GREMLIN Database
XDHA - Probable xanthine dehydrogenase subunit A
UniProt: O32147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (305)
Sequences: 2008 (1433)
Seq/√Len: 82.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V101_A4.1931.00
17_E42_K4.0301.00
314_V321_I3.5331.00
76_P98_H3.3961.00
25_Q98_H3.0031.00
249_A266_L2.9851.00
206_F321_I2.8901.00
19_V67_G2.8681.00
202_A227_D2.8271.00
187_L198_A2.7441.00
24_V74_L2.7031.00
26_V30_A2.7001.00
185_L248_A2.6591.00
16_E41_K2.5181.00
201_A317_V2.5181.00
21_A99_V2.5041.00
275_G300_V2.4511.00
239_S265_F2.4071.00
249_A271_L2.3801.00
58_D62_R2.3801.00
200_L314_V2.3681.00
317_V320_I2.3261.00
268_S292_P2.2821.00
244_F247_D2.2711.00
284_K288_S2.2281.00
37_S177_Q2.2191.00
50_L99_V2.2041.00
190_A212_D2.1641.00
290_K294_S2.1421.00
185_L201_A2.1301.00
243_F247_D2.0811.00
281_N285_R2.0781.00
200_L317_V2.0691.00
184_R209_I2.0681.00
13_E113_E2.0231.00
287_L290_K2.0191.00
271_L274_I1.9781.00
21_A101_A1.9411.00
271_L295_H1.9141.00
232_A240_E1.8891.00
10_A14_D1.8691.00
118_C123_K1.8621.00
16_E42_K1.8611.00
58_D77_Y1.8531.00
263_I276_L1.8481.00
269_Q295_H1.8411.00
232_A236_Q1.8321.00
273_Y319_E1.8281.00
185_L320_I1.8251.00
199_N225_K1.7701.00
46_R60_F1.7611.00
204_T317_V1.7561.00
188_F262_I1.7451.00
114_K118_C1.7111.00
200_L203_D1.7031.00
76_P96_I1.7021.00
55_V97_I1.6961.00
9_D13_E1.6811.00
51_S54_C1.6721.00
283_T287_L1.6611.00
186_I249_A1.6051.00
11_L18_A1.5991.00
62_R75_I1.5861.00
126_T176_I1.5601.00
297_Y319_E1.5531.00
283_T298_S1.5521.00
22_T102_E1.5521.00
269_Q274_I1.5451.00
41_K45_R1.5431.00
130_K133_S1.5300.99
199_N203_D1.5140.99
306_A325_K1.5140.99
17_E103_R1.5120.99
248_A272_H1.4670.99
197_L316_V1.4410.99
197_L250_V1.4180.99
251_V266_L1.4000.99
207_S228_Q1.3970.99
6_T120_H1.3940.99
128_V174_M1.3890.99
9_D113_E1.3590.99
306_A311_E1.3550.99
123_K140_T1.3540.99
132_E173_N1.3460.99
287_L296_F1.3400.99
128_V176_I1.3360.99
62_R73_T1.3260.99
274_I296_F1.3230.98
304_I312_I1.3230.98
250_V300_V1.3190.98
210_V226_A1.3180.98
182_K205_G1.3070.98
32_R309_P1.3060.98
207_S227_D1.3040.98
29_S52_G1.2980.98
322_Q326_R1.2980.98
196_P310_E1.2880.98
19_V66_L1.2740.98
102_E136_Y1.2460.98
245_P270_N1.2410.98
308_G311_E1.2400.98
86_S90_G1.2390.98
232_A237_M1.2330.98
54_C282_R1.2310.98
314_V320_I1.2210.97
31_Y193_D1.2150.97
187_L197_L1.2100.97
243_F249_A1.2010.97
7_M11_L1.1980.97
210_V229_L1.1850.97
18_A39_L1.1840.97
297_Y323_T1.1820.97
183_P324_R1.1820.97
213_W258_H1.1800.97
198_A210_V1.1790.97
94_N256_Y1.1790.97
162_T165_L1.1780.97
130_K174_M1.1740.97
264_N268_S1.1700.97
84_D88_G1.1590.96
54_C254_H1.1530.96
213_W254_H1.1510.96
237_M241_F1.1390.96
115_V125_V1.1380.96
118_C125_V1.1320.96
31_Y92_G1.1280.96
319_E322_Q1.1210.96
185_L250_V1.1080.95
51_S254_H1.1070.95
90_G212_D1.1050.95
218_C229_L1.1050.95
74_L98_H1.1010.95
31_Y94_N1.0980.95
58_D61_Q1.0810.95
51_S282_R1.0740.95
23_I50_L1.0730.95
202_A225_K1.0620.94
206_F248_A1.0610.94
266_L274_I1.0490.94
17_E105_T1.0490.94
161_S164_H1.0430.94
21_A59_V1.0420.94
193_D277_L1.0410.94
215_P231_T1.0380.94
304_I311_E1.0340.93
59_V282_R1.0320.93
266_L271_L1.0210.93
31_Y279_S1.0200.93
100_H129_I1.0150.93
292_P295_H1.0140.93
197_L200_L1.0050.92
187_L194_N0.9960.92
249_A274_I0.9920.92
110_R114_K0.9910.92
23_I34_A0.9800.91
65_A69_Q0.9780.91
214_R217_Y0.9710.91
12_L113_E0.9640.91
85_L88_G0.9580.91
213_W255_H0.9500.90
92_G193_D0.9440.90
306_A315_S0.9380.90
94_N279_S0.9360.90
64_S67_G0.9340.89
24_V100_H0.9300.89
260_Q285_R0.9290.89
256_Y260_Q0.9260.89
6_T10_A0.9160.88
219_T231_T0.9130.88
66_L103_R0.9040.88
39_L47_I0.9030.88
129_I177_Q0.9020.88
250_V320_I0.9020.88
115_V138_F0.9010.88
186_I247_D0.9000.88
184_R207_S0.8980.87
8_L104_I0.8980.87
186_I211_T0.8970.87
115_V179_I0.8950.87
27_E79_M0.8940.87
193_D312_I0.8910.87
49_L192_P0.8910.87
66_L72_S0.8880.87
7_M47_I0.8870.87
199_N310_E0.8850.87
251_V263_I0.8840.87
255_H258_H0.8840.87
92_G254_H0.8840.87
204_T314_V0.8810.86
138_F143_G0.8800.86
202_A208_V0.8750.86
69_Q73_T0.8720.86
197_L317_V0.8720.86
163_L171_T0.8580.85
275_G320_I0.8500.84
106_Q110_R0.8490.84
253_T259_D0.8480.84
126_T178_R0.8460.84
64_S68_D0.8450.84
32_R51_S0.8450.84
12_L18_A0.8420.84
17_E67_G0.8410.84
276_L283_T0.8390.84
289_G293_P0.8370.84
277_L300_V0.8340.83
59_V99_V0.8330.83
161_S165_L0.8310.83
201_A208_V0.8270.83
61_Q64_S0.8220.82
19_V63_I0.8210.82
193_D279_S0.8170.82
206_F324_R0.8140.82
54_C58_D0.8110.82
161_S166_P0.8080.81
7_M10_A0.8080.81
32_R94_N0.8070.81
251_V259_D0.8070.81
71_T103_R0.8050.81
75_I78_D0.8040.81
77_Y271_L0.8030.81
59_V192_P0.7990.81
84_D87_W0.7980.81
111_H127_S0.7910.80
188_F251_V0.7900.80
27_E96_I0.7900.80
114_K239_S0.7840.79
17_E106_Q0.7830.79
195_V199_N0.7820.79
30_A97_I0.7740.78
79_M87_W0.7730.78
33_K307_E0.7720.78
116_R119_L0.7710.78
188_F253_T0.7680.78
243_F271_L0.7680.78
252_A279_S0.7660.78
26_V34_A0.7660.78
63_I67_G0.7660.78
91_A255_H0.7630.77
129_I136_Y0.7620.77
236_Q239_S0.7600.77
102_E129_I0.7590.77
28_G35_G0.7580.77
291_H294_S0.7580.77
31_Y256_Y0.7570.77
8_L112_Y0.7550.77
311_E321_I0.7510.76
186_I209_I0.7500.76
92_G286_L0.7460.76
22_T37_S0.7430.76
293_P296_F0.7420.75
49_L256_Y0.7410.75
41_K47_I0.7410.75
282_R286_L0.7360.75
11_L39_L0.7360.75
49_L56_E0.7300.74
4_F8_L0.7290.74
112_Y116_R0.7220.73
276_L298_S0.7220.73
183_P248_A0.7210.73
55_V191_G0.7210.73
173_N326_R0.7160.73
11_L16_E0.7140.73
218_C231_T0.7140.73
4_F39_L0.7130.73
196_P199_N0.7130.73
80_R86_S0.7120.72
81_S84_D0.7120.72
277_L307_E0.7120.72
321_I325_K0.7100.72
213_W262_I0.7080.72
50_L210_V0.7060.72
74_L100_H0.7060.72
91_A285_R0.7050.72
4_F16_E0.7030.71
62_R77_Y0.7000.71
51_S92_G0.6990.71
16_E43_K0.6960.71
230_I240_E0.6940.71
9_D120_H0.6930.70
203_D317_V0.6910.70
117_D121_S0.6880.70
26_V193_D0.6870.70
67_G101_A0.6870.70
261_T264_N0.6860.70
29_S259_D0.6800.69
185_L287_L0.6780.69
121_S124_A0.6770.69
59_V101_A0.6760.69
302_L305_G0.6750.68
20_L37_S0.6740.68
32_R36_A0.6700.68
162_T166_P0.6670.67
65_A73_T0.6660.67
186_I241_F0.6650.67
130_K172_T0.6610.67
42_K68_D0.6580.66
198_A225_K0.6570.66
17_E319_E0.6560.66
263_I274_I0.6520.66
81_S86_S0.6500.65
302_L319_E0.6440.65
54_C91_A0.6440.65
107_E230_I0.6420.65
187_L321_I0.6420.65
110_R113_E0.6420.65
31_Y49_L0.6390.64
251_V298_S0.6370.64
210_V223_F0.6370.64
120_H290_K0.6370.64
133_S172_T0.6360.64
105_T114_K0.6350.64
273_Y300_V0.6350.64
270_N292_P0.6330.63
204_T308_G0.6310.63
24_V98_H0.6310.63
226_A280_A0.6310.63
14_D290_K0.6300.63
111_H138_F0.6290.63
67_G103_R0.6280.63
51_S277_L0.6270.63
8_L39_L0.6270.63
72_S100_H0.6260.63
57_E94_N0.6260.63
208_V226_A0.6260.63
99_V183_P0.6250.62
192_P222_L0.6250.62
99_V113_E0.6250.62
5_H79_M0.6250.62
255_H276_L0.6230.62
66_L129_I0.6220.62
276_L286_L0.6210.62
32_R267_F0.6200.62
140_T144_H0.6200.62
89_M97_I0.6180.62
101_A310_E0.6180.62
194_N223_F0.6170.61
219_T229_L0.6140.61
168_F173_N0.6140.61
110_R220_S0.6130.61
66_L69_Q0.6120.61
234_P254_H0.6120.61
31_Y253_T0.6110.61
51_S58_D0.6110.61
218_C223_F0.6110.61
65_A68_D0.6110.61
34_A247_D0.6080.60
8_L50_L0.6080.60
80_R96_I0.6070.60
40_F59_V0.6050.60
188_F250_V0.6050.60
11_L41_K0.6040.60
31_Y52_G0.6040.60
27_E98_H0.6030.60
235_E304_I0.6010.59
188_F249_A0.6000.59
107_E114_K0.5940.59
54_C93_C0.5910.58
196_P279_S0.5900.58
211_T277_L0.5890.58
199_N316_V0.5890.58
219_T287_L0.5890.58
253_T258_H0.5880.58
201_A205_G0.5880.58
39_L241_F0.5880.58
70_L103_R0.5860.58
18_A104_I0.5830.57
209_I228_Q0.5810.57
49_L255_H0.5800.57
20_L39_L0.5790.57
162_T167_H0.5790.57
190_A214_R0.5750.56
320_I324_R0.5730.56
204_T321_I0.5730.56
194_N250_V0.5720.56
117_D224_P0.5680.55
311_E314_V0.5680.55
33_K36_A0.5670.55
132_E291_H0.5650.55
70_L73_T0.5630.55
31_Y196_P0.5630.55
265_F296_F0.5630.55
8_L15_Q0.5620.54
116_R120_H0.5620.54
192_P298_S0.5610.54
123_K132_E0.5610.54
167_H245_P0.5580.54
269_Q292_P0.5580.54
58_D252_A0.5570.54
117_D120_H0.5570.54
161_S167_H0.5570.54
51_S77_Y0.5560.54
132_E135_H0.5550.54
97_I310_E0.5540.53
219_T222_L0.5510.53
188_F237_M0.5500.53
206_F314_V0.5460.52
113_E117_D0.5460.52
115_V210_V0.5450.52
305_G326_R0.5440.52
51_S97_I0.5440.52
161_S168_F0.5430.52
92_G279_S0.5430.52
186_I238_L0.5420.52
248_A324_R0.5410.52
41_K46_R0.5390.51
251_V296_F0.5380.51
40_F63_I0.5370.51
52_G56_E0.5370.51
71_T291_H0.5360.51
57_E282_R0.5360.51
218_C263_I0.5360.51
254_H282_R0.5340.51
50_L192_P0.5330.51
235_E261_T0.5330.51
12_L105_T0.5330.51
105_T108_K0.5320.51
91_A286_L0.5310.50
230_I237_M0.5300.50
182_K206_F0.5300.50
92_G255_H0.5300.50
261_T265_F0.5290.50
226_A229_L0.5290.50
92_G252_A0.5280.50
214_R253_T0.5270.50
115_V127_S0.5270.50
12_L106_Q0.5260.50
85_L90_G0.5260.50
80_R85_L0.5260.50
95_G259_D0.5260.50
20_L315_S0.5240.49
122_G127_S0.5240.49
184_R247_D0.5240.49
223_F226_A0.5240.49
29_S275_G0.5230.49
196_P200_L0.5220.49
115_V119_L0.5220.49
256_Y277_L0.5200.49
12_L104_I0.5190.49
171_T229_L0.5180.49
279_S283_T0.5170.49
63_I66_L0.5150.48
52_G94_N0.5130.48
130_K173_N0.5100.48
275_G278_G0.5090.47
29_S298_S0.5070.47
21_A40_F0.5070.47
31_Y259_D0.5060.47
30_A107_E0.5060.47
213_W233_F0.5040.47
305_G322_Q0.5040.47
5_H181_P0.5040.47
213_W266_L0.5030.47
255_H266_L0.5020.47
49_L191_G0.5020.47
124_A281_N0.5020.47
198_A226_A0.5010.46
9_D116_R0.5000.46
4_F7_M0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2we8A 2 0.9455 100 0.105 Contact Map
3on5A 4 0.9788 100 0.116 Contact Map
1id1A 2 0.4242 97.2 0.921 Contact Map
2g1uA 2 0.4 97.1 0.923 Contact Map
3l9wA 2 0.4212 97 0.923 Contact Map
3fwzA 2 0.4091 96.9 0.924 Contact Map
3q2oA 2 0.4242 96.6 0.928 Contact Map
3llvA 2 0.397 96.5 0.928 Contact Map
3l4bC 2 0.4121 96.3 0.93 Contact Map
1lssA 3 0.3909 96.2 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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