_G0.6971.00
206_M273_L0.6951.00
382_G386_V0.6911.00
293_E296_R0.6901.00
291_R368_G0.6881.00
144_H182_V0.6871.00
301_A376_V0.6861.00
379_V382_G0.6861.00
71_S75_I0.6851.00
177_I182_V0.6841.00
317_D320_K0.6831.00
92_P142_M0.6811.00
176_T180_C0.6801.00
310_G331_G0.6791.00
312_R315_G0.6751.00
182_V187_W0.6751.00
60_K212_N0.6731.00
338_V383_L0.6731.00
184_V187_W0.6711.00
188_K212_N0.6701.00
37_Q41_A0.6681.00
93_I117_C0.6681.00
190_D214_R0.6681.00
356_P359_G0.6681.00
370_S376_V0.6681.00
23_D26_V0.6661.00
144_H171_V0.6661.00
52_M280_V0.6661.00
333_I337_S0.6661.00
329_I332_G0.6651.00
302_L305_G0.6611.00
157_A161_A0.6611.00
333_I338_V0.6591.00
156_K188_K0.6591.00
54_R62_R0.6581.00
287_G291_R0.6581.00
303_A320_K0.6581.00
48_E51_E0.6581.00
41_A44_G0.6561.00
173_A177_I0.6561.00
339_R350_I0.6561.00
377_L380_L0.6561.00
45_I48_E0.6541.00
129_I132_I0.6531.00
106_E114_M0.6501.00
54_R59_T0.6481.00
132_I165_E0.6471.00
90_L115_L0.6471.00
91_I141_A0.6461.00
91_I102_T0.6461.00
297_H300_A0.6461.00
174_V195_G0.6451.00
55_E58_Q0.6411.00
72_R76_E0.6411.00
149_T152_I0.6401.00
253_Q256_D0.6401.00
142_M153_H0.6391.00
168_L214_R0.6381.00
78_V209_I0.6381.00
79_L139_I0.6361.00
289_E292_F0.6361.00
30_M33_P0.6361.00
277_R280_V0.6331.00
102_T114_M0.6331.00
130_R134_K0.6331.00
258_W265_H0.6281.00
131_E135_V0.6281.00
286_E291_R0.6221.00
126_E157_A0.6211.00
111_N136_K0.6201.00
341_M382_G0.6191.00
302_L306_I0.6171.00
303_A321_M0.6161.00
133_K164_T0.6161.00
46_M270_T0.6151.00
295_H323_V0.6151.00
56_L284_L0.6121.00
51_E61_N0.6111.00
30_M271_T0.6101.00
323_V326_C0.6101.00
159_G162_C0.6091.00
128_I132_I0.6091.00
76_E80_A0.6081.00
52_M56_L0.6071.00
64_A185_D0.6071.00
346_F386_V0.6071.00
281_R284_L0.6051.00
87_D111_N0.6041.00
131_E134_K0.6011.00
57_F177_I0.6011.00
124_D130_R0.6011.00
19_P197_Q0.5981.00
184_V192_A0.5951.00
115_L127_D0.5941.00
211_Y216_A0.5911.00
184_V188_K0.5901.00
217_D220_A0.5901.00
144_H173_A0.5901.00
71_S193_I0.5891.00
91_I112_V0.5881.00
294_R372_R0.5871.00
320_K324_V0.5871.00
42_F46_M0.5851.00
329_I338_V0.5851.00
38_F349_E0.5841.00
298_H366_T0.5841.00
61_N213_E0.5831.00
78_V82_V0.5831.00
132_I140_V0.5831.00
220_A223_K0.5821.00
169_F189_I0.5821.00
213_E216_A0.5801.00
47_N50_M0.5771.00
24_P31_S0.5771.00
265_H268_E0.5741.00
159_G171_V0.5721.00
177_I280_V0.5711.00
64_A212_N0.5701.00
146_E151_R0.5701.00
80_A222_R0.5691.00
59_T192_A0.5671.00
283_V288_L0.5661.00
206_M276_L0.5651.00
246_S254_L0.5651.00
89_V139_I0.5651.00
335_G352_S0.5641.00
275_A278_E0.5631.00
219_I223_K0.5611.00
50_M260_E0.5611.00
303_A317_D0.5611.00
124_D128_I0.5611.00
104_I109_G0.5601.00
280_V284_L0.5601.00
351_A354_F0.5601.00
364_I383_L0.5591.00
139_I168_L0.5581.00
309_M388_L0.5581.00
105_A112_V0.5561.00
158_I169_F0.5551.00
294_R373_K0.5551.00
338_V362_W0.5521.00
159_G189_I0.5491.00
201_S368_G0.5491.00
141_A193_I0.5491.00
40_P43_T0.5471.00
366_T370_S0.5461.00
155_L169_F0.5411.00
91_I101_L0.5391.00
27_L32_T0.5391.00
279_G283_V0.5391.00
342_L382_G0.5371.00
30_M272_M0.5371.00
122_V153_H0.5331.00
211_Y219_I0.5321.00
79_L141_A0.5321.00
75_I79_L0.5311.00
254_L258_W0.5311.00
94_Y151_R0.5301.00
215_V218_V0.5291.00
43_T46_M0.5281.00
121_T312_R0.5281.00
208_P276_L0.5271.00
171_V192_A0.5261.00
53_L194_G0.5261.00
137_P167_A0.5241.00
37_Q344_A0.5241.00
271_T275_A0.5231.00
182_V192_A0.5231.00
219_I222_R0.5231.00
75_I141_A0.5221.00
155_L189_I0.5211.00
144_H152_I0.5201.00
83_I87_D0.5201.00
90_L132_I0.5201.00
114_M117_C0.5191.00
196_T200_L0.5191.00
204_S270_T0.5171.00
26_V278_E0.5161.00
78_V170_I0.5161.00
118_E121_T0.5151.00
181_E185_D0.5151.00
84_E138_K0.5141.00
22_V26_V0.5131.00
309_M387_L0.5131.00
115_L118_E0.5121.00
184_V189_I0.5111.00
125_P158_I0.5101.00
344_A349_E0.5091.00
288_L292_F0.5091.00
123_F128_I0.5091.00
191_A209_I0.5081.00
80_A104_I0.5081.00
306_I311_L0.5071.00
181_E187_W0.5041.00
153_H158_I0.5031.00
50_M54_R0.5011.00
32_T45_I0.5011.00
128_I161_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3islA 2 0.9255 100 0.355 Contact Map
3nnkA 5 0.9639 100 0.408 Contact Map
2z9vA 4 0.9327 100 0.41 Contact Map
2hufA 2 0.9014 100 0.412 Contact Map
3e9kA 2 0.8798 100 0.414 Contact Map
3kgwA 2 0.8966 100 0.417 Contact Map
2dr1A 2 0.8966 100 0.42 Contact Map
1vjoA 2 0.8894 100 0.423 Contact Map
3zrpA 2 0.887 100 0.426 Contact Map
2yrrA 2 0.8413 100 0.428 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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