GREMLIN Database
PUCB - Purine catabolism protein PucB
UniProt: O32146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (184)
Sequences: 8628 (6600)
Seq/√Len: 486.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E39_K4.7161.00
48_H77_S3.0021.00
7_I104_A2.6951.00
24_L112_A2.5491.00
19_M26_L2.5391.00
8_G41_A2.5281.00
32_N35_S2.5161.00
9_V95_G2.5121.00
121_H187_E2.3111.00
106_G129_A2.2811.00
8_G46_L2.2771.00
118_S187_E2.2721.00
193_T196_E2.2331.00
7_I48_H2.2251.00
41_A110_L2.0661.00
31_E36_L1.9901.00
50_L79_H1.8641.00
26_L197_Y1.8171.00
86_K90_H1.8111.00
191_I200_V1.7661.00
116_Q200_V1.7471.00
9_V107_I1.7321.00
155_Y171_S1.7101.00
35_S39_K1.6861.00
110_L122_L1.6771.00
111_L114_Q1.6161.00
42_L75_R1.6151.00
141_A145_P1.6111.00
7_I99_A1.5951.00
83_D86_K1.5711.00
43_S119_V1.5641.00
31_E35_S1.5631.00
81_C90_H1.5041.00
56_E62_W1.4911.00
99_A107_I1.4821.00
108_V122_L1.4711.00
164_G167_R1.4441.00
57_H80_V1.4271.00
64_G80_V1.4251.00
50_L98_K1.4211.00
40_T119_V1.3951.00
57_H64_G1.3891.00
118_S121_H1.3761.00
35_S66_P1.3671.00
97_R157_K1.3631.00
119_V123_N1.3621.00
189_D199_M1.3481.00
150_S153_F1.3301.00
10_F38_L1.3211.00
129_A134_A1.3141.00
52_V95_G1.3131.00
155_Y172_G1.2991.00
96_V157_K1.2941.00
92_V109_I1.2831.00
142_F145_P1.2651.00
90_H93_S1.2651.00
53_E57_H1.2621.00
168_L172_G1.2421.00
15_K85_E1.2381.00
110_L117_L1.2371.00
133_F172_G1.2341.00
189_D200_V1.2291.00
16_S21_Q1.2031.00
51_V76_W1.1941.00
54_R85_E1.1891.00
137_S179_V1.1881.00
33_I191_I1.1791.00
28_L33_I1.1611.00
106_G130_P1.1581.00
196_E199_M1.1521.00
42_L49_V1.1451.00
7_I50_L1.1391.00
28_L200_V1.1391.00
38_L49_V1.1091.00
135_V142_F1.1041.00
53_E78_L1.1011.00
92_V165_A1.0961.00
10_F37_S1.0961.00
6_L106_G1.0951.00
166_R170_K1.0951.00
62_W65_A1.0811.00
6_L126_V1.0751.00
90_H94_S1.0741.00
148_F151_T1.0721.00
53_E64_G1.0721.00
22_N56_E1.0591.00
96_V107_I1.0531.00
128_L131_E1.0521.00
27_P32_N1.0461.00
29_K36_L1.0451.00
10_F41_A1.0431.00
35_S74_K1.0411.00
86_K163_E1.0401.00
32_N36_L1.0371.00
127_A131_E1.0341.00
27_P30_G1.0321.00
106_G149_S1.0221.00
44_S123_N1.0131.00
155_Y158_G1.0101.00
64_G78_L1.0081.00
149_S152_C1.0061.00
77_S98_K1.0051.00
93_S157_K0.9921.00
83_D90_H0.9891.00
19_M194_P0.9861.00
96_V153_F0.9841.00
140_G145_P0.9821.00
38_L76_W0.9821.00
198_D201_R0.9801.00
133_F136_S0.9741.00
133_F137_S0.9601.00
9_V52_V0.9551.00
103_G150_S0.9541.00
53_E80_V0.9481.00
37_S40_T0.9471.00
77_S80_V0.9421.00
36_L40_T0.9411.00
123_N127_A0.9291.00
152_C155_Y0.9281.00
197_Y201_R0.9221.00
155_Y168_L0.9211.00
148_F152_C0.9091.00
21_Q194_P0.9071.00
128_L178_A0.9061.00
45_R123_N0.9011.00
32_N66_P0.9001.00
137_S181_E0.8981.00
132_S176_A0.8951.00
178_A181_E0.8951.00
93_S97_R0.8941.00
9_V109_I0.8901.00
79_H94_S0.8901.00
124_A127_A0.8901.00
106_G147_Y0.8791.00
154_P158_G0.8661.00
129_A149_S0.8571.00
12_A51_V0.8531.00
92_V111_L0.8471.00
33_I112_A0.8461.00
148_F156_V0.8431.00
25_A66_P0.8401.00
154_P157_K0.8371.00
26_L194_P0.8321.00
21_Q26_L0.8281.00
16_S24_L0.8261.00
191_I197_Y0.8171.00
132_S149_S0.8171.00
134_A137_S0.8171.00
124_A128_L0.8161.00
99_A104_A0.8091.00
104_A150_S0.8091.00
135_V138_F0.8071.00
7_I103_G0.8061.00
108_V126_V0.8061.00
167_R170_K0.8031.00
139_L143_T0.7971.00
85_E90_H0.7971.00
128_L180_L0.7881.00
182_A188_L0.7871.00
89_G156_V0.7871.00
81_C91_S0.7851.00
50_L77_S0.7841.00
143_T146_I0.7801.00
132_S137_S0.7761.00
140_G143_T0.7721.00
139_L142_F0.7671.00
29_K201_R0.7641.00
54_R57_H0.7611.00
186_G189_D0.7531.00
40_T43_S0.7441.00
195_E198_D0.7411.00
7_I105_D0.7321.00
33_I37_S0.7321.00
141_A144_P0.7291.00
48_H104_A0.7251.00
52_V79_H0.7221.00
149_S153_F0.7211.00
108_V147_Y0.7201.00
152_C172_G0.7171.00
120_D123_N0.7161.00
120_D124_A0.7141.00
151_T154_P0.7141.00
139_L145_P0.7131.00
21_Q24_L0.7131.00
48_H100_E0.7131.00
138_F143_T0.7111.00
142_F179_V0.7101.00
176_A180_L0.7101.00
87_G90_H0.7041.00
10_F34_G0.7001.00
133_F169_L0.7001.00
38_L42_L0.6991.00
107_I153_F0.6941.00
125_L134_A0.6911.00
93_S96_V0.6811.00
126_V130_P0.6791.00
163_E167_R0.6791.00
142_F146_I0.6791.00
139_L144_P0.6771.00
134_A138_F0.6771.00
9_V50_L0.6761.00
132_S135_V0.6691.00
22_N55_T0.6661.00
125_L147_Y0.6661.00
9_V99_A0.6651.00
126_V129_A0.6641.00
132_S136_S0.6631.00
16_S197_Y0.6611.00
16_S22_N0.6481.00
81_C94_S0.6431.00
34_G38_L0.6411.00
37_S110_L0.6391.00
137_S140_G0.6391.00
44_S122_L0.6361.00
107_I149_S0.6351.00
129_A147_Y0.6341.00
37_S41_A0.6331.00
35_S73_Q0.6311.00
49_V76_W0.6261.00
165_A168_L0.6231.00
50_L99_A0.6150.99
28_L201_R0.6140.99
195_E199_M0.6130.99
10_F110_L0.6130.99
123_N126_V0.6110.99
162_D167_R0.6110.99
7_I100_E0.6080.99
41_A46_L0.6050.99
46_L108_V0.5990.99
34_G67_Y0.5960.99
79_H95_G0.5950.99
194_P198_D0.5910.99
156_V168_L0.5900.99
88_Q91_S0.5860.99
8_G37_S0.5860.99
39_K42_L0.5840.99
156_V165_A0.5800.99
61_E65_A0.5790.99
13_A88_Q0.5780.99
52_V94_S0.5760.99
33_I197_Y0.5760.99
114_Q188_L0.5760.99
52_V81_C0.5730.99
27_P31_E0.5720.99
34_G51_V0.5690.99
52_V91_S0.5690.99
166_R169_L0.5680.99
14_G18_R0.5640.99
124_A180_L0.5620.99
75_R78_L0.5590.99
6_L46_L0.5570.99
19_M197_Y0.5550.99
100_E104_A0.5540.99
116_Q189_D0.5520.99
27_P197_Y0.5520.99
22_N63_I0.5500.99
11_L111_L0.5450.99
133_F152_C0.5430.99
89_G93_S0.5390.99
177_G182_A0.5380.99
114_Q144_P0.5370.99
132_S152_C0.5360.99
170_K173_Q0.5340.99
140_G144_P0.5330.99
105_D150_S0.5320.98
182_A187_E0.5270.98
53_E63_I0.5210.98
153_F156_V0.5180.98
111_L144_P0.5180.98
125_L136_S0.5130.98
185_S188_L0.5110.98
24_L33_I0.5110.98
63_I67_Y0.5100.98
164_G190_D0.5080.98
27_P201_R0.5060.98
22_N25_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2weeA 1 0.9415 100 0.233 Contact Map
2wawA 1 0.9463 100 0.236 Contact Map
1e5kA 1 0.8829 100 0.275 Contact Map
3d5nA 2 0.8683 100 0.299 Contact Map
2e8bA 1 0.8439 100 0.306 Contact Map
3ngwA 2 0.8732 100 0.339 Contact Map
2xwlA 2 0.9171 100 0.426 Contact Map
4jd0A 1 0.9512 100 0.429 Contact Map
1vpaA 2 0.9268 100 0.429 Contact Map
1i52A 2 0.922 100 0.43 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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