PUCG - BACSU - GREMLIN Contacts

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PUCG - Purine catabolism protein PucG

UniProt:	O32148	Sequences: MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTGIMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGEACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYALREGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGIDGESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNAGIEAGKALQAALDVYENAGRQAAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	416 (341)
Sequences:	38599 (25016)
Seq/√Len:	1354.7

ECOLI - ISCS CSDA SUFS SERC DCEB DCEA LTAE
BACSU - PUCG YCBU ISCS ISCS1 SERC ISCS2 SUFS
HALSA - Q9HMR6 CSD Q9HR11 MFNA Q9HHV3
SULSO - Q97VM5 Q97ZK0 Q97WK1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
301_A	377_L	3.735	1.00
88_D	113_H	3.460	1.00
305_G	380_L	3.229	1.00
159_G	169_F	3.151	1.00
301_A	373_K	3.108	1.00
144_H	176_T	2.975	1.00
154_P	157_A	2.944	1.00
129_I	164_T	2.830	1.00
52_M	281_R	2.713	1.00
88_D	111_N	2.669	1.00
183_K	186_E	2.638	1.00
173_A	192_A	2.588	1.00
93_I	116_E	2.552	1.00
346_F	385_A	2.525	1.00
278_E	281_R	2.521	1.00
88_D	133_K	2.487	1.00
309_M	384_E	2.451	1.00
24_P	28_R	2.447	1.00
129_I	161_A	2.415	1.00
194_G	208_P	2.400	1.00
305_G	308_A	2.356	1.00
297_H	373_K	2.354	1.00
127_D	130_R	2.353	1.00
269_A	272_M	2.291	1.00
55_E	284_L	2.278	1.00
162_C	167_A	2.259	1.00
156_K	160_E	2.182	1.00
159_G	163_R	2.173	1.00
140_V	162_C	2.132	1.00
156_K	186_E	2.107	1.00
312_R	328_E	2.046	1.00
301_A	305_G	2.017	1.00
305_G	377_L	2.001	1.00
75_I	98_G	1.940	1.00
300_A	304_A	1.921	1.00
88_D	137_P	1.895	1.00
160_E	164_T	1.893	1.00
133_K	136_K	1.883	1.00
163_R	190_D	1.881	1.00
87_D	138_K	1.880	1.00
364_I	379_V	1.863	1.00
58_Q	183_K	1.835	1.00
125_P	161_A	1.776	1.00
127_D	131_E	1.771	1.00
139_I	170_I	1.746	1.00
124_D	127_D	1.733	1.00
28_R	32_T	1.731	1.00
116_E	127_D	1.716	1.00
171_V	189_I	1.709	1.00
52_M	277_R	1.709	1.00
378_F	382_G	1.705	1.00
87_D	136_K	1.685	1.00
293_E	297_H	1.683	1.00
314_F	328_E	1.670	1.00
88_D	136_K	1.659	1.00
302_L	366_T	1.640	1.00
346_F	382_G	1.639	1.00
113_H	131_E	1.633	1.00
52_M	284_L	1.618	1.00
189_I	192_A	1.617	1.00
341_M	345_Q	1.615	1.00
304_A	308_A	1.599	1.00
69_G	73_A	1.597	1.00
162_C	169_F	1.580	1.00
27_L	31_S	1.579	1.00
157_A	160_E	1.579	1.00
30_M	275_A	1.576	1.00
78_V	191_A	1.574	1.00
129_I	165_E	1.573	1.00
101_L	105_A	1.543	1.00
126_E	130_R	1.534	1.00
296_R	300_A	1.534	1.00
125_P	157_A	1.531	1.00
142_M	158_I	1.528	1.00
51_E	55_E	1.514	1.00
64_A	213_E	1.512	1.00
373_K	377_L	1.505	1.00
305_G	384_E	1.502	1.00
294_R	298_H	1.499	1.00
118_E	122_V	1.493	1.00
68_D	74_G	1.479	1.00
196_T	276_L	1.477	1.00
289_E	293_E	1.473	1.00
29_V	278_E	1.469	1.00
305_G	309_M	1.463	1.00
326_C	361_I	1.460	1.00
334_D	337_S	1.434	1.00
126_E	129_I	1.430	1.00
372_R	375_N	1.412	1.00
145_G	321_M	1.410	1.00
292_F	296_R	1.401	1.00
299_E	303_A	1.394	1.00
142_M	169_F	1.380	1.00
53_L	208_P	1.376	1.00
163_R	188_K	1.376	1.00
129_I	133_K	1.374	1.00
384_E	388_L	1.373	1.00
23_D	282_L	1.372	1.00
60_K	213_E	1.362	1.00
132_I	161_A	1.353	1.00
44_G	48_E	1.351	1.00
140_V	167_A	1.332	1.00
75_I	170_I	1.331	1.00
93_I	114_M	1.311	1.00
374_E	377_L	1.308	1.00
302_L	376_V	1.307	1.00
161_A	165_E	1.306	1.00
129_I	157_A	1.302	1.00
307_K	316_D	1.281	1.00
90_L	131_E	1.281	1.00
48_E	52_M	1.271	1.00
159_G	188_K	1.254	1.00
304_A	307_K	1.242	1.00
86_E	138_K	1.232	1.00
337_S	341_M	1.224	1.00
290_T	293_E	1.219	1.00
305_G	381_A	1.215	1.00
102_T	105_A	1.211	1.00
115_L	131_E	1.206	1.00
48_E	277_R	1.203	1.00
341_M	386_V	1.198	1.00
378_F	381_A	1.194	1.00
49_T	277_R	1.192	1.00
62_R	213_E	1.191	1.00
28_R	31_S	1.185	1.00
312_R	331_G	1.179	1.00
191_A	211_Y	1.176	1.00
60_K	185_D	1.172	1.00
190_D	212_N	1.170	1.00
200_L	276_L	1.160	1.00
101_L	104_I	1.154	1.00
308_A	384_E	1.152	1.00
25_R	282_L	1.146	1.00
90_L	137_P	1.145	1.00
277_R	281_R	1.144	1.00
162_C	165_E	1.139	1.00
294_R	297_H	1.136	1.00
111_N	133_K	1.134	1.00
103_E	106_E	1.134	1.00
71_S	174_V	1.132	1.00
183_K	187_W	1.132	1.00
58_Q	185_D	1.131	1.00
381_A	385_A	1.123	1.00
177_I	194_G	1.115	1.00
84_E	87_D	1.113	1.00
203_P	275_A	1.111	1.00
303_A	325_T	1.111	1.00
160_E	188_K	1.108	1.00
52_M	55_E	1.107	1.00
45_I	274_Y	1.106	1.00
118_E	124_D	1.106	1.00
25_R	285_E	1.103	1.00
181_E	289_E	1.103	1.00
161_A	164_T	1.101	1.00
170_I	193_I	1.097	1.00
29_V	32_T	1.092	1.00
125_P	129_I	1.089	1.00
128_I	158_I	1.088	1.00
51_E	54_R	1.088	1.00
155_L	171_V	1.078	1.00
303_A	307_K	1.076	1.00
22_V	27_L	1.070	1.00
377_L	381_A	1.070	1.00
74_G	193_I	1.066	1.00
113_H	133_K	1.064	1.00
91_I	114_M	1.059	1.00
48_E	281_R	1.059	1.00
43_T	47_N	1.058	1.00
290_T	294_R	1.057	1.00
336_E	340_D	1.051	1.00
350_I	362_W	1.047	1.00
342_L	350_I	1.047	1.00
152_I	180_C	1.043	1.00
25_R	278_E	1.038	1.00
82_V	168_L	1.035	1.00
141_A	170_I	1.033	1.00
380_L	384_E	1.033	1.00
144_H	192_A	1.032	1.00
327_V	364_I	1.032	1.00
184_V	210_T	1.026	1.00
142_M	155_L	1.018	1.00
163_R	169_F	1.018	1.00
17_P	324_V	1.016	1.00
201_S	367_M	1.014	1.00
170_I	191_A	1.009	1.00
348_I	379_V	1.005	1.00
281_R	285_E	1.002	1.00
104_I	107_R	0.989	1.00
298_H	373_K	0.983	1.00
340_D	344_A	0.983	1.00
176_T	192_A	0.978	1.00
143_V	147_T	0.969	1.00
348_I	382_G	0.966	1.00
291_R	294_R	0.965	1.00
341_M	346_F	0.959	1.00
46_M	273_L	0.957	1.00
104_I	108_Y	0.955	1.00
145_G	176_T	0.952	1.00
348_I	378_F	0.950	1.00
102_T	106_E	0.950	1.00
286_E	290_T	0.950	1.00
168_L	191_A	0.945	1.00
65_Y	210_T	0.944	1.00
298_H	376_V	0.939	1.00
302_L	379_V	0.937	1.00
316_D	319_C	0.937	1.00
182_V	185_D	0.933	1.00
191_A	215_V	0.932	1.00
299_E	325_T	0.931	1.00
382_G	385_A	0.931	1.00
340_D	345_Q	0.927	1.00
302_L	364_I	0.927	1.00
56_L	177_I	0.926	1.00
132_I	137_P	0.921	1.00
120_G	316_D	0.920	1.00
133_K	165_E	0.919	1.00
75_I	193_I	0.915	1.00
366_T	376_V	0.913	1.00
309_M	380_L	0.906	1.00
181_E	292_F	0.905	1.00
82_V	191_A	0.900	1.00
278_E	282_L	0.889	1.00
94_Y	153_H	0.886	1.00
303_A	313_L	0.884	1.00
80_A	255_E	0.875	1.00
350_I	364_I	0.875	1.00
88_D	135_V	0.873	1.00
162_C	166_D	0.869	1.00
306_I	327_V	0.868	1.00
370_S	375_N	0.867	1.00
16_T	20_V	0.860	1.00
339_R	352_S	0.860	1.00
302_L	325_T	0.858	1.00
56_L	280_V	0.853	1.00
16_T	370_S	0.853	1.00
379_V	383_L	0.852	1.00
128_I	140_V	0.845	1.00
125_P	128_I	0.842	1.00
133_K	137_P	0.839	1.00
196_T	202_V	0.835	1.00
276_L	280_V	0.828	1.00
68_D	77_A	0.825	1.00
53_L	280_V	0.825	1.00
374_E	378_F	0.823	1.00
337_S	340_D	0.819	1.00
275_A	279_G	0.816	1.00
16_T	21_E	0.814	1.00
57_F	194_G	0.812	1.00
301_A	304_A	0.810	1.00
59_T	64_A	0.807	1.00
91_I	95_G	0.807	1.00
196_T	206_M	0.805	1.00
145_G	322_P	0.805	1.00
314_F	326_C	0.804	1.00
16_T	367_M	0.803	1.00
105_A	110_A	0.803	1.00
212_N	215_V	0.802	1.00
159_G	187_W	0.802	1.00
47_N	51_E	0.802	1.00
297_H	301_A	0.801	1.00
173_A	176_T	0.797	1.00
140_V	158_I	0.796	1.00
57_F	184_V	0.796	1.00
311_L	329_I	0.794	1.00
49_T	52_M	0.792	1.00
60_K	64_A	0.788	1.00
309_M	381_A	0.787	1.00
89_V	102_T	0.780	1.00
118_E	127_D	0.780	1.00
113_H	137_P	0.779	1.00
90_L	113_H	0.779	1.00
100_L	114_M	0.777	1.00
17_P	365_G	0.776	1.00
287_G	290_T	0.774	1.00
83_I	110_A	0.772	1.00
321_M	324_V	0.767	1.00
168_L	215_V	0.761	1.00
338_V	386_V	0.760	1.00
144_H	187_W	0.760	1.00
25_R	28_R	0.759	1.00
314_F	361_I	0.759	1.00
103_E	107_R	0.752	1.00
291_R	295_H	0.752	1.00
116_E	131_E	0.746	1.00
57_F	210_T	0.745	1.00
160_E	163_R	0.742	1.00
181_E	184_V	0.741	1.00
168_L	190_D	0.740	1.00
206_M	272_M	0.737	1.00
200_L	280_V	0.735	1.00
132_I	167_A	0.732	1.00
376_V	380_L	0.730	1.00
16_T	369_Y	0.730	1.00
92_P	95_G	0.728	1.00
381_A	384_E	0.727	1.00
301_A	380_L	0.723	1.00
51_E	62_R	0.720	1.00
254_L	257_Y	0.719	1.00
24_P	27_L	0.718	1.00
79_L	101_L	0.714	1.00
182_V	186_E	0.713	1.00
181_E	186_E	0.712	1.00
73_A	77_A	0.712	1.00
156_K	187_W	0.711	1.00
177_I	200_L	0.711	1.00
49_T	273_L	0.710	1.00
59_T	210_T	0.710	1.00
198_K	363_R	0.708	1.00
213_E	217_D	0.706	1.00
66_P	77_A	0.704	1.00
142_M	171_V	0.704	1.00
99_Y	141_A	0.700	1.00
144_H	155_L	0.699	1.00
302_L	380_L	0.698	1.00
26_V	279_G	0.697	1.00
206_M	273_L	0.695	1.00
382_G	386_V	0.691	1.00
293_E	296_R	0.690	1.00
291_R	368_G	0.688	1.00
144_H	182_V	0.687	1.00
301_A	376_V	0.686	1.00
379_V	382_G	0.686	1.00
71_S	75_I	0.685	1.00
177_I	182_V	0.684	1.00
317_D	320_K	0.683	1.00
92_P	142_M	0.681	1.00
176_T	180_C	0.680	1.00
310_G	331_G	0.679	1.00
312_R	315_G	0.675	1.00
182_V	187_W	0.675	1.00
60_K	212_N	0.673	1.00
338_V	383_L	0.673	1.00
184_V	187_W	0.671	1.00
188_K	212_N	0.670	1.00
37_Q	41_A	0.668	1.00
93_I	117_C	0.668	1.00
190_D	214_R	0.668	1.00
356_P	359_G	0.668	1.00
370_S	376_V	0.668	1.00
23_D	26_V	0.666	1.00
144_H	171_V	0.666	1.00
52_M	280_V	0.666	1.00
333_I	337_S	0.666	1.00
329_I	332_G	0.665	1.00
302_L	305_G	0.661	1.00
157_A	161_A	0.661	1.00
333_I	338_V	0.659	1.00
156_K	188_K	0.659	1.00
54_R	62_R	0.658	1.00
287_G	291_R	0.658	1.00
303_A	320_K	0.658	1.00
48_E	51_E	0.658	1.00
41_A	44_G	0.656	1.00
173_A	177_I	0.656	1.00
339_R	350_I	0.656	1.00
377_L	380_L	0.656	1.00
45_I	48_E	0.654	1.00
129_I	132_I	0.653	1.00
106_E	114_M	0.650	1.00
54_R	59_T	0.648	1.00
132_I	165_E	0.647	1.00
90_L	115_L	0.647	1.00
91_I	141_A	0.646	1.00
91_I	102_T	0.646	1.00
297_H	300_A	0.646	1.00
174_V	195_G	0.645	1.00
55_E	58_Q	0.641	1.00
72_R	76_E	0.641	1.00
149_T	152_I	0.640	1.00
253_Q	256_D	0.640	1.00
142_M	153_H	0.639	1.00
168_L	214_R	0.638	1.00
78_V	209_I	0.638	1.00
79_L	139_I	0.636	1.00
289_E	292_F	0.636	1.00
30_M	33_P	0.636	1.00
277_R	280_V	0.633	1.00
102_T	114_M	0.633	1.00
130_R	134_K	0.633	1.00
258_W	265_H	0.628	1.00
131_E	135_V	0.628	1.00
286_E	291_R	0.622	1.00
126_E	157_A	0.621	1.00
111_N	136_K	0.620	1.00
341_M	382_G	0.619	1.00
302_L	306_I	0.617	1.00
303_A	321_M	0.616	1.00
133_K	164_T	0.616	1.00
46_M	270_T	0.615	1.00
295_H	323_V	0.615	1.00
56_L	284_L	0.612	1.00
51_E	61_N	0.611	1.00
30_M	271_T	0.610	1.00
323_V	326_C	0.610	1.00
159_G	162_C	0.609	1.00
128_I	132_I	0.609	1.00
76_E	80_A	0.608	1.00
52_M	56_L	0.607	1.00
64_A	185_D	0.607	1.00
346_F	386_V	0.607	1.00
281_R	284_L	0.605	1.00
87_D	111_N	0.604	1.00
131_E	134_K	0.601	1.00
57_F	177_I	0.601	1.00
124_D	130_R	0.601	1.00
19_P	197_Q	0.598	1.00
184_V	192_A	0.595	1.00
115_L	127_D	0.594	1.00
211_Y	216_A	0.591	1.00
184_V	188_K	0.590	1.00
217_D	220_A	0.590	1.00
144_H	173_A	0.590	1.00
71_S	193_I	0.589	1.00
91_I	112_V	0.588	1.00
294_R	372_R	0.587	1.00
320_K	324_V	0.587	1.00
42_F	46_M	0.585	1.00
329_I	338_V	0.585	1.00
38_F	349_E	0.584	1.00
298_H	366_T	0.584	1.00
61_N	213_E	0.583	1.00
78_V	82_V	0.583	1.00
132_I	140_V	0.583	1.00
220_A	223_K	0.582	1.00
169_F	189_I	0.582	1.00
213_E	216_A	0.580	1.00
47_N	50_M	0.577	1.00
24_P	31_S	0.577	1.00
265_H	268_E	0.574	1.00
159_G	171_V	0.572	1.00
177_I	280_V	0.571	1.00
64_A	212_N	0.570	1.00
146_E	151_R	0.570	1.00
80_A	222_R	0.569	1.00
59_T	192_A	0.567	1.00
283_V	288_L	0.566	1.00
206_M	276_L	0.565	1.00
246_S	254_L	0.565	1.00
89_V	139_I	0.565	1.00
335_G	352_S	0.564	1.00
275_A	278_E	0.563	1.00
219_I	223_K	0.561	1.00
50_M	260_E	0.561	1.00
303_A	317_D	0.561	1.00
124_D	128_I	0.561	1.00
104_I	109_G	0.560	1.00
280_V	284_L	0.560	1.00
351_A	354_F	0.560	1.00
364_I	383_L	0.559	1.00
139_I	168_L	0.558	1.00
309_M	388_L	0.558	1.00
105_A	112_V	0.556	1.00
158_I	169_F	0.555	1.00
294_R	373_K	0.555	1.00
338_V	362_W	0.552	1.00
159_G	189_I	0.549	1.00
201_S	368_G	0.549	1.00
141_A	193_I	0.549	1.00
40_P	43_T	0.547	1.00
366_T	370_S	0.546	1.00
155_L	169_F	0.541	1.00
91_I	101_L	0.539	1.00
27_L	32_T	0.539	1.00
279_G	283_V	0.539	1.00
342_L	382_G	0.537	1.00
30_M	272_M	0.537	1.00
122_V	153_H	0.533	1.00
211_Y	219_I	0.532	1.00
79_L	141_A	0.532	1.00
75_I	79_L	0.531	1.00
254_L	258_W	0.531	1.00
94_Y	151_R	0.530	1.00
215_V	218_V	0.529	1.00
43_T	46_M	0.528	1.00
121_T	312_R	0.528	1.00
208_P	276_L	0.527	1.00
171_V	192_A	0.526	1.00
53_L	194_G	0.526	1.00
137_P	167_A	0.524	1.00
37_Q	344_A	0.524	1.00
271_T	275_A	0.523	1.00
182_V	192_A	0.523	1.00
219_I	222_R	0.523	1.00
75_I	141_A	0.522	1.00
155_L	189_I	0.521	1.00
144_H	152_I	0.520	1.00
83_I	87_D	0.520	1.00
90_L	132_I	0.520	1.00
114_M	117_C	0.519	1.00
196_T	200_L	0.519	1.00
204_S	270_T	0.517	1.00
26_V	278_E	0.516	1.00
78_V	170_I	0.516	1.00
118_E	121_T	0.515	1.00
181_E	185_D	0.515	1.00
84_E	138_K	0.514	1.00
22_V	26_V	0.513	1.00
309_M	387_L	0.513	1.00
115_L	118_E	0.512	1.00
184_V	189_I	0.511	1.00
125_P	158_I	0.510	1.00
344_A	349_E	0.509	1.00
288_L	292_F	0.509	1.00
123_F	128_I	0.509	1.00
191_A	209_I	0.508	1.00
80_A	104_I	0.508	1.00
306_I	311_L	0.507	1.00
181_E	187_W	0.504	1.00
153_H	158_I	0.503	1.00
50_M	54_R	0.501	1.00
32_T	45_I	0.501	1.00
128_I	161_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3islA	2	0.9255	100	0.355	Contact Map
3nnkA	5	0.9639	100	0.408	Contact Map
2z9vA	4	0.9327	100	0.41	Contact Map
2hufA	2	0.9014	100	0.412	Contact Map
3e9kA	2	0.8798	100	0.414	Contact Map
3kgwA	2	0.8966	100	0.417	Contact Map
2dr1A	2	0.8966	100	0.42	Contact Map
1vjoA	2	0.8894	100	0.423	Contact Map
3zrpA	2	0.887	100	0.426	Contact Map
2yrrA	2	0.8413	100	0.428	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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