GREMLIN Database
XDHC - Probable xanthine dehydrogenase subunit C
UniProt: O32145 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (262)
Sequences: 5984 (4085)
Seq/√Len: 252.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_R225_E3.7511.00
139_E149_R3.6281.00
77_S168_R3.3791.00
141_I170_I3.2481.00
142_V150_L3.0031.00
141_I168_R2.9911.00
68_G82_T2.7551.00
148_I164_A2.7421.00
141_I147_L2.5361.00
123_A166_V2.4841.00
27_L36_A2.4481.00
149_R170_I2.3231.00
206_S229_M2.2871.00
75_H170_I2.2161.00
243_I264_A2.1641.00
151_P154_A2.1391.00
143_Y147_L2.0881.00
71_T173_R2.0821.00
67_R86_E2.0621.00
82_T87_C2.0081.00
16_R62_G1.9881.00
76_V93_I1.9371.00
19_A22_E1.9361.00
141_I149_R1.9181.00
15_W56_H1.9151.00
140_L166_V1.8401.00
137_G153_G1.8221.00
142_V160_D1.8101.00
202_L206_S1.8001.00
77_S170_I1.7761.00
60_L81_L1.7631.00
143_Y167_T1.7601.00
85_N114_S1.7521.00
25_S29_K1.7501.00
18_A22_E1.7401.00
21_D143_Y1.7401.00
83_S86_E1.7351.00
150_L159_E1.7231.00
71_T96_A1.6531.00
15_W26_L1.6331.00
78_I87_C1.6301.00
139_E170_I1.6271.00
233_W238_L1.6271.00
184_L262_A1.6181.00
85_N89_K1.6121.00
72_S77_S1.6081.00
70_S77_S1.6071.00
119_G166_V1.5941.00
196_V212_G1.5881.00
128_D183_K1.5571.00
239_Y268_M1.5541.00
139_E151_P1.5491.00
27_L58_V1.5311.00
36_A165_I1.5301.00
125_K158_E1.5021.00
226_A229_M1.4721.00
140_L152_L1.4651.00
147_L167_T1.4571.00
36_A60_L1.4551.00
211_A221_L1.4521.00
182_H273_A1.4491.00
75_H173_R1.4321.00
201_F207_I1.4301.00
246_L263_A1.4001.00
153_G222_L1.3951.00
33_D55_Q1.3881.00
223_D245_E1.3851.00
199_G209_L1.3831.00
24_Y144_Q1.3771.00
227_K237_E1.3671.00
20_L165_I1.3531.00
26_L58_V1.3511.00
199_G270_E1.3451.00
207_I229_M1.3431.00
211_A263_A1.3401.00
23_A165_I1.3341.00
261_K265_N1.3281.00
37_A57_L1.3251.00
177_E200_R1.3241.00
131_P212_G1.3201.00
74_T173_R1.3161.00
13_Q56_H1.3091.00
223_D226_A1.3071.00
127_G130_I1.2941.00
27_L163_T1.2871.00
38_S81_L1.2871.00
61_E83_S1.2841.00
134_L152_L1.2751.00
84_L116_A1.2701.00
221_L224_S1.2651.00
182_H269_A1.2641.00
96_A173_R1.2531.00
180_F273_A1.2461.00
72_S75_H1.2351.00
222_L226_A1.2351.00
35_C52_L1.2331.00
17_P60_L1.2231.00
84_L129_F1.2221.00
235_P272_M1.2221.00
14_L59_S1.2181.00
20_L143_Y1.2111.00
24_Y143_Y1.2001.00
71_T92_L1.1961.00
177_E202_L1.1881.00
64_D67_R1.1861.00
16_R59_S1.1801.00
231_P237_E1.1801.00
242_L267_I1.1771.00
67_R83_S1.1711.00
224_S245_E1.1641.00
185_G191_T1.1621.00
22_E25_S1.1581.00
118_I169_V1.1541.00
268_M272_M1.1531.00
34_V58_V1.1521.00
77_S141_I1.1511.00
24_Y165_I1.1461.00
17_P22_E1.1381.00
78_I171_I1.1351.00
135_V210_A1.1291.00
250_S256_A1.1221.00
184_L266_V1.1191.00
234_D237_E1.1161.00
92_L96_A1.1141.00
103_A132_L1.0961.00
178_R274_E1.0961.00
36_A58_V1.0871.00
69_I90_N1.0801.00
100_F129_F1.0771.00
130_I156_L1.0751.00
20_L24_Y1.0691.00
142_V164_A1.0621.00
84_L107_V1.0611.00
107_V116_A1.0601.00
87_C118_I1.0601.00
227_K231_P1.0571.00
80_G119_G1.0571.00
69_I82_T1.0511.00
231_P240_K1.0421.00
22_E26_L1.0391.00
211_A214_A1.0271.00
85_N88_R1.0241.00
68_G168_R1.0201.00
102_D273_A1.0051.00
227_K240_K0.9981.00
270_E274_E0.9951.00
38_S117_T0.9941.00
209_L224_S0.9861.00
221_L245_E0.9821.00
99_C179_V0.9741.00
256_A260_K0.9721.00
235_P239_Y0.9701.00
133_L140_L0.9591.00
161_F164_A0.9571.00
265_N269_A0.9561.00
122_I133_L0.9511.00
21_D65_E0.9491.00
37_A40_S0.9451.00
42_L124_S0.9261.00
207_I228_W0.9221.00
91_P95_R0.9191.00
193_A196_V0.9161.00
214_A263_A0.9141.00
31_A56_H0.9141.00
200_R208_R0.9091.00
75_H172_P0.9081.00
100_F132_L0.9061.00
232_G237_E0.9021.00
83_S117_T0.9001.00
134_L153_G0.8931.00
28_E163_T0.8921.00
20_L65_E0.8801.00
261_K264_A0.8721.00
85_N110_P0.8691.00
18_A62_G0.8691.00
71_T76_V0.8691.00
67_R81_L0.8671.00
254_M259_R0.8640.99
84_L104_A0.8630.99
211_A267_I0.8610.99
179_V200_R0.8570.99
28_E145_K0.8520.99
78_I118_I0.8450.99
182_H270_E0.8430.99
252_V260_K0.8390.99
134_L156_L0.8370.99
153_G220_R0.8350.99
118_I129_F0.8350.99
250_S257_A0.8340.99
122_I253_F0.8340.99
248_F251_D0.8260.99
121_N129_F0.8250.99
133_L171_I0.8240.99
60_L165_I0.8180.99
104_A107_V0.8170.99
140_L155_W0.8110.99
92_L95_R0.8080.99
238_L271_L0.8060.99
133_L138_A0.8060.99
61_E81_L0.8050.99
72_S170_I0.8010.99
82_T118_I0.7980.99
23_A63_I0.7960.99
142_V148_I0.7940.99
137_G220_R0.7940.99
175_E202_L0.7900.99
155_W159_E0.7880.99
237_E240_K0.7880.99
251_D259_R0.7880.99
197_A266_V0.7840.99
210_A220_R0.7820.99
40_S44_Q0.7810.99
223_D244_H0.7750.99
141_I167_T0.7740.99
256_A259_R0.7720.99
181_Y196_V0.7700.99
233_W237_E0.7680.99
21_D25_S0.7680.99
88_R105_S0.7670.99
145_K163_T0.7660.99
251_D255_S0.7630.99
222_L225_E0.7630.99
76_V173_R0.7630.99
152_L156_L0.7620.99
95_R98_S0.7600.99
48_D109_A0.7600.99
97_L171_I0.7590.99
144_Q164_A0.7570.99
228_W241_T0.7550.99
176_G202_L0.7540.99
245_E248_F0.7530.99
24_Y145_K0.7520.99
131_P196_V0.7500.99
182_H266_V0.7480.99
148_I161_F0.7450.98
71_T75_H0.7440.98
20_L66_M0.7420.98
231_P234_D0.7380.98
37_A44_Q0.7350.98
137_G208_R0.7340.98
87_C129_F0.7320.98
237_E241_T0.7310.98
41_T121_N0.7300.98
260_K264_A0.7300.98
135_V198_A0.7290.98
76_V97_L0.7250.98
66_M81_L0.7210.98
102_D180_F0.7190.98
122_I169_V0.7100.98
153_G208_R0.7090.98
215_D219_R0.7040.98
82_T86_E0.6980.98
136_L171_I0.6940.98
34_V56_H0.6930.98
138_A171_I0.6900.98
41_T109_A0.6880.97
90_N93_I0.6850.97
195_A214_A0.6830.97
42_L191_T0.6770.97
84_L108_A0.6770.97
251_D254_M0.6750.97
31_A34_V0.6750.97
97_L173_R0.6690.97
23_A36_A0.6670.97
236_H240_K0.6660.97
42_L192_G0.6660.97
118_I133_L0.6660.97
70_S168_R0.6640.97
102_D179_V0.6630.97
42_L45_L0.6630.97
160_D163_T0.6610.97
37_A43_L0.6580.97
186_R194_A0.6570.97
208_R220_R0.6560.97
137_G151_P0.6560.97
35_C124_S0.6550.97
99_C136_L0.6530.97
124_S127_G0.6520.97
88_R104_A0.6490.96
69_I78_I0.6440.96
209_L221_L0.6430.96
185_G192_G0.6430.96
187_R191_T0.6430.96
155_W160_D0.6400.96
203_K230_A0.6390.96
252_V257_A0.6360.96
94_K101_S0.6340.96
142_V161_F0.6330.96
109_A183_K0.6330.96
108_A112_I0.6300.96
108_A190_F0.6290.96
142_V159_E0.6290.96
254_M257_A0.6280.96
138_A169_V0.6280.96
67_R82_T0.6270.96
82_T119_G0.6250.96
17_P20_L0.6230.96
125_K156_L0.6190.95
38_S60_L0.6190.95
125_K130_I0.6180.95
156_L218_P0.6120.95
68_G86_E0.6120.95
199_G274_E0.6100.95
170_I173_R0.6070.95
238_L241_T0.6050.95
186_R191_T0.6040.95
102_D106_A0.6030.95
219_R246_L0.6010.95
99_C200_R0.6000.95
152_L155_W0.5990.94
75_H171_I0.5970.94
31_A55_Q0.5970.94
242_L247_P0.5960.94
73_D173_R0.5960.94
153_G156_L0.5960.94
126_I213_H0.5960.94
265_N268_M0.5940.94
224_S242_L0.5890.94
179_V198_A0.5880.94
21_D147_L0.5830.94
134_L210_A0.5830.94
124_S192_G0.5830.94
215_D218_P0.5810.94
28_E144_Q0.5780.93
134_L218_P0.5770.93
84_L118_I0.5770.93
42_L46_Q0.5760.93
192_G213_H0.5760.93
128_D181_Y0.5750.93
88_R101_S0.5750.93
48_D181_Y0.5730.93
117_T120_G0.5730.93
140_L156_L0.5730.93
27_L162_R0.5720.93
93_I98_S0.5720.93
88_R110_P0.5710.93
20_L36_A0.5710.93
78_I82_T0.5700.93
66_M80_G0.5660.93
41_T128_D0.5660.93
224_S241_T0.5640.93
15_W22_E0.5630.92
185_G189_A0.5620.92
127_G193_A0.5620.92
201_F274_E0.5620.92
65_E68_G0.5580.92
24_Y28_E0.5570.92
156_L217_T0.5550.92
262_A265_N0.5540.92
140_L150_L0.5510.92
262_A266_V0.5510.92
109_A112_I0.5500.92
257_A261_K0.5500.92
183_K193_A0.5490.91
60_L66_M0.5470.91
207_I225_E0.5460.91
75_H97_L0.5440.91
93_I96_A0.5410.91
236_H239_Y0.5410.91
187_R192_G0.5400.91
137_G172_P0.5400.91
84_L121_N0.5380.91
157_S216_I0.5370.91
87_C104_A0.5360.91
174_A177_E0.5350.90
214_A246_L0.5310.90
144_Q161_F0.5300.90
20_L23_A0.5290.90
209_L267_I0.5280.90
71_T74_T0.5280.90
251_D256_A0.5260.90
84_L87_C0.5250.90
101_S105_S0.5230.89
224_S227_K0.5210.89
25_S145_K0.5210.89
248_F254_M0.5210.89
155_W158_E0.5190.89
27_L35_C0.5180.89
98_S101_S0.5170.89
235_P268_M0.5160.89
84_L191_T0.5150.89
194_A258_Y0.5120.88
257_A260_K0.5110.88
87_C133_L0.5110.88
46_Q52_L0.5110.88
93_I97_L0.5110.88
221_L248_F0.5100.88
127_G192_G0.5090.88
48_D128_D0.5080.88
12_I57_L0.5080.88
93_I101_S0.5020.87
36_A163_T0.5000.87
27_L34_V0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6B 1 0.9675 100 0.146 Contact Map
1t3qC 1 0.9675 100 0.174 Contact Map
1n62C 1 0.9747 100 0.177 Contact Map
3zyvA 3 0.9964 100 0.187 Contact Map
3hrdC 1 0.9711 100 0.202 Contact Map
2w3sA 1 0.9531 100 0.203 Contact Map
1ffvC 1 0.9747 100 0.207 Contact Map
3nvzB 1 0.9928 100 0.218 Contact Map
3uncA 2 0.9964 100 0.221 Contact Map
4pytA 1 0.8375 98 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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