XDHC - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

XDHC - Probable xanthine dehydrogenase subunit C

UniProt:	O32145	Sequences: MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQLQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSDAASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEEDFRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITPRRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	277 (262)
Sequences:	5984 (4085)
Seq/√Len:	252.4

ECOLI - XDHB YAGS YGFM
BACSU - XDHC
SULSO - Q97VI7 Q97W13

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
220_R	225_E	3.751	1.00
139_E	149_R	3.628	1.00
77_S	168_R	3.379	1.00
141_I	170_I	3.248	1.00
142_V	150_L	3.003	1.00
141_I	168_R	2.991	1.00
68_G	82_T	2.755	1.00
148_I	164_A	2.742	1.00
141_I	147_L	2.536	1.00
123_A	166_V	2.484	1.00
27_L	36_A	2.448	1.00
149_R	170_I	2.323	1.00
206_S	229_M	2.287	1.00
75_H	170_I	2.216	1.00
243_I	264_A	2.164	1.00
151_P	154_A	2.139	1.00
143_Y	147_L	2.088	1.00
71_T	173_R	2.082	1.00
67_R	86_E	2.062	1.00
82_T	87_C	2.008	1.00
16_R	62_G	1.988	1.00
76_V	93_I	1.937	1.00
19_A	22_E	1.936	1.00
141_I	149_R	1.918	1.00
15_W	56_H	1.915	1.00
140_L	166_V	1.840	1.00
137_G	153_G	1.822	1.00
142_V	160_D	1.810	1.00
202_L	206_S	1.800	1.00
77_S	170_I	1.776	1.00
60_L	81_L	1.763	1.00
143_Y	167_T	1.760	1.00
85_N	114_S	1.752	1.00
25_S	29_K	1.750	1.00
18_A	22_E	1.740	1.00
21_D	143_Y	1.740	1.00
83_S	86_E	1.735	1.00
150_L	159_E	1.723	1.00
71_T	96_A	1.653	1.00
15_W	26_L	1.633	1.00
78_I	87_C	1.630	1.00
139_E	170_I	1.627	1.00
233_W	238_L	1.627	1.00
184_L	262_A	1.618	1.00
85_N	89_K	1.612	1.00
72_S	77_S	1.608	1.00
70_S	77_S	1.607	1.00
119_G	166_V	1.594	1.00
196_V	212_G	1.588	1.00
128_D	183_K	1.557	1.00
239_Y	268_M	1.554	1.00
139_E	151_P	1.549	1.00
27_L	58_V	1.531	1.00
36_A	165_I	1.530	1.00
125_K	158_E	1.502	1.00
226_A	229_M	1.472	1.00
140_L	152_L	1.465	1.00
147_L	167_T	1.457	1.00
36_A	60_L	1.455	1.00
211_A	221_L	1.452	1.00
182_H	273_A	1.449	1.00
75_H	173_R	1.432	1.00
201_F	207_I	1.430	1.00
246_L	263_A	1.400	1.00
153_G	222_L	1.395	1.00
33_D	55_Q	1.388	1.00
223_D	245_E	1.385	1.00
199_G	209_L	1.383	1.00
24_Y	144_Q	1.377	1.00
227_K	237_E	1.367	1.00
20_L	165_I	1.353	1.00
26_L	58_V	1.351	1.00
199_G	270_E	1.345	1.00
207_I	229_M	1.343	1.00
211_A	263_A	1.340	1.00
23_A	165_I	1.334	1.00
261_K	265_N	1.328	1.00
37_A	57_L	1.325	1.00
177_E	200_R	1.324	1.00
131_P	212_G	1.320	1.00
74_T	173_R	1.316	1.00
13_Q	56_H	1.309	1.00
223_D	226_A	1.307	1.00
127_G	130_I	1.294	1.00
27_L	163_T	1.287	1.00
38_S	81_L	1.287	1.00
61_E	83_S	1.284	1.00
134_L	152_L	1.275	1.00
84_L	116_A	1.270	1.00
221_L	224_S	1.265	1.00
182_H	269_A	1.264	1.00
96_A	173_R	1.253	1.00
180_F	273_A	1.246	1.00
72_S	75_H	1.235	1.00
222_L	226_A	1.235	1.00
35_C	52_L	1.233	1.00
17_P	60_L	1.223	1.00
84_L	129_F	1.222	1.00
235_P	272_M	1.222	1.00
14_L	59_S	1.218	1.00
20_L	143_Y	1.211	1.00
24_Y	143_Y	1.200	1.00
71_T	92_L	1.196	1.00
177_E	202_L	1.188	1.00
64_D	67_R	1.186	1.00
16_R	59_S	1.180	1.00
231_P	237_E	1.180	1.00
242_L	267_I	1.177	1.00
67_R	83_S	1.171	1.00
224_S	245_E	1.164	1.00
185_G	191_T	1.162	1.00
22_E	25_S	1.158	1.00
118_I	169_V	1.154	1.00
268_M	272_M	1.153	1.00
34_V	58_V	1.152	1.00
77_S	141_I	1.151	1.00
24_Y	165_I	1.146	1.00
17_P	22_E	1.138	1.00
78_I	171_I	1.135	1.00
135_V	210_A	1.129	1.00
250_S	256_A	1.122	1.00
184_L	266_V	1.119	1.00
234_D	237_E	1.116	1.00
92_L	96_A	1.114	1.00
103_A	132_L	1.096	1.00
178_R	274_E	1.096	1.00
36_A	58_V	1.087	1.00
69_I	90_N	1.080	1.00
100_F	129_F	1.077	1.00
130_I	156_L	1.075	1.00
20_L	24_Y	1.069	1.00
142_V	164_A	1.062	1.00
84_L	107_V	1.061	1.00
107_V	116_A	1.060	1.00
87_C	118_I	1.060	1.00
227_K	231_P	1.057	1.00
80_G	119_G	1.057	1.00
69_I	82_T	1.051	1.00
231_P	240_K	1.042	1.00
22_E	26_L	1.039	1.00
211_A	214_A	1.027	1.00
85_N	88_R	1.024	1.00
68_G	168_R	1.020	1.00
102_D	273_A	1.005	1.00
227_K	240_K	0.998	1.00
270_E	274_E	0.995	1.00
38_S	117_T	0.994	1.00
209_L	224_S	0.986	1.00
221_L	245_E	0.982	1.00
99_C	179_V	0.974	1.00
256_A	260_K	0.972	1.00
235_P	239_Y	0.970	1.00
133_L	140_L	0.959	1.00
161_F	164_A	0.957	1.00
265_N	269_A	0.956	1.00
122_I	133_L	0.951	1.00
21_D	65_E	0.949	1.00
37_A	40_S	0.945	1.00
42_L	124_S	0.926	1.00
207_I	228_W	0.922	1.00
91_P	95_R	0.919	1.00
193_A	196_V	0.916	1.00
214_A	263_A	0.914	1.00
31_A	56_H	0.914	1.00
200_R	208_R	0.909	1.00
75_H	172_P	0.908	1.00
100_F	132_L	0.906	1.00
232_G	237_E	0.902	1.00
83_S	117_T	0.900	1.00
134_L	153_G	0.893	1.00
28_E	163_T	0.892	1.00
20_L	65_E	0.880	1.00
261_K	264_A	0.872	1.00
85_N	110_P	0.869	1.00
18_A	62_G	0.869	1.00
71_T	76_V	0.869	1.00
67_R	81_L	0.867	1.00
254_M	259_R	0.864	0.99
84_L	104_A	0.863	0.99
211_A	267_I	0.861	0.99
179_V	200_R	0.857	0.99
28_E	145_K	0.852	0.99
78_I	118_I	0.845	0.99
182_H	270_E	0.843	0.99
252_V	260_K	0.839	0.99
134_L	156_L	0.837	0.99
153_G	220_R	0.835	0.99
118_I	129_F	0.835	0.99
250_S	257_A	0.834	0.99
122_I	253_F	0.834	0.99
248_F	251_D	0.826	0.99
121_N	129_F	0.825	0.99
133_L	171_I	0.824	0.99
60_L	165_I	0.818	0.99
104_A	107_V	0.817	0.99
140_L	155_W	0.811	0.99
92_L	95_R	0.808	0.99
238_L	271_L	0.806	0.99
133_L	138_A	0.806	0.99
61_E	81_L	0.805	0.99
72_S	170_I	0.801	0.99
82_T	118_I	0.798	0.99
23_A	63_I	0.796	0.99
142_V	148_I	0.794	0.99
137_G	220_R	0.794	0.99
175_E	202_L	0.790	0.99
155_W	159_E	0.788	0.99
237_E	240_K	0.788	0.99
251_D	259_R	0.788	0.99
197_A	266_V	0.784	0.99
210_A	220_R	0.782	0.99
40_S	44_Q	0.781	0.99
223_D	244_H	0.775	0.99
141_I	167_T	0.774	0.99
256_A	259_R	0.772	0.99
181_Y	196_V	0.770	0.99
233_W	237_E	0.768	0.99
21_D	25_S	0.768	0.99
88_R	105_S	0.767	0.99
145_K	163_T	0.766	0.99
251_D	255_S	0.763	0.99
222_L	225_E	0.763	0.99
76_V	173_R	0.763	0.99
152_L	156_L	0.762	0.99
95_R	98_S	0.760	0.99
48_D	109_A	0.760	0.99
97_L	171_I	0.759	0.99
144_Q	164_A	0.757	0.99
228_W	241_T	0.755	0.99
176_G	202_L	0.754	0.99
245_E	248_F	0.753	0.99
24_Y	145_K	0.752	0.99
131_P	196_V	0.750	0.99
182_H	266_V	0.748	0.99
148_I	161_F	0.745	0.98
71_T	75_H	0.744	0.98
20_L	66_M	0.742	0.98
231_P	234_D	0.738	0.98
37_A	44_Q	0.735	0.98
137_G	208_R	0.734	0.98
87_C	129_F	0.732	0.98
237_E	241_T	0.731	0.98
41_T	121_N	0.730	0.98
260_K	264_A	0.730	0.98
135_V	198_A	0.729	0.98
76_V	97_L	0.725	0.98
66_M	81_L	0.721	0.98
102_D	180_F	0.719	0.98
122_I	169_V	0.710	0.98
153_G	208_R	0.709	0.98
215_D	219_R	0.704	0.98
82_T	86_E	0.698	0.98
136_L	171_I	0.694	0.98
34_V	56_H	0.693	0.98
138_A	171_I	0.690	0.98
41_T	109_A	0.688	0.97
90_N	93_I	0.685	0.97
195_A	214_A	0.683	0.97
42_L	191_T	0.677	0.97
84_L	108_A	0.677	0.97
251_D	254_M	0.675	0.97
31_A	34_V	0.675	0.97
97_L	173_R	0.669	0.97
23_A	36_A	0.667	0.97
236_H	240_K	0.666	0.97
42_L	192_G	0.666	0.97
118_I	133_L	0.666	0.97
70_S	168_R	0.664	0.97
102_D	179_V	0.663	0.97
42_L	45_L	0.663	0.97
160_D	163_T	0.661	0.97
37_A	43_L	0.658	0.97
186_R	194_A	0.657	0.97
208_R	220_R	0.656	0.97
137_G	151_P	0.656	0.97
35_C	124_S	0.655	0.97
99_C	136_L	0.653	0.97
124_S	127_G	0.652	0.97
88_R	104_A	0.649	0.96
69_I	78_I	0.644	0.96
209_L	221_L	0.643	0.96
185_G	192_G	0.643	0.96
187_R	191_T	0.643	0.96
155_W	160_D	0.640	0.96
203_K	230_A	0.639	0.96
252_V	257_A	0.636	0.96
94_K	101_S	0.634	0.96
142_V	161_F	0.633	0.96
109_A	183_K	0.633	0.96
108_A	112_I	0.630	0.96
108_A	190_F	0.629	0.96
142_V	159_E	0.629	0.96
254_M	257_A	0.628	0.96
138_A	169_V	0.628	0.96
67_R	82_T	0.627	0.96
82_T	119_G	0.625	0.96
17_P	20_L	0.623	0.96
125_K	156_L	0.619	0.95
38_S	60_L	0.619	0.95
125_K	130_I	0.618	0.95
156_L	218_P	0.612	0.95
68_G	86_E	0.612	0.95
199_G	274_E	0.610	0.95
170_I	173_R	0.607	0.95
238_L	241_T	0.605	0.95
186_R	191_T	0.604	0.95
102_D	106_A	0.603	0.95
219_R	246_L	0.601	0.95
99_C	200_R	0.600	0.95
152_L	155_W	0.599	0.94
75_H	171_I	0.597	0.94
31_A	55_Q	0.597	0.94
242_L	247_P	0.596	0.94
73_D	173_R	0.596	0.94
153_G	156_L	0.596	0.94
126_I	213_H	0.596	0.94
265_N	268_M	0.594	0.94
224_S	242_L	0.589	0.94
179_V	198_A	0.588	0.94
21_D	147_L	0.583	0.94
134_L	210_A	0.583	0.94
124_S	192_G	0.583	0.94
215_D	218_P	0.581	0.94
28_E	144_Q	0.578	0.93
134_L	218_P	0.577	0.93
84_L	118_I	0.577	0.93
42_L	46_Q	0.576	0.93
192_G	213_H	0.576	0.93
128_D	181_Y	0.575	0.93
88_R	101_S	0.575	0.93
48_D	181_Y	0.573	0.93
117_T	120_G	0.573	0.93
140_L	156_L	0.573	0.93
27_L	162_R	0.572	0.93
93_I	98_S	0.572	0.93
88_R	110_P	0.571	0.93
20_L	36_A	0.571	0.93
78_I	82_T	0.570	0.93
66_M	80_G	0.566	0.93
41_T	128_D	0.566	0.93
224_S	241_T	0.564	0.93
15_W	22_E	0.563	0.92
185_G	189_A	0.562	0.92
127_G	193_A	0.562	0.92
201_F	274_E	0.562	0.92
65_E	68_G	0.558	0.92
24_Y	28_E	0.557	0.92
156_L	217_T	0.555	0.92
262_A	265_N	0.554	0.92
140_L	150_L	0.551	0.92
262_A	266_V	0.551	0.92
109_A	112_I	0.550	0.92
257_A	261_K	0.550	0.92
183_K	193_A	0.549	0.91
60_L	66_M	0.547	0.91
207_I	225_E	0.546	0.91
75_H	97_L	0.544	0.91
93_I	96_A	0.541	0.91
236_H	239_Y	0.541	0.91
187_R	192_G	0.540	0.91
137_G	172_P	0.540	0.91
84_L	121_N	0.538	0.91
157_S	216_I	0.537	0.91
87_C	104_A	0.536	0.91
174_A	177_E	0.535	0.90
214_A	246_L	0.531	0.90
144_Q	161_F	0.530	0.90
20_L	23_A	0.529	0.90
209_L	267_I	0.528	0.90
71_T	74_T	0.528	0.90
251_D	256_A	0.526	0.90
84_L	87_C	0.525	0.90
101_S	105_S	0.523	0.89
224_S	227_K	0.521	0.89
25_S	145_K	0.521	0.89
248_F	254_M	0.521	0.89
155_W	158_E	0.519	0.89
27_L	35_C	0.518	0.89
98_S	101_S	0.517	0.89
235_P	268_M	0.516	0.89
84_L	191_T	0.515	0.89
194_A	258_Y	0.512	0.88
257_A	260_K	0.511	0.88
87_C	133_L	0.511	0.88
46_Q	52_L	0.511	0.88
93_I	97_L	0.511	0.88
221_L	248_F	0.510	0.88
127_G	192_G	0.509	0.88
48_D	128_D	0.508	0.88
12_I	57_L	0.508	0.88
93_I	101_S	0.502	0.87
36_A	163_T	0.500	0.87
27_L	34_V	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rm6B	1	0.9675	100	0.146	Contact Map
1t3qC	1	0.9675	100	0.174	Contact Map
1n62C	1	0.9747	100	0.177	Contact Map
3zyvA	3	0.9964	100	0.187	Contact Map
3hrdC	1	0.9711	100	0.202	Contact Map
2w3sA	1	0.9531	100	0.203	Contact Map
1ffvC	1	0.9747	100	0.207	Contact Map
3nvzB	1	0.9928	100	0.218	Contact Map
3uncA	2	0.9964	100	0.221	Contact Map
4pytA	1	0.8375	98	0.88	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.